Abstract：
:In modern societies, diseases that are driven by dysregulated immune responses are increasing at an alarming pace, such as inflammatory bowel diseases and diabetes. There is an urgent need to understand these epidemiological trends, which are likely to be driven by the changing environment of the last few decades. There are complex interactions between human genetic factors and this changing environment that is leading to the increasing prevalence of metabolic and inflammatory diseases. Alterations to human gut bacterial communities (the microbiota) and lowered prevalence of helminth infections are potential environmental factors contributing to immune dysregulation. Helminths have co-evolved with the gut microbiota and their mammalian hosts. This three-way interaction is beginning to be characterized, and the knowledge gained may enable the design of new therapeutic strategies to treat metabolic and inflammatory diseases. However, these complex interactions need to be carefully investigated in the context of host genetic backgrounds to identify optimal treatment strategies. The complex nature of these interactions raises the possibility that only with highly personalized treatment, with knowledge of individual genetic and microbiota communities, will therapeutic interventions be successful for a majority of the individuals suffering from these complex diseases of immune dysregulation.
journal_name
Parasite Immunoljournal_title
Parasite immunologyauthors
Loke P,Lim YAdoi
10.1111/pim.12193subject
Has Abstractpub_date
2015-06-01 00:00:00pages
314-23issue
6eissn
0141-9838issn
1365-3024journal_volume
37pub_type
杂志文章,评审abstract：:Modulation of macrophage/dendritic cell (DC) cytokine production by the filarial nematode phosphorylcholine (PC)-containing product, ES-62, is mediated by Toll-like receptor (TLR) 4 and signal transduction depends on the TLR adaptor MyD88. Intriguingly, comparison of TLR4 knock-out (ko) mice with TLR4 mutant C3H/HeJ m...
journal_title：Parasite immunology
pub_type： 杂志文章
doi：10.1111/j.1365-3024.2006.00926.x
更新日期：2007-03-01 00:00:00
abstract：:The serodiagnosis of human toxocariasis is difficult. Specific IgGs detected routinely with ELISA based on Toxocara excretory-secretory (TES) antigens often persist for years at an elevated level, which does not allow either the differentiation between an active and persistent infection or monitoring of the effect of ...
journal_title：Parasite immunology
pub_type： 临床试验,杂志文章
doi：10.1111/pim.12400
更新日期：2017-01-01 00:00:00
abstract：:We investigated the immune effector mechanisms that underlie protection against F. hepatica in the gut wall of immune rats, using (immuno)histochemistry. In the lamina propria of immune Wistar rats, four weeks after oral infection, frequencies of IgE-positive cells, eosinophils and mucosal mast cells were significantl...
journal_title：Parasite immunology
pub_type： 杂志文章
doi：10.1046/j.1365-3024.1998.00144.x
更新日期：1998-06-01 00:00:00
abstract：:Toxoplasma gondii is a highly successful parasite that can manipulate host immune responses to optimize its persistence and spread. As a result, a highly complex relationship exists between T. gondii and the immune system of the host. Advances in imaging techniques, and in particular, the application of two-photon mic...
journal_title：Parasite immunology
pub_type： 杂志文章,评审
doi：10.1111/pim.12161
更新日期：2015-03-01 00:00:00
abstract：:Host cell death induced by Entamoeba histolytica is an important mechanism for both host defence and microbial immune evasion during human amoebiasis. However, the signalling pathways underlying cell death induced by E. histolytica are not fully understood. This study investigated the involvement of the protein tyrosi...
journal_title：Parasite immunology
pub_type： 杂志文章
doi：10.1111/j.1365-3024.2009.01175.x
更新日期：2010-03-01 00:00:00
abstract：:Cells collected from C57B1/6 mice infected with monomorphic and pleomorphic clones of Trypanosoma brucei parasites (ILTat 1.4 and GUTat 3.1) were analysed for the incorporation of 125I-Iododeoxyuridine into DNA of total splenic lymphocytes and of B and T lymphocytes isolated on a fluorescence activated cell sorter. Th...
journal_title：Parasite immunology
pub_type： 杂志文章
doi：10.1111/j.1365-3024.1986.tb00860.x
更新日期：1986-09-01 00:00:00
abstract：:Leishmaniasis has recently garnered attention as one of the diseases 'most neglected' by drug research and development, as the current therapeutic modalities available for the patients are ridden with unacceptable toxicity due to high dosage of the drug, prolonged treatment schedules, resistance and prohibitive costs....
journal_title：Parasite immunology
pub_type： 杂志文章
doi：10.1111/pim.12071
更新日期：2014-01-01 00:00:00
abstract：:On a B10 (Lshs) genetic background, the development of acquired T cell mediated immunity to Leishmania donovani infection in mice is under H-2 linked genetic control. Following intravenous inoculation of 10(7) amastigotes three phenotypic patterns of recovery have been described: 'early cure' (H-2r,s), 'cure' (H-2b) a...
