Avian coccidiosis: changes in intestinal lymphocyte populations associated with the development of immunity to Eimeria maxima.


:The effect of infection and subsequent challenge with Eimeria maxima on the populations of lymphocytes in the small intestine of Light Sussex chickens was assessed by immunohistochemistry. T cells were characterized for CD3, CD4, CD8, TCR1 (gamma delta heterodimer) or TCR2 (alpha beta 1 heterodimer) markers, and B cells for the expression of IgM, IgA and IgG. After a primary inoculum there were, in both the epithelium and the lamina propria, two distinct increases in the numbers of T lymphocytes. The first peaked on days 3-5 and the second, greater influx, on day 11 after infection. CD4+ and CD8+ cells were represented in both peaks but, whereas CD4+ cells were found almost exclusively in the lamina propria, CD8+ cells were present in both sites. The area staining positive for CD8+ cells was somewhat greater than the value obtained for CD4+ cells. In the epithelium there was an early, small increase in TCR1(+)-staining, followed by a larger rise to the second peak, at which time there was also an increase in the lamina propria. Staining for TCR2+ cells followed the same pattern with a reversed distribution between epithelium and lamina propria. Changes after challenge were minimal and confined to the epithelium. The most notable changes in the expression of immunoglobulins were, in the lamina propria, a biphasic increase in the amount of IgM(+)-staining in the course of primary infection (corresponding approximately to that of the T cells), and in IgA+ cells shortly after challenge.


Parasite Immunol


Parasite immunology


Rothwell L,Gramzinski RA,Rose ME,Kaiser P




Has Abstract


1995-10-01 00:00:00












  • Antinuclear antibodies and interleukin responses in patients with Schistosoma japonicum infection.

    abstract::Schistosomiasis poses a serious threat to public health, and the infection will develop into chronic and advanced late-stage disease if not treated. Apart from the clinical signs due to immune reactions to schistosome eggs trapped in host tissues, it also increases the risk for the development of autoimmunity reflecte...

    journal_title:Parasite immunology

    pub_type: 杂志文章


    authors: Wang X,Fu Q,Song R,Duan B,Bergquist R,Xu J,Li S,Zhou D,Qin Z

    更新日期:2018-10-01 00:00:00

  • Natural antibody response to Plasmodium falciparum Exp-1, MSP-3 and GLURP long synthetic peptides and association with protection.

    abstract::A longitudinal study was undertaken in Burkina Faso among 293 children aged 6 months to 9 years in order to determine the correlation between an antibody response to several individual malarial antigens and malarial infection. It was found that the presence of a positive antibody response at the beginning of the rainy...

    journal_title:Parasite immunology

    pub_type: 杂志文章


    authors: Meraldi V,Nebié I,Tiono AB,Diallo D,Sanogo E,Theisen M,Druilhe P,Corradin G,Moret R,Sirima BS

    更新日期:2004-06-01 00:00:00

  • MicroRNA-mediated regulation of immune responses to intestinal helminth infections.

    abstract::Intestinal helminth infections are highly prevalent in the developing world, often resulting in chronic infection and inflicting high host morbidity. With the emergence of drug-resistant parasites, a limited number of chemotherapeutic drugs available and stalling vaccine efforts, an increased understanding of antihelm...

    journal_title:Parasite immunology

    pub_type: 杂志文章,评审


    authors: Entwistle LJ,Wilson MS

    更新日期:2017-02-01 00:00:00

  • Vaccination of goats against the trematode Schistosoma bovis with a recombinant homologous schistosome-derived glutathione S-transferase.

    abstract::We assayed the vaccine potentialities of a recombinant S. bovis-derived glutathione S-transferase (rSb28GST), member of a molecular family already shown to have protective capacities in the S. mansoni and S. japonicum models. Injection of the rSb28GST in Freund's Complete Adjuvant resulted in good specific IgG respons...

    journal_title:Parasite immunology

    pub_type: 杂志文章


    authors: Boulanger D,Trottein F,Mauny F,Bremond P,Couret D,Pierce RJ,Kadri S,Godin C,Sellin E,Lecocq JP

