Abstract：
:Potassium ions in dentifrices for treating 'hypersensitive' dentin are believed to act directly on intradental nerves by raising extracellular potassium ion concentration ([K+]o) sufficiently to prevent action potential generation by axonal accommodation. However, the [K+]o necessary to block nerve conduction is not precisely known, nor is it certain that K+ can diffuse from a dentifrice in sufficient amounts to inactivate intradental nerves. To establish more accurately the [K+]o required to block nerve conduction under controlled conditions, we studied the effects of increased [K+]o on the sizes of compound action potentials (CAP) recorded from rat spinal nerves in vitro. [K+]o was increased by the addition of either KCl or KNO3 to Krebs' solutions applied to the central portion of the nerves. CAP attenuation increased in a dose-dependent manner as [K+]o was raised in the 8 to 64 mmol/L range, and complete block was generally produced with solutions containing at least 32 mmol/L K+. CAP attenuation was reversible, and recovery times increased with increasing [K+]o. The effects of KCl and KNO3 solutions were the same for all [K+]o tested. Half-maximal (50%) reduction in the A beta-fiber component of the CAP occurred with 17.4 mmol/L K+, and with 17.8 mmol/L and 19.3 mmol/L K+, respectively, for the A delta- and C-fiber components. Control experiments with glucose and choline chloride confirmed that the conduction block observed with increased [K+]o was not due to increased solution osmolarity or ionic strength.(ABSTRACT TRUNCATED AT 250 WORDS)
journal_name
J Dent Resjournal_title
Journal of dental researchauthors
Peacock JM,Orchardson Rdoi
10.1177/00220345950740020301subject
Has Abstractpub_date
1995-02-01 00:00:00pages
634-41issue
2eissn
0022-0345issn
1544-0591journal_volume
74pub_type
杂志文章abstract：:Mixtures containing two bacterial species were analyzed using flow cytometric techniques. Light scattering characteristics of Streptococcus mutans and Actinomyces viscosus show unique profiles for pure cultures. However, the light scatter analysis of a mixture containing these two species demonstrates overlapping near...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/00220345840630080501
更新日期：1984-08-01 00:00:00
abstract：:Patients suffering from temporomandibular dysfunction exhibit clinical findings such as fatigue, painful muscles, and muscles that are tender to palpation, not only in the temporomandibular area, but also in the neck/shoulder region. The mechanisms behind this are not known, although previous studies of similar spread...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/00220345000790101401
更新日期：2000-10-01 00:00:00
abstract：:As an approach for improving the outcome and predictability of periodontal regenerative therapies, we have focused on determining the responses of cells within the local environment to putative regenerative factors. This study examined the effects of bone morphogenetic protein-2 (BMP-2) on murine cementoblasts in vitr...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/154405910308200106
更新日期：2003-01-01 00:00:00
abstract：:The aim of this study was to investigate whether the release of fluoride and the antimicrobial effect of freshly mixed glass ionomers could be prolonged by application of fluoride on aged material. Test slabs of freshly mixed and aged (14 d in water) conventional and silver glass ionomer (Ketac-Fil and Ketac-Silver, E...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/00220345930720090901
更新日期：1993-09-01 00:00:00
abstract：:Known antimalarial compunds from several chemical classes were tested for their ability to inhibit in vitro growth of microorganisms causing dental plaque and to prevent the development of plaque in a hamster model. Approximately a third of the compounds tested inhibited in vitro growth; however, none prevented develo...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/00220345750540030901
更新日期：1975-05-01 00:00:00
abstract：:Dental porcelains rely on the high-thermal-expansion mineral leucite to elevate their bulk thermal expansion to levels compatible with dental PFM alloys. The microcracks that form around these leucite particles when cooled during porcelain manufacture are a potential source of change in bulk porcelain thermal expansio...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/00220345960750070801
更新日期：1996-07-01 00:00:00
abstract：:Rat parotid secretory granule membranes were examined for the presence of calcium-dependent protein kinase activities and kinase substrates. Protein kinase C (C-kinase), which is stimulated by certain phospholipids, was present in the membranes, as indicated by its ability to catalyze the phosphorylation of histone. T...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/00220345870660022901
更新日期：1987-02-01 00:00:00
abstract：:It was the aim of this 24-mo randomized controlled clinical trial to investigate whether the survival of a single median implant placed in the edentulous mandible to retain a complete denture is not compromised by immediate loading. Secondary outcomes were differences in prosthetic complications between the loading pr...
