A heart-specific CD4+ T-cell line obtained from a chronic chagasic mouse induces carditis in heart-immunized mice and rejection of normal heart transplants in the absence of Trypanosoma cruzi.

abstract：:The pathogenesis of the tissue lesions observed in American trypanosomiasis (Chagas' disease) seems to depend on a variety of mechanisms. The present study was dedicated to the investigation of the evolution of muscle lesions and its relationship with immunological and parasitological parameters. Mice were infected i....

journal_title：Parasite immunology

authors： Silva JC,Pirmez C,Morgado MG,Galvão-Castro B

更新日期：1985-09-01 00:00:00

abstract：:In schistosomiasis endemic areas, intensities of reinfection after treatment are greater amongst young children than amongst adults, and high levels of parasite-specific IgE are associated with resistance to reinfection in an age-dependent manner. Previously we have reported that, in Western blots, a 22 kDa band was r...

journal_title：Parasite immunology

authors： Dunne DW,Webster M,Smith P,Langley JG,Richardson BA,Fulford AJ,Butterworth AE,Sturrock RF,Kariuki HC,Ouma JH

更新日期：1997-02-01 00:00:00

abstract：:After several in vitro treatments of a virulent population of Leishmania major with the mutagen, N-methyl-N'-nitro-N-nitrosoguanidine (MNNG), five clones (vir-) were obtained that did not produce cutaneous lesions after subcutaneous injection of 10(6) promastigotes. All the control clones (vir+) obtained from the non-...

journal_title：Parasite immunology

authors： Marchand M,Daoud S,Titus RG,Louis J,Boon T

更新日期：1987-01-01 00:00:00

abstract：:The life cycle of Taenia solium, the pork tapeworm, is continuously closed in many rural settings in developing countries when free roaming pigs ingest human stools containing T. solium eggs and develop cysticercosis, and humans ingest pork infected with cystic larvae and develop intestinal taeniasis, or may also acci...

journal_title：Parasite immunology

authors： Garcia HH,Rodriguez S,Friedland JS,Cysticercosis Working Group in Peru.

更新日期：2014-08-01 00:00:00

abstract：:The protective effect of specific vaccination against Plasmodium berghei (P. berghei) was compared in terms of survival percentage in DBA/2, C3H, outbred albino mice and in two lines of mice produced by selective breeding for either high or low antibody responsiveness to sheep erythrocyte (H and L lines respectively)....

journal_title：Parasite immunology

authors： Heumann AM,Bucci A,Stiffel C,Casaglia O,Zenobi P,Biozzi G

更新日期：1983-03-01 00:00:00

abstract：:In this study, supplementation with the probiotic Saccharomyces boulardii promoted a reduction in intensity of infection by Toxocara canis and modulates cytokines mRNA expression in experimentally infected mice. IL-12 gene transcription had 40-fold increase in S. boulardii supplemented uninfected mice and sevenfold in...

journal_title：Parasite immunology

authors： de Avila LF,de Leon PM,de Moura MQ,Berne ME,Scaini CJ,Leivas Leite FP

更新日期：2016-05-01 00:00:00

abstract：:The merozoite surface protein 2 of P. falciparum is highly polymorphic in nature, but has regions of almost complete conservation at its N- and C-termini. We produced a chimeric recombinant protein comprising these regions only (hereafter termed NC). Mice immunized with the NC antigen produce antibodies at levels comp...

journal_title：Parasite immunology

authors： Lawrence N,Stowers A,Mann V,Taylor D,Saul A

更新日期：2000-05-01 00:00:00

abstract：:Mice can be immunized to Plasmodium vinckei by repeated infections followed by cure. Such immunity is dependent on CD4 T cells and an architecturally modified spleen, but has little requirement for antibody. Thus, athymic mice can be exposed to P. vinckei and cured, but do not develop immunity. They are resistant to c...

journal_title：Parasite immunology

authors： Winkel KD,Good MF

更新日期：1991-09-01 00:00:00

abstract：:The chromadorea abundant larval transcript (ALT) family of proteins contains ALT one of the most studied putative vaccine candidate in experimental filariasis. This study reports the characterization of Wuchereria bancrofti 20/22 (Wb20/22) as a member of chromadorea, the ALT family of proteins from the L3 stage of W. ...

journal_title：Parasite immunology

authors： Aparnaa R,Mahalakshmi N,Harini A,Jeyaprita PJ,Anugraha G,Amdare NP,Khatri VK,Reddy MV,Kaliraj P

更新日期：2014-10-01 00:00:00

abstract：:Leishmania enter macrophages through receptor-mediated phagocytosis and survive the harsh environment of a phagolysosome. Here, we investigated the interaction between mannose receptor (MR), Toll-like receptor 2 (TLR2), and Leishmania, and the subsequent impact on phagosome maturation. Leishmania parasites are able to...

