Dynamic two-photon imaging of the immune response to Toxoplasma gondii infection.

abstract：:To investigate whether soluble Plasmodium falciparum antigens possess endotoxin-like properties, the interaction of Limulus amoebocyte lysate (LAL) with defined soluble antigens from Plasmodium falciparum was studied by various crossed immunoelectrophoretic methods and immunoblotting. The soluble P. falciparum antigen...

journal_title：Parasite immunology

authors： Jakobsen PH,Baek L,Jepsen S

更新日期：1988-11-01 00:00:00

abstract：:The role of CD4+ and CD8+ T lymphocytes in the development of a protective immune response against Cryptosporidium muris infection was studied by the reconstitution of severe combined immunodeficient (SCID) mice with well-defined populations of either naive or immune CD8+ or CD4+ T lymphocytes. Adoptive transfer of bo...

journal_title：Parasite immunology

authors： Kváč M,Kodádková A,Sak B,Květoňová D,Jalovecká M,Rost M,Salát J

更新日期：2011-04-01 00:00:00

abstract：:The effect of Toxocara (T.) canis antigen (TcAg) on lymphocytes was studied in vitro using normal murine spleen cells and human peripheral blood lymphocytes. TcAg prepared from adult worms stimulated murine spleen cells to proliferate at concentrations of 1-125 micrograms/ml. The responder cells TcAg are B cells, beca...

journal_title：Parasite immunology

authors： Wang MQ,Jiang HJ,Inoue H,Myozaki M,Yamashita U

更新日期：1995-12-01 00:00:00

abstract：:The zymosan-triggered chemiluminescence response of peritoneal exudate cells from mice infected with relatively virulent or avirulent Toxoplasma gondii strains was examined at various intervals after infection. Toxoplasma infections increased the background chemiluminescence compared with controls, but higher values w...

journal_title：Parasite immunology

authors： Masihi KN,Werner H,Gillert KE,Lange W

更新日期：1984-05-01 00:00:00

abstract：:The overall performance of quantitative assays in the detection of anti-Toxoplasma IgG is satisfactory, but discrepancies between assays are not uncommon especially when IgG concentrations are close to the limit of detection of the tests. The purpose of our study was to identify soluble and membrane antigens extracted...

journal_title：Parasite immunology

authors： Khammari I,Saghrouni F,Lakhal S,Bougmiza I,Bouratbine A,Ben Said M,Boukadida J

更新日期：2014-12-01 00:00:00

abstract：:The K1 peptide is a CD8(+)T cell HLA-A*0201-restricted epitope derived from the Trypanosoma cruzi KMP-11 protein. We have previously shown that this peptide induces IFN-gamma secretion by CD8(+)T cells. The aim of this study was to characterize the frequency of K1-specific CD8(+)T cells in chagasic patients. Nineteen ...

journal_title：Parasite immunology

authors： Lasso P,Mesa D,Cuéllar A,Guzmán F,Bolaños N,Rosas F,Velasco V,Thomas Mdel C,Lopez MC,Gonzalez JM,Puerta CJ

更新日期：2010-07-01 00:00:00

abstract：:The pathogenesis of Acanthamoeba keratitis (AK) is complicated. In our previous studies, TLR4 was found involved in the process of infection by Acanthamoeba in human corneal cells. The purpose of this study was to investigate the role of Toll-like receptor 4 (TLR4) signalling pathway in Wistar rats challenged with Aca...

journal_title：Parasite immunology

authors： Ren MY,Wu XY

更新日期：2011-01-01 00:00:00

abstract：:The serodiagnosis of human toxocariasis is difficult. Specific IgGs detected routinely with ELISA based on Toxocara excretory-secretory (TES) antigens often persist for years at an elevated level, which does not allow either the differentiation between an active and persistent infection or monitoring of the effect of ...

journal_title：Parasite immunology

authors： Rudzińska M,Kowalewska B,Sikorska K

更新日期：2017-01-01 00:00:00

abstract：:We investigated the immune effector mechanisms that underlie protection against F. hepatica in the gut wall of immune rats, using (immuno)histochemistry. In the lamina propria of immune Wistar rats, four weeks after oral infection, frequencies of IgE-positive cells, eosinophils and mucosal mast cells were significantl...

journal_title：Parasite immunology

authors： Van Milligen FJ,Cornelissen JB,Hendriks IM,Gaasenbeek CP,Bokhout BA

更新日期：1998-06-01 00:00:00

abstract：:The anti-leishmanial effect of the 'carbohydrate-fraction', isolated from an edible mushroom Astraeus hygrometricus, was evaluated against Leishmania donovani infection both in vitro and in vivo. Ahf-Car induced the expression of inducible nitric oxide synthase 2 (iNOS2) and pro-inflammatory cytokines like TNF-α and I...

