Frequency of specific CD8+ T cells for a promiscuous epitope derived from Trypanosoma cruzi KMP-11 protein in chagasic patients.

abstract：:The protective effect of specific vaccination against Plasmodium berghei (P. berghei) was compared in terms of survival percentage in DBA/2, C3H, outbred albino mice and in two lines of mice produced by selective breeding for either high or low antibody responsiveness to sheep erythrocyte (H and L lines respectively)....

journal_title：Parasite immunology

authors： Heumann AM,Bucci A,Stiffel C,Casaglia O,Zenobi P,Biozzi G

更新日期：1983-03-01 00:00:00

abstract：:Attempts to produce monoclonal antibodies specific for a parasite-encoded or induced antigen on the surface of Theileria parva lawrencei-transformed bovine lymphocytes resulted in the identification of the monoclonal antibody J7. This antibody recognizes a membrane glycoprotein on some T.p. lawrencei-infected bovine l...

journal_title：Parasite immunology

authors： Newson J,Naessens J,Stagg DA,Black SJ

更新日期：1986-03-01 00:00:00

abstract：:Use of the pig as an animal model in schistosomiasis research is increasing, but knowledge of the porcine immune response to schistosome infection is still very limited. We investigated the immunohistology of different maturation stages of the Schistosoma japonicum egg granuloma in pigs. Liver sections from pigs exper...

journal_title：Parasite immunology

authors： Hurst MH,Willingham AL,Lindberg R

更新日期：2002-03-01 00:00:00

abstract：:To determine the role of T cells and mast cells in intestinal pathology and immune expulsion of intestinal nematodes, worm burdens, goblet cell responses and villus structures were analysed in T- and B-cell-deficient severe combined immunodeficiency (SCID) mice, athymic nu/nu mice and mast cell deficient W/W(v) mice a...

journal_title：Parasite immunology

authors： Hashimoto K,Uchikawa R,Tegoshi T,Takeda K,Yamada M,Arizono N

更新日期：2009-08-01 00:00:00

abstract：:A number of T cell hybridomas were produced to adult worm homogenate (AWH) antigen of the nematode parasite Heligmosomoides polygyrus. All of the hybridomas were of the H-2d haplotype and could potentially accept antigen in the context of either the Ad or Ed, H-2 molecules. Three types of antigen presentation were obs...

journal_title：Parasite immunology

authors： Robinson M,Gustad TR,Garner SD,David CS

更新日期：1995-05-01 00:00:00

abstract：:Indonesian thin-tail (ITT) sheep can resist infection with Fasciola gigantica but not F. hepatica and presents an ideal model to investigate the mechanisms of liver fluke resistance in a natural host. This study examines the local and systemic immune responses of sheep during Fasciola infection and demonstrates that d...

journal_title：Parasite immunology

authors： Pleasance J,Wiedosari E,Raadsma HW,Meeusen E,Piedrafita D

更新日期：2011-09-01 00:00:00

abstract：:TSOL18 is a recombinant protein that has been shown in repeated experimental trials to be capable of protecting pigs against challenge infection with the cestode parasite Taenia solium. Antibodies raised by the vaccine are capable of killing the parasite in an in vitro culture and it is believed that antibody and comp...

journal_title：Parasite immunology

authors： Assana E,Gauci CG,Kyngdon CT,Zoli AP,Dorny P,Geerts S,Lightowlers MW

更新日期：2010-06-01 00:00:00

abstract：:Although the precise host-defence mechanisms are not completely understood, T-cell-mediated immune responses are believed to play a pivotal role in controlling parasite infection. In this study, the potential HLA*A2 restricted peptides were predicted and the ability of peptides to bind HLA-A*02 was confirmed by a MHC ...

journal_title：Parasite immunology

authors： Dikhit MR,Amit A,Singh AK,Kumar A,Mansuri R,Sinha S,Topno RK,Mishra R,Das VNR,Pandey K,Sahoo GC,Ali V,Bimal S,Das P

更新日期：2017-09-01 00:00:00

abstract：:Onchocerca volvulus and the human immunodeficiency virus (HIV) are two immunocompromising infectious agents of major public health concern in Uganda. To examine the effect of coinfection with O. volvulus and HIV on cellular immune responses, lymphocyte proliferative responses and cytokine production of peripheral bloo...

journal_title：Parasite immunology

authors： Sentongo E,Rubaale T,Büttner DW,Brattig NW

更新日期：1998-09-01 00:00:00

abstract：:Culex pipiens and Aedes aegypti mosquitoes were fed on C3H/HeJ mice and systemic cytokine production was quantified from stimulated lymphocytes harvested four to ten days after feeding. Mosquito feeding on C3H/HeJ mice significantly down regulated IFN gamma production seven to ten days post feeding by Cx. pipiens and ...

