Myocardial fibrosis in chagas disease and molecules related to fibrosis.

Abstract:

:Chronic Chagas cardiomyopathy (CCC) is responsible for the disease's greater morbidity and poor prognosis. Although understanding the pathophysiology of CCC and the fundamentals of its clinical management derives from research related to other cardiomyopathies, there are peculiarities that distinguish CCC from the others. CCC is the most fibrous heart disease, and its myocardial involvement is important as it disorganizes or disrupts the extracellular matrix, creating an environment conducive to the formation of arrhythmogenic foci. It is also considered the most arrhythmogenic of the known heart diseases, giving rise to complex arrhythmias, usually associated with varying degrees of stimulus conduction disorders. The central proposal of this review is to describe a possible association between the distribution and degree of myocardial fibrosis and cardiac arrhythmogenicity in patients with Chagas cardiomyopathy, drawing attention to the importance of noninvasive biomarkers for the quantification of myocardial fibrosis.

journal_name

Parasite Immunol

journal_title

Parasite immunology

authors

Chaves AT,Menezes CAS,Costa HS,Nunes MCP,Rocha MOC

doi

10.1111/pim.12663

subject

Has Abstract

pub_date

2019-10-01 00:00:00

pages

e12663

issue

10

eissn

0141-9838

issn

1365-3024

journal_volume

41

pub_type

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