A 99mTc-labeled gemcitabine bisphosphonate drug conjugate as a probe to assess the potential for targeted chemotherapy of metastatic bone cancer.

abstract：:Indium-111 labeled, Trastuzumab-Doxorubicin Conjugated, and APTES-PEG coated magnetic nanoparticles were designed for tumor targeting, drug delivery, controlled drug release, and dual-modal tumor imaging. Superparamagnetic iron oxide nanoparticles (SPIONs) were synthesized by thermal decomposition method to obtain nar...

journal_title：Nuclear medicine and biology

authors： Zolata H,Abbasi Davani F,Afarideh H

更新日期：2015-02-01 00:00:00

abstract：:Dual probe microdialysis was employed in intact rat brain to investigate the effect of intrastriatal perfusion with selective dopamine D1 and D2 receptor agonists and with c-fos antisense oligonucleotide on (a) local GABA release in the striatum; (b) the internal segment of the globus pallidus and the substantia nigra...

journal_title：Nuclear medicine and biology

authors： O'Connor WT

更新日期：1998-11-01 00:00:00

abstract：:A simple method is described for affinity purification of radiolabeled antibodies using glutaraldehyde-fixed tumor target cells. The cell-bound antibody fraction is removed from the cells by an acid wash and then immediately subjected to buffer-exchange chromatography. The method was applied to the D3 murine monoclona...

journal_title：Nuclear medicine and biology

authors： Juweid M,Sato J,Paik C,Onay-Basaran S,Weinstein JN,Neumann RD

更新日期：1993-04-01 00:00:00

abstract：:Deuteron-induced nuclear reactions for generation of no-carrier-added (NCA) Lu isotopes were investigated using the stacked-foil activation technique on natural Yb targets at energies up to Ed=18.18MeV. The decay curve of ¹⁷⁷Yb, the growth curve of the cumulative (direct and indirect) and the direct production of (177...

journal_title：Nuclear medicine and biology

authors： Manenti S,Bonardi ML,Gini L,Groppi F

更新日期：2014-05-01 00:00:00

abstract：INTRODUCTION:Current guidelines for brain PET imaging advice against the injection of diazepam prior to brain FDG-PET examination in order to avoid possible interactions of benzodiazepines with the radiotracer uptake. Nevertheless, many patients undergoing PET studies are likely to be under chronic treatment with benzo...

journal_title：Nuclear medicine and biology

authors： Silva-Rodríguez J,García-Varela L,López-Arias E,Domínguez-Prado I,Cortés J,Pardo-Montero J,Fernández-Ferreiro A,Ruibal Á,Sobrino T,Aguiar P

更新日期：2016-12-01 00:00:00

abstract：UNLABELLED:The purpose of this study is to reveal characteristics of (64)Cu-labeled diacetyl-bis(N(4)-methylthiosemicarbazone) ([(64)Cu]Cu-ATSM) during cell proliferation and hypoxia by autoradiography imaging and immunohistochemical staining. METHODS:The intratumoral distributions of [(64)Cu]Cu-ATSM and [(18)F]-2-flu...

journal_title：Nuclear medicine and biology

authors： Oh M,Tanaka T,Kobayashi M,Furukawa T,Mori T,Kudo T,Fujieda S,Fujibayashi Y

更新日期：2009-05-01 00:00:00

abstract：:An iodinated analog of PK11195, 1-(2-chlorophenyl)-N-methyl-N-(1-methylpropyl)isoquinoline-3-carboxamide , a specific antagonist of the peripheral-type benzodiazepine receptor (omega 3), has been synthesized in three steps with an overall chemical yield of 40%. Both [123I]- and [125I]-Iodo-PK11195 have been synthesize...

journal_title：Nuclear medicine and biology

authors： Gildersleeve DL,Van Dort ME,Johnson JW,Sherman PS,Wieland DM

更新日期：1996-01-01 00:00:00

abstract：:A simple, rapid, and reproducible micromethod for quantification of sulfhydryl (SH) groups generated after reduction of monoclonal antibody (MAb) disulfide bonds with 2-mercaptoethanol (2-ME) is described. The number of SH groups per molecule of antibody in the 2-ME and in the other reducing agents was calculated from...