journal_title：Parasite immunology

authors： Zeidner NS,Higgs S,Happ CM,Beaty BJ,Miller BR

更新日期：1999-01-01 00:00:00

abstract：:Antigenic proteins of Echinostoma caproni (Trematoda) against mouse IgM, IgA, IgG, IgG1 and IgG2a were investigated by immunoproteomics. Excretory/secretory products (ESP) of E. caproni separated by two-dimensional (2D) gel electrophoresis were transferred to nitrocellulose membranes and probed with the different mous...

journal_title：Parasite immunology

authors： Sotillo J,Valero L,Sánchez Del Pino MM,Fried B,Esteban JG,Marcilla A,Toledo R

更新日期：2008-05-01 00:00:00

abstract：:Inhibitory monoclonal antibody (MoAb) 8E7/55 recognizes a parasitophorous vacuole membrane (PVM) antigen in Plasmodium falciparum. Previous studies have identified the epitope, DNNLVSGP, recognized by the MoAb. A synthetic peptide containing this sequence was synthesized and coupled to diphtheria toxoid (DT) and was f...

journal_title：Parasite immunology

authors： Lord R,Jones GL,Spencer L,Saul A

更新日期：1993-11-01 00:00:00

abstract：:Cells collected from C57B1/6 mice infected with monomorphic and pleomorphic clones of Trypanosoma brucei parasites (ILTat 1.4 and GUTat 3.1) were analysed for the incorporation of 125I-Iododeoxyuridine into DNA of total splenic lymphocytes and of B and T lymphocytes isolated on a fluorescence activated cell sorter. Th...

journal_title：Parasite immunology

authors： Sendashonga CN,Black SJ

更新日期：1986-09-01 00:00:00

abstract：:Lymphoid cells from genetically-susceptible BALB/c mice immunized against a glycoconjugate of the protozoan parasite, Leishmania major, promote chronic cutaneous disease in BALB/c nude mice. This cell population therefore differs from cells harvested from non-immunized BALB/c mice that are known to be potent mediators...

journal_title：Parasite immunology

authors： Mitchell GF,Handman E

更新日期：1986-05-01 00:00:00

abstract：:In a double-blind study 393 seronegative dogs, residing in a holoendemic area for Leishmania donovani infantum infection, were randomly assigned to an immunization with a partly purified L.d. infantum-derived preparation, or received adjuvant only. During the first year of the study period the rate of infection was si...

journal_title：Parasite immunology

authors： Dunan S,Frommel D,Monjour L,Ogunkolade BW,Cruz A,Quilici M

更新日期：1989-07-01 00:00:00

abstract：AIMS:Schistosomiasis and malaria are endemic in sub-Saharan Africa where Schistosoma haematobium (Sh) and Plasmodium falciparum (Pf) coinfections are thus frequent. We explored the effect of Sh infection on antibody responses directed to Pf merozoite antigens and on malaria susceptibility in Beninese children. METHODS...

journal_title：Parasite immunology

authors： Tokplonou L,Nouatin O,Sonon P,M'po G,Glitho S,Agniwo P,Gonzalez-Ortiz D,Tchégninougbo T,Ayitchédji A,Favier B,Donadi EA,Milet J,Luty AJF,Massougbodji A,Garcia A,Ibikounlé M,Courtin D

更新日期：2020-04-01 00:00:00

abstract：:Peripheral blood eosinophilia, histology of skeletal muscle and brain, and larval recovery were compared between congenitally athymic nude mice (nu/nu) and thymus-bearing heterozygous littermates (nu/+) for 6 weeks following oral infection with Toxocara canis eggs. By comparing patterns of peripheral blood eosinophil ...

journal_title：Parasite immunology

authors： Sugane K,Oshima T

更新日期：1982-09-01 00:00:00

abstract：:A longitudinal study was undertaken in Burkina Faso among 293 children aged 6 months to 9 years in order to determine the correlation between an antibody response to several individual malarial antigens and malarial infection. It was found that the presence of a positive antibody response at the beginning of the rainy...

journal_title：Parasite immunology

authors： Meraldi V,Nebié I,Tiono AB,Diallo D,Sanogo E,Theisen M,Druilhe P,Corradin G,Moret R,Sirima BS

更新日期：2004-06-01 00:00:00

abstract：:We have assessed the role of tumour necrosis factor-alpha (TNF) during cutaneous leishmaniasis and demonstrated that significant levels of TNF were released by spleen cells from infected mice after in vitro restimulation with Leishmania major promastigotes. Spleen cells from both genetically resistant and genetically ...

journal_title：Parasite immunology

authors： Moll H,Binöder K,Bogdan C,Solbach W,Röllinghoff M

更新日期：1990-09-01 00:00:00

abstract：:Groups of five dogs were vaccinated against Babesia canis using soluble parasite (SPA) antigens from in vitro cultures. Although vaccination did not significantly alter peripheral parasitaemia upon challenge, protected animals had lower levels of SPA in the plasma after a challenge infection. The severity of anaemia c...

