Synthesis and evaluation of [123I]-iodo-PK11195 for mapping peripheral-type benzodiazepine receptors (omega 3) in heart.

abstract：:The imaging of the distribution of beta-amyloid (Abeta) plaques in the brain is becoming an important diagnostic modality in Alzheimer's disease (AD). Here, we synthesized novel benzothiophene derivatives and labeled them with (18)F for the potential diagnostic imaging of AD patients using positron emission tomography...

journal_title：Nuclear medicine and biology

authors： Chang YS,Jeong JM,Lee YS,Kim HW,Ganesha RB,Kim YJ,Lee DS,Chung JK,Lee MC

更新日期：2006-08-01 00:00:00

abstract：INTRODUCTION:Image-derived input functions (IDIFs) represent a promising non-invasive alternative to arterial blood sampling for quantification in positron emission tomography (PET) studies. However, routine applications in patients and longitudinal designs are largely missing despite widespread attempts in healthy sub...

journal_title：Nuclear medicine and biology

authors： Hahn A,Nics L,Baldinger P,Wadsak W,Savli M,Kraus C,Birkfellner W,Ungersboeck J,Haeusler D,Mitterhauser M,Karanikas G,Kasper S,Frey R,Lanzenberger R

更新日期：2013-04-01 00:00:00

abstract：:A new positron emission tomography (PET) radioligand for the serotonin transporter (SERT), [(11)C]2-[2-[[(dimethylamino)methyl]phenyl]thio]-5-(2-fluoroethyl)phenylamine ([(11)C]AFE, 12), was synthesized and evaluated in vivo in rats and baboons. [(11)C]AFE (12) was prepared from its monomethylamino precursor 11 by rea...

journal_title：Nuclear medicine and biology

authors： Zhu Z,Guo N,Narendran R,Erritzoe D,Ekelund J,Hwang DR,Bae SA,Laruelle M,Huang Y

更新日期：2004-11-01 00:00:00

abstract：:Pharmacokinetic computer simulations reveal a discrepancy between the in vivo and in vitro neuroreceptor subtype selectivity of radioligands. For radioligands with an in vitro neuroreceptor subtype selectivity between 0.1 and 10.0, the in vivo neuroreceptor subtype selectivity appears to be constrained to be between 0...

journal_title：Nuclear medicine and biology

authors： Zeeberg BR

更新日期：1999-10-01 00:00:00

abstract：:Technetium-99m-modified polylysine (MPL) is a mild and efficient method for cell labeling that is easily applicable to human lymphocytes. 99mTc-MPL uptake is maximal in 40 min at room temperature. Cell labeling efficiency (from 60 to 80%) increases with rising concentrations of cells and labeling agent. In vitro stabi...

journal_title：Nuclear medicine and biology

authors： Delmon-Moingeon LI,Mahmood A,Davison A,Jones AG

更新日期：1996-01-01 00:00:00

abstract：:We prepared 5-HT(1A) receptor ligands (S)-N-[[1-(2-phenylethyl)pyrrolidin-2-yl]methyl]-3-[11C]methylthiobenzamide ([11C](S)-PPMMB) (Ki = 4.3 nM) and the less active [(11)C](R)-PPMMB (Ki = 160 nM) by reduction of the disulfide dimer and subsequent [(11)C]methylation of demethyl (S)- and (R)-PPMMB, respectively. Both ra...

journal_title：Nuclear medicine and biology

authors： Fujio M,Nagata S,Kawamura K,Sugiyama N,Tanaka H,Uno K,Ishiwata K

更新日期：2002-08-01 00:00:00

abstract：:The syntheses and radiolabelling of 27 new N-(alkylaminoalkyl)-4-methoxy-, -4-hydroxy-, and -4-aminobenzamides are described and evaluated in C57B1/6 mice with subcutaneously transplanted B16 melanoma in order to screen the optimal chemical structure for melanoma scintigraphy. Using T1(TFA)3 for 131I- labelling, a ser...

