Abstract：
:Groups of five dogs were vaccinated against Babesia canis using soluble parasite (SPA) antigens from in vitro cultures. Although vaccination did not significantly alter peripheral parasitaemia upon challenge, protected animals had lower levels of SPA in the plasma after a challenge infection. The severity of anaemia correlated with the SPA-load during the post-challenge period in that high levels of SPA were associated with low haematocrit values. In addition, it was found that recovery was associated with the production of antibodies against SPA. The results suggest that SPA induce anaemia during B. canis infection, and that vaccination with SPA results in antibody production that can neutralize the effects of SPA after a challenge infection.
journal_name
Parasite Immunoljournal_title
Parasite immunologyauthors
Schetters TP,Scholtes NC,Kleuskens JA,Bos HJdoi
10.1046/j.1365-3024.1996.d01-1.xsubject
Has Abstractpub_date
1996-01-01 00:00:00pages
1-6issue
1eissn
0141-9838issn
1365-3024journal_volume
18pub_type
杂志文章abstract：:Hyporesponsiveness induced by Heligmosomoides polygyrus was quantified and the relationship between TGF-beta and inflammation was identified in BALB/c mice. The immune response and pathological changes modified by neutralization of TGF-beta were characterized in vivo. Nine and twelve days following infection, BALB/c m...
journal_title：Parasite immunology
pub_type： 杂志文章
doi：10.1111/j.1365-3024.2006.00845.x
更新日期：2006-08-01 00:00:00
abstract：AIMS:Our aim was to investigate the skin-homing T-cell immune responses triggered in patients with Demodex infestation and/or rosacea. METHODS:Collected whole blood samples were divided into four groups: control subjects; nonrosacea patients with Demodex infestation (Demodex group); papulopustular rosacea (PPR) patien...
journal_title：Parasite immunology
pub_type： 杂志文章
doi：10.1111/pim.12658
更新日期：2019-08-01 00:00:00
abstract：:Fulani and Masaleit, sympatric tribes in eastern Sudan, are characterized by marked differences in susceptibility to Plasmodium falciparum malaria. To determine whether the two tribes differ in the frequency of immunoglobulin GM/KM allotypes, which are associated with immunity to several pathogens, serum samples from ...
journal_title：Parasite immunology
pub_type： 杂志文章
doi：10.1111/j.1365-3024.2007.00938.x
更新日期：2007-05-01 00:00:00
abstract：:We have previously reported the usefulness of a 26-28 kDa coproantigen of Fasciola hepatica for diagnosis of infection. In this study, the 26-28 kDa coproantigen was biochemically characterized with the aid of monoclonal antibodies (MoAb) in an effort to better understand the biology of the antigen. Differential stain...
journal_title：Parasite immunology
pub_type： 杂志文章
doi：10.1046/j.1365-3024.1999.00191.x
更新日期：1999-06-01 00:00:00
abstract：:The zymosan-triggered chemiluminescence response of peritoneal exudate cells from mice infected with relatively virulent or avirulent Toxoplasma gondii strains was examined at various intervals after infection. Toxoplasma infections increased the background chemiluminescence compared with controls, but higher values w...
journal_title：Parasite immunology
pub_type： 杂志文章
doi：10.1111/j.1365-3024.1984.tb00796.x
更新日期：1984-05-01 00:00:00
abstract：:This study examines several aspects of a polymorphic, immunodominant molecule (PIM) found in the protozoan parasite, Theileria parva. The antigen is present in all T.p. parva stocks examined, and in the related subspecies, T.p.bovis and T.p.lawrencei. It is the predominant antigen recognized by antisera from immune ca...
journal_title：Parasite immunology
pub_type： 杂志文章
doi：10.1111/j.1365-3024.1991.tb00262.x
更新日期：1991-01-01 00:00:00
abstract：:Use of the pig as an animal model in schistosomiasis research is increasing, but knowledge of the porcine immune response to schistosome infection is still very limited. We investigated the immunohistology of different maturation stages of the Schistosoma japonicum egg granuloma in pigs. Liver sections from pigs exper...
journal_title：Parasite immunology
pub_type： 杂志文章
doi：10.1046/j.1365-3024.2002.00448.x
更新日期：2002-03-01 00:00:00
abstract：:The course of primary infections with Nippostrongylus brasiliensis was followed in nude (CBH/R nu/nu) and heterozygote (CBH/R nu/+) rats. In both nude and heterozygote rats peak egg production by N. brasiliensis occurred on days 7 and 8 post-infection. However, whereas in heterozygote rats egg production declined rapi...
journal_title：Parasite immunology
pub_type： 杂志文章
doi：10.1111/j.1365-3024.1991.tb00553.x
更新日期：1991-11-01 00:00:00
abstract：:The development of a malaria vaccine is a priority for improved and sustained malaria control. Optimal use of a vaccine in Africa will only be achieved if it can be delivered through the Expanded Programme of Immunization (EPI). We have completed a trial of the peptide vaccine SPf66 in Tanzanian infants, given alongsi...
