Radioiodinated N-(alkylaminoalkyl)-substituted 4-methoxy-, 4-hydroxy-, and 4-aminobenzamides: biological investigations for the improvement of melanoma-imaging agents.

abstract：INTRODUCTION:Tetradentate acyclic and macrocyclic diphosphine ligands (P(2)N(2) and P(2)S(2)) have been synthesized and characterized as potential chelates for Rh(III). METHODS:The coordination complexes [RhCl(2)(L1)]Cl, trans-[RhCl(2)(L2)]PF(6), [Ni(L2)](PF(6))(2), [Ni(L3)](PF(6))(2), [RhCl(2)(L4)]PF(6) and [RhCl(2)(...

journal_title：Nuclear medicine and biology

authors： Cagnolini A,Ballard B,Engelbrecht HP,Rold TL,Barnes C,Cutler C,Hoffman TJ,Kannan R,Katti K,Jurisson SS

更新日期：2011-01-01 00:00:00

abstract：:Fluorine-18 labeled 2beta-carbomethoxy-3beta-(4-chlorophenyl)-8-(2-fluoroethyl)nort ropane (FECNT) was synthesized in the development of a dopamine transporter (DAT) imaging ligand for positron emission tomography (PET). The methods of radiolabeling and ligand synthesis of FECNT, and the results of the in vitro charac...

journal_title：Nuclear medicine and biology

authors： Goodman MM,Kilts CD,Keil R,Shi B,Martarello L,Xing D,Votaw J,Ely TD,Lambert P,Owens MJ,Camp VM,Malveaux E,Hoffman JM

更新日期：2000-01-01 00:00:00

abstract：PURPOSE:The aim of this study was to investigate the biodistribution and localization of an anti-inflammatory nonapeptide coupled to synovial targeting peptide (HAP-1) in rat adjuvant-induced arthritis. PROCEDURE:N(ε)-functionalized histidine derivative was coupled to the N-terminus of core peptide (CP) and HAP-1 to a...

journal_title：Nuclear medicine and biology

authors： Ali M,Vanniasinghe A,Kumar V,Barnett R,Alberto R,Manolios N

更新日期：2011-07-01 00:00:00

abstract：OBJECTIVES:Radiolabeled amino acids have proven utility for imaging brain tumors in humans, particularly those that target system L amino acid transport. We have prepared the novel phenylalanine analogue, (FMePhe, 9), as part of an effort to develop new system L tracers that can be prepared in high radiochemical yield ...

journal_title：Nuclear medicine and biology

authors： Huang C,Yuan L,Rich KM,McConathy J

更新日期：2013-05-01 00:00:00

abstract：INTRODUCTION:Thymidylate synthase and folate receptors are well-developed targets of cancer therapy. Discovery of a simple and fast method for the conversion of 11CH3Ito[11C]-formaldehyde (11CH2O) encouraged us to label the co-factor of this enzyme. Preliminary studies conducted on cell lines have demonstrated a prefer...

journal_title：Nuclear medicine and biology

authors： Saeed M,Tewson TJ,Erdahl CE,Kohen A

更新日期：2012-07-01 00:00:00

abstract：INTRODUCTION:VEGF receptors play a key role in angiogenesis and are important targets for several approved and many experimental drugs. Imaging of VEGF receptor expression in malignant tumors would provide important information, which can influence patient management. The aim of this study was the development of an eas...

journal_title：Nuclear medicine and biology

authors： Eder M,Krivoshein AV,Backer M,Backer JM,Haberkorn U,Eisenhut M

更新日期：2010-05-01 00:00:00

abstract：:A no-carrier-added, high specific activity synthesis of [11C-methyl]-thymidine is reported. Reaction of 3'. 5'-O-bis-(tetrahydropyramyl)-5-bromo-2'-deoxyuridine with n-butylithium produced a diamion which was alkylated with [11C]-methyl iodide, and on subsequent hydrolysis, yielded [IIC-methyl]-thymidine. The labeled ...

journal_title：Nuclear medicine and biology

authors： Alauddin MM,Ravert HT,Musachio JL,Mathews WB,Dannals RF,Conti PS

更新日期：1995-08-01 00:00:00

abstract：:The aggregative condition of albumin was investigated using bovine serum albumin (BSA) as a model for quality control of 99mTc-macroaggregated albumin (99mTc-MAA). Uniformalized aggregates were obtained from the oxidized non-mercapt-type of BSA by heating. The size of the aggregates was affected by the pH and the type...

