201Tl, 99mTc-MIBI, 99mTc-tetrofosmin and 99mTc-furifosmin: relative retention and clearance kinetics in retrogradely perfused guinea pig hearts.

abstract：INTRODUCTION:Targeted alpha therapy (TAT) has the potential for killing micro-metastases with minimum collateral damage to surrounding healthy tissue. In-vivo generator radionuclides, such as(223)Ra, (225)Ra, and (225)Ac, are of special interest for radiotherapeutic applications as they emit multiple α-particles during...

journal_title：Nuclear medicine and biology

authors： Rojas JV,Woodward JD,Chen N,Rondinone AJ,Castano CH,Mirzadeh S

更新日期：2015-07-01 00:00:00

abstract：:We have previously performed quantitative kinetic modeling of [(123)I]CNS 1261, a new SPET ligand for the MK801 intrachannel site of the NMDA receptor. We now report a bolus-infusion protocol, which eliminates the need for arterial blood sampling. Dynamic SPET scanning and venous blood sampling were performed in 7 hea...

journal_title：Nuclear medicine and biology

authors： Bressan RA,Erlandsson K,Mulligan RS,Gunn RN,Cunningham VJ,Owens J,Cullum ID,Ell PJ,Pilowsky LS

更新日期：2004-02-01 00:00:00

abstract：:A new 99mTc labelling method using a cleavable chelator, RP-1, was developed. In this study Balb/c mice with ovarian carcinoma xenografts received various Fab' fragments labelled with 99mTc either directly or via RP-1. Kidney uptake was significantly lower for the RP-1 linked conjugates. Tumour uptake showed no signif...

journal_title：Nuclear medicine and biology

authors： Tibben JG,Massuger LF,Boerman OC,Claessens RA,Borm GF,Pak KY,Koenders EB,Corstens FH

更新日期：1994-01-01 00:00:00

abstract：INTRODUCTION:We synthesized and evaluated (64)Cu-labeled tetraiodothyroacetic acid (tetrac)-conjugated liposomes for PET imaging of tumor angiogenesis, because tetrac inhibits angiogenesis via integrin αVβ3. METHODS:Tetrac-PEG-DSPE and DOTA-PEG-DSPE were synthesized and formulated with other lipids into liposomes. The...

journal_title：Nuclear medicine and biology

authors： Kang CM,Koo HJ,Lee S,Lee KC,Oh YK,Choe YS

更新日期：2013-11-01 00:00:00

abstract：INTRODUCTION:Hypoxia plays a negative role in the clinical management of cancer. Detection of hypoxic status of a cancer is important for selecting patients for hypoxia directed therapy. Though [(18)F]fluoromisonidazole ([(18)F]FMISO), a PET radiopharmaceutical, is presently being used in the clinic for the detection o...

journal_title：Nuclear medicine and biology

authors： Mallia MB,Subramanian S,Mathur A,Sarma HD,Banerjee S

更新日期：2014-08-01 00:00:00

abstract：:We describe the synthesis of 2'-[(18)F]fluoroflumazenil (FFMZ), which differs from the typically used [(18)F]fluoroethylflumazenil (FEFMZ) for benzodiazepine receptor imaging. For one-pot one-step labeling, the precursors, 2'-tosyloxyflumazenil (TFMZ) and 2'-mesyloxyflumazenil (MFMZ), were synthesized in three steps. ...

journal_title：Nuclear medicine and biology

authors： Yoon YH,Jeong JM,Kim HW,Hong SH,Lee YS,Kil HS,Chi DY,Lee DS,Chung JK,Lee MC

更新日期：2003-07-01 00:00:00

abstract：INTRODUCTION:Bromodomain and extra-terminal domain (BET) family proteins play a vital role in the epigenetic regulation process by interacting with acetylated lysine (Ac-K) residues in histones. BET inhibitors have become promising candidates to treat various diseases through the inhibition of the interaction between B...

