Abstract：
:Growth factors such as epidermal growth factor (EGF) and transforming growth factor-alpha (TGF-alpha) play an important role in cell proliferation during embryogenesis. The purposes of the study were to characterize the expression patterns of EGF and TGF-alpha and their receptor, EGF receptor (EGF-R), and to analyze regional patterns of cell proliferation during primary palate morphogenesis when facial primordia outgrow and fuse to form the premaxillary and upper lip regions. The expression of all molecules was studied with indirect immunohistochemistry with conventional and/or confocal microscopes in normal days 10 and 11 CD1 mice. 5-Bromodeoxyuridine (BrdU) and proliferating cell nuclear antigen (PCNA) were used as markers of cell proliferation. EGF, TGF-alpha, and EGF-R were found to have similar distribution patterns at all stages examined. In the anterior region of the face, the molecules were intensely localized at the tips and peripheral regions of the medial and lateral nasal prominences. Upon fusion of the facial prominences, all three molecules were present mainly at the fusion area and the tips and peripheral areas of the maxillary and nasal prominences. BrdU and PCNA were found to have distribution patterns similar to those of EGF, TGF-alpha, and EGF-R, with intense staining at the tips and peripheral regions of the facial prominences. These results show that EGF, TGF-alpha, and their receptor were expressed more intensely in regions of the developing primary palate where cell proliferation was most pronounced, and suggest that EGF, TGF-alpha, and EGF-R may play a role in cell proliferation during morphogenesis of the primary palate.
journal_name
J Dent Resjournal_title
Journal of dental researchauthors
Iamaroon A,Tait B,Diewert VMdoi
10.1177/00220345960750080301subject
Has Abstractpub_date
1996-08-01 00:00:00pages
1534-9issue
8eissn
0022-0345issn
1544-0591journal_volume
75pub_type
杂志文章abstract：:As a major intracellular degradation and recycling machinery, autophagy plays an important role in maintaining cellular homeostasis and remodeling during normal development. Our previous study showed that fluorapatite (FA) crystal-coated electrospun polycaprolactone (PCL) was capable of inducing differentiation and mi...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/0022034516636852
更新日期：2016-06-01 00:00:00
abstract：:The cacao bean husk has been shown to possess two types of cariostatic substances, one showing anti-glucosyltransferase (GTF) activity and the other antibacterial activity, and to inhibit experimental dental caries in rats infected with mutans streptococci. In the present study, chromatographic purification revealed h...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/00220345010800111001
更新日期：2001-11-01 00:00:00
abstract：:microRNAs could be mechanosensitive and emerge as critical posttranscriptional regulators in the bone-remodeling process. During orthodontic tooth movement (OTM), the application of mechanical force induces alveolar bone remodeling, but whether microRNAs respond to orthodontic force and contribute to OTM is unknown. m...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/0022034516657043
更新日期：2016-11-01 00:00:00
abstract：:Evidence from epidemiologic studies suggests that periodontal infections are independently associated with subclinical and clinical atherosclerotic vascular disease. Although the strength of the reported associations is modest, the consistency of the data across diverse populations and a variety of exposure and outcom...
