当前位置： SCI文献检索 > NUCLEAR MEDICINE AND BIOLOGY期刊下所有文献 > Preparation and biodistribution of copper-67-labeled porphyrins and porphyrin-A6H immunoconjugates.

Preparation and biodistribution of copper-67-labeled porphyrins and porphyrin-A6H immunoconjugates.

Abstract：

:The synthetic porphyrins, N-benzyl-5,10,15,20-tetrakis (4-carboxyphenyl) porphine (N-bzHTCPP) and N-4-nitrobenzyl-5-(4-carboxyphenyl)-10,15,20-tris(4-sulfophenyl) porphine (N-bzHCS3P), represent excellent radiocopper chelating agents that may find utility in antibody-mediated diagnosis and/or therapy. N-bzHCS3P was conjugated to an anti-renal cell carcinoma (RCC) antibody, A6H, and labeled with copper-67. 67CuCS3P-A6H was studied for its biodistribution in human RCC xenograft-bearing nude mice, along with the radiolabeled free porphyrins. The porphyrins resulted in tumor:blood ratios in the range of 3 to 4 after 48 h. The radiolabeled antibody achieved a tumor:blood ratio of over 16 after 45 h, indicating accumulation at the desired site. However, unwanted localization also occurred in the liver and spleen, which will have to be rectified before realizing the full potential of this approach.

journal_name

Nucl Med Biol

journal_title

Nuclear medicine and biology

authors

Bhalgat MK,Roberts JC,Mercer-Smith JA,Knotts BD,Vessella RL,Lavallee DK

doi

10.1016/s0969-8051(96)00215-6

subject

Has Abstract

pub_date

1997-02-01 00:00:00

pages

179-85

issue

2

eissn

0969-8051

issn

1872-9614

pii

S0969-8051(96)00215-6

journal_volume

24

pub_type

杂志文章

相关文献

NUCLEAR MEDICINE AND BIOLOGY文献大全
  • Whole-body distribution and radiation dosimetry of [11C]telmisartan as a biomarker for hepatic organic anion transporting polypeptide (OATP) 1B3.

    abstract：INTRODUCTION:Telmisartan, a nonpeptide angiotensin II AT1 receptor antagonist used as an antihypertensive drug, is specifically taken up by the liver through the OATP1B3. PET imaging with [(11)C]telmisartan is expected to provide information about the whole body pharmacokinetics of telmisartan as well as its transport ...

    journal_title：Nuclear medicine and biology

    pub_type： 临床试验,杂志文章

    doi：10.1016/j.nucmedbio.2012.01.008

    authors： Shimizu K,Takashima T,Yamane T,Sasaki M,Kageyama H,Hashizume Y,Maeda K,Sugiyama Y,Watanabe Y,Senda M

    更新日期：2012-08-01 00:00:00

  • In vitro evaluation of herpes simplex virus type 1 thymidine kinase reporter system in dynamic studies of transcriptional gene regulation.

    abstract：:The herpes simplex virus type 1 thymidine kinase (HSV1-TK) reporter system is being used to directly and indirectly monitor therapeutic gene expression, immune cell trafficking and protein-protein interactions in various living animals. However, the issues of HSV1-TK enzyme stability in living cells and whether this r...

    journal_title：Nuclear medicine and biology

    pub_type： 杂志文章

    doi：10.1016/j.nucmedbio.2006.04.001

    authors： Hsieh CH,Liu RS,Wang HE,Hwang JJ,Deng WP,Chen JC,Chen FD

    更新日期：2006-07-01 00:00:00

  • Synthesis, in vitro pharmacologic characterization, and preclinical evaluation of N-[2-(1'-piperidinyl)ethyl]-3-[125I]iodo-4-methoxybenzamide (P[125I]MBA) for imaging breast cancer.

    abstract：:The goal of this study was to investigate the potential use of a radioiodinated benzamide, N-[2-(1'-piperidinyl)ethyl]-3-iodo[125I]-4-methoxybenzamide (P[125I]MBA), a sigma receptor binding radioligand for imaging breast cancer. The chemical and radiochemical syntheses of PIMBA are described. The pharmacological evalu...