journal_title：Parasite immunology
pub_type： 杂志文章
doi：10.1111/j.1365-3024.1983.tb00760.x
更新日期：1983-09-01 00:00:00
abstract：:Human toxocariasis is a helminth zoonosis resulting from accidental infection of humans by the roundworms Toxocara canis (T. canis) and cati (T. cati). The infection occurs in five forms: systemic (VLM), ocular, neurological, covert and asymptomatic. The aim of this study was to characterize the radiological and immun...
journal_title：Parasite immunology
pub_type： 杂志文章
doi：10.1111/pim.12143
更新日期：2014-12-01 00:00:00
abstract：:Leishmania major causes mild-to-severe cutaneous lesions resulting in significant disfigurations, if untreated. The drugs are toxic, and drug-resistance parasites are emerging. Therefore, a prophylactic vaccination is an urgent need. As no vaccine is available, we compared the genes expressed by virulent and avirulent...
journal_title：Parasite immunology
pub_type：
doi：10.1111/pim.12688
更新日期：2020-02-01 00:00:00
abstract：:Culex pipiens and Aedes aegypti mosquitoes were fed on C3H/HeJ mice and systemic cytokine production was quantified from stimulated lymphocytes harvested four to ten days after feeding. Mosquito feeding on C3H/HeJ mice significantly down regulated IFN gamma production seven to ten days post feeding by Cx. pipiens and ...
journal_title：Parasite immunology
pub_type： 杂志文章
doi：10.1046/j.1365-3024.1999.00199.x
更新日期：1999-01-01 00:00:00
abstract：:Soluble extracts from salivarian trypanosomes (Trypanosoma brucei brucei, T. evansi and T. congolense) were shown to be capable of inducing murine tumour necrosis factor (mTNF) secretion, both in vivo and in vitro, whereas the soluble extract of an intracellular trypanosome (T. cruzi) failed to do so. Furthermore, the...
journal_title：Parasite immunology
pub_type： 杂志文章
doi：10.1111/j.1365-3024.1993.tb00577.x
更新日期：1993-11-01 00:00:00
abstract：:This study examines several aspects of a polymorphic, immunodominant molecule (PIM) found in the protozoan parasite, Theileria parva. The antigen is present in all T.p. parva stocks examined, and in the related subspecies, T.p.bovis and T.p.lawrencei. It is the predominant antigen recognized by antisera from immune ca...
journal_title：Parasite immunology
pub_type： 杂志文章
doi：10.1111/j.1365-3024.1991.tb00262.x
更新日期：1991-01-01 00:00:00
abstract：:Leishmaniasis is a parasitic disease transmitted by the bite of Leishmania-infected sand flies. Here we show for the first time the ability of Maxadilan (Max), a vasodilatory peptide isolated from the sand fly Lutzomyia longipalpis, and salivary gland lysate (SGL) from Phlebotomus papatasi to decrease the secretion of...
journal_title：Parasite immunology
pub_type： 杂志文章
doi：10.1046/j.1365-3024.2003.00623.x
更新日期：2003-03-01 00:00:00
abstract：:Golden hamsters (Mesocricetus auratus) infected with Leishmania donovani develop a disease similar to human kala-azar. There is conspicuous hypergammaglobulinaemia and their T cells do not respond to stimulation by parasite antigens. The impairment of the cellular immune response seems to be restricted to parasite ant...
journal_title：Parasite immunology
pub_type： 杂志文章
doi：10.1111/j.1365-3024.1992.tb00005.x
更新日期：1992-01-01 00:00:00
abstract：:Longitudinal cohort studies are important to describe the dynamics of naturally acquired antibody response profiles to defined Plasmodium falciparum malaria antigens relative to clinical malaria episodes. In children under 7 years of age in The Gambia, serum IgG responses were measured to P. falciparum merozoite antig...
journal_title：Parasite immunology
pub_type： 杂志文章
doi：10.1111/j.1365-3024.2009.01193.x
更新日期：2010-04-01 00:00:00
abstract：:The ability of Toxoplasma gondii to cause clinical disease in immune-competent and immune-deficient hosts coupled with its ease of use in vitro and availability of murine models has led to its use as a model organism to study how the immune system controls an intracellular infection. This article reviews the studies t...
journal_title：Parasite immunology
pub_type： 杂志文章,评审
doi：10.1111/pim.12712
更新日期：2020-07-01 00:00:00
abstract：:The natural site of infection for T. gondii is the mucosal surface of the intestine, so the protective immunity obtained after natural infection with T. gondii points to the importance of developing a vaccine that stimulates mucosal defences. In this study, an aroA- and aroD- attenuated strain of Salmonella typhimuriu...
journal_title：Parasite immunology
pub_type： 杂志文章
doi：10.1111/j.1365-3024.2005.00738.x
更新日期：2005-01-01 00:00:00
abstract：:In vitro released products of the adult stage of the bovine lungworm. Dictyocaulus viviparus, were characterized according to their SDS-PAGE profile, glycosylation pattern, in vitro synthesis and antigenicity in the context of infection and vaccination with irradiated larvae. Biosynthetic labelling experiments with 35...
