In vitro metabolism studies of (18)F-labeled 1-phenylpiperazine using mouse liver S9 fraction.

abstract：:High-affinity iodine- and ethyl-C-5 substituted analogs of 4-hydroxy-3-(3-[11C]methoxyphenyl)-2(1H)-quinolone ([11C]4HQ) were synthesized as new positron emission tomography radioligands for the glycine-binding sites of the N-methyl-d-aspartate (NMDA) ion channel. Although both radioligands showed high in vitro specif...

journal_title：Nuclear medicine and biology

authors： Fuchigami T,Haradahira T,Fujimoto N,Okauchi T,Maeda J,Suzuki K,Suhara T,Yamamoto F,Sasaki S,Mukai T,Yamaguchi H,Ogawa M,Magata Y,Maeda M

更新日期：2008-02-01 00:00:00

abstract：INTRODUCTION:Carbonic anhydrase (CA) IX is a transmembrane protein overexpressed in many frequently occurring tumors associated with tumor hypoxia. Sulfonamides and their bioisosteres are known to inhibit CA IX activity. In this study, 4-(2-aminoethyl)benzenesulfonamide was conjugated to a tridentate ligand, N-2-picoly...

journal_title：Nuclear medicine and biology

authors： Akurathi V,Dubois L,Lieuwes NG,Chitneni SK,Cleynhens BJ,Vullo D,Supuran CT,Verbruggen AM,Lambin P,Bormans GM

更新日期：2010-07-01 00:00:00

abstract：INTRODUCTION:Pathological formation of fibrosis, is an important feature in many diseases. Fibrosis in liver and pancreas has been associated to metabolic disease including type 1 and 2 diabetes. The current methods for detecting and diagnosing fibrosis are either invasive, or their sensitivity to detect fibrosis in ea...

journal_title：Nuclear medicine and biology

authors： Rosestedt M,Velikyan I,Rosenström U,Estrada S,Åberg O,Weis J,Westerlund C,Ingvast S,Korsgren O,Nordeman P,Eriksson O

更新日期：2020-11-28 00:00:00

abstract：:The serotonin 5-HT(1B) receptors regulate the release of serotonin and are involved in various disease states, including depression and schizophrenia. The goal of the study was to evaluate a high affinity and high selectivity antagonist, [(11)C]P943, as a positron emission tomography (PET) tracer for imaging the 5-HT(...

journal_title：Nuclear medicine and biology

authors： Nabulsi N,Huang Y,Weinzimmer D,Ropchan J,Frost JJ,McCarthy T,Carson RE,Ding YS

更新日期：2010-02-01 00:00:00

abstract：:Packed capillary liquid chromatography with electrospray mass spectrometry was used for direct determination of the specific radioactivity by calculation of isotope ratios between the (76)Br- and (79)Br-labeled analogues of N-((3-aminomethyl)benzyl)-4-bromobenzamide. Using 20 microL injections on packed capillary colu...

journal_title：Nuclear medicine and biology

authors： Forngren BH,Yngve U,Forngren T,Långström B

更新日期：2000-11-01 00:00:00

abstract：:105Rhodium(III) complexes with three different acyclic tetrathioether ligands containing pendant carboxylic acid groups have been synthesized and characterized. The complexes were evaluated for stability under physiological conditions and the most promising complexes were evaluated in vivo in normal mice. The primary ...

journal_title：Nuclear medicine and biology

authors： Goswami N,Higginbotham C,Volkert W,Alberto R,Nef W,Jurisson S

更新日期：1999-11-01 00:00:00

abstract：INTRODUCTION:Sepantronium bromide (YM155) is an antitumor drug in development and is a first-in-class chemical entity, which is a survivin suppressant. We developed a radiosynthesis of [(11)C]YM155 to non-invasively evaluate its tissue and tumor distribution in mice bearing human prostate tumor xenografts. METHODS:Met...

journal_title：Nuclear medicine and biology

authors： Murakami Y,Matsuya T,Kita A,Yamanaka K,Noda A,Mitsuoka K,Nakahara T,Miyoshi S,Nishimura S