    journal_title：Nuclear medicine and biology

    pub_type： 杂志文章

    doi：10.1016/s0969-8051(98)00104-8

    authors： John CS,Bowen WD,Fisher SJ,Lim BB,Geyer BC,Vilner BJ,Wahl RL

    更新日期：1999-05-01 00:00:00

  • Biodistribution of (125)I-labeled anti-endoglin antibody using SPECT/CT imaging: Impact of in vivo deiodination on tumor accumulation in mice.

    abstract：INTRODUCTION:Radiolabeled antibodies directed against endoglin (CD105) are promising tools for imaging and antiangiogenic cancer therapy. To validate iodinated antibodies as reliable tracers, we investigated the influence of the radiolabeling method (direct or indirect) on their in vivo stability. METHODS:Anti-CD105 m...

    journal_title：Nuclear medicine and biology

    pub_type： 杂志文章

    doi：10.1016/j.nucmedbio.2016.03.007

    authors： Karmani L,Levêque P,Bouzin C,Bol A,Dieu M,Walrand S,Vander Borght T,Feron O,Grégoire V,Bonifazi D,Michiels C,Lucas S,Gallez B

    更新日期：2016-07-01 00:00:00

  • Methoxyphenylethynyl, methoxypyridylethynyl and phenylethynyl derivatives of pyridine: synthesis, radiolabeling and evaluation of new PET ligands for metabotropic glutamate subtype 5 receptors.

    abstract：:We have synthesized three different PET ligands to investigate the physiological function of metabotropic glutamate subtype 5 receptors (mGluR5) in vivo: 2-[(11)C]methyl-6-(2-phenylethynyl)pyridine ([(11)C]MPEP), 2-(2-(3-[(11)C]methoxyphenyl)ethynyl)pyridine ([(11)C]M-MPEP) and 2-(2-(5-[(11)C]methoxypyridin-3-yl)ethyn...

    journal_title：Nuclear medicine and biology

    pub_type： 杂志文章

    doi：10.1016/j.nucmedbio.2005.05.004

    authors： Yu M,Tueckmantel W,Wang X,Zhu A,Kozikowski AP,Brownell AL

    更新日期：2005-08-01 00:00:00

  • Glucose and methionine uptake by rat brain tumor treated with prodrug-activated gene therapy.

    abstract：:The effect of acyclovir (ACV) on the metabolism of rat 9L-gliosarcoma cells expressing the herpes simplex virus-thymidine kinase gene was studied using 2-deoxy-2-[18F]fluoro-D-glucose (FDG) and L-[methyl-11C]methionine. Though the average weight of the tumors treated with ACV was significantly lower than that of the s...

    journal_title：Nuclear medicine and biology

    pub_type： 杂志文章

    doi：10.1016/s0969-8051(97)00171-6

    authors： Namba H,Iwadate Y,Iyo M,Fukushi K,Irie T,Sueyoshi K,Tagawa M,Sakiyama S

    更新日期：1998-04-01 00:00:00

  • [11C]CURB: Evaluation of a novel radiotracer for imaging fatty acid amide hydrolase by positron emission tomography.

    abstract：INTRODUCTION:Fatty acid amide hydrolase (FAAH) is the enzyme responsible for metabolising the endogenous cannabinoid, anandamide, and thus represents an important target for molecular imaging. To date, no radiotracer has been shown to be useful for imaging of FAAH using either positron emission tomography (PET) or sing...

    journal_title：Nuclear medicine and biology

    pub_type： 杂志文章

    doi：10.1016/j.nucmedbio.2010.08.001

    authors： Wilson AA,Garcia A,Parkes J,Houle S,Tong J,Vasdev N

    更新日期：2011-02-01 00:00:00

  • Synthesis, characterization and theranostic evaluation of Indium-111 labeled multifunctional superparamagnetic iron oxide nanoparticles.

    abstract：:Indium-111 labeled, Trastuzumab-Doxorubicin Conjugated, and APTES-PEG coated magnetic nanoparticles were designed for tumor targeting, drug delivery, controlled drug release, and dual-modal tumor imaging. Superparamagnetic iron oxide nanoparticles (SPIONs) were synthesized by thermal decomposition method to obtain nar...

