Glucose and methionine uptake by rat brain tumor treated with prodrug-activated gene therapy.

abstract：:The anabolism of isotopically labeled amino acids was compared between the cerebrum and the cerebellum in conscious rat at three feeding conditions. After L-[2-18F]fluorophenylalanine and L-[2,6-3H]phenylalanine injections, the incorporation rate of both radioactivity into protein fraction showed no difference between...

journal_title：Nuclear medicine and biology

authors： Nakamichi H,Murakami M,Miura S,Kondoh Y,Mizusawa S,Ono Y

更新日期：1994-10-01 00:00:00

abstract：OBJECTIVE:Pretargeting is the concept that combines optimal delivery of the antibody and rapid capture and elimination of the radioactivity. In this study, we evaluated the potential of antibody pretargeting to enable the tumor-targeting (212)Pb for in vivo generation of (212)Bi for alpha particle radiotherapy. METHOD...

journal_title：Nuclear medicine and biology

authors： Su FM,Beaumier P,Axworthy D,Atcher R,Fritzberg A

更新日期：2005-10-01 00:00:00

abstract：:A simple, rapid, and reproducible micromethod for quantification of sulfhydryl (SH) groups generated after reduction of monoclonal antibody (MAb) disulfide bonds with 2-mercaptoethanol (2-ME) is described. The number of SH groups per molecule of antibody in the 2-ME and in the other reducing agents was calculated from...

journal_title：Nuclear medicine and biology

authors： Iznaga Escobar N,Morales A,Núñez G

更新日期：1996-07-01 00:00:00

abstract：INTRODUCTION:Radiolabeled 2-nitroimidazoles (azomycins) are a prominent class of biomarkers for PET imaging of hypoxia. [18F]Fluoro-azomycin-α-arabinoside ([18F]FAZA) - already in clinical use - may be seen as α-configuration nucleoside, but enters cells only via diffusion and is not transported by cellular nucleoside ...

journal_title：Nuclear medicine and biology

authors： Schweifer A,Maier F,Ehrlichmann W,Lamparter D,Kneilling M,Pichler BJ,Hammerschmidt F,Reischl G

更新日期：2016-12-01 00:00:00

abstract：INTRODUCTION:The in vitro and in vivo behavior of the radiolabeled monoclonal antibody MORAb-003 was investigated as a prelude to a clinical trial. METHODS:The cellular retention of 111In- and 131I-labeled MORAb-003 was investigated using IGROV1 and SW620 cells. Biodistribution studies in tumor-bearing mice were perfo...

journal_title：Nuclear medicine and biology

authors： Smith-Jones PM,Pandit-Taskar N,Cao W,O'Donoghue J,Philips MD,Carrasquillo J,Konner JA,Old LJ,Larson SM

更新日期：2008-04-01 00:00:00

abstract：INTRODUCTION:Our objective was to evaluate the effect of epidermal growth factor receptor(s) (EGFR) density on the importation and nuclear localization of 111In-labeled diethylenetriaminepentaacetic acid human epidermal growth factor ([111In]DTPA-hEGF) in breast cancer (BC) cells in vitro and in tumor xenografts and no...

journal_title：Nuclear medicine and biology

authors： Hu M,Scollard D,Chan C,Chen P,Vallis K,Reilly RM

更新日期：2007-11-01 00:00:00

abstract：INTRODUCTION:Fatty acid amide hydrolase (FAAH) is the enzyme responsible for metabolising the endogenous cannabinoid, anandamide, and thus represents an important target for molecular imaging. To date, no radiotracer has been shown to be useful for imaging of FAAH using either positron emission tomography (PET) or sing...

journal_title：Nuclear medicine and biology

authors： Wilson AA,Garcia A,Parkes J,Houle S,Tong J,Vasdev N

更新日期：2011-02-01 00:00:00

abstract：:We investigated sigma(1) and dopamine D(2) receptor occupancy in mouse brain after a single injection of haloperidol, nemonapride, or spiperone using [(11)C]SA4503 and [(11)C]raclopride, respectively. Co-injection of the three compounds significantly blocked the uptake of each radioligand. Six hours later, only halope...

