Abstract:
:Groups of five dogs were vaccinated against Babesia canis using soluble parasite (SPA) antigens from in vitro cultures. Although vaccination did not significantly alter peripheral parasitaemia upon challenge, protected animals had lower levels of SPA in the plasma after a challenge infection. The severity of anaemia correlated with the SPA-load during the post-challenge period in that high levels of SPA were associated with low haematocrit values. In addition, it was found that recovery was associated with the production of antibodies against SPA. The results suggest that SPA induce anaemia during B. canis infection, and that vaccination with SPA results in antibody production that can neutralize the effects of SPA after a challenge infection.
journal_name
Parasite Immunoljournal_title
Parasite immunologyauthors
Schetters TP,Scholtes NC,Kleuskens JA,Bos HJdoi
10.1046/j.1365-3024.1996.d01-1.xsubject
Has Abstractpub_date
1996-01-01 00:00:00pages
1-6issue
1eissn
0141-9838issn
1365-3024journal_volume
18pub_type
杂志文章abstract::Infections with the nematode Nematospiroides dubius fail to elicit mucosal mast cell (MMC) responses in the intestines of host mice, and suppress MMC responses generated by heterologous infection. Larval N. dubius have the capacity to prime for mastocytosis, and to elicit this response in primed mice during a challeng...
journal_title:Parasite immunology
pub_type: 杂志文章
doi:10.1111/j.1365-3024.1988.tb00205.x
更新日期:1988-01-01 00:00:00
abstract::Gastrointestinal (GI) nematodes are a group of successful multicellular parasites that have evolved to coexist within the intestinal niche of multiple species. It is estimated that over 10% of the world's population are chronically infected by GI nematodes, making this group of parasitic nematodes a major burden to gl...
journal_title:Parasite immunology
pub_type: 杂志文章,评审
doi:10.1111/pim.12517
更新日期:2018-04-01 00:00:00
abstract::Sheep scab is caused by the noninvasive mite, Psoroptes ovis, which initiates a profound pro-inflammatory skin response leading to lesion development. To investigate these early events between the skin and the parasite, primary ovine epidermal keratinocyte cultures were generated and challenged with mite derived antig...
journal_title:Parasite immunology
pub_type: 杂志文章
doi:10.1111/j.1365-3024.2009.01103.x
更新日期:2009-06-01 00:00:00
abstract::The present study was designed to investigate the role of neutrophils during the development of Schistosoma japonicum egg granulomas, in C57BL/6 and CBA mice. Laid eggs were implanted into the liver and monoclonal antibody, RB6-8C5, was used to eliminate neutrophils. After daily antibody treatment between days 9 and 1...
journal_title:Parasite immunology
pub_type: 杂志文章
doi:10.1046/j.1365-3024.2002.00491.x
更新日期:2002-09-01 00:00:00
abstract::Modulation of macrophage/dendritic cell (DC) cytokine production by the filarial nematode phosphorylcholine (PC)-containing product, ES-62, is mediated by Toll-like receptor (TLR) 4 and signal transduction depends on the TLR adaptor MyD88. Intriguingly, comparison of TLR4 knock-out (ko) mice with TLR4 mutant C3H/HeJ m...
journal_title:Parasite immunology
pub_type: 杂志文章
doi:10.1111/j.1365-3024.2006.00926.x
更新日期:2007-03-01 00:00:00
abstract::Toxoplasma gondii is a highly successful parasite that can manipulate host immune responses to optimize its persistence and spread. As a result, a highly complex relationship exists between T. gondii and the immune system of the host. Advances in imaging techniques, and in particular, the application of two-photon mic...
journal_title:Parasite immunology
pub_type: 杂志文章,评审
doi:10.1111/pim.12161
更新日期:2015-03-01 00:00:00
abstract::Human toxocariasis is a helminth zoonosis resulting from accidental infection of humans by the roundworms Toxocara canis (T. canis) and cati (T. cati). The infection occurs in five forms: systemic (VLM), ocular, neurological, covert and asymptomatic. The aim of this study was to characterize the radiological and immun...
journal_title:Parasite immunology
pub_type: 杂志文章
doi:10.1111/pim.12143
更新日期:2014-12-01 00:00:00
abstract::We have previously reported the usefulness of a 26-28 kDa coproantigen of Fasciola hepatica for diagnosis of infection. In this study, the 26-28 kDa coproantigen was biochemically characterized with the aid of monoclonal antibodies (MoAb) in an effort to better understand the biology of the antigen. Differential stain...
journal_title:Parasite immunology
pub_type: 杂志文章
doi:10.1046/j.1365-3024.1999.00191.x
更新日期:1999-06-01 00:00:00
abstract::Leishmania donovani, the causative parasite of Visceral Leishmaniasis (VL), deviously manipulates host monocytes/macrophages to ensure its survival. Although monocytes/macrophages from patients with VL have demonstrated an impaired oxidative burst and antigen presentation, an unanswered yet pertinent question remains ...
