Avian coccidiosis: changes in intestinal lymphocyte populations associated with the development of immunity to Eimeria maxima.


:The effect of infection and subsequent challenge with Eimeria maxima on the populations of lymphocytes in the small intestine of Light Sussex chickens was assessed by immunohistochemistry. T cells were characterized for CD3, CD4, CD8, TCR1 (gamma delta heterodimer) or TCR2 (alpha beta 1 heterodimer) markers, and B cells for the expression of IgM, IgA and IgG. After a primary inoculum there were, in both the epithelium and the lamina propria, two distinct increases in the numbers of T lymphocytes. The first peaked on days 3-5 and the second, greater influx, on day 11 after infection. CD4+ and CD8+ cells were represented in both peaks but, whereas CD4+ cells were found almost exclusively in the lamina propria, CD8+ cells were present in both sites. The area staining positive for CD8+ cells was somewhat greater than the value obtained for CD4+ cells. In the epithelium there was an early, small increase in TCR1(+)-staining, followed by a larger rise to the second peak, at which time there was also an increase in the lamina propria. Staining for TCR2+ cells followed the same pattern with a reversed distribution between epithelium and lamina propria. Changes after challenge were minimal and confined to the epithelium. The most notable changes in the expression of immunoglobulins were, in the lamina propria, a biphasic increase in the amount of IgM(+)-staining in the course of primary infection (corresponding approximately to that of the T cells), and in IgA+ cells shortly after challenge.


Parasite Immunol


Parasite immunology


Rothwell L,Gramzinski RA,Rose ME,Kaiser P




Has Abstract


1995-10-01 00:00:00












  • Not peripheral parasitaemia but the level of soluble parasite antigen in plasma correlates with vaccine efficacy against Babesia canis.

    abstract::Groups of five dogs were vaccinated against Babesia canis using soluble parasite (SPA) antigens from in vitro cultures. Although vaccination did not significantly alter peripheral parasitaemia upon challenge, protected animals had lower levels of SPA in the plasma after a challenge infection. The severity of anaemia c...

    journal_title:Parasite immunology

    pub_type: 杂志文章


    authors: Schetters TP,Scholtes NC,Kleuskens JA,Bos HJ

    更新日期:1996-01-01 00:00:00

  • Functional correlations between mucosal mast cell activity and immunity to Trichinella spiralis in high and low responder mice.

    abstract::Levels of intestinal mast cell protease (IMCP) were quantified in serum, gut tissue and in intestinal fluids taken from mice infected with Trichinella spiralis during primary and secondary infections. The ability to generate a mast cell response was dependent on the response phenotype of the mouse strain used. The mas...

    journal_title:Parasite immunology

    pub_type: 杂志文章


    authors: Tuohy M,Lammas DA,Wakelin D,Huntley JF,Newlands GF,Miller HR

    更新日期:1990-11-01 00:00:00

  • Suppressive macrophages occurring in murine Trypanosoma brucei infection inhibit T-cell responses in vivo and in vitro.

    abstract::Intraperitoneal injection of Trypanosoma brucei AnTat 1.1 into mice of the C3H.He, BALB/c or C57BL/6 strains resulted in impaired immune responses from day 3 onwards, as measured by the reduction in DNA synthesis in spleen cell populations stimulated with concanavalin A (Con-A) in vitro. Adherent cells from the perito...

    journal_title:Parasite immunology

    pub_type: 杂志文章


    authors: Borowy NK,Sternberg JM,Schreiber D,Nonnengasser C,Overath P

    更新日期:1990-05-01 00:00:00

  • Mechanisms of leucocyte recruitment to the inflamed large intestine: redundancy in integrin and addressin usage.

    abstract::The caecal-dwelling nematode Trichuris muris provides a natural model of human whipworm infection. Resistance to T. muris is dependent on a host Th2 response, and CD4+Th2 cells migrate to the gut-associated lymphoid tissue (GALT) to elicit parasite expulsion. Thus, CD4+T cells infiltrate the caecal lamina propria duri...