journal_title：Nuclear medicine and biology

authors： Ishiwata K,Kawamura K,Kobayashi T,Matsuno K

更新日期：2003-05-01 00:00:00

abstract：:As PET metabolic imaging becomes routine in clinical practice, there is a tendency to make imaging and data analysis fast and simple, but interpretation of these pictures by visual inspection does not do justice to the power of PET technology. Tissue data and blood data can be analyzed mathematically to provide parame...

journal_title：Nuclear medicine and biology

authors： Krohn KA,Mankoff DA,Muzi M,Link JM,Spence AM

更新日期：2005-10-01 00:00:00

abstract：:A paired-label study was performed in athymic mice bearing subcutaneous D-54 MG human glioma xenografts to compare the localization of human/mouse anti-tenascin chimeric antibody 81C6 labeled by reaction with N-succinimidyl 3-[211At]astatobenzoate and N-succinimidyl 3-[131I]iodobenzoate. Over the 48-h observation peri...

journal_title：Nuclear medicine and biology

authors： Zalutsky MR,Stabin MG,Larsen RH,Bigner DD

更新日期：1997-04-01 00:00:00

abstract：INTRODUCTION:Targeted alpha therapy (TAT) has the potential for killing micro-metastases with minimum collateral damage to surrounding healthy tissue. In-vivo generator radionuclides, such as(223)Ra, (225)Ra, and (225)Ac, are of special interest for radiotherapeutic applications as they emit multiple α-particles during...

journal_title：Nuclear medicine and biology

authors： Rojas JV,Woodward JD,Chen N,Rondinone AJ,Castano CH,Mirzadeh S

更新日期：2015-07-01 00:00:00

abstract：:188Re-perrhenate has been reported effective in preventing restenosis after percutaneous transluminal coronary angioplasty. However, if the balloon ruptures, 188Re-perrhenate is released into the circulation, causing high radiation dosing to the thyroid and stomach. In this study, we evaluated the effects of perchlora...

journal_title：Nuclear medicine and biology

authors： Lin WY,Hsieh JF,Tsai SC,Yen TC,Wang SJ,Knapp FF Jr

更新日期：2000-01-01 00:00:00

abstract：INTRODUCTION:Positron emission tomography (PET) is extensively used in clinical oncology for tumor detection. This study aimed to explore the application of the radiotracers [18F]fluorodeoxyglucose ([18F]FDG), 3'-deoxy-3'- [18F]fluorothymidine ([18F]FLT), and [18F]fluoromisonidazole ([18F]FMISO) in the diagnosis and mo...

journal_title：Nuclear medicine and biology

authors： Jiang H,Zhang R,Jiang H,Zhang M,Guo W,Feng G,Pan W,Xu H,Wang S

更新日期：2019-01-01 00:00:00

abstract：INTRODUCTION:The use of α-emitting isotopes for radionuclide therapy is a promising treatment strategy for small micro-metastatic disease. The radioisotope (213)Bi is a nuclide that has found substantial use for targeted α-therapy (TAT). The relatively unexplored aqueous chemistry of Bi(3+), however, hinders the develo...

journal_title：Nuclear medicine and biology

authors： Wilson JJ,Ferrier M,Radchenko V,Maassen JR,Engle JW,Batista ER,Martin RL,Nortier FM,Fassbender ME,John KD,Birnbaum ER

更新日期：2015-05-01 00:00:00

abstract：INTRODUCTION:Detection of vulnerable plaques is critically important for the selection of appropriate treatment and/or the prevention of atherosclerosis and ensuing cardiovascular diseases. In order to clarify the utility of [11C]acetate for atherosclerosis imaging, we determined the uptake and metabolism of acetate by...

journal_title：Nuclear medicine and biology

authors： Yamasaki K,Yamashita A,Zhao Y,Shimizu Y,Nishii R,Kawai K,Tamaki N,Zhao S,Asada Y,Kuge Y

更新日期：2018-01-01 00:00:00

abstract：:Myocellular kinetics of 201Tl, 99mTc-MIBI, 99mTc-tetrofosmin and 99mTc-furifosmin were investigated using retrogradely-perfused guinea-pig hearts. Relative retention decreased in the order 99mTc-MIBI ==> 99mTc-tetrofosmin ==> 99mTc-furifosmin. 201Tl and 99mTc-MIBI exhibited bi- (t1,t2), 99mTc-tetrofosmin and 99mTc-fur...