journal_title:Parasite immunology
pub_type: 杂志文章
doi:10.1111/pim.12535
更新日期:2018-07-01 00:00:00
abstract::Inhibitory monoclonal antibody (MoAb) 8E7/55 recognizes a parasitophorous vacuole membrane (PVM) antigen in Plasmodium falciparum. Previous studies have identified the epitope, DNNLVSGP, recognized by the MoAb. A synthetic peptide containing this sequence was synthesized and coupled to diphtheria toxoid (DT) and was f...
journal_title:Parasite immunology
pub_type: 杂志文章
doi:10.1111/j.1365-3024.1993.tb00574.x
更新日期:1993-11-01 00:00:00
abstract::Attempts to produce monoclonal antibodies specific for a parasite-encoded or induced antigen on the surface of Theileria parva lawrencei-transformed bovine lymphocytes resulted in the identification of the monoclonal antibody J7. This antibody recognizes a membrane glycoprotein on some T.p. lawrencei-infected bovine l...
journal_title:Parasite immunology
pub_type: 杂志文章
doi:10.1111/j.1365-3024.1986.tb00841.x
更新日期:1986-03-01 00:00:00
abstract::SUMMARY Previous experiments have shown that genetic resistance to infection by Teladorsagia circumcincta in sheep can be measured by the level of IgA in gastric mucus, jointly with other parameters. The aim of this study has been to observe the influence of IgA on adult worms. The experiment was carried out with Chur...
journal_title:Parasite immunology
pub_type: 杂志文章
doi:10.1111/j.1365-3024.2005.00769.x
更新日期:2005-06-01 00:00:00
abstract::In order to gain insights into the immune response in onchocerciasis during early infection, laboratory-reared calves were infected with 1000 Onchocerca lienalis infective larvae and examined serologically over a period of 508 days. Levels of serum antibodies measured by ELISA against adult worm extract revealed a mul...
journal_title:Parasite immunology
pub_type: 杂志文章
doi:10.1111/j.1365-3024.1995.tb00907.x
更新日期:1995-08-01 00:00:00
abstract::An attenuated line of Leishmania mexicana (the L. mexicana H-line) has been established by culturing in vitro under gentamicin pressure. BALB/c mice infected with the L. mexicana H-line developed a CD4(+)Th1-like response, indicated by the cytokine profile of their splenocytes stimulated by L. mexicana wild-type (WT) ...
journal_title:Parasite immunology
pub_type: 杂志文章
doi:10.1111/j.0141-9838.2004.00671.x
更新日期:2003-11-01 00:00:00
abstract::Schistosomiasis japonicum is one of the most serious zoonotic diseases in the world. There is increasing evidence to show that host miRNAs are modulated following Schistosoma japonicum infection, and some of these miRNAs may play important regulatory roles in response to schistosome infection. Several host miRNAs have...
journal_title:Parasite immunology
pub_type: 杂志文章,评审
doi:10.1111/pim.12416
更新日期:2017-02-01 00:00:00
abstract::Phosphorylcholine-bearing component levels in extracts of various parasites were determined by a capillary precipitin test using anti-phosphorylcholine Ig A myeloma protein. TEPC-15. Phosphorylcholine was demonstrated as a structural component not only in nematodes but also in trematodes and cestodes. The phosphorylch...
journal_title:Parasite immunology
pub_type: 杂志文章
doi:10.1111/j.1365-3024.1983.tb00754.x
更新日期:1983-07-01 00:00:00
abstract::We investigated the immune effector mechanisms that underlie protection against F. hepatica in the gut wall of immune rats, using (immuno)histochemistry. In the lamina propria of immune Wistar rats, four weeks after oral infection, frequencies of IgE-positive cells, eosinophils and mucosal mast cells were significantl...
journal_title:Parasite immunology
pub_type: 杂志文章
doi:10.1046/j.1365-3024.1998.00144.x
更新日期:1998-06-01 00:00:00
abstract::The course of primary infections with Nippostrongylus brasiliensis was followed in nude (CBH/R nu/nu) and heterozygote (CBH/R nu/+) rats. In both nude and heterozygote rats peak egg production by N. brasiliensis occurred on days 7 and 8 post-infection. However, whereas in heterozygote rats egg production declined rapi...
journal_title:Parasite immunology
pub_type: 杂志文章
doi:10.1111/j.1365-3024.1991.tb00553.x
更新日期:1991-11-01 00:00:00
abstract::Parasitic nematodes are constantly exposed to the immune effector mechanisms of their hosts. One strategy of the worms to cope with these defence reactions is the secretion of modulatory proteins that down-regulate cell-mediated immune responses. We analysed the proliferation of mesenteric lymph node cells of mice inf...