    journal_title：Nuclear medicine and biology

    pub_type： 杂志文章

    doi：10.1016/j.nucmedbio.2014.09.007

    authors： Zolata H,Abbasi Davani F,Afarideh H

    更新日期：2015-02-01 00:00:00

  • [⁶⁸Ga]NS₃-RGD and [⁶⁸Ga] Oxo-DO3A-RGD for imaging α(v)β₃ integrin expression: synthesis, evaluation, and comparison.

    abstract：INTRODUCTION:⁶⁸Ga-labeled RGD peptides in combination with PET allow non-invasive determination of α(v)β₃ integrin expression which is highly increased during tumor-induced angiogenesis. The aim of this study was to synthesize and evaluate two RGD peptides containing alternative chelating systems, namely [⁶⁸Ga]NS₃-RGD-...

    journal_title：Nuclear medicine and biology

    pub_type： 杂志文章

    doi：10.1016/j.nucmedbio.2012.09.006

    authors： Knetsch PA,Petrik M,Rangger C,Seidel G,Pietzsch HJ,Virgolini I,Decristoforo C,Haubner R

    更新日期：2013-01-01 00:00:00

  • Synthesis of [11C]interleukin 8 using a cell-free translation system and L-[11C]methionine.

    abstract：:Positron emission tomography (PET), which requires a compound labeled with a positron emitter radioisotope as an imaging probe, is one of the most useful and valuable imaging modalities in molecular imaging. It has several advantages over other imaging modalities, particularly in sensitive and quantitative investigati...

    journal_title：Nuclear medicine and biology

    pub_type： 杂志文章

    doi：10.1016/j.nucmedbio.2011.07.005

    authors： Harada R,Furumoto S,Yoshikawa T,Ishikawa Y,Shibuya K,Okamura N,Iwata R,Yanai K

    更新日期：2012-01-01 00:00:00

  • Radiochemical synthesis and in vivo evaluation of [18F]AZ11637326: an agonist probe for the α7 nicotinic acetylcholine receptor.

    abstract：INTRODUCTION:The alpha-7 nicotinic acetylcholine receptor (α7 nAChR) is key in brain communication and has been implicated in the pathophysiology of diseases of the central nervous system. A positron-emitting radioligand targeting the α7 nAChR would enable better understanding of a variety of neuropsychiatric illnesses...

    journal_title：Nuclear medicine and biology

    pub_type： 杂志文章

    doi：10.1016/j.nucmedbio.2013.04.005

    authors： Ravert HT,Dorff P,Foss CA,Mease RC,Fan H,Holmquist CR,Phillips E,McCarthy DJ,Heys JR,Holt DP,Wang Y,Endres CJ,Dannals RF,Pomper MG

    更新日期：2013-08-01 00:00:00

  • Desferrioxamine as an appropriate chelator for 90Nb: comparison of its complexation properties for M-Df-Octreotide (M = Nb, Fe, Ga, Zr).

    abstract：:The niobium-90 radioisotope ((90)Nb) holds considerable promise for use in immuno-PET, due to its decay parameters (t½ = 14.6h, positron yield=53%, Eß(+)(mean) = 0.35 MeV and Eß(+)(max) = 1.5 MeV). In particular, (90)Nb appears well suited to detect in vivo the pharmacokinetics of large targeting vectors (50-150 kDa)....

    journal_title：Nuclear medicine and biology

    pub_type： 杂志文章

    doi：10.1016/j.nucmedbio.2014.06.006

    authors： Radchenko V,Busse S,Roesch F

    更新日期：2014-10-01 00:00:00

  • Preparation and pharmacokinetics of 11C labeled stavudine (d4T).

    abstract：:Stavudine, a potent antiviral agent for treating human immunodeficiency virus (HIV) infections, was radiolabeled with (11)C by methylation of a specifically designed precursor, 5'-O-(2-tetrahydropyranyl)-5-bromo-2',3'-didehydro-3'-deoxythymidine, with (11)C H(3)I. The radiolabeled drug was isolated by reverse phase HP...

    journal_title：Nuclear medicine and biology

    pub_type： 杂志文章

    doi：10.1016/j.nucmedbio.2003.11.006

    authors： Livni E,Berker M,Hillier S,Waller SC,Ogan MD,Discordia RP,Rienhart JK,Rubin RH,Fischman AJ

    更新日期：2004-07-01 00:00:00

  • Comparison of (18)F-FET and (18)F-FLT small animal PET for the assessment of anti-VEGF treatment response in an orthotopic model of glioblastoma.

