The Salmonella typhimurium flgM gene, which encodes a negative regulator of flagella synthesis and is involved in virulence, is present and functional in other Salmonella species.

Abstract:

:FlgM inhibits the flagella-specific sigma factor FliA and is involved in the mouse-virulence of Salmonella typhimurium. In recent experiments, we observed that: (i) a flgM gene that could function to negatively regulate flagella synthesis was present in a variety of salmonellae; and (ii) the flgM gene derived from Salmonella species that are not normally virulent in mice could complement the S. typhimurium flgM mutant for virulence. Our results suggest that a functional flgM has been retained in most, and perhaps all, Salmonella species, regardless of the motility or virulence phenotype of the strain.

journal_name

FEMS Microbiol Lett

authors

Schmitt CK,Darnell SC,O'Brien AD

doi

10.1111/j.1574-6968.1996.tb08002.x

subject

Has Abstract

pub_date

1996-01-15 00:00:00

pages

281-5

issue

2-3

eissn

0378-1097

issn

1574-6968

journal_volume

135

pub_type

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