journal_title:Parasite immunology
pub_type: 杂志文章
doi:10.1111/j.1365-3024.2006.00891.x
更新日期:2006-09-01 00:00:00
abstract:BACKGROUND:Fasciola hepatica causes economically important disease in livestock worldwide. The relevance of this parasitic infection extends beyond its direct consequences due to its immunoregulatory properties. OBJECTIVES:Given the importance of the T helper 1 (Th1) immune response in controlling infections with Myco...
journal_title:Parasite immunology
pub_type: 杂志文章
doi:10.1111/pim.12779
更新日期:2020-11-01 00:00:00
abstract::We describe an ELISA for trophozoite-specific IgA in the intestinal secretions of mice infected with Giardia muris. Using this method, trophozoite-specific IgA was demonstrated in intestinal secretions of Giardia-infected immunocompetent BALB/c mice. Such antibody was undetectable in the intestinal secretions of Giard...
journal_title:Parasite immunology
pub_type: 杂志文章
doi:10.1111/j.1365-3024.1988.tb00257.x
更新日期:1988-11-01 00:00:00
abstract::Infective larvae of Toxocara canis are well suited for studies of nematode antigen expression in vitro. Larvae were labelled with 3H-glucosamine, an approach permitting dual analysis of antigen quantity and composition. Their excretory/secretory (E/S) glycoproteins were efficiently labelled and antigen identity confir...
journal_title:Parasite immunology
pub_type: 杂志文章
doi:10.1111/j.1365-3024.1990.tb00946.x
更新日期:1990-03-01 00:00:00
abstract::The role of CD4+ and CD8+ T lymphocytes in the development of a protective immune response against Cryptosporidium muris infection was studied by the reconstitution of severe combined immunodeficient (SCID) mice with well-defined populations of either naive or immune CD8+ or CD4+ T lymphocytes. Adoptive transfer of bo...
journal_title:Parasite immunology
pub_type: 杂志文章
doi:10.1111/j.1365-3024.2010.01271.x
更新日期:2011-04-01 00:00:00
abstract::As an orally acquired pathogen, the immune response to Toxoplasma gondii unfolds in the small intestinal mucosa. There, an array of regulatory and effector immune cells are elicited to combat the parasite through secretion of inflammatory mediators, normally resulting in host protection and pathogen control. Recent st...
journal_title:Parasite immunology
pub_type: 杂志文章,评审
doi:10.1111/pim.12164
更新日期:2015-03-01 00:00:00
abstract::The development of a malaria vaccine is a priority for improved and sustained malaria control. Optimal use of a vaccine in Africa will only be achieved if it can be delivered through the Expanded Programme of Immunization (EPI). We have completed a trial of the peptide vaccine SPf66 in Tanzanian infants, given alongsi...
journal_title:Parasite immunology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1046/j.1365-3024.2000.00322.x
更新日期:2000-09-01 00:00:00
abstract::During African trypanosomiasis, macrophages play a central role in T cell hyporesponsiveness to parasite-related and unrelated antigens. In this study, the ability of macrophages from Trypanosoma b. brucei-infected mice to present exogenous antigens to a major histocompatibility complex (MHC) class II-restricted CD4+ ...
journal_title:Parasite immunology
pub_type: 杂志文章
doi:10.1046/j.1365-3024.2000.00314.x
更新日期:2000-07-01 00:00:00
abstract::The pathogenesis of Acanthamoeba keratitis (AK) is complicated. In our previous studies, TLR4 was found involved in the process of infection by Acanthamoeba in human corneal cells. The purpose of this study was to investigate the role of Toll-like receptor 4 (TLR4) signalling pathway in Wistar rats challenged with Aca...
journal_title:Parasite immunology
pub_type: 杂志文章
doi:10.1111/j.1365-3024.2010.01247.x
更新日期:2011-01-01 00:00:00
abstract::Antibodies and B cells are critical in the protective immune response to the blood stage of the malaria parasite, Plasmodium chabaudi. However, little is known about the development of memory B cells and their differentiation into plasma cells during infection or after re-infection. Here we have shown that B cells wit...
journal_title:Parasite immunology
pub_type: 杂志文章
doi:10.1111/j.1365-3024.2008.01066.x
更新日期:2009-01-01 00:00:00
abstract::Immunity to Schistosoma mansoni in the mouse was induced by vaccination with adult worm surface membrane (mb-S). Of several adjuvants tested, including Freund's, BCG and alum, 50 micrograms of saponin per mouse given subcutaneously with the antigen was the easiest to administer, and gave consistent protection, approac...
journal_title:Parasite immunology
pub_type: 杂志文章
doi:10.1111/j.1365-3024.1989.tb00669.x
更新日期:1989-07-01 00:00:00
abstract::Ascariasis is the most frequent soil transmitted helminthiasis and, as well as other helminth infections, is expected to influence the clinical presentation of allergic diseases such as asthma. Indeed, several clinical and experimental works have shown an important impact either increasing or suppressing symptoms, and...
journal_title:Parasite immunology
pub_type: 杂志文章,评审
doi:10.1111/pim.12595
更新日期:2019-06-01 00:00:00