journal_title：Nuclear medicine and biology

authors： Bai P,Lu X,Lan Y,Chen Z,Patnaik D,Fiedler S,Striar R,Haggarty SJ,Wang C

更新日期：2020-01-01 00:00:00

abstract：:Since elevated levels of gelatinases [matrix metalloproteinase (MMP)-2 and MMP-9] are associated with a poor prognosis in cancer patients, these enzymes are potential targets for tumor imaging. In the present study, a cyclic decapeptide, cCTTHWGFTLC (CTT), was selected as a mother compound because of its selective inh...

journal_title：Nuclear medicine and biology

authors： Hanaoka H,Mukai T,Habashita S,Asano D,Ogawa K,Kuroda Y,Akizawa H,Iida Y,Endo K,Saga T,Saji H

更新日期：2007-07-01 00:00:00

abstract：:The niobium-90 radioisotope ((90)Nb) holds considerable promise for use in immuno-PET, due to its decay parameters (t½ = 14.6h, positron yield=53%, Eß(+)(mean) = 0.35 MeV and Eß(+)(max) = 1.5 MeV). In particular, (90)Nb appears well suited to detect in vivo the pharmacokinetics of large targeting vectors (50-150 kDa)....

journal_title：Nuclear medicine and biology

authors： Radchenko V,Busse S,Roesch F

更新日期：2014-10-01 00:00:00

abstract：INTRODUCTION:The present article demonstrates a 'mix-and-use' approach for radiolabeling RGD peptide derivative with (68)Ga, which is easily adaptable in hospital radiopharmacy practice. The radiotracer thus formulated was successfully used for positron emission tomography (PET) imaging of breast cancer in human patien...

journal_title：Nuclear medicine and biology

authors： Chakraborty S,Chakravarty R,Vatsa R,Bhusari P,Sarma HD,Shukla J,Mittal BR,Dash A

更新日期：2016-01-01 00:00:00

abstract：INTRODUCTION:The remarkable stability of the 89Zr-DOTA complex has been shown in recent literature. The formation of this complex appears to require 89Zr-chloride as the complexation precursor rather than the more conventional 89Zr-oxalate. In this work we present a method for the direct isolation of 89Zr-chloride from...

journal_title：Nuclear medicine and biology

authors： Graves SA,Kutyreff C,Barrett KE,Hernandez R,Ellison PA,Happel S,Aluicio-Sarduy E,Barnhart TE,Nickles RJ,Engle JW

更新日期：2018-01-01 00:00:00

abstract：INTRODUCTION:The commercially available 68Ge/68Ga generators are generally used in clinical context in conjunction with automated or semi-automated modules for the syntheses of 68Ga radiopharmaceuticals. It is desirable to develop strategies for the formulation of 68Ga-radiopharmaceuticals without use of such expensive...

journal_title：Nuclear medicine and biology

authors： Chakravarty R,Chakraborty S,Radhakrishnan ER,Kamaleshwaran K,Shinto A,Dash A

更新日期：2017-03-01 00:00:00

abstract：:The in vitro stability and animal pharmacokinetics of 99mTc bound to Sandoz and C110 IgG antibodies via a modified MAG3 has been compared with the hydrazino nicotinamide (SHNH) moiety as standard. For both antibodies, the stabilities of the label to challenge at up to 50:1 cysteine: IgG molar ratio were comparable, bu...

journal_title：Nuclear medicine and biology

authors： Lei K,Rusckowski M,Chang F,Qu T,Mardirossian G,Hnatowich DJ

更新日期：1996-10-01 00:00:00

abstract：OBJECTIVES:Positron emission tomography (PET) using O-(2-[(18)F]fluoroethyl)-l-tyrosine (FET) has been successfully employed in the diagnostic workup of brain tumors. Knowledge on the mechanisms of the uptake of radiolabeled amino acids into thyroidal tissues and well-differentiated thyroid carcinomas is limited. We th...

journal_title：Nuclear medicine and biology

authors： Prante O,Bläser D,Maschauer S,Kuwert T

更新日期：2007-04-01 00:00:00

abstract：OBJECTIVE:Pretargeting is the concept that combines optimal delivery of the antibody and rapid capture and elimination of the radioactivity. In this study, we evaluated the potential of antibody pretargeting to enable the tumor-targeting (212)Pb for in vivo generation of (212)Bi for alpha particle radiotherapy. METHOD...