journal_title：Parasite immunology

authors： Polando RE,Jones BC,Ricardo C,Whitcomb J,Ballhorn W,McDowell MA

更新日期：2018-04-01 00:00:00

abstract：:Hyporesponsiveness induced by Heligmosomoides polygyrus was quantified and the relationship between TGF-beta and inflammation was identified in BALB/c mice. The immune response and pathological changes modified by neutralization of TGF-beta were characterized in vivo. Nine and twelve days following infection, BALB/c m...

journal_title：Parasite immunology

authors： Doligalska M,Rzepecka J,Drela N,Donskow K,Gerwel-Wronka M

更新日期：2006-08-01 00:00:00

abstract：:Chronic Chagas cardiomyopathy (CCC) is responsible for the disease's greater morbidity and poor prognosis. Although understanding the pathophysiology of CCC and the fundamentals of its clinical management derives from research related to other cardiomyopathies, there are peculiarities that distinguish CCC from the oth...

journal_title：Parasite immunology

authors： Chaves AT,Menezes CAS,Costa HS,Nunes MCP,Rocha MOC

更新日期：2019-10-01 00:00:00

abstract：:The K1 peptide is a CD8(+)T cell HLA-A*0201-restricted epitope derived from the Trypanosoma cruzi KMP-11 protein. We have previously shown that this peptide induces IFN-gamma secretion by CD8(+)T cells. The aim of this study was to characterize the frequency of K1-specific CD8(+)T cells in chagasic patients. Nineteen ...

journal_title：Parasite immunology

authors： Lasso P,Mesa D,Cuéllar A,Guzmán F,Bolaños N,Rosas F,Velasco V,Thomas Mdel C,Lopez MC,Gonzalez JM,Puerta CJ

更新日期：2010-07-01 00:00:00

abstract：:The zoonotic pathogen Toxoplasma gondii infects over 30% of the human population. The intracellular parasite can persist lifelong in the CNS within neurons modifying their function and structure, thus leading to specific behavioural changes of the host. In recent years, several in vitro studies and murine models have ...

journal_title：Parasite immunology

authors： Parlog A,Schlüter D,Dunay IR

更新日期：2015-03-01 00:00:00

abstract：:The overall performance of quantitative assays in the detection of anti-Toxoplasma IgG is satisfactory, but discrepancies between assays are not uncommon especially when IgG concentrations are close to the limit of detection of the tests. The purpose of our study was to identify soluble and membrane antigens extracted...

journal_title：Parasite immunology

authors： Khammari I,Saghrouni F,Lakhal S,Bougmiza I,Bouratbine A,Ben Said M,Boukadida J

更新日期：2014-12-01 00:00:00

abstract：:A model for the in vitro infection of ovine cells with Toxoplasma gondii tachyzoites has been developed and used to investigate the effect of treatment with ovine recombinant interferon-gamma (ov.rIFN gamma) on parasite replication. Treatment of both alveolar macrophages and fibroblast cells either 24 h pre-infection ...

journal_title：Parasite immunology

authors： Oura CA,Innes EA,Wastling JM,Entrican G,Panton WR

更新日期：1993-09-01 00:00:00

abstract：:The zymosan-triggered chemiluminescence response of peritoneal exudate cells from mice infected with relatively virulent or avirulent Toxoplasma gondii strains was examined at various intervals after infection. Toxoplasma infections increased the background chemiluminescence compared with controls, but higher values w...

journal_title：Parasite immunology

authors： Masihi KN,Werner H,Gillert KE,Lange W

更新日期：1984-05-01 00:00:00

abstract：:Attempts to produce monoclonal antibodies specific for a parasite-encoded or induced antigen on the surface of Theileria parva lawrencei-transformed bovine lymphocytes resulted in the identification of the monoclonal antibody J7. This antibody recognizes a membrane glycoprotein on some T.p. lawrencei-infected bovine l...

journal_title：Parasite immunology

authors： Newson J,Naessens J,Stagg DA,Black SJ

更新日期：1986-03-01 00:00:00

abstract：:Cryptocaryon irritans is one of the most important ectoparasites of marine fish. To identify the potential role of immune-related genes in antiparasitic immune responses in fish, we monitored the expression change of IL-8, COX-2, C-type lectin and transferrin in local and systemic immune organs of orange-spotted group...

journal_title：Parasite immunology

authors： Li YW,Dan XM,Zhang TW,Luo XC,Li AX

更新日期：2011-12-01 00:00:00

abstract：AIMS:Our aim was to investigate the skin-homing T-cell immune responses triggered in patients with Demodex infestation and/or rosacea. METHODS:Collected whole blood samples were divided into four groups: control subjects; nonrosacea patients with Demodex infestation (Demodex group); papulopustular rosacea (PPR) patien...

