Abstract：
:As an orally acquired pathogen, the immune response to Toxoplasma gondii unfolds in the small intestinal mucosa. There, an array of regulatory and effector immune cells are elicited to combat the parasite through secretion of inflammatory mediators, normally resulting in host protection and pathogen control. Recent studies largely in mice have found that a productive immune response requires the combined recognition of parasite- and commensal-derived antigens by mucosal leucocytes. However, despite the fine-tuned regulatory mechanisms in place to prevent immunopathology, dysregulated responses can occur in genetically susceptible subjects, leading to lethal pro-inflammatory-mediated intestinal damage. Here, we describe the current understanding of the inflammatory players involved in orchestrating immunity or immunopathology in the intestine during the mucosal response to Toxoplasma infection.
journal_name
Parasite Immunoljournal_title
Parasite immunologyauthors
Cohen SB,Denkers EYdoi
10.1111/pim.12164subject
Has Abstractpub_date
2015-03-01 00:00:00pages
108-17issue
3eissn
0141-9838issn
1365-3024journal_volume
37pub_type
杂志文章,评审abstract：:We have cloned the cDNA of TBA-1, the Nematode polyprotein allergen (NPA) of Toxocara canis and found it to be most similar to ABA-1, the Ascaris NPA, on the basis of amino acid sequence. We could study the antigenic properties of an E-coli synthesized fusion protein prepared with the cloned gene since no glycosylatio...
journal_title：Parasite immunology
pub_type： 杂志文章
doi：10.1046/j.1365-3024.1998.00160.x
更新日期：1998-08-01 00:00:00
abstract：:We have tested the hypothesis that activation of T cells by exposure to malaria antigens facilitates both de novo HIV infection and viral reactivation and replication. PBMC from malaria-naive HIV-uninfected European donors could be productively infected with HIV following in vitro stimulation with a lysate of Plasmodi...
journal_title：Parasite immunology
pub_type： 杂志文章
doi：10.1111/j.0141-9838.2004.00701.x
更新日期：2004-05-01 00:00:00
abstract：:An essential element for continuing transmission of Plasmodium falciparum is the availability of mature gametocytes in human peripheral circulation for uptake by mosquitoes. Natural immune responses to circulating gametocytes may play a role in reducing transmission from humans to mosquitoes. Here, antibody recognitio...
journal_title：Parasite immunology
pub_type： 杂志文章
doi：10.1111/pim.12323
更新日期：2016-06-01 00:00:00
abstract：:We have assessed the role of tumour necrosis factor-alpha (TNF) during cutaneous leishmaniasis and demonstrated that significant levels of TNF were released by spleen cells from infected mice after in vitro restimulation with Leishmania major promastigotes. Spleen cells from both genetically resistant and genetically ...
journal_title：Parasite immunology
pub_type： 杂志文章
doi：10.1111/j.1365-3024.1990.tb00983.x
更新日期：1990-09-01 00:00:00
abstract：:In the present study we have investigated and compared in vitro the specific complement (C) activating activity of three metacestode preparations of Echinococcus granulosus. Extracts from hydatid cyst fluid (HCF-ext), protoscoleces (PSC-ext) and hydatid cyst membrane (HCM-ext) activated human C producing C3 conversion...
journal_title：Parasite immunology
pub_type： 杂志文章
doi：10.1046/j.1365-3024.1996.d01-112.x
更新日期：1996-07-01 00:00:00
abstract：:Changes in phagocytic and adherent cell numbers were compared during the course of infections of mice with Plasmodium yoelii (Py) and P. berghei (Pb) and in vaccinated mice challenged with homologous parasites. Nucleated cells in the spleen increased in number in Py-infected mice and were maximal at the time of recove...
journal_title：Parasite immunology
pub_type： 杂志文章
doi：10.1111/j.1365-3024.1979.tb00696.x
更新日期：1979-04-01 00:00:00
abstract：AIMS:Schistosomiasis and malaria are endemic in sub-Saharan Africa where Schistosoma haematobium (Sh) and Plasmodium falciparum (Pf) coinfections are thus frequent. We explored the effect of Sh infection on antibody responses directed to Pf merozoite antigens and on malaria susceptibility in Beninese children. METHODS...
journal_title：Parasite immunology
pub_type： 杂志文章
doi：10.1111/pim.12702
更新日期：2020-04-01 00:00:00
abstract：:Two monoclonal antibodies against the surface of S. mansoni schistosomula were found to confer significant passive protection to mice (M7B3A, range 28-70%; M22H12C, range 14-58%). No additive effect was observed when both were transferred together. Neither McAb bound to the cercarial surface but both bound to the surf...
journal_title：Parasite immunology
pub_type： 杂志文章
doi：10.1111/j.1365-3024.1986.tb00836.x
更新日期：1986-01-01 00:00:00
abstract：:The kinetics of macrophage activation were compared among inbred strains of mice (C3H, BALB, B6 and B10.A) that are known to differ in their relative resistance to infections with the myotropic strains (Colombian and CL) of Trypanosoma cruzi. The parameters utilized to measure macrophage activation were rapid spreadin...