journal_title：Journal of dental research
pub_type： 杂志文章,多中心研究,随机对照试验
doi：10.1177/0022034517736063
更新日期：2018-02-01 00:00:00
abstract：:During the polymerization of multifunctional monomers for dental restorations, typical final double-bond conversions range from 55 to 75%. The low conversion results in a large amount of extractable monomer, reduced adhesion to the filler, and the potential for increased swelling. In this work, the ability to increase...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/00220345960750081301
更新日期：1996-08-01 00:00:00
abstract：:The cartilaginous nasal septa of 28 albino rats were marked with pairs of wire implants. Measurements obtained from cephalometric radiographs taken at 30 and 60 days revealed that the implants invariably separatd and did so at a rate that was highly correlated with the growth of the rest of the snout. ...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/00220345800590081601
更新日期：1980-08-01 00:00:00
abstract：:The creatinine-adjusted urinary concentration of mercury in 73 schoolchildren with a mean age of 12 years was determined. In addition, the number of amalgam restorations and their size, prevalence of allergy, and days absent from school due to illness were recorded for each individual. A significant positive correlati...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/00220345870660061701
更新日期：1987-06-01 00:00:00
abstract：:The experiment was designed to determine the pathway taken to the brain stem by periodontal afferents responsible for the digastric jaw-opening reflex induced by tooth-tapping. Cutting the trigeminal sensory roots of anesthetized decerebrate cats eliminated the ipsilateral periodontally-induced reflex, although the st...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/00220345870660100401
更新日期：1987-10-01 00:00:00
abstract：:During amelogenesis in the rat incisor, modulating ruffle-ended (RA) and smooth-ended (SA) ameloblasts are distributed as bands in the enamel organ of the maturation zone. This distribution of the two cell types has been shown to be precisely correlated with a banding of the underlying enamel, as shown by staining and...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/00220345890680020101
更新日期：1989-02-01 00:00:00
abstract：:Restriction endonuclease analysis (REA) was performed on the total cellular DNA from each of 396 strains of mutans streptococci (1) to determine its potential usefulness for the study of transmission of the organism and (2) to document the proportions and variety of strains harbored by members of a small group of fami...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/00220345890680070401
更新日期：1989-07-01 00:00:00
abstract：:Locally applied bisphosphonates may improve the fixation of metal implants in bone. However, systemic bisphosphonate treatment is associated with a risk of osteonecrosis of the jaw (ONJ). We hypothesized that local delivery of bisphosphonate from the implant surface improves the fixation of dental implants without com...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/0022034512472335
更新日期：2013-03-01 00:00:00
abstract：:T6 antigen is a highly specific marker for human Langerhans cells (LC). Previous studies have demonstrated that Interleukin-1 (IL-1) and an IL-1 inhibitor (ILS) modulate LC T6 expression (T6E) in explant culture. The present study examined the in vitro modulation of T6E by two molecules: epidermal-cell-derived thymocy...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/00220345870660031201
更新日期：1987-03-01 00:00:00
abstract：:This study describes the formation of a calcium polyacrylate-hydroxyapatite cement. Our hypothesis was that calcium phosphates would rapidly hydrolyze in the presence of polyacrylic acid (PAA) to form a cement. PAA, tetracalcium phosphate (TetCP), and dicalcium phosphate (DCP) were reacted together and formed calcium ...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/00220345940730030501
更新日期：1994-03-01 00:00:00
abstract：:The effects of oral rinses on enamel fluoride uptake, caries, and plaque pH in rats were investigated by use of (1) an acidic calcium phosphate solution (CPS) saturated with dicalcium phosphate dihydrate (DCPD) and (2) a 1% fluoride solution. Osborne-Mendel rats, 19 days of age, were randomly assigned to one of four m...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/00220345880670061401
更新日期：1988-06-01 00:00:00
abstract：:The importance of assessing the impact of treatments for chronic conditions on an individual's quality of life has been well-established. In this randomized clinical trial, oral-health-related quality of life, measured with the Oral Health Impact Profile (OHIP), was compared between two groups of edentulous patients. ...