    abstract：BACKGROUND:The radiolabeled amino acid O-(2-(18)F-fluoroethyl)-L-tyrosine (FET) and thymidine analogue 3'-deoxy-3'-(18)F-fluorothymidine (FLT) are widely used for positron emission tomography (PET) brain tumor imaging; however, comparative studies are scarce. The aim of this study therefore was to compare FLT and FET P...

    journal_title：Nuclear medicine and biology

    pub_type： 杂志文章

    doi：10.1016/j.nucmedbio.2015.12.002

    authors： Nedergaard MK,Michaelsen SR,Perryman L,Erler J,Poulsen HS,Stockhausen MT,Lassen U,Kjaer A

    更新日期：2016-03-01 00:00:00

  • Cellular distribution of 111In-LDTPA galactose BSA in normal and asialoglycoprotein receptor-deficient mouse liver.

    abstract：:111In-LDTPA galactose BSA (bovine serum albumin) was used to evaluate the asialoglycoprotein receptor (ASGPR) system in both normal and ASGPR-deficient mice. The radiolabeled glycoprotein had complete liver uptake in both normal and ASGPR-deficient mice. Metabolism and hepatic cell-type distribution studies were perfo...

    journal_title：Nuclear medicine and biology

    pub_type： 杂志文章

    doi：10.1016/s0969-8051(97)00222-9

    authors： Deal KA,Cristel ME,Welch MJ

    更新日期：1998-05-01 00:00:00

  • Scintimammography with Tc-99m MIBI in patients with suspicion of primary breast cancer.

    abstract：:The aim of the study was to evaluate the diagnostic accuracy of scintimammography with Tc-99m MIBI for the detection of breast cancer. Patients with a suspicious lesion detected by palpation or mammography were included in the study. Excisional biopsy was performed on all patients. Mammography was performed within 3 w...

    journal_title：Nuclear medicine and biology

    pub_type： 临床试验,杂志文章

    doi：10.1016/0969-8051(96)00084-4

    authors： Palmedo H,Schomburg A,Grünwald F,Mallmann P,Boldt I,Biersack HJ

    更新日期：1996-08-01 00:00:00

  • Current trends in the use of O-(2-[18F]fluoroethyl)-L-tyrosine ([18F]FET) in neurooncology.

    abstract：:The diagnostic potential of PET using the amino acid analogue O-(2-[18F]fluoroethyl)-L-tyrosine ([18F]FET) in brain tumor diagnostics has been proven in many studies during the last two decades and is still the subject of multiple studies every year. In addition to standard magnetic resonance imaging (MRI), positron e...

    journal_title：Nuclear medicine and biology

    pub_type： 杂志文章,评审

    doi：10.1016/j.nucmedbio.2020.02.006

    authors： Stegmayr C,Stoffels G,Filß C,Heinzel A,Lohmann P,Willuweit A,Ermert J,Coenen HH,Mottaghy FM,Galldiks N,Langen KJ

    更新日期：2020-02-19 00:00:00

  • Repeated administration of D-amphetamine induces loss of [123I]FP-CIT binding to striatal dopamine transporters in rat brain: a validation study.

    abstract：UNLABELLED:In recent years, several PET and SPECT studies have shown loss of striatal dopamine transporter (DAT) binding in amphetamine (AMPH) users. However, the use of DAT SPECT tracers to detect AMPH-induced changes in DAT binding has not been validated. We therefore examined if repeated administration of D-AMPH or ...

    journal_title：Nuclear medicine and biology

    pub_type： 杂志文章

    doi：10.1016/j.nucmedbio.2005.12.007

    authors： Booij J,de Bruin K,Gunning WB

    更新日期：2006-04-01 00:00:00

  • Labeling and preliminary in vivo assessment of niobium-labeled radioactive species: A proof-of-concept study.

    abstract：:The application of radionuclide-labeled biomolecules such as monoclonal antibodies or antibody fragments for imaging purposes is called immunoscintigraphy. More specifically, when the nuclides used are positron emitters, such as zirconium-89, the technique is referred to as immuno-PET. Currently, there is an urgent ne...