journal_title：Nuclear medicine and biology

authors： Mohammed A,Nicholl C,Titsch U,Eisenhut M

更新日期：1997-07-01 00:00:00

abstract：:The gastrin releasing peptide (GRP) receptor is becoming an increasingly attractive target for development of new radiolabeled peptides with diagnostic and therapeutic potential. The attractiveness of the GRP receptor as a target is based upon the functional expression of GRP receptors in several tumors of neuroendocr...

journal_title：Nuclear medicine and biology

authors： Smith CJ,Volkert WA,Hoffman TJ

更新日期：2003-11-01 00:00:00

abstract：:To fully exploit the potential of positron emission tomography (PET) imaging to assess drug distribution and pharmacokinetics in the central nervous system, the contribution of radiometabolites to the PET signal has to be determined for correct interpretation of data. However, radiosynthesis and extensive study of rad...

journal_title：Nuclear medicine and biology

authors： Auvity S,Breuil L,Goislard M,Bottlaender M,Kuhnast B,Tournier N,Caillé F

更新日期：2020-01-01 00:00:00

abstract：INTRODUCTION:We examined whether the amino acid PET tracers, trans-1-amino-3-(18)F-fluorocyclobutanecarboxylic acid (anti-(18)F-FACBC) and (11)C-methyl-l-methionine ((11)C-Met), are suitable for detecting early responses to combination therapies including temozolomide (TMZ), interferon-β (IFN), and bevacizumab (Bev) in...

journal_title：Nuclear medicine and biology

authors： Ono T,Sasajima T,Doi Y,Oka S,Ono M,Kanagawa M,Baden A,Mizoi K,Shimizu H

更新日期：2015-07-01 00:00:00

abstract：INTRODUCTION:Dedifferentiated thyroid cancer is often incurable because it does not respond to radioiodine. This study aimed to investigate iodide uptake and the expressions of thyroid-specific molecules after the transfection of human thyrotropin receptor (hTSHR) gene in poorly differentiated follicular thyroid cancer...

journal_title：Nuclear medicine and biology

authors： Cheng W,Fu H,Feng F,Ma C,Li J,Chen S,Wang H

更新日期：2013-05-01 00:00:00

abstract：:The advent of antibody-based cancer therapeutics has led to the concomitant rise in the development of companion diagnostics for these therapies, particularly nuclear imaging agents. A number of radioisotopes have been employed for antibody-based PET and SPECT imaging, notably ⁶⁴Cu, ¹²⁴I, ¹¹¹In, and (99m)Tc; in recent...

journal_title：Nuclear medicine and biology

authors： Deri MA,Zeglis BM,Francesconi LC,Lewis JS

更新日期：2013-01-01 00:00:00

abstract：:A recently developed pinhole high-resolution SPECT system was used to measure striatal to non-specific binding ratios in rats (n = 9), after injection of the dopamine transporter ligand (123)I-FP-CIT, and to assess its test/retest reproducibility. For co-alignment purposes, the rat brain was imaged on a 1.5 Tesla clin...

journal_title：Nuclear medicine and biology

authors： Booij J,de Bruin K,de Win MM,Lavini C,den Heeten GJ,Habraken JB

更新日期：2003-08-01 00:00:00

abstract：:Multiple myeloma and other hematological malignancies have been treated by myeloablative radiotherapy/chemotherapy and subsequent stem cell transplantation. [(166)Dy]Dy/(166)Ho-ethylenediaminetetramethylene phosphonate (EDTMP) forms a stable in vivo generator system with selective skeletal uptake in mice; therefore, i...

journal_title：Nuclear medicine and biology

authors： Pedraza-López M,Ferro-Flores G,Arteaga de Murphy C,Morales-Ramírez P,Piedras-Ross J,Murphy-Stack E,Hernández-Oviedo O

更新日期：2004-11-01 00:00:00

abstract：:ABSTRACT. The aim of the present study was to investigate the lymphatic cardiac circulation in an experimental model of ischemia plus reperfusion in mongrel dogs (Canis familiaris L). As radiotracer we used 0.2-0.25 ml (111 MBq) of 99mTc-Re2S7 colloid (+/-10 microm), injected subcapsullary below the second diagonal of...

journal_title：Nuclear medicine and biology

authors： Santos AC,de Lima JJ,Botelho MF,Pacheco MF,Sousa P,Bernardo J,Ferreira N,Gonçalves L,Aguiar J,Providência LA,Pauwels EK