    更新日期:1994-08-01 00:00:00

  • T cell responses in coinfection with Onchocerca volvulus and the human immunodeficiency virus type 1.

    abstract::Onchocerca volvulus and the human immunodeficiency virus (HIV) are two immunocompromising infectious agents of major public health concern in Uganda. To examine the effect of coinfection with O. volvulus and HIV on cellular immune responses, lymphocyte proliferative responses and cytokine production of peripheral bloo...

    journal_title:Parasite immunology

    pub_type: 杂志文章


    authors: Sentongo E,Rubaale T,Büttner DW,Brattig NW

    更新日期:1998-09-01 00:00:00

  • Eosinophilia, granuloma formation and migratory behaviour of larvae in the congenitally athymic mouse infected with Toxocara canis.

    abstract::Peripheral blood eosinophilia, histology of skeletal muscle and brain, and larval recovery were compared between congenitally athymic nude mice (nu/nu) and thymus-bearing heterozygous littermates (nu/+) for 6 weeks following oral infection with Toxocara canis eggs. By comparing patterns of peripheral blood eosinophil ...

    journal_title:Parasite immunology

    pub_type: 杂志文章


    authors: Sugane K,Oshima T

    更新日期:1982-09-01 00:00:00

  • Frequency of specific CD8+ T cells for a promiscuous epitope derived from Trypanosoma cruzi KMP-11 protein in chagasic patients.

    abstract::The K1 peptide is a CD8(+)T cell HLA-A*0201-restricted epitope derived from the Trypanosoma cruzi KMP-11 protein. We have previously shown that this peptide induces IFN-gamma secretion by CD8(+)T cells. The aim of this study was to characterize the frequency of K1-specific CD8(+)T cells in chagasic patients. Nineteen ...

    journal_title:Parasite immunology

    pub_type: 杂志文章


    authors: Lasso P,Mesa D,Cuéllar A,Guzmán F,Bolaños N,Rosas F,Velasco V,Thomas Mdel C,Lopez MC,Gonzalez JM,Puerta CJ

    更新日期:2010-07-01 00:00:00

  • Immunology of Taenia solium taeniasis and human cysticercosis.

    abstract::The life cycle of Taenia solium, the pork tapeworm, is continuously closed in many rural settings in developing countries when free roaming pigs ingest human stools containing T. solium eggs and develop cysticercosis, and humans ingest pork infected with cystic larvae and develop intestinal taeniasis, or may also acci...

    journal_title:Parasite immunology

    pub_type: 杂志文章,评审


    authors: Garcia HH,Rodriguez S,Friedland JS,Cysticercosis Working Group in Peru.

    更新日期:2014-08-01 00:00:00

  • Prospect for an Entamoeba histolytica Gal-lectin-based vaccine.

    abstract::Entamoeba histolytica is the aetiological agent of invasive amoebiasis, the third leading parasitic cause of mortality in the world. The disease can be easily cured by chemotherapy; however, prevention, mainly in the form of vaccination, could greatly decrease the incidence of the disease, and possibly help in its era...

    journal_title:Parasite immunology

    pub_type: 杂志文章,评审


    authors: Gaucher D,Chadee K

    更新日期:2003-02-01 00:00:00

  • Schistosoma haematobium infection modulates Plasmodium falciparum parasite density and antimalarial antibody responses.

    abstract:AIMS:Schistosomiasis and malaria are endemic in sub-Saharan Africa where Schistosoma haematobium (Sh) and Plasmodium falciparum (Pf) coinfections are thus frequent. We explored the effect of Sh infection on antibody responses directed to Pf merozoite antigens and on malaria susceptibility in Beninese children. METHODS...

    journal_title:Parasite immunology

    pub_type: 杂志文章


    authors: Tokplonou L,Nouatin O,Sonon P,M'po G,Glitho S,Agniwo P,Gonzalez-Ortiz D,Tchégninougbo T,Ayitchédji A,Favier B,Donadi EA,Milet J,Luty AJF,Massougbodji A,Garcia A,Ibikounlé M,Courtin D

    更新日期:2020-04-01 00:00:00

  • Elevated levels of IgG3 and IgG4 subclass in paediatric cases of kala azar.