journal_title：Nuclear medicine and biology

authors： Schaefer WM,Moka D,Brockmann HA,Schomaecker K,Schicha H

更新日期：2002-02-01 00:00:00

abstract：UNLABELLED:(99m)Tc-TRODAT-1 is the first clinical routine (99m)Tc radiopharmaceutical to evaluate dopamine neurons loss in Parkinson's disease (PD). (18)F-AV-133 is a novel PET radiotracer targeting the vesicular monoamine transporter type 2 (VMAT2) to detect monoaminergic terminal reduction in PD patients. The aim of ...

journal_title：Nuclear medicine and biology

authors： Hsiao IT,Weng YH,Lin WY,Hsieh CJ,Wey SP,Yen TC,Kung MP,Lu CS,Lin KJ

更新日期：2014-04-01 00:00:00

abstract：:In this study, the (+)-enantiomer of radioiodinated 2-[4-(4-iodophenyl)piperidino]cyclohexanol [(+)-[(125)I]-p-iodovesamicol] [(+)-[(125)I]pIV], which is reported to bind with high affinity to sigma-1 receptors in vitro, was tested for its usefulness in imaging sigma-1 receptors in the central nervous system (CNS) in ...

journal_title：Nuclear medicine and biology

authors： Akhter N,Shiba K,Ogawa K,Kinuya S,Nakajima K,Mori H

更新日期：2007-08-01 00:00:00

abstract：UNLABELLED:The purpose of this study was to compare the diagnostic value of positron emission tomography (PET) using [(18)F]-fluorodeoxyglucose ((18)F-FDG) and O-(2-[(18)F]fluoroethyl)-l-tyrosine ((18)F-FET) in patients with brain lesions suspicious of cerebral gliomas. METHODS:Fifty-two patients with suspicion of cer...

journal_title：Nuclear medicine and biology

authors： Pauleit D,Stoffels G,Bachofner A,Floeth FW,Sabel M,Herzog H,Tellmann L,Jansen P,Reifenberger G,Hamacher K,Coenen HH,Langen KJ

更新日期：2009-10-01 00:00:00

abstract：:In developing radioiodinated agents for pancreatic and brain tumor imaging by single photon emission tomography (SPET), we prepared p-amino-3-[123I]iodo-l-phenylalanine (IAPA), p-[123I]iodo-l-phenylalanine (IPA), L-8-[123I]iodo-1,2,3,4-tetrahydro-7-hydroxyisoquinoline-3-carboxylic acid (ITIC) and L-3-[123I]iodo-alpha-...

journal_title：Nuclear medicine and biology

authors： Samnick S,Schaefer A,Siebert S,Richter S,Vollmar B,Kirsch CM

更新日期：2001-01-01 00:00:00

abstract：INTRODUCTION:Choline, acetate and glucose ([2-(18)F]fluoro-2-deoxyglucose, [(18)F]FDG) analogs are under investigation as positron emission tomography (PET) tracers for the imaging of prostate cancer; however, their response to tumor hypoxia has not been clarified. METHODS:The uptake of [methyl-(3)H]choline, [1-(14)C]...

journal_title：Nuclear medicine and biology

authors： Hara T,Bansal A,DeGrado TR

更新日期：2006-11-01 00:00:00

abstract：:By variation of reaction parameters iodination of 3-(9,10-didehydro-6-methyl-8 alpha-ergolinyl)-1,1-diethylurea (lisuride) was performed with the radiohalogen [123I]iodine (t1/2 = 13.3 h). For comparative experiments and stability studies the beta(-)-emitting radioisotope [131I]iodine (t1/2 = 8.04 d) was also used. Re...

journal_title：Nuclear medicine and biology

authors： Bier D,Dutschka K,Knust EJ

更新日期：1996-04-01 00:00:00

abstract：UNLABELLED:(11)C-ABP-688 is a selective tracer for the mGluR5 receptor. Its kinetics is fast and thus favourable for an equilibrium approach to determine receptor-related parameters. The purpose of this study was to test the hypothesis that the pattern of the (11)C-ABP688 uptake using a bolus-plus-infusion (B/I) protoc...