journal_title：Journal of dental research
pub_type： 杂志文章,评审
doi：10.1177/0022034510375281
更新日期：2010-09-01 00:00:00
abstract：:A new type of hydraulic cement has been developed. This cement consists of a mixture of cement powder and setting agent powder and therefore has only to be kneaded with a little amount of water when being used. ...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/00220345790580050601
更新日期：1979-05-01 00:00:00
abstract：:Dentin Matrix Protein 1 (DMP1) is highly expressed in alveolar bone and cementum, which are important components of the periodontium. Therefore, we hypothesized that Dmp1 is critical for the integrity of the periodontium, and that deletion may lead to increased susceptibility to disease. An early-onset periodontal def...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/154405910808700708
更新日期：2008-07-01 00:00:00
abstract：:Acidic proline-rich proteins were localized histologically by means of the indirect immunoperoxidase technique in the acinar cells of parotid and submandibular gland sections of both man and Macaca fascicularis. These proteins were also identified as constituents of the long term in vivo-formed acquired pellicle on hu...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/00220345800590081201
更新日期：1980-08-01 00:00:00
abstract：:Eighteen different Streptococcus strains including S mutans, sanguis, mitis, salivarius, bovis, and 2F2, were assayed for their relative adsorption to synthetic hydroxyapatite and for quantities of lactic acid produced while in the adsorbed state. The results indicated that all S mutans and some S sanguis have an enha...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/00220345770560101401
更新日期：1977-10-01 00:00:00
abstract：:The efficacy of a new remineralization system was determined in vivo by maintaining a low concentration of approximately 1 ppm fluoride for 48 hrs against a demineralized human tooth. Human subjects were selected who wore removable partial dentures containing two or more of the demineralized teeth with film system. Th...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/00220345800590030501
更新日期：1980-03-01 00:00:00
abstract：:Adenosine has various biological effects on human gingival fibroblasts (HGF) and epithelial cells closely associated with inflammation, such as cytokine production and cell adhesion. However, the mechanism of adenosine formation in periodontal tissues is not yet defined. In this study, we examined the involvement of C...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/154405910308201108
更新日期：2003-11-01 00:00:00
abstract：:Macrophage colony-stimulating factor (CSF-1) is a key regulatory cytokine for amelogenesis, and ameloblasts synthesize CSF-1. We hypothesized that PDGF stimulates DNA synthesis and regulates CSF-1 in these cells. We determined the effect of PDGF on CSF-1 expression using MEOE-3M ameloblasts as a model. By RT-PCR, MEOE...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/154405910808700105
更新日期：2008-01-01 00:00:00
abstract：:Erupting first permanent molars of 5 1/2 to 6 1/2 year-olds are eminently suited for the clinical testing of potential caries-inhibiting techniques. Due to the rapid onset of caries in these teeth, accurate monitoring of new materials/regimes can be instituted and meaningful data obtained within one year of trial comm...
journal_title：Journal of dental research
pub_type： 临床试验,杂志文章
doi：10.1177/002203457705600301011
更新日期：1977-10-01 00:00:00
abstract：:The differential diagnosis of dental wear lesions affects their clinical management. We hypothesized that surface texture parameters can differentiate simulated erosion, abrasion, and erosion-abrasion lesions on human enamel and dentin. This in vitro study comprised 2 parts (both factorial 4 × 2), with 4 lesion types ...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/0022034516629941
更新日期：2016-05-01 00:00:00
abstract：:The ability of human oral bacteria to inhibit Streptococcus mutans was studied under a variety of in vitro conditions using an agar overlay assay. Extensive inherent variability in microbial antagonism by certain organisms was demonstrated. Antagonistic activity was also significantly influenced by changes in the assa...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/00220345800590110501
更新日期：1980-11-01 00:00:00
abstract：:A procedure for measuring nasal airway resistance using posterior rhinorheometry is described. Baseline nasal airway resistances +/- 1 S.D. at an airflow of 0.5 L/sec were found to be 1.077 +/- 0.683 cm H2O for inhalation and 1.359 +/- 0.792 cm H2O for exhalation. Application of either cold water (4 to 6 C) or warm wa...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/00220345770560110301
更新日期：1977-11-01 00:00:00
abstract：:Human saliva contains a number of phosphorylated acidic proline-rich proteins (APRP). Monkey parotid saliva contains a similar protein with the same phosphorylated sequences as the human proteins. A crude protein kinase was prepared from Macaca fascicularis parotid glands which phosphorylated human APRP. The enzyme wa...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/00220345860650030601
更新日期：1986-03-01 00:00:00
abstract：:This study was undertaken in order to correlate the immune status of persons with various types of immune dysfunctions with the incidence of dental caries. Preliminary data on caries experience and the microbial composition of plaque in these individuals are presented. The findings suggest that persons with immunoglob...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/00220345770560030201