journal_title：Nuclear medicine and biology

authors： Iznaga Escobar N,Morales A,Núñez G

更新日期：1996-07-01 00:00:00

abstract：:Three 3-pyridyl ether nicotinic ligands-(S)-5-Iodo-3-[(2-pyrrolidinyl)-methoxy]pyridine (5-iodo-A-85865), (S)-5-Iodo-3-[1-(methyl)-2-pyrrolidinyl-methoxy]pyridine (5-Iodo-A-84543), and (S)-5-iodo-3-[1-methyl-(2-azetidinyl)-methoxy]pyridine (5-iodo-N-Me-A-85380) were labeled with I-125/I-123, and their ability to label...

journal_title：Nuclear medicine and biology

authors： Fan H,Scheffel UA,Rauseo P,Xiao Y,Dogan AS,Yokoi F,Hilton J,Kellar KJ,Wong DF,Musachio JL

更新日期：2001-11-01 00:00:00

abstract：:In connection with pretargeting, an amine-derivatized morpholino phosphorodiamidate oligomer (NH(2)-cMORF) was conjugated conventionally with p-isothiocyanate benzyl-DTPA (p-SCN-Bn-DTPA). However, after (111)In radiolabeling, unexpected label instability was observed. To understand this instability, the NH(2)-cMORF an...

journal_title：Nuclear medicine and biology

authors： Liu G,Dou S,Liu Y,Liang M,Chen L,Cheng D,Greiner D,Rusckowski M,Hnatowich DJ

更新日期：2011-02-01 00:00:00

abstract：:To evaluate the ability of [1-11C]octanoate as a PET tracer for imaging the brain, we examined its distribution in the brain and surrounding tissues in rats and cats with PET. In rats, owing to the accumulated radioactivity in the harderian glands, clear brain images were not obtained at rostral levels. In cats, the b...

journal_title：Nuclear medicine and biology

authors： Kuge Y,Kawashima H,Yamazaki S,Hashimoto N,Miyake Y

更新日期：1996-11-01 00:00:00

abstract：INTRODUCTION:The functions of I₂-imidazoline receptors (I₂Rs) are unknown, but evidence exists for their involvement in various neuropsychiatric disorders. Although a few positron emission tomography (PET) I₂R ligands have been developed, of which [(11)C]FTIMD and [(11)C]BU99008 were evaluated as PET I₂R imaging ligand...

journal_title：Nuclear medicine and biology

authors： Kawamura K,Shimoda Y,Kumata K,Fujinaga M,Yui J,Yamasaki T,Xie L,Hatori A,Wakizaka H,Kurihara Y,Ogawa M,Nengaki N,Zhang MR

更新日期：2015-04-01 00:00:00

abstract：INTRODUCTION:The purpose of the study was to examine potential of 131I-labeled chitosan hydrogels (Chi) for treatment of liver cancer. METHODS:Orthotopic hepatoma was induced by McA-RH7777-fLuc cells (1×107) that were injected into the left hepatic lobe of rats. Ten days later, tumor-bearing rats evidenced by biolumin...

journal_title：Nuclear medicine and biology

authors： Hwang H,Kim KI,Kwon J,Kim BS,Jeong HS,Jang SJ,Oh PS,Park HS,Lim ST,Sohn MH,Jeong HJ

更新日期：2017-09-01 00:00:00

abstract：:As PET metabolic imaging becomes routine in clinical practice, there is a tendency to make imaging and data analysis fast and simple, but interpretation of these pictures by visual inspection does not do justice to the power of PET technology. Tissue data and blood data can be analyzed mathematically to provide parame...

journal_title：Nuclear medicine and biology

authors： Krohn KA,Mankoff DA,Muzi M,Link JM,Spence AM

更新日期：2005-10-01 00:00:00

abstract：:A paired-label biodistribution was performed in athymic mice bearing SK-N-SH human neuroblastoma xenografts to compare the tissue uptake of meta-[211At]astatobenzylguanidine ([211At]MABG) and [131I]MIBG. Significantly higher (p < 0.05) uptake of [211At]MABG was seen in tumor (3.8 +/- 0.8% ID/g vs. 3.1 +/- 0.7% ID/g at...