journal_title：Parasite immunology

authors： Schetters TP,Scholtes NC,Kleuskens JA,Bos HJ

更新日期：1996-01-01 00:00:00

abstract：:Isotype/subclass-specific antibody responses to adult Onchocerca volvulus extract (OvAg) were assessed by both ELISA and immunoblotting for a group of putatively immune individuals (PIs, n = 29) from a hyperendemic area in Ecuador and for a group of infected individuals (INFs, n = 470) from the same regions. As a grou...

journal_title：Parasite immunology

authors： Stewart GR,Elson L,Araujo E,Guderian R,Nutman TB,Bradley JE

更新日期：1995-07-01 00:00:00

abstract：:Humoral immunity develops in the spleen during blood-stage Plasmodium infection. This elicits parasite-specific IgM and IgG, which control parasites and protect against malaria. Studies in mice have elucidated cells and molecules driving humoral immunity to Plasmodium, including CD4+ T cells, B cells, interleukin (IL)...

journal_title：Parasite immunology

authors： Sebina I,Fogg LG,James KR,Soon MSF,Akter J,Thomas BS,Hill GR,Engwerda CR,Haque A

更新日期：2017-10-01 00:00:00

abstract：:Malaria remains one of the most serious health problems globally, but our understanding of the biology of the parasite and the pathogenesis of severe disease is still limited. Multiple cellular effector mechanisms that mediate parasite elimination from the liver have been described, but how effector cells use classica...

journal_title：Parasite immunology

authors： Frevert U,Nacer A

更新日期：2013-09-01 00:00:00

abstract：:In this study, supplementation with the probiotic Saccharomyces boulardii promoted a reduction in intensity of infection by Toxocara canis and modulates cytokines mRNA expression in experimentally infected mice. IL-12 gene transcription had 40-fold increase in S. boulardii supplemented uninfected mice and sevenfold in...

journal_title：Parasite immunology

authors： de Avila LF,de Leon PM,de Moura MQ,Berne ME,Scaini CJ,Leivas Leite FP

更新日期：2016-05-01 00:00:00

abstract：:The kinetics of macrophage activation were compared among inbred strains of mice (C3H, BALB, B6 and B10.A) that are known to differ in their relative resistance to infections with the myotropic strains (Colombian and CL) of Trypanosoma cruzi. The parameters utilized to measure macrophage activation were rapid spreadin...

journal_title：Parasite immunology

authors： Russo M,Starobinas N,Ribeiro-Dos-Santos R,Minoprio P,Eisen H,Hontebeyrie-Joskowicz M

更新日期：1989-07-01 00:00:00

abstract：:In endemic areas, asymptomatic infection by the malaria parasite Plasmodium falciparum was found associated with elevated percentages of human host's mononuclear cell spontaneous in-vitro apoptosis. In Dielmo, a village where malaria is holoendemic, apoptosis was age-and parasite-dependent. In-vitro exposure of periph...

journal_title：Parasite immunology

authors： Balde AT,Aribot G,Tall A,Spiegel A,Roussilhon C

更新日期：2000-06-01 00:00:00

abstract：:Activation of macrophages is a key step in the initiation of immune responses, but the transcriptional mechanisms governing macrophage activation during infection are not fully understood. It was recently shown that the AP-1 family transcription factor JUNB positively regulates macrophage activation in response to Tol...

journal_title：Parasite immunology

authors： Fontana MF,Baccarella A,Kellar D,Oniskey TK,Terinate P,Rosenberg SD,Huang EJ,Herbert DR,Kim CC

更新日期：2015-09-01 00:00:00

abstract：:The anti-leishmanial effect of the 'carbohydrate-fraction', isolated from an edible mushroom Astraeus hygrometricus, was evaluated against Leishmania donovani infection both in vitro and in vivo. Ahf-Car induced the expression of inducible nitric oxide synthase 2 (iNOS2) and pro-inflammatory cytokines like TNF-α and I...

journal_title：Parasite immunology

authors： Hussain A,Ghosh S,Roy K,Nath S,Sarkar B,Dutta A,Maji P,Basu S,Paul S,Dey S,Chakraborty K,Raychaudhury B,Acharya K,Ganguly J,Pal C

更新日期：2020-10-31 00:00:00

abstract：:The overall performance of quantitative assays in the detection of anti-Toxoplasma IgG is satisfactory, but discrepancies between assays are not uncommon especially when IgG concentrations are close to the limit of detection of the tests. The purpose of our study was to identify soluble and membrane antigens extracted...

journal_title：Parasite immunology

authors： Khammari I,Saghrouni F,Lakhal S,Bougmiza I,Bouratbine A,Ben Said M,Boukadida J

更新日期：2014-12-01 00:00:00

abstract：:The zoonotic pathogen Toxoplasma gondii infects over 30% of the human population. The intracellular parasite can persist lifelong in the CNS within neurons modifying their function and structure, thus leading to specific behavioural changes of the host. In recent years, several in vitro studies and murine models have ...

journal_title：Parasite immunology

authors： Parlog A,Schlüter D,Dunay IR

更新日期：2015-03-01 00:00:00