Experimental radiation synovectomy in rabbit knee with holmium-166 ferric hydroxide macroaggregate.

abstract：:Stavudine, a potent antiviral agent for treating human immunodeficiency virus (HIV) infections, was radiolabeled with (11)C by methylation of a specifically designed precursor, 5'-O-(2-tetrahydropyranyl)-5-bromo-2',3'-didehydro-3'-deoxythymidine, with (11)C H(3)I. The radiolabeled drug was isolated by reverse phase HP...

journal_title：Nuclear medicine and biology

authors： Livni E,Berker M,Hillier S,Waller SC,Ogan MD,Discordia RP,Rienhart JK,Rubin RH,Fischman AJ

更新日期：2004-07-01 00:00:00

abstract：:A glucose analogue labelled with iodine-123 in position 6 has been synthesized: [123I]-6-deoxy-6-iodo-D-glucose (6DIG). The aim of this study was to examine its biological behaviour in order to assess whether it could be used to evaluate glucose transport with SPECT. To establish whether 6DIG enters the cells using th...

journal_title：Nuclear medicine and biology

authors： Henry C,Koumanov F,Ghezzi C,Morin C,Mathieu JP,Vidal M,de Leiris J,Comet M,Fagret D

更新日期：1997-08-01 00:00:00

abstract：OBJECTIVES:Radiolabeled amino acids have proven utility for imaging brain tumors in humans, particularly those that target system L amino acid transport. We have prepared the novel phenylalanine analogue, (FMePhe, 9), as part of an effort to develop new system L tracers that can be prepared in high radiochemical yield ...

journal_title：Nuclear medicine and biology

authors： Huang C,Yuan L,Rich KM,McConathy J

更新日期：2013-05-01 00:00:00

abstract：:We have identified the value of 18F-fallypride [(S)-N-[(1-allyl-2-pyrrolidinyl)methyl]-5-(3-[18F]fluoropropyl)-2, 3-dimethoxybenzamide], as a dopamine D-2 receptor radiotracer for the study of striatal and extrastriatal receptors. Fallypride exhibits high affinities for D-2 and D-3 subtypes and low affinity for D-4 (3...

journal_title：Nuclear medicine and biology

authors： Mukherjee J,Yang ZY,Brown T,Lew R,Wernick M,Ouyang X,Yasillo N,Chen CT,Mintzer R,Cooper M

更新日期：1999-07-01 00:00:00

abstract：:Applications of oligodeoxynucleotides to modulate gene expression have been the subject of much recent research. We have sought to develop a method to permanently inactivate a gene, or potentially kill cells containing abnormal genes. In this report, we show that a DNA intercalator conjugated to a triplex-forming olig...

journal_title：Nuclear medicine and biology

authors： Orson FM,McShan WM,Kinsey BM

更新日期：1996-05-01 00:00:00

abstract：:Since elevated levels of gelatinases [matrix metalloproteinase (MMP)-2 and MMP-9] are associated with a poor prognosis in cancer patients, these enzymes are potential targets for tumor imaging. In the present study, a cyclic decapeptide, cCTTHWGFTLC (CTT), was selected as a mother compound because of its selective inh...

journal_title：Nuclear medicine and biology

authors： Hanaoka H,Mukai T,Habashita S,Asano D,Ogawa K,Kuroda Y,Akizawa H,Iida Y,Endo K,Saga T,Saji H

更新日期：2007-07-01 00:00:00

abstract：:Cholinergic system in the central nervous system is involved in the memory function. Thus, because the dysfunction of cholinergic system that project to the cerebral cortex from nucleus basalis of Meynert (nbM) would be implicated in the memory function deficits in Alzheimer's disease (AD), evaluating cholinergic func...

journal_title：Nuclear medicine and biology

authors： Ogawa M,Iida Y,Nakagawa M,Kuge Y,Kawashima H,Tominaga A,Ueda M,Magata Y,Saji H

更新日期：2006-02-01 00:00:00

abstract：:Most radioligands are substantially metabolised in peripheral organs during the course of positron emission tomography (PET) recordings. Accurate determination of plasma concentrations of unmetabolised radioligands is often important for quantification of data from PET studies. The fractions of untransformed radioliga...

