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Lipiodol solution of a lipophilic agent, (188)Re-TDD, for the treatment of liver cancer.

Abstract：

:Radiolabeled lipiodol has been used for targeting liver cancer. We developed a lipiodol solution of (188)Re-TDD (2,2,9,9-tetramethyl-4,7-diaza-1,10-decanedithiol) and investigated its feasibility for the treatment of liver cancer. The lipiodol solution of (188)Re-TDD was well-retained in the lipiodol phase in vitro. After injection through the tail veins of mice, high lung-uptake was investigated which is evidence of embolizing activity. We also found high accumulation in hepatoma after injection through the hepatic arteries of hepatoma-bearing rats. In conclusion, the lipiodol solution of (188)Re-TDD is a promising agent for liver cancer therapy.

journal_name

Nucl Med Biol

journal_title

Nuclear medicine and biology

authors

Jeong JM,Kim YJ,Lee YS,Ko JI,Son M,Lee DS,Chung JK,Park JH,Lee MC

doi

10.1016/s0969-8051(00)00208-0

keywords:

subject

Has Abstract

pub_date

2001-02-01 00:00:00

pages

197-204

issue

2

eissn

0969-8051

issn

1872-9614

pii

S0969-8051(00)00208-0

journal_volume

28

pub_type

杂志文章

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