journal_title：Nuclear medicine and biology

authors： Vaidyanathan G,Friedman HS,Keir ST,Zalutsky MR

更新日期：1996-08-01 00:00:00

abstract：INTRODUCTION:Positron emission tomography (PET) is extensively used in clinical oncology for tumor detection. This study aimed to explore the application of the radiotracers [18F]fluorodeoxyglucose ([18F]FDG), 3'-deoxy-3'- [18F]fluorothymidine ([18F]FLT), and [18F]fluoromisonidazole ([18F]FMISO) in the diagnosis and mo...

journal_title：Nuclear medicine and biology

authors： Jiang H,Zhang R,Jiang H,Zhang M,Guo W,Feng G,Pan W,Xu H,Wang S

更新日期：2019-01-01 00:00:00

abstract：:We describe the synthesis of 2'-[(18)F]fluoroflumazenil (FFMZ), which differs from the typically used [(18)F]fluoroethylflumazenil (FEFMZ) for benzodiazepine receptor imaging. For one-pot one-step labeling, the precursors, 2'-tosyloxyflumazenil (TFMZ) and 2'-mesyloxyflumazenil (MFMZ), were synthesized in three steps. ...

journal_title：Nuclear medicine and biology

authors： Yoon YH,Jeong JM,Kim HW,Hong SH,Lee YS,Kil HS,Chi DY,Lee DS,Chung JK,Lee MC

更新日期：2003-07-01 00:00:00

abstract：INTRODUCTION:After its intravenous injection, [18F]fluorocholine is oxidized by choline-oxidase into its main plasma metabolite, [18F]fluorobetaine. If PET kinetic modeling quantification of [18F]fluorocholine uptake is intended, the plasma input time-activity-curve of the parent tracer must be obtained, i.e., the frac...

journal_title：Nuclear medicine and biology

authors： Villar M,Valiente M,Toscano M,Galmés M,González C,Ortiz M,Vega F,Oporto M,Bibiloni P,Chinchilla JL,Molina J,Ríos Á,Peña C,Rubí S

更新日期：2019-01-01 00:00:00

abstract：:We investigated sigma(1) and dopamine D(2) receptor occupancy in mouse brain after a single injection of haloperidol, nemonapride, or spiperone using [(11)C]SA4503 and [(11)C]raclopride, respectively. Co-injection of the three compounds significantly blocked the uptake of each radioligand. Six hours later, only halope...

journal_title：Nuclear medicine and biology

authors： Ishiwata K,Kawamura K,Kobayashi T,Matsuno K

更新日期：2003-05-01 00:00:00

abstract：INTRODUCTION:As the use of metallic radionuclides increases, so does the demand for a simple production method. In this study, we demonstrated an in situ target processing concept for automated metallic radionuclide production without the use of any robotic device. METHODS:An alumina ceramic vessel for a vertical irra...

journal_title：Nuclear medicine and biology

authors： Nagatsu K,Suzuki H,Fukada M,Minegishi K,Tsuji A,Fukumura T

更新日期：2012-11-01 00:00:00

abstract：:The synthetic porphyrins, N-benzyl-5,10,15,20-tetrakis (4-carboxyphenyl) porphine (N-bzHTCPP) and N-4-nitrobenzyl-5-(4-carboxyphenyl)-10,15,20-tris(4-sulfophenyl) porphine (N-bzHCS3P), represent excellent radiocopper chelating agents that may find utility in antibody-mediated diagnosis and/or therapy. N-bzHCS3P was co...

journal_title：Nuclear medicine and biology

authors： Bhalgat MK,Roberts JC,Mercer-Smith JA,Knotts BD,Vessella RL,Lavallee DK

更新日期：1997-02-01 00:00:00

abstract：:Positron-emission tomography (PET) provides potential in neuropsychiatric drug development by expanding knowledge of drug action in the living human brain and reducing time consumption and costs. The 5-hydroxytryptamine(1A) (5-HT(1A)) receptor is of central interest as a target for the treatment of anxiety, depression...