journal_title：Parasite immunology
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1046/j.1365-3024.2000.00322.x
更新日期：2000-09-01 00:00:00
abstract：:Despite the plethora of evidence on the consequences of host nutrition on their immune responses to gastrointestinal parasites, the identity of molecules and mechanisms that drive the manifestations of immunity under nutrient abundance are not yet known. This is partly due to limitations of the methodologies employed ...
journal_title：Parasite immunology
pub_type： 杂志文章,评审
doi：10.1111/j.1365-3024.2008.00993.x
更新日期：2008-02-01 00:00:00
abstract：:Studies to clarify the mechanisms of apoptosis in host cells, A31 (BALB/3T3 clone A31 fibroblasts), caused by two intracellular protozoan parasites, Toxoplasma gondii and Neospora caninum, were carried out in an in vitro system. The viability of N. caninum-infected cells was significantly reduced following treatment w...
journal_title：Parasite immunology
pub_type： 杂志文章
doi：10.1046/j.1365-3024.2002.00476.x
更新日期：2002-07-01 00:00:00
abstract：:Trypanosoma congolense is one of the main species responsible for Animal African Trypanosomosis (AAT). As preventive vaccination strategies for AAT have been unsuccessful so far, investigating the mechanisms underlying vaccine failure has to be prioritized. In T. brucei and T. vivax infections, recent studies revealed...
journal_title：Parasite immunology
pub_type： 杂志文章
doi：10.1111/pim.12099
更新日期：2014-05-01 00:00:00
abstract：:Eleven strains of Trypanosoma cruzi, originating from a variety of vertebrate and invertebrate hosts in distinct geographical regions, were examined for the reactivity of metacyclic stages with the monoclonal antibody 1G7. Trypomastigotes of five strains were susceptible to complement-dependent 1G7-mediated lysis. Hig...
journal_title：Parasite immunology
pub_type： 杂志文章
doi：10.1111/j.1365-3024.1988.tb00227.x
更新日期：1988-07-01 00:00:00
abstract：:CBA/J mice are resistant to Leishmania major infection but are permissive to L. amazonensis infection. In addition, CBA/J macrophages control L. major but not L. amazonensis infection in vitro. Phagocytosis by macrophages is known to determine the outcome of Leishmania infection. Pattern recognition receptors (PRR) ad...
journal_title：Parasite immunology
pub_type： 杂志文章
doi：10.1111/j.1365-3024.2009.01093.x
更新日期：2009-04-01 00:00:00
abstract：:A 120 kDa antigen containing SDS-PAGE fraction BmA-2 isolated from Brugia malayi adult parasite was highly reactive with normal sera from filarial endemic area. BmA-2 was analysed for its prophylactic potential in in vitro and in vivo. Sera collected from BmA-2 immunized jirds induced a significant level (80 to 90%) o...
journal_title：Parasite immunology
pub_type： 杂志文章
doi：10.1111/j.1365-3024.1995.tb00893.x
更新日期：1995-06-01 00:00:00
abstract：:The present paper reviews the available literature on the development of immunity to animal Schistosoma infections. The majority of the studies on animal schistosomiasis were performed in cattle and pigs and only Schistosoma mattheei, S. bovis and S. japonicum received particular attention, mainly because of their rec...
journal_title：Parasite immunology
pub_type： 杂志文章,评审
doi：10.1111/j.1365-3024.2005.00766.x
更新日期：2005-07-01 00:00:00
abstract：:The variant surface glycoprotein (VSG) coat of African trypanosomes exhibits immunobiological functions distinct from its prominent role as a variant surface antigen. In order to address questions regarding immune stealth effects of VSG switch-variant coats, and the innate immune system activating effects of shed VSG ...
journal_title：Parasite immunology
pub_type： 杂志文章,评审
doi：10.1111/j.1365-3024.2007.01003.x
更新日期：2008-04-01 00:00:00
abstract：:A whole-killed malaria blood-stage vaccine (WKV) is promising in reducing the morbidity and mortality of malaria patients, but its efficacy needs to be improved. We found that the antimalarial drug chloroquine could augment the protective efficacy of the WKV of Plasmodium yoelii. The direct antimalarial effect of chlo...
journal_title：Parasite immunology
pub_type： 杂志文章
doi：10.1111/pim.12682
更新日期：2020-01-01 00:00:00
abstract：:In this study, we investigated the characteristics of the infection and subsequent immunity induced by Strongyloides venezuelensis in Lewis rats. Animals were infected with 4000 L3 of S. venezuelensis and number of eggs per gram of faeces indicated an acute phase around day 8 and a recovery phase around day 32 after i...
journal_title：Parasite immunology
pub_type： 杂志文章
doi：10.1111/j.1365-3024.2009.01160.x
更新日期：2010-01-01 00:00:00
abstract：:Cryptocaryon irritans is one of the most important ectoparasites of marine fish. To identify the potential role of immune-related genes in antiparasitic immune responses in fish, we monitored the expression change of IL-8, COX-2, C-type lectin and transferrin in local and systemic immune organs of orange-spotted group...