journal_title：Nuclear medicine and biology

authors： Fukuoka M,Kobayashi T,Satoh T,Tanaka A,Kubodera A

更新日期：1993-07-01 00:00:00

abstract：:An iodinated analog of PK11195, 1-(2-chlorophenyl)-N-methyl-N-(1-methylpropyl)isoquinoline-3-carboxamide , a specific antagonist of the peripheral-type benzodiazepine receptor (omega 3), has been synthesized in three steps with an overall chemical yield of 40%. Both [123I]- and [125I]-Iodo-PK11195 have been synthesize...

journal_title：Nuclear medicine and biology

authors： Gildersleeve DL,Van Dort ME,Johnson JW,Sherman PS,Wieland DM

更新日期：1996-01-01 00:00:00

abstract：:Radiolabeled lipiodol has been used for targeting liver cancer. We developed a lipiodol solution of (188)Re-TDD (2,2,9,9-tetramethyl-4,7-diaza-1,10-decanedithiol) and investigated its feasibility for the treatment of liver cancer. The lipiodol solution of (188)Re-TDD was well-retained in the lipiodol phase in vitro. A...

journal_title：Nuclear medicine and biology

authors： Jeong JM,Kim YJ,Lee YS,Ko JI,Son M,Lee DS,Chung JK,Park JH,Lee MC

更新日期：2001-02-01 00:00:00

abstract：INTRODUCTION:Current guidelines for brain PET imaging advice against the injection of diazepam prior to brain FDG-PET examination in order to avoid possible interactions of benzodiazepines with the radiotracer uptake. Nevertheless, many patients undergoing PET studies are likely to be under chronic treatment with benzo...

journal_title：Nuclear medicine and biology

authors： Silva-Rodríguez J,García-Varela L,López-Arias E,Domínguez-Prado I,Cortés J,Pardo-Montero J,Fernández-Ferreiro A,Ruibal Á,Sobrino T,Aguiar P

更新日期：2016-12-01 00:00:00

abstract：:Positron-emission tomography (PET) provides potential in neuropsychiatric drug development by expanding knowledge of drug action in the living human brain and reducing time consumption and costs. The 5-hydroxytryptamine(1A) (5-HT(1A)) receptor is of central interest as a target for the treatment of anxiety, depression...

journal_title：Nuclear medicine and biology

authors： Andrée B,Halldin C,Thorberg SO,Sandell J,Farde L

更新日期：2000-07-01 00:00:00

abstract：:meta-[18F]Fluorobenzylguanidine ([18F]MFBG) and para-[18F]fluorobenzylguanidine ([18F]PFBG) were synthesized in three steps beginning with a fluoro for nitro exchange reaction on 3- and 4-nitrobenzonitrile, respectively. Overall radiochemical yields were 10-15% for [18F]MFBG and 50-55% for [18F]PFBG in a total synthes...

journal_title：Nuclear medicine and biology

authors： Garg PK,Garg S,Zalutsky MR

更新日期：1994-01-01 00:00:00

abstract：INTRODUCTION:Radiolabeled antibodies directed against endoglin (CD105) are promising tools for imaging and antiangiogenic cancer therapy. To validate iodinated antibodies as reliable tracers, we investigated the influence of the radiolabeling method (direct or indirect) on their in vivo stability. METHODS:Anti-CD105 m...

journal_title：Nuclear medicine and biology

authors： Karmani L,Levêque P,Bouzin C,Bol A,Dieu M,Walrand S,Vander Borght T,Feron O,Grégoire V,Bonifazi D,Michiels C,Lucas S,Gallez B

更新日期：2016-07-01 00:00:00

abstract：:We evaluated 99mTc-labeled mercaptoacetyltriglycine (99mTc-MAG3)-biocytin as a hepatobiliary imaging agent in the absence and presence of bilirubin in mice. We then compared its pharmacokinetic parameters; peak liver/heart activity ratio (rmax) and half clearance time (HCT) with those of 99mTc-labeled diisopropyl-imin...

journal_title：Nuclear medicine and biology

authors： Kim M,Seidel J,Le N,Kim IS,Yoo TM,Barker C,Kobayashi H,Green MV,Carrasquillo JA,Paik CH