journal_title：Parasite immunology

authors： Hussain A,Ghosh S,Roy K,Nath S,Sarkar B,Dutta A,Maji P,Basu S,Paul S,Dey S,Chakraborty K,Raychaudhury B,Acharya K,Ganguly J,Pal C

更新日期：2020-10-31 00:00:00

abstract：AIMS:Merozoite surface protein 8 (MSP-8) of Plasmodium parasites plays an important role in erythrocyte invasion and is a potential malaria vaccine candidate. METHODS AND RESULTS:In this study, virus-like particles (VLPs) expressing MSP-8 of Plasmodium berghei on the surface of influenza virus matrix protein 1 (M1) co...

journal_title：Parasite immunology

authors： Lee SH,Chu KB,Kang HJ,Basak S,Kim MJ,Park H,Jin H,Moon EK,Quan FS

更新日期：2020-11-01 00:00:00

abstract：:The incidence of both type 1 (T1D) and type 2 diabetes (T2D) is drastically increasing, and it is predicted that the global prevalence of diabetes will reach almost 600 million cases by 2035. Even though the pathogenesis of both types of diabetes is distinct, the immune system is actively involved in both forms of the...

journal_title：Parasite immunology

authors： Surendar J,Indulekha K,Hoerauf A,Hübner MP

更新日期：2017-05-01 00:00:00

abstract：:Carboxy-terminus of merozoite surface protein-1 (MSP-1(19) ) is the major protein on the surface of the plasmodial merozoite that acts as one of the most important blood-stage vaccine candidates. The present investigation was designed to evaluate the immune responses when either two recombinant antigens (rPvMSP-1(19) ...

journal_title：Parasite immunology

authors： Mehrizi AA,Zakeri S,Rafati S,Salmanian AH,Djadid ND

更新日期：2011-11-01 00:00:00

abstract：:Ascariasis is the most frequent soil transmitted helminthiasis and, as well as other helminth infections, is expected to influence the clinical presentation of allergic diseases such as asthma. Indeed, several clinical and experimental works have shown an important impact either increasing or suppressing symptoms, and...

journal_title：Parasite immunology

authors： Caraballo L,Acevedo N,Zakzuk J

更新日期：2019-06-01 00:00:00

abstract：:There is good evidence for costs to both the uses of immune defences and their development and maintenance. The optimal defence will be a balance of these costs with the risk of infection and the virulence of the disease. It is therefore clear that the life-history characteristics of both host and parasite will impact...

journal_title：Parasite immunology

authors： Boots M,Donnelly R,White A

更新日期：2013-11-01 00:00:00

abstract：:Immunization of mammals with irradiated malaria sporozoites protects from a subsequent contact with the parasite. Protective immunity is directed against the pre-erythrocytic stages of the parasite, sporozoites and liver stages. Specific antibodies neutralize part of the infectious sporozoites infected by the mosquito...

journal_title：Parasite immunology

authors： Renggli J,Hahne M,Matile H,Betschart B,Tschopp J,Corradin G

更新日期：1997-03-01 00:00:00

abstract：:A number of T cell hybridomas were produced to adult worm homogenate (AWH) antigen of the nematode parasite Heligmosomoides polygyrus. All of the hybridomas were of the H-2d haplotype and could potentially accept antigen in the context of either the Ad or Ed, H-2 molecules. Three types of antigen presentation were obs...

journal_title：Parasite immunology

authors： Robinson M,Gustad TR,Garner SD,David CS

更新日期：1995-05-01 00:00:00

abstract：:Plasmodium falciparum-specific antibodies tend to be short-lived, but their cognate memory B cells (MBCs) circulate in the peripheral blood of exposed subjects for several months or years after the last infection. However, the time course of antigen-specific antibodies and B-cell responses to the relatively neglected ...

journal_title：Parasite immunology

authors： Soares RR,Cunha CF,Ferraz-Nogueira R,Marins-Dos-Santos A,Rodrigues-da-Silva RN,da Silva Soares I,da Costa Lima-Junior J,Bertho AL,Ferreira MU,Scopel KKG

更新日期：2019-09-01 00:00:00

abstract：:Translationally controlled tumour protein (TCTP) may play an important role in the establishment or maintenance of parasitemia in a malarial infection. In this study, the potential of TCTP as a malaria vaccine was investigated in two trials. In the initial vaccine trial, Plasmodium falciparum TCTP (PfTCTP) was express...

journal_title：Parasite immunology

authors： Taylor KJ,Van TT,MacDonald SM,Meshnick SR,Fernley RT,Macreadie IG,Smooker PM

更新日期：2015-01-01 00:00:00

abstract：:During African trypanosomiasis, macrophages play a central role in T cell hyporesponsiveness to parasite-related and unrelated antigens. In this study, the ability of macrophages from Trypanosoma b. brucei-infected mice to present exogenous antigens to a major histocompatibility complex (MHC) class II-restricted CD4+ ...

