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Functional neuroanatomy of the basal ganglia as studied by dual-probe microdialysis.

Abstract：

:Dual probe microdialysis was employed in intact rat brain to investigate the effect of intrastriatal perfusion with selective dopamine D1 and D2 receptor agonists and with c-fos antisense oligonucleotide on (a) local GABA release in the striatum; (b) the internal segment of the globus pallidus and the substantia nigra pars reticulata, which is the output site of the strionigral GABA pathway; and (c) the external segment of the globus pallidus, which is the output site of the striopallidal GABA pathway. The data provide functional in vivo evidence for a selective dopamine D1 receptor-mediated activation of the direct strionigral GABA pathway and a selective dopamine D2 receptor inhibition of the indirect striopallidal GABA pathway and provides a neuronal substrate for parallel processing in the basal ganglia regulation of motor function. Taken together, these findings offer new therapeutic strategies for the treatment of dopamine-linked disorders such as Parkinson's disease, Huntington's disease, and schizophrenia.

journal_name

Nucl Med Biol

journal_title

Nuclear medicine and biology

authors

O'Connor WT

doi

10.1016/s0969-8051(98)00066-3

subject

Has Abstract

pub_date

1998-11-01 00:00:00

pages

743-6

issue

8

eissn

0969-8051

issn

1872-9614

pii

S0969-8051(98)00066-3

journal_volume

25

pub_type

杂志文章

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