更新日期：1999-01-01 00:00:00

abstract：:A new tetrahydrazido-germanium (GeTH) ligand was synthesized, characterized and complexed with 99mTc. The negatively charged 99mTc-chelate was shown to form in high yields at neutral pH in the absence of other reducing agents and exhibits high in vitro and in vivo stability. ...

journal_title：Nuclear medicine and biology

authors： Singh PR,Katti KK,Katti KV,Corlija M,Ketring AR,Volkert WA,Holmes RR

更新日期：1994-11-01 00:00:00

abstract：:The in vitro metabolism of 1-(4-[(18)F]fluoromethylbenzyl)-4-phenylpiperazine ([(18)F]1) and 1-(4-[(18)F]fluorobenzyl)-4-phenylpiperazine ([(18)F]2) was investigated using mouse liver S9 fraction. Results were compared to those of in vivo metabolism using mouse blood and bone and to in vitro metabolism using mouse liv...

journal_title：Nuclear medicine and biology

authors： Ryu EK,Choe YS,Kim DH,Ko BH,Choi Y,Lee KH,Kim BT

更新日期：2006-02-01 00:00:00

abstract：:A folate-receptor-targeting radiopharmaceutical, Ga(III)-deferoxamine-folate (Ga-DF-Folate), was radiolabeled with two positron-emitting isotopes of gallium, cyclotron-produced (66)Ga (9.5 hour half-life) and generator-produced (68)Ga (68 minute half-life). The [(66)Ga]Ga-DF-Folate was administered to athymic mice wit...

journal_title：Nuclear medicine and biology

authors： Mathias CJ,Lewis MR,Reichert DE,Laforest R,Sharp TL,Lewis JS,Yang ZF,Waters DJ,Snyder PW,Low PS,Welch MJ,Green MA

更新日期：2003-10-01 00:00:00

abstract：:The pharmacokinetics and internal radionuclide therapy of intraperitoneally administrated (188)Re-N,N-bis(2-mercaptoethyl)-N',N'-diethylethylenediamine (BMEDA)-labeled pegylated liposomal doxorubicin ((188)Re-DXR-liposome) were investigated in the C26 murine colon carcinoma ascites mouse model. After intraperitoneal a...

journal_title：Nuclear medicine and biology

authors： Chen LC,Chang CH,Yu CY,Chang YJ,Wu YH,Lee WC,Yeh CH,Lee TW,Ting G

更新日期：2008-11-01 00:00:00

abstract：INTRODUCTION:Image-derived input functions (IDIFs) represent a promising non-invasive alternative to arterial blood sampling for quantification in positron emission tomography (PET) studies. However, routine applications in patients and longitudinal designs are largely missing despite widespread attempts in healthy sub...

journal_title：Nuclear medicine and biology

authors： Hahn A,Nics L,Baldinger P,Wadsak W,Savli M,Kraus C,Birkfellner W,Ungersboeck J,Haeusler D,Mitterhauser M,Karanikas G,Kasper S,Frey R,Lanzenberger R

更新日期：2013-04-01 00:00:00

abstract：:The aim of this study was to assess the biological behavior of new radiolabeled glucose analogues proposed as tracers of glucose uptake in vivo and iodinated in position 3, 4, or 6. Biological results obtained in vitro on adipocytes and erythrocytes and in vivo in mice were compared to those obtained with the gold-sta...

journal_title：Nuclear medicine and biology

authors： Perret P,Ghezzi C,Ogier L,Abbadi M,Morin C,Mathieu JP,Fagret D

更新日期：2004-02-01 00:00:00

abstract：:Melanin, a natural biological pigment present in many organisms, has been found to exhibit multiple functions. An important property of melanin is its ability to chelate metal ions strongly, which might be developed as an iron chelator for iron overload therapy. Herein, we prepared the ultrasmall water-soluble melanin...

journal_title：Nuclear medicine and biology

authors： Zhang P,Yue Y,Pan D,Yang R,Xu Y,Wang L,Yan J,Li X,Yang M

更新日期：2016-09-01 00:00:00

abstract：:The application of radionuclide-labeled biomolecules such as monoclonal antibodies or antibody fragments for imaging purposes is called immunoscintigraphy. More specifically, when the nuclides used are positron emitters, such as zirconium-89, the technique is referred to as immuno-PET. Currently, there is an urgent ne...