更新日期：2013-02-01 00:00:00

abstract：:To clarify the contribution of apoptosis to cell death in four human solid tumor cell lines, clonogenic cell survival (indicator of radiosensitivity) and induction of caspase-3 (CASP-3)/caspase-3-like proteases (CASP-3LP) and the production of DNA fragmentation (markers for apoptosis) were studied in RKO, LS174T, MCF7...

journal_title：Nuclear medicine and biology

authors： Urashima T,Nagasawa H,Wang K,Adelstein SJ,Little JB,Kassis AI

更新日期：2006-11-01 00:00:00

abstract：:A simple, rapid, and reproducible micromethod for quantification of sulfhydryl (SH) groups generated after reduction of monoclonal antibody (MAb) disulfide bonds with 2-mercaptoethanol (2-ME) is described. The number of SH groups per molecule of antibody in the 2-ME and in the other reducing agents was calculated from...

journal_title：Nuclear medicine and biology

authors： Iznaga Escobar N,Morales A,Núñez G

更新日期：1996-07-01 00:00:00

abstract：:Quantitative imaging of glucose metabolism of human brain tumors with PET utilizes 2-[(18)F]-fluorodeoxy-D-glucose (FDG) and a conversion factor called the lumped constant (LC), which relates the metabolic rate of FDG to glucose. Since tumors have greater uptake of FDG than would be predicted by the metabolism of nati...

journal_title：Nuclear medicine and biology

authors： Muzi M,Freeman SD,Burrows RC,Wiseman RW,Link JM,Krohn KA,Graham MM,Spence AM

更新日期：2001-02-01 00:00:00

abstract：:A consensus has emerged that early imaging (within 20 min post-injection [p.i.] of sestamibi) has the highest diagnostic yield. Tc-99m-sestamibi uptake has been associated with P-glycoprotein-mediated multi-drug resistance (MDR), tumor vascularization, invasiveness, and cell proliferation. The aim of this study was to...

journal_title：Nuclear medicine and biology

authors： Leitha T,Glaser C,Lang S

更新日期：1998-08-01 00:00:00

abstract：INTRODUCTION:After its intravenous injection, [18F]fluorocholine is oxidized by choline-oxidase into its main plasma metabolite, [18F]fluorobetaine. If PET kinetic modeling quantification of [18F]fluorocholine uptake is intended, the plasma input time-activity-curve of the parent tracer must be obtained, i.e., the frac...

journal_title：Nuclear medicine and biology

authors： Villar M,Valiente M,Toscano M,Galmés M,González C,Ortiz M,Vega F,Oporto M,Bibiloni P,Chinchilla JL,Molina J,Ríos Á,Peña C,Rubí S

更新日期：2019-01-01 00:00:00

abstract：:We report herein the preparation and biological evaluation of two radioastatinated biotin conjugates, (3-[211At]astatobenzoyl)norbiotinamide and ((5-[211At]astato-3-pyridinyl)carbonyl)norbiotinamide. Both conjugates were stable in the presence of human serum and cerebrospinal fluid as well as murine serum, indicating ...

journal_title：Nuclear medicine and biology

authors： Foulon CF,Alston KL,Zalutsky MR

更新日期：1998-02-01 00:00:00

abstract：INTRODUCTION:The cardinal pathological feature of Parkinson's disease (PD) is progressive loss of dopaminergic neurons. Since dopamine transporter (DAT) is a protein located presynaptically on dopaminergic nerve terminals, radioligands that bind to these sites are promising radiopharmaceuticals for evaluation of the in...

journal_title：Nuclear medicine and biology

authors： Liu L,Wang Y,Li B,Jia J,Sun Z,Zhang J,Tian J,Wang X

更新日期：2009-11-01 00:00:00

abstract：UNLABELLED:The radiolabelled bombesin analogue AMBA shows high potential for diagnosis and treatment of prostate and breast cancer, but the influence of different chelators, which differ in terms of radiochemical reactivity and stability, have not been explored so far. In order to find the best suitable chelator for la...

journal_title：Nuclear medicine and biology

authors： Asti M,Iori M,Capponi PC,Atti G,Rubagotti S,Martin R,Brennauer A,Müller M,Bergmann R,Erba PA,Versari A