journal_title：Parasite immunology

authors： Namangala B,Brys L,Magez S,De Baetselier P,Beschin A

更新日期：2000-07-01 00:00:00

abstract：:We have characterized various anti-schistosomular surface MoAbs previously shown to partially block in-vitro killing of schistosomula by human sera and eosinophils (Dunne et al. 1987). Immunodiffusion analysis showed that four IgM and one IgG3 MoAbs recognized periodate sensitive epitopes on the same molecular species...

journal_title：Parasite immunology

authors： Bickle QD,Andrews BJ

更新日期：1988-03-01 00:00:00

abstract：:On a B10 (Lshs) genetic background, the development of acquired T cell mediated immunity to Leishmania donovani infection in mice is under H-2 linked genetic control. Following intravenous inoculation of 10(7) amastigotes three phenotypic patterns of recovery have been described: 'early cure' (H-2r,s), 'cure' (H-2b) a...

journal_title：Parasite immunology

authors： Ulczak OM,Blackwell JM

更新日期：1983-09-01 00:00:00

abstract：:Toxoplasma gondii is a worldwide protozoan parasite which causes severe disease in congenitally infected children and in immunocompromised patients. Besides the well-defined cytoplasmic and membrane antigens of tachyzoites, we felt that excreted/secreted antigens could play a major role in the immune response. We firs...

journal_title：Parasite immunology

authors： Darcy F,Deslee D,Santoro F,Charif H,Auriault C,Decoster A,Duquesne V,Capron A

更新日期：1988-09-01 00:00:00

abstract：:Nematode parasites cause significant infections in both humans and animals. They are complex, multicellular organisms that present unique challenges for the host, in particular with respect to the recognition of their unusual surface structures by the innate defence system. The innate immune system is now recognized t...

journal_title：Parasite immunology

authors： de Veer MJ,Kemp JM,Meeusen EN

更新日期：2007-01-01 00:00:00

abstract：BACKGROUND:More than 11 million people were estimated to have been infected by Schistosoma japonicum in China before the 1950s. However, few studies have been conducted to evaluate the longitudinal effects of previous schistosome infection (PSI). OBJECTIVE:We aimed to evaluate the association of PSI with fatty liver a...

journal_title：Parasite immunology

authors： Zou ZQ,Liu M,Zhong HQ,Guan GY

更新日期：2021-01-17 00:00:00

abstract：:We compared the antigenicity of p126 Plasmodium falciparum peptides with predicted antigenic regions identified using the methods described by Garnier et al. (1978) and Chou & Fasman (1974). For this purpose nine different P. falciparum peptides were synthesized in accordance with the deduced amino acid sequence of th...

journal_title：Parasite immunology

authors： Ferreira-da-Cruz Mde F,Giovanni-de-Simone S,Banic DM,Canto-Cavalheiro M,Camus D,Daniel-Ribeiro CT

更新日期：1996-03-01 00:00:00

abstract：:Attempts to produce monoclonal antibodies specific for a parasite-encoded or induced antigen on the surface of Theileria parva lawrencei-transformed bovine lymphocytes resulted in the identification of the monoclonal antibody J7. This antibody recognizes a membrane glycoprotein on some T.p. lawrencei-infected bovine l...

journal_title：Parasite immunology

authors： Newson J,Naessens J,Stagg DA,Black SJ

更新日期：1986-03-01 00:00:00

abstract：:Nitric oxide (NO) plays diverse roles in a variety of pathological processes. We investigated the role of NO in Schistosoma japonicum egg-induced granuloma formation in a mouse hepatic model. Immunohistological analysis revealed that there is the most intense and extensive inducible nitric oxide (iNOS) expression 2 we...

journal_title：Parasite immunology

authors： Hirata M,Hirata K,Kage M,Zhang M,Hara T,Fukuma T

更新日期：2001-06-01 00:00:00

abstract：:Type I hypersensitivity reactions in the intestinal tract of sensitized animals may contribute to resistance to reinfection with Fasciola hepatica. Colonic mucosae isolated from previously infected rats were voltage clamped in Ussing chambers. Antigen was prepared as a crude homogenate from adult liver fluke. Assay of...

journal_title：Parasite immunology

authors： O'Malley KE,Sloan T,Joyce P,Baird AW

更新日期：1993-08-01 00:00:00

abstract：:The development of a malaria vaccine is a priority for improved and sustained malaria control. Optimal use of a vaccine in Africa will only be achieved if it can be delivered through the Expanded Programme of Immunization (EPI). We have completed a trial of the peptide vaccine SPf66 in Tanzanian infants, given alongsi...

journal_title：Parasite immunology

authors： Galindo CM,Acosta CJ,Schellenberg D,Aponte JJ,Roca A,Oettli A,Urassa H,Armstrong Schellenberg J,Kahigwa E,Ascaso C,Mshinda H,Lwilla F,Vidal J,Menendez C,Tanner M,Alonso PL

更新日期：2000-09-01 00:00:00