更新日期：1998-10-01 00:00:00

abstract：:Liposomes encapsulating both glutathione and deferoxamine were labeled with 99mTc-HMPAO and 111In-oxine at the same time. These dual radiolabeled liposomes were intravenously injected in rats with S. aureus infection in thigh. The target-to-background ratio (T/BG) increased from 2.9 at 2 h to 4.4 at 8 h in 99mTc image...

journal_title：Nuclear medicine and biology

authors： Awasthi VD,Goins B,Klipper R,Phillips WT

更新日期：1998-02-01 00:00:00

abstract：:Chondroitin sulfate (CS) is used in the treatment of human osteoarthritis as a slow-acting symptomatic drug. For this reason, we performed uptake studies with (99m)TcCS using different chondrocyte cultures, as well as cartilage tissue in vitro. For uptake studies, adherent monolayer cultures of human chondrocytes (2.7...

journal_title：Nuclear medicine and biology

authors： Sobal G,Menzel J,Sinzinger H

更新日期：2009-01-01 00:00:00

abstract：:Cholinergic system in the central nervous system is involved in the memory function. Thus, because the dysfunction of cholinergic system that project to the cerebral cortex from nucleus basalis of Meynert (nbM) would be implicated in the memory function deficits in Alzheimer's disease (AD), evaluating cholinergic func...

journal_title：Nuclear medicine and biology

authors： Ogawa M,Iida Y,Nakagawa M,Kuge Y,Kawashima H,Tominaga A,Ueda M,Magata Y,Saji H

更新日期：2006-02-01 00:00:00

abstract：INTRODUCTION:Detection of vulnerable plaques is critically important for the selection of appropriate treatment and/or the prevention of atherosclerosis and ensuing cardiovascular diseases. In order to clarify the utility of [11C]acetate for atherosclerosis imaging, we determined the uptake and metabolism of acetate by...

journal_title：Nuclear medicine and biology

authors： Yamasaki K,Yamashita A,Zhao Y,Shimizu Y,Nishii R,Kawai K,Tamaki N,Zhao S,Asada Y,Kuge Y

更新日期：2018-01-01 00:00:00

abstract：:18Fluoro-norchloroepibatidine (exo-2-(6-fluoro-3-pyridyl)-7-azabicyclo-[2.2.1]heptane [NFEP]), a labeled derivative of epibatidine, has shown promise for imaging brain nicotinic acetylcholine receptors with PET. We determined the dose-dependent effects of NFEP in conscious rats. NFEP (1.5 microg/kg; administered intra...

journal_title：Nuclear medicine and biology

authors： Molina PE,Ding YS,Carroll FI,Liang F,Volkow ND,Pappas N,Kuhar M,Abumrad N,Gatley SJ,Fowler JS

更新日期：1997-11-01 00:00:00

abstract：INTRODUCTION:(99m)Tc-BnAO is one of the nonnitroimidazole hypoxia markers with the highest citation and could be potentially useful in both oncology and other clinical applications. However, it appears inferior in vitro due to lower absolute accumulation and smaller anoxic/normoxic uptake ratio. It is possible that the...

journal_title：Nuclear medicine and biology

authors： Sun X,Chu T,Wang X

更新日期：2010-02-01 00:00:00

abstract：:The in vitro stability and animal pharmacokinetics of 99mTc bound to Sandoz and C110 IgG antibodies via a modified MAG3 has been compared with the hydrazino nicotinamide (SHNH) moiety as standard. For both antibodies, the stabilities of the label to challenge at up to 50:1 cysteine: IgG molar ratio were comparable, bu...

journal_title：Nuclear medicine and biology

authors： Lei K,Rusckowski M,Chang F,Qu T,Mardirossian G,Hnatowich DJ

更新日期：1996-10-01 00:00:00

abstract：:A cleaning resin has been developed for the non-chromatographic purification of 99mTc-labeled monoclonal antibodies (MAbs). The resin used is a modified form of thiopropylsepharose 6B resin, in which its sulfhydryl groups have been tinylated with stannous chloride. The method requires only simple stirring of the radio...