更新日期：2014-01-01 00:00:00

abstract：:PET centers without particle accelerators make clinical PET widely available at reduced cost. For myocardial perfusion tracers, these satellite PET centers are limited to generator- produced 82Rb(+) and 62Cu[PTSM]. Their limitations motivate a search for transportable alternatives. In search of new tracers we have syn...

journal_title：Nuclear medicine and biology

authors： Studenov AR,Berridge MS

更新日期：2001-08-01 00:00:00

abstract：:The application of radionuclide-labeled biomolecules such as monoclonal antibodies or antibody fragments for imaging purposes is called immunoscintigraphy. More specifically, when the nuclides used are positron emitters, such as zirconium-89, the technique is referred to as immuno-PET. Currently, there is an urgent ne...

journal_title：Nuclear medicine and biology

authors： Radchenko V,Bouziotis P,Tsotakos T,Paravatou-Petsotas M,la Fuente Ad,Loudos G,Harris AL,Xanthopoulos S,Filosofov D,Hauser H,Eisenhut M,Ponsard B,Roesch F

更新日期：2016-05-01 00:00:00

abstract：INTRODUCTION:The in vitro and in vivo behavior of the radiolabeled monoclonal antibody MORAb-003 was investigated as a prelude to a clinical trial. METHODS:The cellular retention of 111In- and 131I-labeled MORAb-003 was investigated using IGROV1 and SW620 cells. Biodistribution studies in tumor-bearing mice were perfo...

journal_title：Nuclear medicine and biology

authors： Smith-Jones PM,Pandit-Taskar N,Cao W,O'Donoghue J,Philips MD,Carrasquillo J,Konner JA,Old LJ,Larson SM

更新日期：2008-04-01 00:00:00

abstract：:Melanin, a natural biological pigment present in many organisms, has been found to exhibit multiple functions. An important property of melanin is its ability to chelate metal ions strongly, which might be developed as an iron chelator for iron overload therapy. Herein, we prepared the ultrasmall water-soluble melanin...

journal_title：Nuclear medicine and biology

authors： Zhang P,Yue Y,Pan D,Yang R,Xu Y,Wang L,Yan J,Li X,Yang M

更新日期：2016-09-01 00:00:00

abstract：UNLABELLED:[(18)F]-labelled choline analogues, such as 2-[(18)F]fluoroethylcholine ((18)FECH), have suggested to be a new class of choline derivatives highly useful for the imaging of prostate and brain tumours. In fact, tumour cells with enhanced proliferation rate usually exhibit an improved choline uptake due to the...

journal_title：Nuclear medicine and biology

authors： Asti M,Farioli D,Iori M,Guidotti C,Versari A,Salvo D

更新日期：2010-04-01 00:00:00

abstract：:A radioiodinated ligand, (R)-N-methyl-(2-[(125)I]iodo-phenoxy)-3-phenylpropylamine, [(125)I]2-INXT, targeting norepinephrine transporters (NET), was successfully prepared. A no-carrier-added product, [(125)I]2-INXT, displayed a saturable binding with a high affinity (K(d)=0.06 nM) in the homogenates prepared from rat ...

journal_title：Nuclear medicine and biology

authors： Kung MP,Choi SR,Hou C,Zhuang ZP,Foulon C,Kung HF

更新日期：2004-07-01 00:00:00

abstract：INTRODUCTION:Myocardial perfusion gating techniques offer the possibility of measurement of left ventricular end-systolic (ESV) and end-diastolic volume (EDV) and left ventricular ejection fraction (LVEF) in clinical and preclinical trials. The aim of this study was to evaluate left ventricular volumes (LVV) and LVEF w...

journal_title：Nuclear medicine and biology

authors： Szymanski MK,Kruizinga S,Tio RA,Willemsen AT,Schäfers MA,Stegger L,Dierckx RA,Hillege HL,Slart RH

更新日期：2012-07-01 00:00:00

abstract：INTRODUCTION:Human epidermal growth factor receptor type 2 (HER2) overexpression supports proliferation of androgen-independent prostate cancer (PC). Radionuclide molecular imaging of HER2 expression in disseminated PC would aid in the selection of patients who are likely responders to HER2 targeting therapy. In this s...