    journal_title:Parasite immunology

    pub_type: 杂志文章


    authors: Bell LV,Else KJ

    更新日期:2008-03-01 00:00:00

  • Immunomodulation by helminths: Similar impact on type 1 and type 2 diabetes?

    abstract::The incidence of both type 1 (T1D) and type 2 diabetes (T2D) is drastically increasing, and it is predicted that the global prevalence of diabetes will reach almost 600 million cases by 2035. Even though the pathogenesis of both types of diabetes is distinct, the immune system is actively involved in both forms of the...

    journal_title:Parasite immunology

    pub_type: 杂志文章,评审


    authors: Surendar J,Indulekha K,Hoerauf A,Hübner MP

    更新日期:2017-05-01 00:00:00

  • Genetic manipulation of African trypanosomes as a tool to dissect the immunobiology of infection.

    abstract::The variant surface glycoprotein (VSG) coat of African trypanosomes exhibits immunobiological functions distinct from its prominent role as a variant surface antigen. In order to address questions regarding immune stealth effects of VSG switch-variant coats, and the innate immune system activating effects of shed VSG ...

    journal_title:Parasite immunology

    pub_type: 杂志文章,评审


    authors: Mansfield JM,Paulnock DM

    更新日期:2008-04-01 00:00:00

  • Germinal centre and marginal zone B cells expand quickly in a second Plasmodium chabaudi malaria infection producing mature plasma cells.

    abstract::Antibodies and B cells are critical in the protective immune response to the blood stage of the malaria parasite, Plasmodium chabaudi. However, little is known about the development of memory B cells and their differentiation into plasma cells during infection or after re-infection. Here we have shown that B cells wit...

    journal_title:Parasite immunology

    pub_type: 杂志文章


    authors: Stephens R,Ndungu FM,Langhorne J

    更新日期:2009-01-01 00:00:00

  • Antibody responses in onchocerciasis as a function of age and infection intensity.

    abstract::Onchocerciasis is caused by the filarial nematode Onchocerca volvulus and is a major public health problem in West and Central Africa. With only partial and long-term treatment currently available, there is a need to develop a suitable vaccine. We analysed the antibody response to infective L3 larvae because this stag...

    journal_title:Parasite immunology

    pub_type: 杂志文章


    authors: Faulkner H,Gardon J,Kamgno J,Enyong P,Boussinesq M,Bradley JE

    更新日期:2001-09-01 00:00:00

  • A DNA-prime/protein-boost vaccination regimen enhances Th2 immune responses but not protection following Schistosoma mansoni infection.

    abstract::DNA immunization represents a promising vaccine strategy that has been reasonably successful, and will likely play an even greater role in vaccine development as these vaccines continue to be improved. We have developed a partially protective DNA vaccine against schistosome infection based on a 23-kDa integral membran...

    journal_title:Parasite immunology

    pub_type: 杂志文章


    authors: Da'Dara AA,Skelly PJ,Walker CM,Harn DA

    更新日期:2003-08-01 00:00:00

  • Mannose receptor (MR) and Toll-like receptor 2 (TLR2) influence phagosome maturation during Leishmania infection.

    abstract::Leishmania enter macrophages through receptor-mediated phagocytosis and survive the harsh environment of a phagolysosome. Here, we investigated the interaction between mannose receptor (MR), Toll-like receptor 2 (TLR2), and Leishmania, and the subsequent impact on phagosome maturation. Leishmania parasites are able to...

    journal_title:Parasite immunology

    pub_type: 杂志文章


    authors: Polando RE,Jones BC,Ricardo C,Whitcomb J,Ballhorn W,McDowell MA

    更新日期:2018-04-01 00:00:00

  • Identification of immunodominant Leishmania major antigenic markers of the early C57BL/6 and BALB/c mice infection stages.

    abstract::The C57BL/6 mouse strain is resistant to Leishmania (L.) major infection and, unlike susceptible BALB/c, develops small self-healing cutaneous lesions. The specific antibody responses of C57BL/6 and BALB/c mice were previously characterized by the predominance of IgG2a ('resistant' isotype associated with Th1) and IgG...