journal_title：Parasite immunology
pub_type： 杂志文章
doi：10.1111/j.1365-3024.2011.01337.x
更新日期：2011-12-01 00:00:00
abstract：:Leishmaniasis has recently garnered attention as one of the diseases 'most neglected' by drug research and development, as the current therapeutic modalities available for the patients are ridden with unacceptable toxicity due to high dosage of the drug, prolonged treatment schedules, resistance and prohibitive costs....
journal_title：Parasite immunology
pub_type： 杂志文章
doi：10.1111/pim.12071
更新日期：2014-01-01 00:00:00
abstract：:Naegleria fowleri, a free-living amoeba, is the causative pathogen of primary amoebic meningoencephalitis in humans and experimental mice. N. fowleri is capable of destroying tissues and host cells through lytic necrosis. However, the mechanism by which N. fowleri induces host cell death is unknown. Electron microscop...
journal_title：Parasite immunology
pub_type： 杂志文章
doi：10.1111/j.1365-3024.2011.01297.x
更新日期：2011-07-01 00:00:00
abstract：:Theileria parva is a tick-borne intracellular protozoan of cattle, with obligate sequential differentiation stages in lymphocytes and erythrocytes. Immunity is mediated by cytotoxic T lymphocytes (CTL) that target and clear parasitized lymphocytes but allow persistence of infected erythrocytes, which are required for ...
journal_title：Parasite immunology
pub_type： 杂志文章,评审
doi：10.1111/j.1365-3024.2006.00824.x
更新日期：2006-07-01 00:00:00
abstract：:The caecal-dwelling nematode Trichuris muris provides a natural model of human whipworm infection. Resistance to T. muris is dependent on a host Th2 response, and CD4+Th2 cells migrate to the gut-associated lymphoid tissue (GALT) to elicit parasite expulsion. Thus, CD4+T cells infiltrate the caecal lamina propria duri...
journal_title：Parasite immunology
pub_type： 杂志文章
doi：10.1111/j.1365-3024.2007.01017.x
更新日期：2008-03-01 00:00:00
abstract：:A surface enriched fraction was prepared from adults of Onchocerca volvulus by brief extraction of entire worms with detergent. This was then gel filtered to yield a low molecular weight fraction which functioned specifically in ELISA analysis. An identical result was also obtained when the related cattle parasite, O....
journal_title：Parasite immunology
pub_type： 杂志文章
doi：10.1111/j.1365-3024.1987.tb00487.x
更新日期：1987-01-01 00:00:00
abstract：:A recent working group convened by the World Health Organization recommended that time to first or only episode of clinical malaria should be used to evaluate vaccine efficacy in phase III trials. However, calculating vaccine efficacy based on this endpoint misses important aspects of malaria disease and transmission....
journal_title：Parasite immunology
pub_type： 杂志文章,评审
doi：10.1111/j.1365-3024.2009.01144.x
更新日期：2009-09-01 00:00:00
abstract：:The soluble portion of a large particle fraction which was derived from the muscle larva of T. spiralis was subjected to molecular sizing column chromatography using Sephacryl S-200. Five major peaks of 280 nm absorbing material were obtained. Analysis by immunoelectrophoresis revealed that each peak contained antigen...
journal_title：Parasite immunology
pub_type： 杂志文章
doi：10.1111/j.1365-3024.1981.tb00405.x
更新日期：1981-10-01 00:00:00
abstract：:To study the role of autoreactive T cells in the pathogenesis of cardiomyopathy in Chagas' disease, we generated a cell line by repeated in vitro antigenic stimulation of purified splenic CD4+ T lymphocytes from a chronically Trypanosoma cruzi-infected mouse. Cells from this line were confirmed to be CD4+ CD8- and pro...
journal_title：Parasite immunology
pub_type： 杂志文章
doi：10.1046/j.1365-3024.2001.00368.x
更新日期：2001-02-01 00:00:00
abstract：:A longitudinal study was undertaken in Burkina Faso among 293 children aged 6 months to 9 years in order to determine the correlation between an antibody response to several individual malarial antigens and malarial infection. It was found that the presence of a positive antibody response at the beginning of the rainy...
journal_title：Parasite immunology
pub_type： 杂志文章
doi：10.1111/j.0141-9838.2004.00705.x
更新日期：2004-06-01 00:00:00
abstract：:To determine the role of T cells and mast cells in intestinal pathology and immune expulsion of intestinal nematodes, worm burdens, goblet cell responses and villus structures were analysed in T- and B-cell-deficient severe combined immunodeficiency (SCID) mice, athymic nu/nu mice and mast cell deficient W/W(v) mice a...
journal_title：Parasite immunology
pub_type： 杂志文章
doi：10.1111/j.1365-3024.2009.01123.x
更新日期：2009-08-01 00:00:00