journal_title：Parasite immunology

authors： Gazi U,Gureser AS,Oztekin A,Karasartova D,Kosar-Acar N,Derici MK,Artuz F,Mumcuoglu KY,Taylan-Ozkan A

更新日期：2019-08-01 00:00:00

abstract：:CD4(+) T cells play a critical role in determining the disease outcome in murine cutaneous leishmaniasis, and selective usage of T-cell receptor (TCR) is implied in promoting Leishmania major infection. However, little information is available on TCR usage in Leishmania-specific, IFN-γ-producing CD4(+) T cells. In thi...

journal_title：Parasite immunology

authors： Xin L,Wanderley JL,Wang Y,Vargas-Inchaustegui DA,Soong L

更新日期：2011-03-01 00:00:00

abstract：:The development of a malaria vaccine is a priority for improved and sustained malaria control. Optimal use of a vaccine in Africa will only be achieved if it can be delivered through the Expanded Programme of Immunization (EPI). We have completed a trial of the peptide vaccine SPf66 in Tanzanian infants, given alongsi...

journal_title：Parasite immunology

authors： Galindo CM,Acosta CJ,Schellenberg D,Aponte JJ,Roca A,Oettli A,Urassa H,Armstrong Schellenberg J,Kahigwa E,Ascaso C,Mshinda H,Lwilla F,Vidal J,Menendez C,Tanner M,Alonso PL

更新日期：2000-09-01 00:00:00

abstract：:Indonesian thin-tail (ITT) sheep can resist infection with Fasciola gigantica but not F. hepatica and presents an ideal model to investigate the mechanisms of liver fluke resistance in a natural host. This study examines the local and systemic immune responses of sheep during Fasciola infection and demonstrates that d...

journal_title：Parasite immunology

authors： Pleasance J,Wiedosari E,Raadsma HW,Meeusen E,Piedrafita D

更新日期：2011-09-01 00:00:00

abstract：:Lymphoid cells from genetically-susceptible BALB/c mice immunized against a glycoconjugate of the protozoan parasite, Leishmania major, promote chronic cutaneous disease in BALB/c nude mice. This cell population therefore differs from cells harvested from non-immunized BALB/c mice that are known to be potent mediators...

journal_title：Parasite immunology

authors： Mitchell GF,Handman E

更新日期：1986-05-01 00:00:00

abstract：:Previous work has shown that a protein extract enriched for cysteine protease activity (TSBP) prepared from adult Haemonchus contortus using thiol sepharose affinity chromatography confers substantial protection against a single challenge infection. TSBP comprised proteases and other proteins. Here, TSBP were further ...

journal_title：Parasite immunology

authors： Knox DP,Smith SK,Redmond DL,Smith WD

更新日期：2005-04-01 00:00:00

abstract：:The capacity of peritoneal exudate cells (PEC) obtained from mice infected or immunized with Plasmodium berghei to produce reactive oxygen species (ROS) and the biological basis of this response was investigated, using luminol-dependent zymosan-triggered chemiluminescence (CL). CL response of PEC from infected mice in...

journal_title：Parasite immunology

authors： Li M,Li YJ

更新日期：1987-05-01 00:00:00

abstract：:Leishmania major causes mild-to-severe cutaneous lesions resulting in significant disfigurations, if untreated. The drugs are toxic, and drug-resistance parasites are emerging. Therefore, a prophylactic vaccination is an urgent need. As no vaccine is available, we compared the genes expressed by virulent and avirulent...

journal_title：Parasite immunology

authors： Zutshi S,Kumar S,Sarode A,Roy S,Sarkar A,Saha B

更新日期：2020-02-01 00:00:00

abstract：:The experimental protocol of immunization tested here confirms its protective effect against Haemonchus contortus in goats. This protection translated into a 65.5% mean reduction in adult worm burden after a homologous challenge, and a significant decrease (73.2%) in cumulative faecal egg counts (FECs). These parasito...

journal_title：Parasite immunology

authors： Molina JM,Hernández YI,Martín S,Ferrer O,Rodríguez F,Ruiz A

更新日期：2018-09-01 00:00:00

abstract：:The present paper reviews the available literature on the development of immunity to animal Schistosoma infections. The majority of the studies on animal schistosomiasis were performed in cattle and pigs and only Schistosoma mattheei, S. bovis and S. japonicum received particular attention, mainly because of their rec...

journal_title：Parasite immunology

authors： Vercruysse J,Gabriel S

更新日期：2005-07-01 00:00:00

abstract：:On a B10 (Lshs) genetic background, the development of acquired T cell mediated immunity to Leishmania donovani infection in mice is under H-2 linked genetic control. Following intravenous inoculation of 10(7) amastigotes three phenotypic patterns of recovery have been described: 'early cure' (H-2r,s), 'cure' (H-2b) a...

journal_title：Parasite immunology

authors： Ulczak OM,Blackwell JM

更新日期：1983-09-01 00:00:00