journal_title：Nuclear medicine and biology

authors： Gillings NM,Bender D,Falborg L,Marthi K,Munk OL,Cumming P

更新日期：2001-01-01 00:00:00

abstract：INTRODUCTION:[(18)F]Nifene is a novel radiotracer specific to the nicotinic acetylcholine α4β2 receptor class. In preparation for using this tracer in humans we have performed whole-body PET studies in mice to evaluate the in vivo biodistribution and dosimetry of [(18)F]Nifene. METHODS:Seven BALB/c mice (3 males, 4 fe...

journal_title：Nuclear medicine and biology

authors： Constantinescu CC,Garcia A,Mirbolooki MR,Pan ML,Mukherjee J

更新日期：2013-02-01 00:00:00

abstract：:[11C]Methamphetamine, a psychotropic agent, was synthesized by N-methylation of amphetamine with [11C]CH3 I in hopes that it could be applied in the near future to assist positron emission tomography (PET) in the imaging of its distribution in the human brain. The regional distribution of [11C]methamphetamine was inve...

journal_title：Nuclear medicine and biology

authors： Mizugaki M,Hishinuma T,Nakamura H,Yamashita M,Shimomura K,Itoh K,Hirose A,Tomioka Y,Aso H,Edo K

更新日期：1993-05-01 00:00:00

abstract：INTRODUCTION:Radiolabeled 2-nitroimidazoles (azomycins) are a prominent class of biomarkers for PET imaging of hypoxia. [18F]Fluoro-azomycin-α-arabinoside ([18F]FAZA) - already in clinical use - may be seen as α-configuration nucleoside, but enters cells only via diffusion and is not transported by cellular nucleoside ...

journal_title：Nuclear medicine and biology

authors： Schweifer A,Maier F,Ehrlichmann W,Lamparter D,Kneilling M,Pichler BJ,Hammerschmidt F,Reischl G

更新日期：2016-12-01 00:00:00

abstract：INTRODUCTION:Severe brain hypoxia in the territory of the occluded artery is a key feature of ischemic stroke. This region can be imaged using positron emission tomography (PET) and the standard hypoxia radiotracer (18)F-fluoromisonidazole ((18)F-FMISO). However, the utility of (18)F-FMISO is limited by its slow accumu...

journal_title：Nuclear medicine and biology

authors： Williamson DJ,Ejaz S,Sitnikov S,Fryer TD,Sawiak SJ,Burke P,Baron JC,Aigbirhio FI

更新日期：2013-04-01 00:00:00

abstract：INTRODUCTION:This paper proposes liposomes as a potential new tool for radioimmunotherapy in solid tumours with a two step targeting system. Tumour pretargeting is obtained by using a monoclonal bispecific antibody (BsmAb, anti CEA x anti-DTPA-In) and pegylated liposomes containing lipid-hapten (DSPE-DTPA-In or DSPE-PE...

journal_title：Nuclear medicine and biology

authors： Rauscher A,Frindel M,Maurel C,Maillasson M,Le Saëc P,Rajerison H,Gestin JF,Barbet J,Faivre-Chauvet A,Mougin-Degraef M

更新日期：2014-05-01 00:00:00

abstract：INTRODUCTION:Bromodomain and extra-terminal domain (BET) family proteins play a vital role in the epigenetic regulation process by interacting with acetylated lysine (Ac-K) residues in histones. BET inhibitors have become promising candidates to treat various diseases through the inhibition of the interaction between B...

journal_title：Nuclear medicine and biology

authors： Bai P,Lu X,Lan Y,Chen Z,Patnaik D,Fiedler S,Striar R,Haggarty SJ,Wang C

更新日期：2020-01-01 00:00:00

abstract：INTRODUCTION:Our objective was to compare the cell penetration and nuclear importation properties of 111In-labeled and 123I-labeled immunoconjugates (ICs) composed of 16-mer peptides (GRKKRRQRRRPPQGYG) derived from HIV-1 transactivator of transcription (tat) protein and anti-mouse IgG (mIgG) in BT-474 breast cancer (BC...