journal_title：Nuclear medicine and biology

authors： Su FM,Beaumier P,Axworthy D,Atcher R,Fritzberg A

更新日期：2005-10-01 00:00:00

abstract：INTRODUCTION:The cardinal pathological feature of Parkinson's disease (PD) is progressive loss of dopaminergic neurons. Since dopamine transporter (DAT) is a protein located presynaptically on dopaminergic nerve terminals, radioligands that bind to these sites are promising radiopharmaceuticals for evaluation of the in...

journal_title：Nuclear medicine and biology

authors： Liu L,Wang Y,Li B,Jia J,Sun Z,Zhang J,Tian J,Wang X

更新日期：2009-11-01 00:00:00

abstract：INTRODUCTION:This study investigated radiolabeled bacteriophages for specific detection of infection through gamma imaging. Previously, a (99m)Tc-labeled M13 phage demonstrated specific binding for its host Escherichia coli in vitro and in mice through imaging. METHODS:This study was extended to phages P22, E79, VD-13...

journal_title：Nuclear medicine and biology

authors： Rusckowski M,Gupta S,Liu G,Dou S,Hnatowich DJ

更新日期：2008-05-01 00:00:00

abstract：INTRODUCTION:Therapeutic application of intravenous administered (IV) human bone marrow-derived mesenchymal stem cells (ahMSCs) appears to have as main drawback the massive retention of cells in the lung parenchyma, questioning the suitability of this via of administration. Intraarticular administration (IAR) could be ...

journal_title：Nuclear medicine and biology

authors： Meseguer-Olmo L,Montellano AJ,Martínez T,Martínez CM,Revilla-Nuin B,Roldán M,Mora CF,López-Lucas MD,Fuente T

更新日期：2017-03-01 00:00:00

abstract：INTRODUCTION:We measured the tiagabine-induced enhancement of the GABAA receptor's affinity for benzodiazepine ligands ("GABA shift") using [18F]flumazenil (FMZ) PET with preclinical application of bolus plus constant infusion (B/I). Differences in quantified results of [18F]FMZ binding were compared to that of [18F]FM...

journal_title：Nuclear medicine and biology

authors： Kim W,Park HS,Moon BS,Lee BC,Kim SE

更新日期：2017-02-01 00:00:00

abstract：:The prospective therapeutic, propionyl-L-carnitine, was labelled in the N-methyl position with the positron-emitter, carbon-11 (t1/2 = 20.4 min), with a view to studying its pharmacokinetics in humans using PET. Labelling was achieved by methylating nor-propionyl-L-carnitine hydrochloride with no-carrier-added [11C]io...

journal_title：Nuclear medicine and biology

authors： Davenport RJ,Law MP,Pike VW,Osman S,Poole KG

更新日期：1995-08-01 00:00:00

abstract：:Holmium-166 ferric hydroxide macroaggregate (Ho-166 FHMA) particles possess two important properties for radiosynovectomy; relatively short half-life of the radioisotope and appropriate carrier size. Both these minimize radioactive leakage from the treated joint. This study was conducted to assess the effects of Ho-16...

journal_title：Nuclear medicine and biology

authors： Mäkelä O,Penttilä P,Kolehmainen E,Sukura A,Sankari S,Tulamo RM

更新日期：2002-07-01 00:00:00

abstract：:In the quantitative studies of presynaptic dopamine metabolism by PET with 6-[18F]fluoro-L-dopa (6-[18F]FDOPA), metabolic analysis in the plasma is required to determine the precise input function because of susceptibility of the compound to peripheral metabolism. In this study, we prepared 6-[18F]-fluoro-O-pivaloyl-L...

journal_title：Nuclear medicine and biology

authors： Ishiwata K,Shinoda M,Ishii S,Nozaki T,Senda M

更新日期：1996-04-01 00:00:00

abstract：:We have identified the value of 18F-fallypride [(S)-N-[(1-allyl-2-pyrrolidinyl)methyl]-5-(3-[18F]fluoropropyl)-2, 3-dimethoxybenzamide], as a dopamine D-2 receptor radiotracer for the study of striatal and extrastriatal receptors. Fallypride exhibits high affinities for D-2 and D-3 subtypes and low affinity for D-4 (3...