    journal_title：Nuclear medicine and biology

    pub_type： 杂志文章

    doi：10.1016/j.nucmedbio.2016.02.003

    authors： Radchenko V,Bouziotis P,Tsotakos T,Paravatou-Petsotas M,la Fuente Ad,Loudos G,Harris AL,Xanthopoulos S,Filosofov D,Hauser H,Eisenhut M,Ponsard B,Roesch F

    更新日期：2016-05-01 00:00:00

  • Sigma1 and dopamine D2 receptor occupancy in the mouse brain after a single administration of haloperidol and two dopamine D2-like receptor ligands.

    abstract：:We investigated sigma(1) and dopamine D(2) receptor occupancy in mouse brain after a single injection of haloperidol, nemonapride, or spiperone using [(11)C]SA4503 and [(11)C]raclopride, respectively. Co-injection of the three compounds significantly blocked the uptake of each radioligand. Six hours later, only halope...

    journal_title：Nuclear medicine and biology

    pub_type： 杂志文章

    doi：10.1016/s0969-8051(03)00003-9

    authors： Ishiwata K,Kawamura K,Kobayashi T,Matsuno K

    更新日期：2003-05-01 00:00:00

  • 18F-labeled norepinephrine transporter tracer [18F]NS12137: radiosynthesis and preclinical evaluation.

    abstract：INTRODUCTION:Several psychiatric and neurodegenerative diseases are associated with malfunction of brain norepinephrine transporter (NET). However, current clinical evaluations of NET function are limited by the lack of sufficiently sensitive methods of detection. To this end, we have synthesized exo-3-[(6-[18F]fluoro-...

    journal_title：Nuclear medicine and biology

    pub_type： 杂志文章

    doi：10.1016/j.nucmedbio.2017.10.005

    authors： Kirjavainen AK,Forsback S,López-Picón FR,Marjamäki P,Takkinen J,Haaparanta-Solin M,Peters D,Solin O

    更新日期：2018-01-01 00:00:00

  • Pharmacokinetic computer simulations of the relationship between in vivo and in vitro neuroreceptor subtype selectivity of radioligands.

    abstract：:Pharmacokinetic computer simulations reveal a discrepancy between the in vivo and in vitro neuroreceptor subtype selectivity of radioligands. For radioligands with an in vitro neuroreceptor subtype selectivity between 0.1 and 10.0, the in vivo neuroreceptor subtype selectivity appears to be constrained to be between 0...

    journal_title：Nuclear medicine and biology

    pub_type： 杂志文章

    doi：10.1016/s0969-8051(99)00061-x

    authors： Zeeberg BR

    更新日期：1999-10-01 00:00:00

  • Comparison of N-[(11)C]methyl-norchloroepibatidine and N-[(11)C]methyl-2-(2-pyridyl)-7-azabicyclo[2.2.1]heptane with N-[(11)C]methyl-epibatidine in small animal PET studies.

    abstract：:Structural variations of the nicotinic acetylcholine receptor radioligand N-[(11)C]methyl-epibatidine were made to form (11)C-labeled N-methyl-norchloroepibatidine (N-methyl-NorchloroEPB) and N-methyl-2-(2-pyridyl)-7-azabicyclo[2.2.1]heptane (N-methyl-2PABH). Radiosyntheses were performed by methylation with high radi...

    journal_title：Nuclear medicine and biology

    pub_type： 杂志文章

    doi：10.1016/s0969-8051(00)00080-9

    authors： Spang JE,Patt JT,Westera G,Schubiger PA

    更新日期：2000-04-01 00:00:00

  • 99Mo/(99m)Tc separation: an assessment of technology options.

    abstract：:Several strategies for the effective separation of (99m)Tc from (99)Mo have been developed and validated. Due to the success of column chromatographic separation using acidic alumina coupled with high specific activity fission (99)Mo (F (99)Mo) for production of (99)Mo/(99m)Tc generators, however, most technologies un...

    journal_title：Nuclear medicine and biology

    pub_type： 杂志文章,评审

    doi：10.1016/j.nucmedbio.2012.10.005

    authors： Dash A,Knapp FF Jr,Pillai MR

    更新日期：2013-02-01 00:00:00

  • Studies of quality control of 99mTc-labelled macroaggregated albumin--Part 1. Aggregation of non-mercaptalbumin and its conformation.