journal_title：Nuclear medicine and biology

authors： Cornelissen B,Hu M,McLarty K,Costantini D,Reilly RM

更新日期：2007-01-01 00:00:00

abstract：:[(123)I]AIBZM, (S)-5-[(123)I]-Iodo-N-[(1-ethyl-2-pyrrolidinyl)]methyl-4-amine-2-methoxybenzamide is a derivative with high affinity for the D2 receptor. Labeling was achieved by the Iodogen method. The in vivo affinity for the D2 receptor and the biological characteristics were performed in rats. The brain uptake of [...

journal_title：Nuclear medicine and biology

authors： Li H,Gildehaus FJ,Dresel S,Patt JT,Shen M,Zhu T,Liu B,Tang Z,Tatsch K,Hahn K

更新日期：2001-05-01 00:00:00

abstract：:Because more and more PET centres are using small proton cyclotrons there is a renewed interest in methods for the production of electrophilic 18F by proton irradiation of [18O]O2. A method for the routine production of clinically useful quantities of [18F]F2 having a specific activity of 35 Ci/mmol has been developed...

journal_title：Nuclear medicine and biology

authors： Chirakal R,Adams RM,Firnau G,Schrobilgen GJ,Coates G,Garnett ES

更新日期：1995-01-01 00:00:00

abstract：INTRODUCTION:The tricyclic indole compound, [(18)F]GE-180 has been previously identified as a promising positron emission tomography (PET) imaging agent of the translocator protein (TSPO) with the potential to aid in the diagnosis, prognosis and therapy monitoring of degenerative neuroinflammatory conditions such as mu...

journal_title：Nuclear medicine and biology

authors： Chau WF,Black AM,Clarke A,Durrant C,Gausemel I,Khan I,Mantzilas D,Oulie I,Rogstad A,Trigg W,Jones PA

更新日期：2015-09-01 00:00:00

abstract：:Brofaromine (4-5(-methoxy-7-bromobenzofuranyl)-2-piperidine-HCl) is a potent and selective inhibitor of monoamine oxidase (MAO) A. Two methods for its synthesis and a preliminary positron emission tomography (PET) evaluation in monkey brain are described. The first method, at low carrier concentration of CO2, consiste...

journal_title：Nuclear medicine and biology

authors： Ametamey SM,Beer HF,Guenther I,Antonini A,Leenders KL,Waldmeier PC,Schubiger PA

更新日期：1996-04-01 00:00:00

abstract：:Pharmacokinetic computer simulations reveal a discrepancy between the in vivo and in vitro neuroreceptor subtype selectivity of radioligands. For radioligands with an in vitro neuroreceptor subtype selectivity between 0.1 and 10.0, the in vivo neuroreceptor subtype selectivity appears to be constrained to be between 0...

journal_title：Nuclear medicine and biology

authors： Zeeberg BR

更新日期：1999-10-01 00:00:00

abstract：:Copper-64-labeled monoclonal antibodies (mAbs) have previously demonstrated unexpectedly effective tumor control in rodent models of cancer at relatively low tumor-absorbed radiation doses. This property has been associated with delivery platforms resulting in cellular internalization. The purpose of the present studi...

journal_title：Nuclear medicine and biology

authors： Bryan JN,Jia F,Mohsin H,Sivaguru G,Miller WH,Anderson CJ,Henry CJ,Lewis MR

更新日期：2005-11-01 00:00:00

abstract：:We prepared 5-HT(1A) receptor ligands (S)-N-[[1-(2-phenylethyl)pyrrolidin-2-yl]methyl]-3-[11C]methylthiobenzamide ([11C](S)-PPMMB) (Ki = 4.3 nM) and the less active [(11)C](R)-PPMMB (Ki = 160 nM) by reduction of the disulfide dimer and subsequent [(11)C]methylation of demethyl (S)- and (R)-PPMMB, respectively. Both ra...

journal_title：Nuclear medicine and biology

authors： Fujio M,Nagata S,Kawamura K,Sugiyama N,Tanaka H,Uno K,Ishiwata K

更新日期：2002-08-01 00:00:00

abstract：:We report a single pass gas phase route to [11C]CH3I based on production of I from I2 at elevated temperature. I abstracts H from CH4 to yield CH3, which reacts with I2 to form CH3I. A fiber optic spectrometer was used to measure the I2 vapor concentration. [11C]CH3I yield increased with I2 concentration until excessi...