journal_title：Nuclear medicine and biology

authors： Burger C,Deschwanden A,Ametamey S,Johayem A,Mancosu B,Wyss M,Hasler G,Buck A

更新日期：2010-10-01 00:00:00

abstract：INTRODUCTION:We measured the tiagabine-induced enhancement of the GABAA receptor's affinity for benzodiazepine ligands ("GABA shift") using [18F]flumazenil (FMZ) PET with preclinical application of bolus plus constant infusion (B/I). Differences in quantified results of [18F]FMZ binding were compared to that of [18F]FM...

journal_title：Nuclear medicine and biology

authors： Kim W,Park HS,Moon BS,Lee BC,Kim SE

更新日期：2017-02-01 00:00:00

abstract：:We describe the synthesis of 2'-[(18)F]fluoroflumazenil (FFMZ), which differs from the typically used [(18)F]fluoroethylflumazenil (FEFMZ) for benzodiazepine receptor imaging. For one-pot one-step labeling, the precursors, 2'-tosyloxyflumazenil (TFMZ) and 2'-mesyloxyflumazenil (MFMZ), were synthesized in three steps. ...

journal_title：Nuclear medicine and biology

authors： Yoon YH,Jeong JM,Kim HW,Hong SH,Lee YS,Kil HS,Chi DY,Lee DS,Chung JK,Lee MC

更新日期：2003-07-01 00:00:00

abstract：INTRODUCTION:The dopamine D4 receptor (D4R) has attracted considerable attention as potential target for the treatment of a broad range of central nervous system disorders. Although many efforts have been made to improve the performance of putative radioligand candidates, there is still a lack of D4R selective tracers ...

journal_title：Nuclear medicine and biology

authors： Willmann M,Ermert J,Prante O,Hübner H,Gmeiner P,Neumaier B

更新日期：2020-07-16 00:00:00

abstract：:A cleaning resin has been developed for the non-chromatographic purification of 99mTc-labeled monoclonal antibodies (MAbs). The resin used is a modified form of thiopropylsepharose 6B resin, in which its sulfhydryl groups have been tinylated with stannous chloride. The method requires only simple stirring of the radio...

journal_title：Nuclear medicine and biology

authors： Rosenzweig HS,Ranadive GN,Seskey T,Epperly MW,Bloomer WD

更新日期：1994-02-01 00:00:00

abstract：INTRODUCTION:Histone deacetylases (HDACs) are enzymes involved in epigenetic modifications that shift the balance toward chromatin condensation and silencing of gene expression. Here, we evaluate the utility of 6-([(18)F]fluoroacetamido)-1-hexanoicanilide ([(18)F]FAHA) for positron emission tomography imaging of HDAC a...

journal_title：Nuclear medicine and biology

authors： Reid AE,Hooker J,Shumay E,Logan J,Shea C,Kim SW,Collins S,Xu Y,Volkow N,Fowler JS

更新日期：2009-04-01 00:00:00

abstract：BACKGROUND:The radiolabeled amino acid O-(2-(18)F-fluoroethyl)-L-tyrosine (FET) and thymidine analogue 3'-deoxy-3'-(18)F-fluorothymidine (FLT) are widely used for positron emission tomography (PET) brain tumor imaging; however, comparative studies are scarce. The aim of this study therefore was to compare FLT and FET P...

journal_title：Nuclear medicine and biology

authors： Nedergaard MK,Michaelsen SR,Perryman L,Erler J,Poulsen HS,Stockhausen MT,Lassen U,Kjaer A

更新日期：2016-03-01 00:00:00

abstract：:A column-switch high performance liquid chromatography method for the analysis of 4 mL of plasma is described with six examples of chromatography of [(11)C]-labeled positron-emission tomography imaging agents. Complete extraction of all but the most polar metabolites by the reverse phase capture column is achieved by ...

journal_title：Nuclear medicine and biology

authors： Hilton J,Yokoi F,Dannals RF,Ravert HT,Szabo Z,Wong DF

更新日期：2000-08-01 00:00:00