    journal_title:Parasite immunology

    pub_type: 杂志文章


    authors: Sassi A,Kaak O,Ben Ammar Elgaied A

    更新日期:2015-10-01 00:00:00

  • Skin-homing T-cell responses associated with Demodex infestation and rosacea.

    abstract:AIMS:Our aim was to investigate the skin-homing T-cell immune responses triggered in patients with Demodex infestation and/or rosacea. METHODS:Collected whole blood samples were divided into four groups: control subjects; nonrosacea patients with Demodex infestation (Demodex group); papulopustular rosacea (PPR) patien...

    journal_title:Parasite immunology

    pub_type: 杂志文章


    authors: Gazi U,Gureser AS,Oztekin A,Karasartova D,Kosar-Acar N,Derici MK,Artuz F,Mumcuoglu KY,Taylan-Ozkan A

    更新日期:2019-08-01 00:00:00

  • The role of CD4+ and CD8+ T cells in protective immunity to the murine nematode parasite Trichuris muris.

    abstract::The role of CD4+ and CD8+ T cells in protective immunity to Trichuris muris was studied in CD4+ or CD8+ or both CD4+ and CD8+ T cell-depleted BALB/c mice. To assess in vivo depletion of T-cell subsets, CD4+ and CD8+ T cells in the Peyer's patches, the mesenteric lymph nodes (MLN), and the spleens of mice treated with ...

    journal_title:Parasite immunology

    pub_type: 杂志文章


    authors: Koyama K,Tamauchi H,Ito Y

    更新日期:1995-03-01 00:00:00

  • Platelet mediated killing of larvae from different filarial species in the presence of Dipetalonema viteae stimulated IgE antibodies.

    abstract::The platelets from normal rats interact with microfilariae of Dipetalonema viteae in vitro in the presence of antibodies leading to the killing of the parasite. The antibody involved in this reaction is identified as IgE because the absorption of immune rat serum on anti-rat IgE column or the pretreatment of platelets...

    journal_title:Parasite immunology

    pub_type: 杂志文章


    authors: Haque A,Cuna W,Bonnel B,Capron A,Joseph M

    更新日期:1985-09-01 00:00:00

  • Fact or hypothesis: Taenia crassiceps as a model for Taenia solium, and the S3Pvac vaccine.

    abstract::Research undertaken over the past 40 years has established many of the general principals concerning immunity to taeniid cestodes. Although much is well understood about the host-protective mechanisms against taeniids and this knowledge has been exploited in studies on vaccine development, many aspects require further...

    journal_title:Parasite immunology

    pub_type: 杂志文章,评审


    authors: Lightowlers MW

    更新日期:2010-11-01 00:00:00

  • Reactive oxygen species-dependent necroptosis in Jurkat T cells induced by pathogenic free-living Naegleria fowleri.

    abstract::Naegleria fowleri, a free-living amoeba, is the causative pathogen of primary amoebic meningoencephalitis in humans and experimental mice. N. fowleri is capable of destroying tissues and host cells through lytic necrosis. However, the mechanism by which N. fowleri induces host cell death is unknown. Electron microscop...

    journal_title:Parasite immunology

    pub_type: 杂志文章


    authors: Song KJ,Jang YS,Lee YA,Kim KA,Lee SK,Shin MH

    更新日期:2011-07-01 00:00:00

  • Brugia pahangi in cats: the passive transfer of anti-microfilarial immunity from immune to non-immune cats.

    abstract::Serum from cats (Felis catus) that were repeatedly infected with Brugia pahangi and had become amicrofilaraemic (mf-ve) was injected intravenously into microfilaraemic (mf+ve) cats. If more than 1 microliter of immune serum per 1000 mf was injected, microfilarial counts fell dramatically within minutes and, in some ca...

    journal_title:Parasite immunology

    pub_type: 杂志文章


    authors: Medeiros F,Baldwin CI,Denham DA

    更新日期:1996-02-01 00:00:00

  • Identification of soluble and membrane antigenic markers of acquired toxoplasmosis by immunoblot.