journal_title：Parasite immunology
pub_type： 杂志文章
doi：10.1111/j.1365-3024.1993.tb00596.x
更新日期：1993-03-01 00:00:00
abstract：:Immunohistochemistry and immunofluorescence with confocal microscopy were used to localize the host-protective antigens of Taenia saginata (TSA9 and TSA18) and Taenia solium (TSOL16, TSOL18 and TSOL45). In nonactivated oncospheres, TSA9 and TSOL45 antigens were found primarily in the cytoplasm of the penetration gland...
journal_title：Parasite immunology
pub_type： 杂志文章
doi：10.1111/j.1365-3024.2010.01230.x
更新日期：2010-09-01 00:00:00
abstract：:Athymic nude mice of the outbred Zur:ICR-nu and inbred BALB/c strain and scid mice were infected with a cloned human isolate of Giardia lamblia (GS/M-83-H7). Changes in the expression of the major surface epitope of the intestinal trophozoites (characterized by the binding capacity of monoclonal antibody MoAbG10/4) as...
journal_title：Parasite immunology
pub_type： 杂志文章
doi：10.1111/j.1365-3024.1991.tb00560.x
更新日期：1991-11-01 00:00:00
abstract：:Type I hypersensitivity reactions in the intestinal tract of sensitized animals may contribute to resistance to reinfection with Fasciola hepatica. Colonic mucosae isolated from previously infected rats were voltage clamped in Ussing chambers. Antigen was prepared as a crude homogenate from adult liver fluke. Assay of...
journal_title：Parasite immunology
pub_type： 杂志文章
doi：10.1111/j.1365-3024.1993.tb00630.x
更新日期：1993-08-01 00:00:00
abstract：:Humoral immunity develops in the spleen during blood-stage Plasmodium infection. This elicits parasite-specific IgM and IgG, which control parasites and protect against malaria. Studies in mice have elucidated cells and molecules driving humoral immunity to Plasmodium, including CD4+ T cells, B cells, interleukin (IL)...
journal_title：Parasite immunology
pub_type： 杂志文章
doi：10.1111/pim.12455
更新日期：2017-10-01 00:00:00
abstract：:Onchocerca volvulus and the human immunodeficiency virus (HIV) are two immunocompromising infectious agents of major public health concern in Uganda. To examine the effect of coinfection with O. volvulus and HIV on cellular immune responses, lymphocyte proliferative responses and cytokine production of peripheral bloo...
journal_title：Parasite immunology
pub_type： 杂志文章
doi：10.1046/j.1365-3024.1998.00170.x
更新日期：1998-09-01 00:00:00
abstract：:ES-62 is a glycoprotein secreted by the filarial nematode Acanthocheilonema viteae that protects against ovalbumin (OVA)-induced airway hyper-responsiveness in mice by virtue of covalently attached anti-inflammatory phosphorylcholine (PC) residues. We have recently generated a library of small molecule analogues (SMAs...
journal_title：Parasite immunology
pub_type： 杂志文章
doi：10.1111/pim.12322
更新日期：2016-06-01 00:00:00
abstract：:Leishmania enter macrophages through receptor-mediated phagocytosis and survive the harsh environment of a phagolysosome. Here, we investigated the interaction between mannose receptor (MR), Toll-like receptor 2 (TLR2), and Leishmania, and the subsequent impact on phagosome maturation. Leishmania parasites are able to...
journal_title：Parasite immunology
pub_type： 杂志文章
doi：10.1111/pim.12521
更新日期：2018-04-01 00:00:00
abstract：:Crude total antigen (CTA) from Leishmania infantum and recombinant antigen K39 (rK39) and recombinant antigen K28 (rK28) were compared using an ELISA for the diagnosis of canine visceral leishmaniosis (CVL). Forty-two blood samples from healthy dogs from a nonendemic area and 80 blood samples from an endemic area for ...
journal_title：Parasite immunology
pub_type： 杂志文章
doi：10.1111/pim.12281
更新日期：2015-12-01 00:00:00
abstract：:Resistance to S. mansoni cercarial challenge, induced by prior infection of rats with cercariae, is analysed by substitution of alternatives to the primary cercarial exposure. Intravenous injections of either live or killed 4-week stage worms have been examined, utilizing two different routes of injection, one or two ...
journal_title：Parasite immunology
pub_type： 杂志文章
doi：10.1111/j.1365-3024.1984.tb00790.x
更新日期：1984-03-01 00:00:00
abstract：:African trypanosomes cause human and animal African trypanosomiases, which are chronic, debilitating and often fatal diseases of people and livestock in sub-Saharan Africa. The extracellular protozoan parasites are exemplars of antigenic variation. They direct host-protective B-cell and T-cell immune responses towards...
journal_title：Parasite immunology
pub_type： 杂志文章,评审
doi：10.1111/pim.12387
更新日期：2016-12-01 00:00:00
abstract：:Infective larvae of Toxocara canis are well suited for studies of nematode antigen expression in vitro. Larvae were labelled with 3H-glucosamine, an approach permitting dual analysis of antigen quantity and composition. Their excretory/secretory (E/S) glycoproteins were efficiently labelled and antigen identity confir...
journal_title：Parasite immunology
pub_type： 杂志文章
doi：10.1111/j.1365-3024.1990.tb00946.x
更新日期：1990-03-01 00:00:00