journal_title：Nuclear medicine and biology

authors： Rosenzweig HS,Ranadive GN,Seskey T,Epperly MW,Bloomer WD

更新日期：1994-02-01 00:00:00

abstract：:9-[(3-[18F]Fluoro-1-hydroxy-2-propoxy)methyl]guanine ([18F]FHPG, 2) has been synthesized by nucleophilic substitution of N(2)-(p-anisyldiphenylmethyl)-9-[[1-(p-anisyldiphenylmethoxy)-3-toluenesulfonyloxy-2-propoxy]methyl]guanine (1) with potassium [18F]fluoride/Kryptofix 2.2.2 followed by deprotection with 1 N HCl and...

journal_title：Nuclear medicine and biology

authors： Shiue GG,Shiue CY,Lee RL,MacDonald D,Hustinx R,Eck SL,Alavi AA

更新日期：2001-10-01 00:00:00

abstract：UNLABELLED:The radiolabelled bombesin analogue AMBA shows high potential for diagnosis and treatment of prostate and breast cancer, but the influence of different chelators, which differ in terms of radiochemical reactivity and stability, have not been explored so far. In order to find the best suitable chelator for la...

journal_title：Nuclear medicine and biology

authors： Asti M,Iori M,Capponi PC,Atti G,Rubagotti S,Martin R,Brennauer A,Müller M,Bergmann R,Erba PA,Versari A

更新日期：2014-01-01 00:00:00

abstract：INTRODUCTION:Comparative imaging of multiple radiotracers in the same animal can be invaluable in elucidating and validating their respective mechanisms of localization. Comparative imaging of PET tracers, particularly in small animals, is problematic, however: such tracers must be administered and imaged separately be...

journal_title：Nuclear medicine and biology

authors： Zanzonico P,Campa J,Polycarpe-Holman D,Forster G,Finn R,Larson S,Humm J,Ling C

更新日期：2006-01-01 00:00:00

abstract：:Poly(adenosine diphosphate-ribose) synthetase (PARS) is a nuclear enzyme that is activated by deoxyribonucleic acid (DNA) strand breaks and participates in DNA repair. Excessive PARS activation, however, leads to cell death due to depletion of adenosine triphosphate (ATP). To evaluate whether it is possible to detect ...

journal_title：Nuclear medicine and biology

authors： Miyake Y,Kuge Y,Shimadzu H,Hashimoto N,Ishida Y,Shibakawa M,Nishimura T

更新日期：2000-11-01 00:00:00

abstract：:The specific binding of [(11)C]doxepin, which has been used as a radioligand for mapping histamine H(1) receptors in human brain by positron emission tomography, was evaluated in five animal species. In mice the [(11)C]doxepin uptake was reduced by treatment with cold doxepin and two H(1) receptor antagonists, but not...

journal_title：Nuclear medicine and biology

authors： Ishiwata K,Kawamura K,Wang WF,Tsukada H,Harada N,Mochizuki H,Kimura Y,Ishii K,Iwata R,Yanai K

更新日期：2004-05-01 00:00:00

abstract：:A radioiodinated ligand, (R)-N-methyl-(2-[(125)I]iodo-phenoxy)-3-phenylpropylamine, [(125)I]2-INXT, targeting norepinephrine transporters (NET), was successfully prepared. A no-carrier-added product, [(125)I]2-INXT, displayed a saturable binding with a high affinity (K(d)=0.06 nM) in the homogenates prepared from rat ...

journal_title：Nuclear medicine and biology

authors： Kung MP,Choi SR,Hou C,Zhuang ZP,Foulon C,Kung HF

更新日期：2004-07-01 00:00:00

abstract：:Positron-emission tomography (PET) provides potential in neuropsychiatric drug development by expanding knowledge of drug action in the living human brain and reducing time consumption and costs. The 5-hydroxytryptamine(1A) (5-HT(1A)) receptor is of central interest as a target for the treatment of anxiety, depression...

journal_title：Nuclear medicine and biology

authors： Andrée B,Halldin C,Thorberg SO,Sandell J,Farde L

更新日期：2000-07-01 00:00:00