    abstract::Visceral leishmaniasis (VL) or Kala azar (KA) is a systemic disease caused by the parasites of the Leishmania donovani complex. Control measures rely on treatment with antileishmanial agents, however, fraught with problems such as toxicity or drug resistance. The incidence rate is on the rise for children, for reasons...

    journal_title:Parasite immunology

    pub_type: 杂志文章


    authors: Ansari NA,Kumar R,Raj A,Salotra P

    更新日期:2008-08-01 00:00:00

  • The immunoepidemiology of human hookworm infection.

    abstract::Advances in hookworm immunoepidemiology are reviewed. Recent studies demonstrate a mixed Th1/Th2 response in human hookworm infection, with immunosuppression of specific and nonspecific IFN-gamma responses. There is increasing evidence for protective immunity in human hookworm infection, including anti-larval IL-5- an...

    journal_title:Parasite immunology

    pub_type: 杂志文章,评审


    authors: Quinnell RJ,Bethony J,Pritchard DI

    更新日期:2004-11-01 00:00:00

  • TLR4 agonist protects against Trypanosoma cruzi acute lethal infection by decreasing cardiac parasite burdens.

    abstract::E6020 is a synthetic agonist of Toll-like receptor-4 (TLR4). The purpose of this study was to evaluate the effect of different doses of E6020-SE on Trypanosoma cruzi-specific immune responses and its ability to confer protection against acute lethal infection in mice. Forty female BALB/c were infected with 500 trypoma...

    journal_title:Parasite immunology

    pub_type: 杂志文章


    authors: Villanueva-Lizama LE,Cruz-Chan JV,Versteeg L,Teh-Poot CF,Hoffman K,Kendricks A,Keegan B,Pollet J,Gusovsky F,Hotez PJ,Bottazzi ME,Jones KM

    更新日期:2020-10-01 00:00:00

  • Acute virulent infection with Plasmodium chabaudi does not impair the generation of a protective immune response.

    abstract::We have investigated whether a protective immune response occurred in mice infected with a virulent cloned strain of Plasmodium chabaudi. Animals inoculated intravenously with 10(7) parasitized erythrocytes (PE) showed an exponentially increasing parasitaemia and died by day 6 of the infection, presenting a pronounced...

    journal_title:Parasite immunology

    pub_type: 杂志文章


    authors: Falanga PB,Pereira da Silva L

    更新日期:1989-11-01 00:00:00

  • Virus-like particles expressing Plasmodium berghei MSP-8 induce protection against P. berghei infection.

    abstract:AIMS:Merozoite surface protein 8 (MSP-8) of Plasmodium parasites plays an important role in erythrocyte invasion and is a potential malaria vaccine candidate. METHODS AND RESULTS:In this study, virus-like particles (VLPs) expressing MSP-8 of Plasmodium berghei on the surface of influenza virus matrix protein 1 (M1) co...

    journal_title:Parasite immunology

    pub_type: 杂志文章


    authors: Lee SH,Chu KB,Kang HJ,Basak S,Kim MJ,Park H,Jin H,Moon EK,Quan FS

    更新日期:2020-11-01 00:00:00

  • Chronic Trypanosoma congolense infections in mice cause a sustained disruption of the B-cell homeostasis in the bone marrow and spleen.

    abstract::Trypanosoma congolense is one of the main species responsible for Animal African Trypanosomosis (AAT). As preventive vaccination strategies for AAT have been unsuccessful so far, investigating the mechanisms underlying vaccine failure has to be prioritized. In T. brucei and T. vivax infections, recent studies revealed...

    journal_title:Parasite immunology

    pub_type: 杂志文章


    authors: Obishakin E,de Trez C,Magez S

    更新日期:2014-05-01 00:00:00

  • Dysregulation of macrophage signal transduction by Toxoplasma gondii: past progress and recent advances.

    abstract::The opportunistic protozoan parasite Toxoplasma gondii is well known as a strong inducer of cell-mediated immunity, largely as a result of proinflammatory cytokine induction during in vivo infection. Yet, during intracellular infection the parasite suppresses signal transduction pathways leading to these proinflammato...