更新日期：1977-03-01 00:00:00
abstract：:Dental composites develop residual stresses during polymerization due to shrinkage. These stresses may change with time because of relaxation and water sorption in the oral environment. This phenomenon is likely dependent on the composition of the materials, specifically their hydrophilic characteristics, and could re...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/0022034513513905
更新日期：2014-02-01 00:00:00
abstract：:The effect of chronic fluoride (F) exposure from the drinking water on parameters related to glucose homeostasis was investigated. Wistar rats were randomly distributed into 2 groups (diabetic [D] and nondiabetic [ND]; n = 54 each). In D, diabetes was induced with streptozotocin. Each group was further divided into 3 ...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/0022034515581186
更新日期：2015-07-01 00:00:00
abstract：:Recent functional animal studies have reported that the motor control of masticatory muscle function is bilaterally guided by both hemispheres, which may fundamentally differ from the cortical control of limb muscle function. In this study, we investigated whether unilateral cortical brain infarction induces different...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/00220345990780120701
更新日期：1999-12-01 00:00:00
abstract：:Resin composites must be improved if they are to overcome the high failure rates in large stress-bearing posterior restorations. This study aimed to improve wear resistance via nano-silica-fused whiskers. It was hypothesized that nano-silica-fused whiskers would significantly improve composite mechanical properties an...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/154405910408301208
更新日期：2004-12-01 00:00:00
abstract：:To understand the role of betel quid (BQ) in the pathogenesis of oral submucous fibrosis (OSF) and oral cancer, we used DNA damage, cytotoxicity, and cell proliferation assays to study the pathobiological effects of aqueous extracts of three BQ constituents [betel nut (Areca catechu, BN), inflorescence of Piper betle ...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/00220345940730050501
更新日期：1994-05-01 00:00:00
abstract：:In this study, the effects of eugenol on human polymorphonuclear (PMN) cell migration and chemiluminescence were examined in vitro. Utilizing zymosan-activated serum or crude Bacteroides sonicate fractions as chemotractants, we found that eugenol inhibits PMN migration at 6.6 X 10(-2) to 6.6 X 10(-5) mol/L (P less tha...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/00220345870660031401
更新日期：1987-03-01 00:00:00
abstract：:Potassium ions in dentifrices for treating 'hypersensitive' dentin are believed to act directly on intradental nerves by raising extracellular potassium ion concentration ([K+]o) sufficiently to prevent action potential generation by axonal accommodation. However, the [K+]o necessary to block nerve conduction is not p...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/00220345950740020301
更新日期：1995-02-01 00:00:00
abstract：:The fluid in and gingival tissue lining periodontal pockets were collected from male patients undergoing periodontal therapy. The collagenolytic activity of the crevicular fluid, and the ability of the gingiva in culture to degrade (a) an exogenous collagen substrate, and (b) endogenous collagen newly synthesized and ...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/00220345790580111601
更新日期：1979-11-01 00:00:00
abstract：:Mechanosensitive osteocytes are essential for bone remodeling. Nitric oxide, an important regulator of bone remodeling, is produced by osteocytes through the activity of constitutive endothelial nitric oxide synthase (eNOS) or inducible nitric oxide synthase (iNOS). We hypothesized that these enzymes regulate the tiss...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/0022034508330861
更新日期：2009-03-01 00:00:00
abstract：:Autoimmune responses to heat-shock protein 60 (HSP60) contribute to the progression of atherosclerosis, whereas immunization with HSP60 may induce atheroprotective responses. We assessed the capacity of an atheroprotective vaccine that targeted a recombinant HSP60 from Porphyromonas gingivalis (rGroEL) to induce a pro...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/0022034514523784
更新日期：2014-04-01 00:00:00
abstract：:Interfacial bonding and stability of gamma-methacryloxypropyltrimethoxysilane with silica surfaces have been studied by means of infrared spectroscopy. The addition of n-propylamine enhances silanization of gamma-methacryloxypropyltrimethoxysilane to silica surfaces in normal aliphatic hydrocarbons, and cyclohexane yi...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/00220345820610121301
更新日期：1982-12-01 00:00:00
abstract：:Cell kinetics of rat molar periodontal ligament (PDL) during orthodontically-induced osteogenesis revealed: 1) primary growth fraction of 59%, 2) proliferating cells from throughout the PDL migrate toward the bone surface, 3) preosteoblasts, capable of forming osteoblasts without synthesizing DNA, are present in the P...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/00220345810600021501
更新日期：1981-02-01 00:00:00
abstract：:The effects of oral rinses on enamel fluoride uptake, caries, and plaque pH in rats were investigated by use of (1) an acidic calcium phosphate solution (CPS) saturated with dicalcium phosphate dihydrate (DCPD) and (2) a 1% fluoride solution. Osborne-Mendel rats, 19 days of age, were randomly assigned to one of four m...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/00220345880670061401
更新日期：1988-06-01 00:00:00