    abstract：:The aggregative condition of albumin was investigated using bovine serum albumin (BSA) as a model for quality control of 99mTc-macroaggregated albumin (99mTc-MAA). Uniformalized aggregates were obtained from the oxidized non-mercapt-type of BSA by heating. The size of the aggregates was affected by the pH and the type...

    journal_title：Nuclear medicine and biology

    pub_type： 杂志文章

    doi：10.1016/0969-8051(93)90034-r

    authors： Fukuoka M,Kobayashi T,Satoh T,Tanaka A,Kubodera A

    更新日期：1993-07-01 00:00:00

  • Evaluation of [11C]laniquidar as a tracer of P-glycoprotein: radiosynthesis and biodistribution in rats.

    abstract：:At present, P-glycoprotein (P-gp) function can be studied using positron emission tomography (PET) together with a labelled P-gp substrate such as R-[11C]verapamil. Such a tracer is, however, less suitable for investigating P-gp (over)expression. Laniquidar is a third-generation P-gp inhibitor, which has been used in ...

    journal_title：Nuclear medicine and biology

    pub_type： 杂志文章

    doi：10.1016/j.nucmedbio.2009.03.004

    authors： Luurtsema G,Schuit RC,Klok RP,Verbeek J,Leysen JE,Lammertsma AA,Windhorst AD

    更新日期：2009-08-01 00:00:00

  • [1-11C]octanoate as a potential PET tracer for studying glial functions: PET evaluation in rats and cats.

    abstract：:To evaluate the ability of [1-11C]octanoate as a PET tracer for imaging the brain, we examined its distribution in the brain and surrounding tissues in rats and cats with PET. In rats, owing to the accumulated radioactivity in the harderian glands, clear brain images were not obtained at rostral levels. In cats, the b...

    journal_title：Nuclear medicine and biology

    pub_type： 杂志文章

    doi：10.1016/s0969-8051(96)00148-5

    authors： Kuge Y,Kawashima H,Yamazaki S,Hashimoto N,Miyake Y

    更新日期：1996-11-01 00:00:00

  • ScVEGF-PEG-HBED-CC and scVEGF-PEG-NOTA conjugates: comparison of easy-to-label recombinant proteins for [68Ga]PET imaging of VEGF receptors in angiogenic vasculature.

    abstract：INTRODUCTION:VEGF receptors play a key role in angiogenesis and are important targets for several approved and many experimental drugs. Imaging of VEGF receptor expression in malignant tumors would provide important information, which can influence patient management. The aim of this study was the development of an eas...

    journal_title：Nuclear medicine and biology

    pub_type： 杂志文章

    doi：10.1016/j.nucmedbio.2010.02.001

    authors： Eder M,Krivoshein AV,Backer M,Backer JM,Haberkorn U,Eisenhut M

    更新日期：2010-05-01 00:00:00

  • Evaluation of the antitumor effects of rilotumumab by PET imaging in a U-87 MG mouse xenograft model.

    abstract：INTRODUCTION:Dysregulation of the hepatocyte growth factor (HGF)/MET pathway has been implicated in various cancers. Rilotumumab is an investigational, fully human monoclonal antibody that binds and neutralizes HGF. The purpose of this study was to evaluate the efficacy of rilotumumab in a U-87 MG mouse xenograft tumor...

    journal_title：Nuclear medicine and biology

    pub_type： 杂志文章

    doi：10.1016/j.nucmedbio.2013.01.004

    authors： Rex K,Lewis XZ,Gobalakrishnan S,Glaus C,Silva MD,Radinsky R,Burgess TL,Gambhir SS,Coxon A

    更新日期：2013-05-01 00:00:00

  • Dopamine transporter imaging in the aged rat: a [¹²³I]FP-CIT SPECT study.

    abstract：INTRODUCTION:Rodent models are extensively used to assess the biochemical and physiological changes associated with aging. They play a major role in the development of therapies for age-related pathologies such as Parkinson's disease. To validate the usefulness of these animal models in aging or age-related disease res...

    journal_title：Nuclear medicine and biology

    pub_type： 杂志文章

    doi：10.1016/j.nucmedbio.2014.12.020

    authors： Niñerola-Baizán A,Rojas S,Roé-Vellvé N,Lomeña F,Ros D,Pavía J

    更新日期：2015-04-01 00:00:00