    abstract::The overall performance of quantitative assays in the detection of anti-Toxoplasma IgG is satisfactory, but discrepancies between assays are not uncommon especially when IgG concentrations are close to the limit of detection of the tests. The purpose of our study was to identify soluble and membrane antigens extracted...

    journal_title:Parasite immunology

    pub_type: 杂志文章


    authors: Khammari I,Saghrouni F,Lakhal S,Bougmiza I,Bouratbine A,Ben Said M,Boukadida J

    更新日期:2014-12-01 00:00:00

  • Protective immunization of mice against Schistosoma mansoni with purified adult worm surface membranes.

    abstract::Immunity to Schistosoma mansoni in the mouse was induced by vaccination with adult worm surface membrane (mb-S). Of several adjuvants tested, including Freund's, BCG and alum, 50 micrograms of saponin per mouse given subcutaneously with the antigen was the easiest to administer, and gave consistent protection, approac...

    journal_title:Parasite immunology

    pub_type: 杂志文章


    authors: Smithers SR,Hackett F,Ali PO,Simpson AJ

    更新日期:1989-07-01 00:00:00

  • A cell surface antigen associated with Theileria parva lawrencei-infected bovine lymphoid cells.

    abstract::Attempts to produce monoclonal antibodies specific for a parasite-encoded or induced antigen on the surface of Theileria parva lawrencei-transformed bovine lymphocytes resulted in the identification of the monoclonal antibody J7. This antibody recognizes a membrane glycoprotein on some T.p. lawrencei-infected bovine l...

    journal_title:Parasite immunology

    pub_type: 杂志文章


    authors: Newson J,Naessens J,Stagg DA,Black SJ

    更新日期:1986-03-01 00:00:00

  • An experimental model for canine visceral leishmaniasis.

    abstract::Seven mixed-breed dogs were challenged with either promastigotes or amastigotes of Leishmania donovani infantum strains recently isolated from naturally infected dogs. Different routes and numbers of parasites were utilized and each dog was monitored for at least 1 year post-infection. Anti-parasite specific antibody ...

    journal_title:Parasite immunology

    pub_type: 杂志文章


    authors: Abranches P,Santos-Gomes G,Rachamim N,Campino L,Schnur LF,Jaffe CL

    更新日期:1991-09-01 00:00:00

  • Characterization of Schistosoma mansoni monoclonal antibodies which block in-vitro killing: failure to demonstrate blockage of immunity in vivo.

    abstract::We have characterized various anti-schistosomular surface MoAbs previously shown to partially block in-vitro killing of schistosomula by human sera and eosinophils (Dunne et al. 1987). Immunodiffusion analysis showed that four IgM and one IgG3 MoAbs recognized periodate sensitive epitopes on the same molecular species...

    journal_title:Parasite immunology

    pub_type: 杂志文章


    authors: Bickle QD,Andrews BJ

    更新日期:1988-03-01 00:00:00

  • Immune-related genes expression profile in orange-spotted grouper during exposure to Cryptocaryon irritans.

    abstract::Cryptocaryon irritans is one of the most important ectoparasites of marine fish. To identify the potential role of immune-related genes in antiparasitic immune responses in fish, we monitored the expression change of IL-8, COX-2, C-type lectin and transferrin in local and systemic immune organs of orange-spotted group...

    journal_title:Parasite immunology

    pub_type: 杂志文章


    authors: Li YW,Dan XM,Zhang TW,Luo XC,Li AX

    更新日期:2011-12-01 00:00:00

  • Immunoprophylactic potential of a 120 kDa Brugia malayi adult antigen fraction, BmA-2, in lymphatic filariasis.

    abstract::A 120 kDa antigen containing SDS-PAGE fraction BmA-2 isolated from Brugia malayi adult parasite was highly reactive with normal sera from filarial endemic area. BmA-2 was analysed for its prophylactic potential in in vitro and in vivo. Sera collected from BmA-2 immunized jirds induced a significant level (80 to 90%) o...