journal_title：Journal of dental research
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1177/00220345000790090401
更新日期：2000-09-01 00:00:00
abstract：:Extracellular vesicles (EVs), several tens to hundreds of nanometers in size, are vesicles secreted by cells for intercellular communication. EVs released from mesenchymal stem cells (MSC-EVs) have the potential to treat multiple diseases. This study aimed to determine the effects of MSC-EVs on bisphosphonate-related ...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/0022034520906793
更新日期：2020-05-01 00:00:00
abstract：:Significant differences exist between human and Macaca fascicularis patterns of mandibular movement during mastication. Macaque patterns display less asymmetry, more uniformity, and limited lateral excursions when compared to humans for mastication of the same food. Different anatomical structures between the two spec...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/00220345780570071301
更新日期：1978-07-01 00:00:00
abstract：:Overgrowth of oral yeast is a common problem among the elderly. Probiotic bacteria are known to inhibit the growth of pathogenic microbes. We tested the hypothesis that cheese containing probiotic bacteria can reduce the prevalence of oral Candida. During this 16-week, randomized, double-blind, placebo-controlled stud...
journal_title：Journal of dental research
pub_type： 杂志文章,随机对照试验
doi：10.1177/154405910708600204
更新日期：2007-02-01 00:00:00
abstract：:Antimicrobial agents, delivered either by mouthrinse or toothpaste, can be used to maintain plaque at levels compatible with oral health by (a) reducing existing plaque, (b) preventing the formation of new plaque, (c) selectively inhibiting those particular bacteria that are associated with disease, and (d) inhibiting...
journal_title：Journal of dental research
pub_type： 杂志文章,评审
doi：10.1177/00220345920710071501
更新日期：1992-07-01 00:00:00
abstract：:We have isolated a specific cell wall antigen of high molecular weight which appears to be unique to virulent strains of A viscosus and A naeslundii. The antigen is composed of two parts: a polysaccharide moiety containing 6-DOT as the major sugar and determinant of serologic specificity, and a small peptide bearing s...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/002203457605500111011
更新日期：1976-01-01 00:00:00
abstract：:The purpose of this work was to determine the influence of chemical food-simulating liquids on the wear of various commercial dental composite restoratives. In many cases, pre-conditioning the restoratives in these liquids for one week produced swelling of the polymer matrix and considerable surface damage. The result...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/00220345850640111601
更新日期：1985-11-01 00:00:00
abstract：:This study aims at modifying dual-cure composite cements by adding thio-urethane oligomers to improve mechanical properties, especially fracture toughness, and reduce polymerization stress. Thiol-functionalized oligomers were synthesized by combining 1,3-bis(1-isocyanato-1-methylethyl)benzene with trimethylol-tris-3-m...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/0022034514551768
更新日期：2014-12-01 00:00:00
abstract：:Tooth enamel is the most highly mineralized tissue in vertebrates. Enamel crystal formation and elongation should be well controlled to achieve an exceptional hardness and a compact microstructure. Enamel matrix calcification occurs with several matrix proteins, such as amelogenin, enamelin, and ameloblastin. Among th...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/0022034514547272
更新日期：2014-10-01 00:00:00
abstract：:Fungal infections in the oral cavity are mainly caused by C. albicans, but other Candida species are also frequently identified. They are increasing in prevalence, especially in denture-wearers and aging people, and may lead to invasive infections, which have a high mortality rate. Attachment to mucosal tissues and to...
journal_title：Journal of dental research
pub_type： 杂志文章,评审
doi：10.1177/0022034508329273
更新日期：2009-02-01 00:00:00
abstract：:Successive active phases observed in periodontal diseases may be explained either by a sudden activation of the pro-forms of tissue-stored degradative enzymes such as metalloproteinases (MMPs) or by an imbalance between metalloproteinases and their tissue inhibitors (TIMPs). To discriminate between these two hypothese...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：
更新日期：2002-03-01 00:00:00
abstract：:During the setting of a resin composite cement (RCC) used as an adhesive between a resin-bonded bridge and tooth structure, the adhesion may be disrupted by the development of shrinkage stress. The aim of this study was to investigate the influence of the shrinkage stress of three different RCCs on their adhesive and ...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/00220345920710021101
更新日期：1992-02-01 00:00:00