journal_title：Parasite immunology
pub_type： 杂志文章
doi：10.1111/j.1365-3024.1989.tb00675.x
更新日期：1989-07-01 00:00:00
abstract：:Toxoplasma gondii-specific murine CD4+ T cell clone 3Tx9 belongs to the Th1 subtype by virtue of secreting high levels of interleukin(IL)-2, interferon-gamma and tumor necrosis factor without producing IL4 and IL10. To characterize the clonal antigen, Toxoplasma lysate-was separated by SDS-PAGE and probed in T cell bl...
journal_title：Parasite immunology
pub_type： 杂志文章
doi：10.1046/j.1365-3024.1997.d01-201.x
更新日期：1997-05-01 00:00:00
abstract：:Sheep scab is caused by the noninvasive mite, Psoroptes ovis, which initiates a profound pro-inflammatory skin response leading to lesion development. To investigate these early events between the skin and the parasite, primary ovine epidermal keratinocyte cultures were generated and challenged with mite derived antig...
journal_title：Parasite immunology
pub_type： 杂志文章
doi：10.1111/j.1365-3024.2009.01103.x
更新日期：2009-06-01 00:00:00
abstract：:Parasitic nematodes of the small-ruminant gastrointestinal tract pose a problem worldwide. The impact of these pathogens is worsened by the emergence of anthelmintic resistance to all three available classes of drugs. In addition to causing considerable economic loss, these parasites are detrimental to the health and ...
journal_title：Parasite immunology
pub_type： 杂志文章,评审
doi：10.1111/j.1365-3024.2009.01110.x
更新日期：2009-07-01 00:00:00
abstract：:Factors governing the sensitization or desensitization of basophils and mast cells are discussed. Mathematical models are proposed which illustrate the effects of rising or falling specific or non-specific IgE titres on the tendency of these cells to degranulate. The models presented are consistent with the hypothesis...
journal_title：Parasite immunology
pub_type： 杂志文章
doi：10.1111/j.1365-3024.1981.tb00394.x
更新日期：1981-07-01 00:00:00
abstract：:Antigenic proteins of Echinostoma caproni (Trematoda) against mouse IgM, IgA, IgG, IgG1 and IgG2a were investigated by immunoproteomics. Excretory/secretory products (ESP) of E. caproni separated by two-dimensional (2D) gel electrophoresis were transferred to nitrocellulose membranes and probed with the different mous...
journal_title：Parasite immunology
pub_type： 杂志文章
doi：10.1111/j.1365-3024.2007.01019.x
更新日期：2008-05-01 00:00:00
abstract：:The ability of Toxoplasma gondii to cause clinical disease in immune-competent and immune-deficient hosts coupled with its ease of use in vitro and availability of murine models has led to its use as a model organism to study how the immune system controls an intracellular infection. This article reviews the studies t...
journal_title：Parasite immunology
pub_type： 杂志文章,评审
doi：10.1111/pim.12712
更新日期：2020-07-01 00:00:00
abstract：:We assayed the vaccine potentialities of a recombinant S. bovis-derived glutathione S-transferase (rSb28GST), member of a molecular family already shown to have protective capacities in the S. mansoni and S. japonicum models. Injection of the rSb28GST in Freund's Complete Adjuvant resulted in good specific IgG respons...
journal_title：Parasite immunology
pub_type： 杂志文章
doi：10.1111/j.1365-3024.1994.tb00367.x
更新日期：1994-08-01 00:00:00
abstract：:Recent advances in molecular genetics and in imaging mean that it is now increasingly feasible to image biological processes within helminth parasites and to visualize interactions between worms and their hosts. Moreover, other innovative imaging approaches that are not dependent on transgenic parasites have been appl...
journal_title：Parasite immunology
pub_type： 杂志文章,评审
doi：10.1111/pim.12051
更新日期：2013-09-01 00:00:00
abstract：:Leishmania major causes mild-to-severe cutaneous lesions resulting in significant disfigurations, if untreated. The drugs are toxic, and drug-resistance parasites are emerging. Therefore, a prophylactic vaccination is an urgent need. As no vaccine is available, we compared the genes expressed by virulent and avirulent...
journal_title：Parasite immunology
pub_type：
doi：10.1111/pim.12688
更新日期：2020-02-01 00:00:00
abstract：:CBA/J mice are resistant to Leishmania major infection but are permissive to L. amazonensis infection. In addition, CBA/J macrophages control L. major but not L. amazonensis infection in vitro. Phagocytosis by macrophages is known to determine the outcome of Leishmania infection. Pattern recognition receptors (PRR) ad...
