Abstract:
:In schistosomiasis endemic areas, intensities of reinfection after treatment are greater amongst young children than amongst adults, and high levels of parasite-specific IgE are associated with resistance to reinfection in an age-dependent manner. Previously we have reported that, in Western blots, a 22 kDa band was recognized by human IgE and that the incidence and intensity of S. mansoni reinfection were significantly lower amongst individuals who had IgE against this band, compared with those who did not (Dunne et al. 1992). Here we report the isolation of a 22 kDa SDS-PAGE band, its incorporation into ELISA and the demonstration that levels of human anti-22 kDa IgE had a significant negative correlation with intensities of subsequent reinfection. Rabbit anti-22 kDa band serum recognized the outer tegument, gut tegument, and the collecting ducts and flame cells of adult worms. The 22 kDa band antigen(s) was also present in "lung'- and "post-lung' schistosomula stages of S. mansoni, and in S. haematobium, S. bovis and S. japonicum adult worms. Metabolic labelling of schistosomula and worms demonstrated the in vitro synthesis and release of 22 kDa antigens.
journal_name
Parasite Immunoljournal_title
Parasite immunologyauthors
Dunne DW,Webster M,Smith P,Langley JG,Richardson BA,Fulford AJ,Butterworth AE,Sturrock RF,Kariuki HC,Ouma JHdoi
10.1046/j.1365-3024.1997.d01-186.xsubject
Has Abstractpub_date
1997-02-01 00:00:00pages
79-89issue
2eissn
0141-9838issn
1365-3024journal_volume
19pub_type
杂志文章abstract::Naturally acquired humoral immune responses to Pfs16, an integral membrane protein expressed in Plasmodium falciparum gametocytes and sporozoites, were investigated in The Gambia. A high prevalence of antibodies to this molecule was detected by peptide ELISA. Ninety-three per cent of the people taking part in a survey...
journal_title:Parasite immunology
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journal_title:Parasite immunology
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journal_title:Parasite immunology
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journal_title:Parasite immunology
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journal_title:Parasite immunology
pub_type: 杂志文章,评审
doi:10.1111/pim.12164
更新日期:2015-03-01 00:00:00
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更新日期:2014-12-01 00:00:00
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journal_title:Parasite immunology
pub_type: 杂志文章
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pub_type: 杂志文章,评审
doi:10.1111/pim.12573
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journal_title:Parasite immunology
pub_type: 杂志文章
doi:10.1046/j.1365-3024.1999.00201.x
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journal_title:Parasite immunology
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journal_title:Parasite immunology
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journal_title:Parasite immunology
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pub_type: 杂志文章,评审
doi:10.1111/j.1365-3024.2009.01110.x
更新日期:2009-07-01 00:00:00
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journal_title:Parasite immunology
pub_type: 杂志文章
doi:10.1046/j.1365-3024.1997.d01-190.x
更新日期:1997-03-01 00:00:00
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journal_title:Parasite immunology
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journal_title:Parasite immunology
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更新日期:1996-07-01 00:00:00
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journal_title:Parasite immunology
pub_type: 杂志文章
doi:10.1046/j.1365-3024.1999.00199.x
更新日期:1999-01-01 00:00:00
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journal_title:Parasite immunology
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更新日期:1998-10-01 00:00:00
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journal_title:Parasite immunology
pub_type: 杂志文章
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更新日期:2011-06-01 00:00:00
abstract::The experimental protocol of immunization tested here confirms its protective effect against Haemonchus contortus in goats. This protection translated into a 65.5% mean reduction in adult worm burden after a homologous challenge, and a significant decrease (73.2%) in cumulative faecal egg counts (FECs). These parasito...
journal_title:Parasite immunology
pub_type: 杂志文章
doi:10.1111/pim.12569
更新日期:2018-09-01 00:00:00
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journal_title:Parasite immunology
pub_type: 杂志文章,评审
doi:10.1111/pim.12595
更新日期:2019-06-01 00:00:00
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journal_title:Parasite immunology
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