journal_title：Nuclear medicine and biology

authors： Radchenko V,Bouziotis P,Tsotakos T,Paravatou-Petsotas M,la Fuente Ad,Loudos G,Harris AL,Xanthopoulos S,Filosofov D,Hauser H,Eisenhut M,Ponsard B,Roesch F

更新日期：2016-05-01 00:00:00

abstract：:A glucose analogue labelled with iodine-123 in position 6 has been synthesized: [123I]-6-deoxy-6-iodo-D-glucose (6DIG). The aim of this study was to examine its biological behaviour in order to assess whether it could be used to evaluate glucose transport with SPECT. To establish whether 6DIG enters the cells using th...

journal_title：Nuclear medicine and biology

authors： Henry C,Koumanov F,Ghezzi C,Morin C,Mathieu JP,Vidal M,de Leiris J,Comet M,Fagret D

更新日期：1997-08-01 00:00:00

abstract：INTRODUCTION:The pyruvaldehyde bis(N(4)-methylthiosemicarbazonato)copper(II) (Cu-PTSM) and diacetyl bis(N(4)-methylthiosemicarbazonato)copper(II) (Cu-ATSM) radiopharmaceuticals exhibit strong, species-dependent binding to the IIA site of human serum albumin (HSA), while the related ethylglyoxal bis(thiosemicarbazonato)...

journal_title：Nuclear medicine and biology

authors： Basken NE,Green MA

更新日期：2009-07-01 00:00:00

abstract：INTRODUCTION:Ultrasound (US) contrast agents based on microbubbles (MBs) are being investigated as platforms for drug and gene delivery. A methodology for determining the distribution and fate of modified MBs quantitatively in vivo can be achieved by tagging MBs directly with (99m)Tc. This creates the opportunity to em...

journal_title：Nuclear medicine and biology

authors： Lazarova N,Causey PW,Lemon JA,Czorny SK,Forbes JR,Zlitni A,Genady A,Foster FS,Valliant JF

更新日期：2011-11-01 00:00:00

abstract：INTRODUCTION:Dopamine D3 receptors are implicated in various neuropsychiatric diseases, drug abuse and alcoholism, but specific agents for D3 molecular imaging are lacking. We evaluated two in vitro selective fluorine-18-labeled radioligand candidates ([(18)F]5 and [(18)F]6) for positron emission tomography (PET) imagi...

journal_title：Nuclear medicine and biology

authors： Hocke C,Cumming P,Maschauer S,Kuwert T,Gmeiner P,Prante O

更新日期：2014-03-01 00:00:00

abstract：OBJECTIVES:Serotonin transporters (SERT) play an important role in controlling serotonin concentration in the synaptic cleft and in managing postsynaptic signal transduction. Inhibitors of SERT binding are well known as selective serotonin reuptake inhibitors (SSRIs) such as fluoxetine, sertraline, paroxetine, and esci...

journal_title：Nuclear medicine and biology

authors： Zhang Y,Liu F,Xiao H,Yao X,Li G,Choi SR,Ploessl K,Zha Z,Zhu L,Kung HF

更新日期：2018-11-01 00:00:00

abstract：:Holmium-166 ferric hydroxide macroaggregate (Ho-166 FHMA) particles possess two important properties for radiosynovectomy; relatively short half-life of the radioisotope and appropriate carrier size. Both these minimize radioactive leakage from the treated joint. This study was conducted to assess the effects of Ho-16...

journal_title：Nuclear medicine and biology

authors： Mäkelä O,Penttilä P,Kolehmainen E,Sukura A,Sankari S,Tulamo RM

更新日期：2002-07-01 00:00:00

abstract：:The diagnostic potential of PET using the amino acid analogue O-(2-[18F]fluoroethyl)-L-tyrosine ([18F]FET) in brain tumor diagnostics has been proven in many studies during the last two decades and is still the subject of multiple studies every year. In addition to standard magnetic resonance imaging (MRI), positron e...

journal_title：Nuclear medicine and biology

authors： Stegmayr C,Stoffels G,Filß C,Heinzel A,Lohmann P,Willuweit A,Ermert J,Coenen HH,Mottaghy FM,Galldiks N,Langen KJ

更新日期：2020-02-19 00:00:00