    journal_title:Parasite immunology

    pub_type: 杂志文章


    authors: Chenthamarakshan V,Reddy MV,Harinath BC

    更新日期:1995-06-01 00:00:00

  • Activated CD8+ T cells contribute to clearance of gastric Cryptosporidium muris infections.

    abstract::The role of CD4+ and CD8+ T lymphocytes in the development of a protective immune response against Cryptosporidium muris infection was studied by the reconstitution of severe combined immunodeficient (SCID) mice with well-defined populations of either naive or immune CD8+ or CD4+ T lymphocytes. Adoptive transfer of bo...

    journal_title:Parasite immunology

    pub_type: 杂志文章


    authors: Kváč M,Kodádková A,Sak B,Květoňová D,Jalovecká M,Rost M,Salát J

    更新日期:2011-04-01 00:00:00

  • Isotype-specific characterization of antibody responses to Onchocerca volvulus in putatively immune individuals.

    abstract::Isotype/subclass-specific antibody responses to adult Onchocerca volvulus extract (OvAg) were assessed by both ELISA and immunoblotting for a group of putatively immune individuals (PIs, n = 29) from a hyperendemic area in Ecuador and for a group of infected individuals (INFs, n = 470) from the same regions. As a grou...

    journal_title:Parasite immunology

    pub_type: 杂志文章


    authors: Stewart GR,Elson L,Araujo E,Guderian R,Nutman TB,Bradley JE

    更新日期:1995-07-01 00:00:00

  • Antigen-specific and concanavalin A-induced lymphocyte blastogenesis responses during the course of Plasmodium berghei infection in rats.

    abstract::Antigen specific and concanavalin A (Con A)-induced lymphocyte blastogenesis responses were monitored in the spleens of rats infected with Plasmodium berghei. Con A responses were depressed only at the time of peak parasitaemia. The antigen specific blastogenesis response was either not in evidence, or at a low level ...

    journal_title:Parasite immunology

    pub_type: 杂志文章


    authors: Raybourne R,Desowitz RS,Sanghirun C

    更新日期:1984-09-01 00:00:00

  • Wuchereria bancrofti 20/22 a homologue of abundant larval transcript L3 stage filarial antigen: molecular and immunological characterization.

    abstract::The chromadorea abundant larval transcript (ALT) family of proteins contains ALT one of the most studied putative vaccine candidate in experimental filariasis. This study reports the characterization of Wuchereria bancrofti 20/22 (Wb20/22) as a member of chromadorea, the ALT family of proteins from the L3 stage of W. ...

    journal_title:Parasite immunology

    pub_type: 杂志文章


    authors: Aparnaa R,Mahalakshmi N,Harini A,Jeyaprita PJ,Anugraha G,Amdare NP,Khatri VK,Reddy MV,Kaliraj P

    更新日期:2014-10-01 00:00:00

  • Boosting antibody responses to Plasmodium falciparum merozoite antigens in children with highly seasonal exposure to infection.

    abstract::Longitudinal cohort studies are important to describe the dynamics of naturally acquired antibody response profiles to defined Plasmodium falciparum malaria antigens relative to clinical malaria episodes. In children under 7 years of age in The Gambia, serum IgG responses were measured to P. falciparum merozoite antig...

    journal_title:Parasite immunology

    pub_type: 杂志文章


    authors: Akpogheneta OJ,Dunyo S,Pinder M,Conway DJ

    更新日期:2010-04-01 00:00:00

  • Regional specialization of the surface of a parasitic nematode.

    abstract::A monoclonal antibody (NIM-M7) has been prepared which reacts with a major surface antigen of adult males and females of Trichinella spiralis. This specificity is only demonstrable when the antigen is liberated by detergent solubilization of surface-labelled worms. When reacted with living adults, on the other hand, N...

    journal_title:Parasite immunology

    pub_type: 杂志文章


    authors: Ortega-Pierres G,Clark NW,Parkhouse RM

    更新日期:1986-11-01 00:00:00