journal_title：Nuclear medicine and biology

authors： Malmberg J,Sandström M,Wester K,Tolmachev V,Orlova A

更新日期：2011-11-01 00:00:00

abstract：INTRODUCTION:Bromodomain and extra-terminal domain (BET) family proteins play a vital role in the epigenetic regulation process by interacting with acetylated lysine (Ac-K) residues in histones. BET inhibitors have become promising candidates to treat various diseases through the inhibition of the interaction between B...

journal_title：Nuclear medicine and biology

authors： Bai P,Lu X,Lan Y,Chen Z,Patnaik D,Fiedler S,Striar R,Haggarty SJ,Wang C

更新日期：2020-01-01 00:00:00

abstract：:ABSTRACT. The aim of the present study was to investigate the lymphatic cardiac circulation in an experimental model of ischemia plus reperfusion in mongrel dogs (Canis familiaris L). As radiotracer we used 0.2-0.25 ml (111 MBq) of 99mTc-Re2S7 colloid (+/-10 microm), injected subcapsullary below the second diagonal of...

journal_title：Nuclear medicine and biology

authors： Santos AC,de Lima JJ,Botelho MF,Pacheco MF,Sousa P,Bernardo J,Ferreira N,Gonçalves L,Aguiar J,Providência LA,Pauwels EK

更新日期：1998-10-01 00:00:00

abstract：INTRODUCTION:Thymidylate synthase and folate receptors are well-developed targets of cancer therapy. Discovery of a simple and fast method for the conversion of 11CH3Ito[11C]-formaldehyde (11CH2O) encouraged us to label the co-factor of this enzyme. Preliminary studies conducted on cell lines have demonstrated a prefer...

journal_title：Nuclear medicine and biology

authors： Saeed M,Tewson TJ,Erdahl CE,Kohen A

更新日期：2012-07-01 00:00:00

abstract：BACKGROUND:The radiolabeled amino acid O-(2-(18)F-fluoroethyl)-L-tyrosine (FET) and thymidine analogue 3'-deoxy-3'-(18)F-fluorothymidine (FLT) are widely used for positron emission tomography (PET) brain tumor imaging; however, comparative studies are scarce. The aim of this study therefore was to compare FLT and FET P...

journal_title：Nuclear medicine and biology

authors： Nedergaard MK,Michaelsen SR,Perryman L,Erler J,Poulsen HS,Stockhausen MT,Lassen U,Kjaer A

更新日期：2016-03-01 00:00:00

abstract：UNLABELLED:In recent years, several PET and SPECT studies have shown loss of striatal dopamine transporter (DAT) binding in amphetamine (AMPH) users. However, the use of DAT SPECT tracers to detect AMPH-induced changes in DAT binding has not been validated. We therefore examined if repeated administration of D-AMPH or ...

journal_title：Nuclear medicine and biology

authors： Booij J,de Bruin K,Gunning WB

更新日期：2006-04-01 00:00:00

abstract：UNLABELLED:The purpose of this study was to compare the diagnostic value of positron emission tomography (PET) using [(18)F]-fluorodeoxyglucose ((18)F-FDG) and O-(2-[(18)F]fluoroethyl)-l-tyrosine ((18)F-FET) in patients with brain lesions suspicious of cerebral gliomas. METHODS:Fifty-two patients with suspicion of cer...

journal_title：Nuclear medicine and biology

authors： Pauleit D,Stoffels G,Bachofner A,Floeth FW,Sabel M,Herzog H,Tellmann L,Jansen P,Reifenberger G,Hamacher K,Coenen HH,Langen KJ

更新日期：2009-10-01 00:00:00

abstract：INTRODUCTION:This paper proposes liposomes as a potential new tool for radioimmunotherapy in solid tumours with a two step targeting system. Tumour pretargeting is obtained by using a monoclonal bispecific antibody (BsmAb, anti CEA x anti-DTPA-In) and pegylated liposomes containing lipid-hapten (DSPE-DTPA-In or DSPE-PE...

journal_title：Nuclear medicine and biology

authors： Rauscher A,Frindel M,Maurel C,Maillasson M,Le Saëc P,Rajerison H,Gestin JF,Barbet J,Faivre-Chauvet A,Mougin-Degraef M

更新日期：2014-05-01 00:00:00