Not peripheral parasitaemia but the level of soluble parasite antigen in plasma correlates with vaccine efficacy against Babesia canis.

Abstract:

:Groups of five dogs were vaccinated against Babesia canis using soluble parasite (SPA) antigens from in vitro cultures. Although vaccination did not significantly alter peripheral parasitaemia upon challenge, protected animals had lower levels of SPA in the plasma after a challenge infection. The severity of anaemia correlated with the SPA-load during the post-challenge period in that high levels of SPA were associated with low haematocrit values. In addition, it was found that recovery was associated with the production of antibodies against SPA. The results suggest that SPA induce anaemia during B. canis infection, and that vaccination with SPA results in antibody production that can neutralize the effects of SPA after a challenge infection.

journal_name

Parasite Immunol

journal_title

Parasite immunology

authors

Schetters TP,Scholtes NC,Kleuskens JA,Bos HJ

doi

10.1046/j.1365-3024.1996.d01-1.x

subject

Has Abstract

pub_date

1996-01-01 00:00:00

pages

1-6

issue

1

eissn

0141-9838

issn

1365-3024

journal_volume

18

pub_type

杂志文章
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