    journal_title:Parasite immunology

    pub_type: 杂志文章,评审


    authors: Leng J,Butcher BA,Denkers EY

    更新日期:2009-12-01 00:00:00

  • Chagasic patients develop a type 1 immune response to Trypanosoma cruzi trans-sialidase.

    abstract::Infective forms of Trypanosoma cruzi, the parasite that causes Chagas' disease, express on their surface an enzyme denominated trans-sialidase (TS). The present study was designed to evaluate the naturally acquired immune responses to a bacterial recombinant protein representing the catalytic domain of TS in chronical...

    journal_title:Parasite immunology

    pub_type: 杂志文章


    authors: Ribeirão M,Pereira-Chioccola VL,Rénia L,Augusto Fragata Filho A,Schenkman S,Rodrigues MM

    更新日期:2000-01-01 00:00:00

  • Antigen-specific and concanavalin A-induced lymphocyte blastogenesis responses during the course of Plasmodium berghei infection in rats.

    abstract::Antigen specific and concanavalin A (Con A)-induced lymphocyte blastogenesis responses were monitored in the spleens of rats infected with Plasmodium berghei. Con A responses were depressed only at the time of peak parasitaemia. The antigen specific blastogenesis response was either not in evidence, or at a low level ...

    journal_title:Parasite immunology

    pub_type: 杂志文章


    authors: Raybourne R,Desowitz RS,Sanghirun C

    更新日期:1984-09-01 00:00:00

  • Immunopathology of the uveitis in canine leishmaniasis.

    abstract::Particular immunopathological features and their effects on the vascular permeability of different ocular structures were analysed in two dogs naturally infected by Leishmania infantum. The existence of specific anti-Leishmania immunoglobulin G (IgG) in the aqueous humour was confirmed by the ELISA technique. There wa...

    journal_title:Parasite immunology

    pub_type: 杂志文章


    authors: García-Alonso M,Blanco A,Reina D,Serrano FJ,Alonso C,Nieto CG

    更新日期:1996-12-01 00:00:00

  • The gut mucosal immune response to Toxoplasma gondii.

    abstract::As an orally acquired pathogen, the immune response to Toxoplasma gondii unfolds in the small intestinal mucosa. There, an array of regulatory and effector immune cells are elicited to combat the parasite through secretion of inflammatory mediators, normally resulting in host protection and pathogen control. Recent st...

    journal_title:Parasite immunology

    pub_type: 杂志文章,评审


    authors: Cohen SB,Denkers EY

    更新日期:2015-03-01 00:00:00

  • Antibody-independent binding and activation of complement by Schistosoma mansoni adult worms.

    abstract::The in vitro binding serum complement (C) components to Schistosoma mansoni worms was studied. By exposing frozen sections of adult male and female parasites to normal human serum, binding of both classical and alternative pathway C components was observed. By immunofluorescence (IFL) microscopy selective binding of C...

    journal_title:Parasite immunology

    pub_type: 杂志文章


    authors: Linder E,Huldt G

    更新日期:1983-03-01 00:00:00

  • Antibody responses to the antigen Sj26 of Schistosoma japonicum worms that is recognized by genetically resistant 129/J mice.

    abstract::Serum antibody responses of mice exposed to Philippine isolates of Schistosoma japonicum have been analysed by immunoprecipitation of exogenously radiolabelled antigens extracted from adult worms. Attention was focused on labelled protein antigens differentially recognized by sera of mice that differ genetically in th...

    journal_title:Parasite immunology

    pub_type: 杂志文章


    authors: Mitchell GF,Beall JA,Cruise KM,Tiu WU,Garcia EG

    更新日期:1985-03-01 00:00:00

  • Evaluation of recombinant P23 protein as a vaccine for passive immunization of newborn calves against Cryptosporidium parvum.

    abstract::Cryptosporidiosis is a zoonotic protozoan disease that affects the gastrointestinal tract of animals and humans. Diarrhoea as the most important indication of the infection leads to high economic losses in livestock industries and is a life threatening infection in immunocompromised individuals. In the absence of the ...

    journal_title:Parasite immunology

    pub_type: 杂志文章


    authors: Askari N,Shayan P,Mokhber-Dezfouli MR,Ebrahimzadeh E,Lotfollahzadeh S,Rostami A,Amininia N,Ragh MJ