journal_title：Parasite immunology
pub_type： 杂志文章
doi：10.1111/j.1365-3024.2009.01093.x
更新日期：2009-04-01 00:00:00
abstract：:Toxoplasma gondii is a highly successful parasite that can manipulate host immune responses to optimize its persistence and spread. As a result, a highly complex relationship exists between T. gondii and the immune system of the host. Advances in imaging techniques, and in particular, the application of two-photon mic...
journal_title：Parasite immunology
pub_type： 杂志文章,评审
doi：10.1111/pim.12161
更新日期：2015-03-01 00:00:00
abstract：:The immunological basis of resistance to Brugia pahangi infection in rats was studied. Infections were investigated in athymic rnu/rnu rats and in rats treated with the immuno-suppressive agents cyclosporin A (CsA) or cyclophosphamide (Cy). The recovery of adult worms in normal rats was 1-2% in comparison to 12.2% rec...
journal_title：Parasite immunology
pub_type： 杂志文章
doi：10.1111/j.1365-3024.1992.tb00012.x
更新日期：1992-07-01 00:00:00
abstract：:Gastrointestinal (GI) nematodes are a group of successful multicellular parasites that have evolved to coexist within the intestinal niche of multiple species. It is estimated that over 10% of the world's population are chronically infected by GI nematodes, making this group of parasitic nematodes a major burden to gl...
journal_title：Parasite immunology
pub_type： 杂志文章,评审
doi：10.1111/pim.12517
更新日期：2018-04-01 00:00:00
abstract：:Onchocerciasis is caused by the filarial nematode Onchocerca volvulus and is a major public health problem in West and Central Africa. With only partial and long-term treatment currently available, there is a need to develop a suitable vaccine. We analysed the antibody response to infective L3 larvae because this stag...
journal_title：Parasite immunology
pub_type： 杂志文章
doi：10.1046/j.1365-3024.2001.00408.x
更新日期：2001-09-01 00:00:00
abstract：:The pathogenesis of Acanthamoeba keratitis (AK) is complicated. In our previous studies, TLR4 was found involved in the process of infection by Acanthamoeba in human corneal cells. The purpose of this study was to investigate the role of Toll-like receptor 4 (TLR4) signalling pathway in Wistar rats challenged with Aca...
journal_title：Parasite immunology
pub_type： 杂志文章
doi：10.1111/j.1365-3024.2010.01247.x
更新日期：2011-01-01 00:00:00
abstract：:The impact of intestinal helminth infection, i.e. Ascaris lumbricoides and Trichuris trichiura, on cellular responsiveness and cytokine production was investigated in young adults. Ascaris-specific cellular responsiveness was higher in parasite-free endemic controls than in patients infected with T. trichiura, or A. l...
journal_title：Parasite immunology
pub_type： 杂志文章
doi：10.1046/j.1365-3024.2002.00600.x
更新日期：2002-11-01 00:00:00
abstract：:In modern societies, diseases that are driven by dysregulated immune responses are increasing at an alarming pace, such as inflammatory bowel diseases and diabetes. There is an urgent need to understand these epidemiological trends, which are likely to be driven by the changing environment of the last few decades. The...
journal_title：Parasite immunology
pub_type： 杂志文章,评审
doi：10.1111/pim.12193
更新日期：2015-06-01 00:00:00
abstract：:Research undertaken over the past 40 years has established many of the general principals concerning immunity to taeniid cestodes. Although much is well understood about the host-protective mechanisms against taeniids and this knowledge has been exploited in studies on vaccine development, many aspects require further...
journal_title：Parasite immunology
pub_type： 杂志文章,评审
doi：10.1111/j.1365-3024.2010.01231.x
更新日期：2010-11-01 00:00:00
abstract：:A 17 kD protein of Necator americanus was isolated by SDS-PAGE and used to raise monospecific antisera in rabbits. ELISA and Western blotting against a range of parasite extracts demonstrated the species specificity of this protein. It is expressed at all stages of the life-cycle, appears to be accumulated through the...
journal_title：Parasite immunology
pub_type： 杂志文章
doi：10.1111/j.1365-3024.1990.tb00953.x
更新日期：1990-05-01 00:00:00
abstract：:Particular immunopathological features and their effects on the vascular permeability of different ocular structures were analysed in two dogs naturally infected by Leishmania infantum. The existence of specific anti-Leishmania immunoglobulin G (IgG) in the aqueous humour was confirmed by the ELISA technique. There wa...
journal_title：Parasite immunology
pub_type： 杂志文章
doi：10.1046/j.1365-3024.1996.d01-39.x
更新日期：1996-12-01 00:00:00
abstract：:Neurocysticercosis (NCC), one of the most common parasitic diseases of the central nervous system, is caused by Taenia solium. This parasite involves two hosts, intermediate hosts (pig and human) and a definitive host (human) and has various stages in its complex life cycle (eggs, oncosphere, cysticerci and adult tape...
journal_title：Parasite immunology
pub_type： 杂志文章,评审
doi：10.1111/pim.12439
更新日期：2017-07-01 00:00:00