journal_title：Nuclear medicine and biology

authors： Andrée B,Halldin C,Thorberg SO,Sandell J,Farde L

更新日期：2000-07-01 00:00:00

abstract：:meta-[18F]Fluorobenzylguanidine ([18F]MFBG) and para-[18F]fluorobenzylguanidine ([18F]PFBG) were synthesized in three steps beginning with a fluoro for nitro exchange reaction on 3- and 4-nitrobenzonitrile, respectively. Overall radiochemical yields were 10-15% for [18F]MFBG and 50-55% for [18F]PFBG in a total synthes...

journal_title：Nuclear medicine and biology

authors： Garg PK,Garg S,Zalutsky MR

更新日期：1994-01-01 00:00:00

abstract：INTRODUCTION:Amino acid based radiotracers target tumor cells through increased uptake by membrane-associated amino acid transport (AAT) systems. In the present study, four structurally related non-natural (18)F-labeled amino acids, (R)- and (S)-[(18)F]FAMP 1 and (R)- and (S)-[(18)F]MeFAMP 2 have been prepared and eval...

journal_title：Nuclear medicine and biology

authors： Yu W,McConathy J,Olson JJ,Goodman MM

更新日期：2015-01-01 00:00:00

abstract：:In this study we demonstrated that significant egress of FDG from myocardium occurs within the first hour after tracer injection leading to nonlinear Patlak plots. There are also significant amounts of acidic FDG metabolites present in the blood. However, the impact of these metabolites on the estimates of myocardial ...

journal_title：Nuclear medicine and biology

authors： Herrero P,Dence CS,Sharp TL,Welch MJ,Gropler RJ

更新日期：2004-10-01 00:00:00

abstract：:New oxotechnetium complexes of general formula [99mTc(O)(PNS)(S(CH2)nOSiR3)] (4-6) were synthesized by direct reduction of [99mTcO4]- with stannous chloride, in the presence of the tridentate heterofunctionalized phosphine H2PNS and of the monodentate silylated thiols [HS(CH2)nOSiR3] (n = 2, R = Ph (1); n = 3, R = Ph ...

journal_title：Nuclear medicine and biology

authors： Fernandes C,Kniess T,Gano L,Seifert S,Spies H,Santos I

更新日期：2004-08-01 00:00:00

abstract：INTRODUCTION:VEGF receptors play a key role in angiogenesis and are important targets for several approved and many experimental drugs. Imaging of VEGF receptor expression in malignant tumors would provide important information, which can influence patient management. The aim of this study was the development of an eas...

journal_title：Nuclear medicine and biology

authors： Eder M,Krivoshein AV,Backer M,Backer JM,Haberkorn U,Eisenhut M

更新日期：2010-05-01 00:00:00

abstract：:[see text for equation] Nucleophilic [(18)F]fluorination of some halo- and mesyloxyalkanes to the corresponding [(18)F]fluoroalkanes with fluoride-18 obtained from an (18)O(p,n) [(18)F]F reaction, using an ionic liquid as a reaction medium, has been studied as a new method for fluorine-18 labeling. Of the various ioni...

journal_title：Nuclear medicine and biology

authors： Kim DW,Choe YS,Chi DY

更新日期：2003-05-01 00:00:00

abstract：INTRODUCTION:Porphyrin and its derivatives exhibit inherent affinity for localization in tumors. Hence, porphyrin derivatives radiolabeled with suitable therapeutic radionuclides could be envisaged as potential agents for targeted tumor therapy. In this direction, a water-soluble porphyrin derivative, viz., 5,10,15,20-...

journal_title：Nuclear medicine and biology

authors： Das T,Chakraborty S,Sarma HD,Banerjee S,Venakatesh M

更新日期：2010-07-01 00:00:00

abstract：:In this study, the (+)-enantiomer of radioiodinated 2-[4-(4-iodophenyl)piperidino]cyclohexanol [(+)-[(125)I]-p-iodovesamicol] [(+)-[(125)I]pIV], which is reported to bind with high affinity to sigma-1 receptors in vitro, was tested for its usefulness in imaging sigma-1 receptors in the central nervous system (CNS) in ...

journal_title：Nuclear medicine and biology

authors： Akhter N,Shiba K,Ogawa K,Kinuya S,Nakajima K,Mori H

更新日期：2007-08-01 00:00:00