    更新日期:2016-05-01 00:00:00

  • Wuchereria bancrofti 20/22 a homologue of abundant larval transcript L3 stage filarial antigen: molecular and immunological characterization.

    abstract::The chromadorea abundant larval transcript (ALT) family of proteins contains ALT one of the most studied putative vaccine candidate in experimental filariasis. This study reports the characterization of Wuchereria bancrofti 20/22 (Wb20/22) as a member of chromadorea, the ALT family of proteins from the L3 stage of W. ...

    journal_title:Parasite immunology

    pub_type: 杂志文章


    authors: Aparnaa R,Mahalakshmi N,Harini A,Jeyaprita PJ,Anugraha G,Amdare NP,Khatri VK,Reddy MV,Kaliraj P

    更新日期:2014-10-01 00:00:00

  • Suppressor T cells in the specific control of the carrier response to schistosomula in mice infected with Schistosoma mansoni.

    abstract::The carrier effect, using TNP-labelled schistosomula was used to measure the helper T-cell activity against the schistosomula surface in CBA mice exposed to 30 cercariae of Schistosoma mansoni. After infection the helper T-cell activity reached a peak in 8--10 days, but by 6 weeks it had declined to background levels....

    journal_title:Parasite immunology

    pub_type: 杂志文章


    authors: Ramalho-Pinto FJ,Smithers SR

    更新日期:1981-10-01 00:00:00

  • MHC-restriction of antibody responses to an 86 kilodalton antigen of Schistosoma mansoni.

    abstract::The previously observed MHC-restriction of the antibody response to an 86kDa S. mansoni antigen has been investigated in more detail. The I-A locus of the H-2 complex has been implicated as conferring responder or non-responder status on mice expressing the k and b alleles respectively. Inheritance of responsiveness w...

    journal_title:Parasite immunology

    pub_type: 杂志文章


    authors: Schweitzer AN,Taylor DW

    更新日期:1991-05-01 00:00:00

  • Identification of HLA-A2 restricted CD8(+) T-lymphocyte responses to Plasmodium vivax circumsporozoite protein in individuals naturally exposed to malaria.

    abstract::Specific CD8(-) T-lymphocyte (CTL) activity against Plasmodium pre-erythrocytic stages (P-ES) derived antigens is considered one of the most important mechanisms for malaria protection. Plasmodium vivax is the second most prevalent human malaria parasite species distributed worldwide. Although several CTL epitopes hav...

    journal_title:Parasite immunology

    pub_type: 杂志文章


    authors: Arévalo-Herrera M,Valencia AZ,Vergara J,Bonelo A,Fleischhauer K,González JM,Restrepo JC,López JA,Valmori D,Corradin G,Herrera S

    更新日期:2002-03-01 00:00:00

  • Biochemical characterization and localization of Fasciola hepatica 26-28 kDa diagnostic coproantigen.

    abstract::We have previously reported the usefulness of a 26-28 kDa coproantigen of Fasciola hepatica for diagnosis of infection. In this study, the 26-28 kDa coproantigen was biochemically characterized with the aid of monoclonal antibodies (MoAb) in an effort to better understand the biology of the antigen. Differential stain...

    journal_title:Parasite immunology

    pub_type: 杂志文章


    authors: Abdel-Rahman S,O'Reilly KL,Malone JB

    更新日期:1999-06-01 00:00:00

  • Regulatory effects of IL-12 and IL-18 on Onchocerca volvulus- and Entamoeba histolytica-specific cellular reactivity and cytokine profiles.

    abstract::In the present study, the cytokines interleukin (IL)-12 and IL-18 were evaluated for their capacity to modulate and to re-direct in vitro parasite antigen-specific cellular responsiveness in patients exposed to Onchocerca volvulus and Entamoeba histolytica infection. We found that IL-18 was highly capable of reducing ...

    journal_title:Parasite immunology

    pub_type: 杂志文章


    authors: Pfaff AW,Kirch AK,Hoffmann WH,Banla M,Schulz-Key H,Geiger SM,Soboslay PT

    更新日期:2003-06-01 00:00:00