Borrelia burgdorferi possesses a collagenolytic activity.

Abstract:

:Lyme disease is a multisystemic disorder caused by Borrelia burgdorferi, an invasive spirochete. B. burgdorferi has a predilection for collagenous tissue and one major clinical manifestation of the disease is arthritis. We have identified a collagenolytic activity in B. burgdorferi detergent lysates using iodinated gelatin as well as iodinated pepsinized human collagen types II and IV as protein substrates. In addition, we describe several proteolytic activities in B. burgdorferi with molecular masses greater than 200 kDa on sodium dodecyl sulfate polyacrylamide gels containing copolymerized gelatin. We propose that the collagenolytic activity of B. burgdorferi has a role in invasion, in the pathogenesis of Lyme arthritis, and perhaps also in other manifestations of Lyme borreliosis.

journal_name

FEMS Microbiol Lett

authors

Grab DJ,Kennedy R,Philipp MT

doi

10.1111/j.1574-6968.1996.tb08506.x

subject

Has Abstract

pub_date

1996-10-15 00:00:00

pages

39-45

issue

1

eissn

0378-1097

issn

1574-6968

pii

0378109796003357

journal_volume

144

pub_type

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