journal_title：Nuclear medicine and biology

authors： Mukherjee J,Yang ZY,Brown T,Lew R,Wernick M,Ouyang X,Yasillo N,Chen CT,Mintzer R,Cooper M

更新日期：1999-07-01 00:00:00

abstract：:Fluorine-18 labeled analogs of 8-fluorooctanoic acid and its structurally modified derivatives with methyl or gem-dimethyl branching or with oxygen substitution at the C3 position were prepared using nucleophilic substitution of the tosylate precursors by [18F]fluoride ion, for evaluation as tracers for cerebral fatty...

journal_title：Nuclear medicine and biology

authors： Nagatsugi F,Sasaki S,Maeda M

更新日期：1994-08-01 00:00:00

abstract：:Conjugates of For-MLFK and For-NleLFNleYK with S-benzyl mercaptoacetyl dipeptides containing, respectively, zero, one, and two carboxyl functions in their structures were prepared and labeled with (99m)Tc. In vitro binding studies using isolated human granulocytes indicated specific receptor binding of the radiolabele...

journal_title：Nuclear medicine and biology

authors： Verbeke K,Snauwaert K,Cleynhens B,Scheers W,Verbruggen A

更新日期：2000-11-01 00:00:00

abstract：INTRODUCTION:Current guidelines for brain PET imaging advice against the injection of diazepam prior to brain FDG-PET examination in order to avoid possible interactions of benzodiazepines with the radiotracer uptake. Nevertheless, many patients undergoing PET studies are likely to be under chronic treatment with benzo...

journal_title：Nuclear medicine and biology

authors： Silva-Rodríguez J,García-Varela L,López-Arias E,Domínguez-Prado I,Cortés J,Pardo-Montero J,Fernández-Ferreiro A,Ruibal Á,Sobrino T,Aguiar P

更新日期：2016-12-01 00:00:00

abstract：:The aim of the study was to evaluate the diagnostic accuracy of scintimammography with Tc-99m MIBI for the detection of breast cancer. Patients with a suspicious lesion detected by palpation or mammography were included in the study. Excisional biopsy was performed on all patients. Mammography was performed within 3 w...

journal_title：Nuclear medicine and biology

authors： Palmedo H,Schomburg A,Grünwald F,Mallmann P,Boldt I,Biersack HJ

更新日期：1996-08-01 00:00:00

abstract：INTRODUCTION:Amino acid based radiotracers target tumor cells through increased uptake by membrane-associated amino acid transport (AAT) systems. In the present study, four structurally related non-natural (18)F-labeled amino acids, (R)- and (S)-[(18)F]FAMP 1 and (R)- and (S)-[(18)F]MeFAMP 2 have been prepared and eval...

journal_title：Nuclear medicine and biology

authors： Yu W,McConathy J,Olson JJ,Goodman MM

更新日期：2015-01-01 00:00:00

abstract：INTRODUCTION:Histone deacetylases (HDACs) are enzymes involved in epigenetic modifications that shift the balance toward chromatin condensation and silencing of gene expression. Here, we evaluate the utility of 6-([(18)F]fluoroacetamido)-1-hexanoicanilide ([(18)F]FAHA) for positron emission tomography imaging of HDAC a...

journal_title：Nuclear medicine and biology

authors： Reid AE,Hooker J,Shumay E,Logan J,Shea C,Kim SW,Collins S,Xu Y,Volkow N,Fowler JS

更新日期：2009-04-01 00:00:00

abstract：:Positron emission tomography (PET), which requires a compound labeled with a positron emitter radioisotope as an imaging probe, is one of the most useful and valuable imaging modalities in molecular imaging. It has several advantages over other imaging modalities, particularly in sensitive and quantitative investigati...

journal_title：Nuclear medicine and biology

authors： Harada R,Furumoto S,Yoshikawa T,Ishikawa Y,Shibuya K,Okamura N,Iwata R,Yanai K

更新日期：2012-01-01 00:00:00