journal_title：Nuclear medicine and biology

authors： Link JM,Krohn KA,Clark JC

更新日期：1997-01-01 00:00:00

abstract：:The niobium-90 radioisotope ((90)Nb) holds considerable promise for use in immuno-PET, due to its decay parameters (t½ = 14.6h, positron yield=53%, Eß(+)(mean) = 0.35 MeV and Eß(+)(max) = 1.5 MeV). In particular, (90)Nb appears well suited to detect in vivo the pharmacokinetics of large targeting vectors (50-150 kDa)....

journal_title：Nuclear medicine and biology

authors： Radchenko V,Busse S,Roesch F

更新日期：2014-10-01 00:00:00

abstract：:The pyridopyrimidinones are a potent class of inhibitors of c-Abl kinase and Bcr-Abl kinase, the causative fusion protein in chronic myelogenous leukemia and Src family kinases. A novel method for routine, high-yield no-carrier-added synthesis of [(124)I]-, [(125)I]- and [(131)I]-6-(2,6-dichlorophenyl)-2-(4-iodophenyl...

journal_title：Nuclear medicine and biology

authors： Veach DR,Namavari M,Beresten T,Balatoni J,Minchenko M,Djaballah H,Finn RD,Clarkson B,Gelovani JG,Bornmann WG,Larson SM

更新日期：2005-05-01 00:00:00

abstract：:The thymidine analog 2'-fluoro-5-methyl-1-beta-D-arabinofuranosyluracil (FMAU) is incorporated into DNA and is resistant to catabolism. We performed pharmacokinetic measurements with [(14)C]FMAU and PET studies with [(11)C]FMAU using rats bearing several different syngeneic tumors. Among normal tissues, FMAU uptake re...

journal_title：Nuclear medicine and biology

authors： Bading JR,Shahinian AH,Vail A,Bathija P,Koszalka GW,Koda RT,Alauddin MM,Fissekis JD,Conti PS

更新日期：2004-05-01 00:00:00

abstract：:The hepatic and renal retention of indium-111 (111In) from 111In-labeled polypeptides has been the subject of many investigations. Because the lysosome is a common intracellular destination for the degradation of polypeptides, we studied the lysosomal metabolism of 111In-DTPA-labeled glycoproteins targeted to cell sur...

journal_title：Nuclear medicine and biology

authors： Franano FN,Edwards WB,Welch MJ,Duncan JR

更新日期：1994-11-01 00:00:00

abstract：:Two photolabile heterobifunctional O-nitrobenzyl reagents were used to modify B72.3 monoclonal antibody followed by immobilization on a solid support. Antibody was labeled with 99mTc and then cleaved from the resin on irradiation with light of peak intensity at 365 nm. The antibody was restored unmodified after cleava...

journal_title：Nuclear medicine and biology

authors： Ranadive GN,Bloomer WD

更新日期：1995-07-01 00:00:00

abstract：:The effect of acyclovir (ACV) on the metabolism of rat 9L-gliosarcoma cells expressing the herpes simplex virus-thymidine kinase gene was studied using 2-deoxy-2-[18F]fluoro-D-glucose (FDG) and L-[methyl-11C]methionine. Though the average weight of the tumors treated with ACV was significantly lower than that of the s...

journal_title：Nuclear medicine and biology

authors： Namba H,Iwadate Y,Iyo M,Fukushi K,Irie T,Sueyoshi K,Tagawa M,Sakiyama S

更新日期：1998-04-01 00:00:00

abstract：INTRODUCTION:Established radiotracers for positron emission tomography (PET) myocardial perfusion study are commonly labeled with short-lived radio-isotopes that limit their widespread clinical use. Thus, we synthesized (2-(2-[(18)F]fluoroethoxy)ethyl)tris(4-methoxyphenyl)phosphonium salt ([(18)F]FETMP) as a novel myoc...

journal_title：Nuclear medicine and biology

authors： Kim DY,Kim HJ,Yu KH,Min JJ

更新日期：2012-10-01 00:00:00