Abstract:
:Type I hypersensitivity reactions in the intestinal tract of sensitized animals may contribute to resistance to reinfection with Fasciola hepatica. Colonic mucosae isolated from previously infected rats were voltage clamped in Ussing chambers. Antigen was prepared as a crude homogenate from adult liver fluke. Assay of serum antibodies against fluke antigen confirmed sensitization. Antigen challenge evoked a rapid onset, transient inward current in sensitized but not in control preparations. Chloride secretion accounted for at least part of the response since the loop diuretic bumetanide reduced the effect of antigen by 61%. Anti-rat IgE mimicked the response to antigen and desensitized tissues to subsequent antigen challenge. Local synthesis of eicosanoids may mediate the response to antigen since the cyclo-oxygenase inhibitor piroxicam reduced the response by 76%. In contrast, mepyramine which is a histamine receptor antagonist did not alter the ion transport response evoked by antigen. Tetrodotoxin reduced the response to antigen by 53% implicating intrinsic neurons within the lamina propria as effector cells in the responses of this tissue to antigen. We propose that antigen stimulation of electrogenic chloride movement and consequent fluid secretion in vivo may contribute to a local effector mechanism in prevention of reinfection of previously sensitized hosts.
journal_name
Parasite Immunoljournal_title
Parasite immunologyauthors
O'Malley KE,Sloan T,Joyce P,Baird AWdoi
10.1111/j.1365-3024.1993.tb00630.xsubject
Has Abstractpub_date
1993-08-01 00:00:00pages
449-53issue
8eissn
0141-9838issn
1365-3024journal_volume
15pub_type
杂志文章abstract::Migration of human peripheral blood granulocytes in response to microfilariae of O. volvulus was demonstrated using modified Boyden chambers. Granulocyte migration was significantly enhanced when microfilariae were preincubated with heat-inactivated immune serum (delta IS), then added to a fresh serum source (P less t...
journal_title:Parasite immunology
pub_type: 杂志文章
doi:10.1111/j.1365-3024.1983.tb00738.x
更新日期:1983-03-01 00:00:00
abstract::Lymphoid cells from genetically-susceptible BALB/c mice immunized against a glycoconjugate of the protozoan parasite, Leishmania major, promote chronic cutaneous disease in BALB/c nude mice. This cell population therefore differs from cells harvested from non-immunized BALB/c mice that are known to be potent mediators...
journal_title:Parasite immunology
pub_type: 杂志文章
doi:10.1111/j.1365-3024.1986.tb01037.x
更新日期:1986-05-01 00:00:00
abstract::Immunohistochemistry and immunofluorescence with confocal microscopy were used to localize the host-protective antigens of Taenia saginata (TSA9 and TSA18) and Taenia solium (TSOL16, TSOL18 and TSOL45). In nonactivated oncospheres, TSA9 and TSOL45 antigens were found primarily in the cytoplasm of the penetration gland...
journal_title:Parasite immunology
pub_type: 杂志文章
doi:10.1111/j.1365-3024.2010.01230.x
更新日期:2010-09-01 00:00:00
abstract::Fasciola hepatica infection has been shown to suppress sheep lymphocyte proliferation in vitro and this is at least partially attributable to excretory/secretory products (ES) released by F. hepatica parasites. We identified a suppressive component in ES by analysing the effect of ES fractions, separated by gel filtra...
journal_title:Parasite immunology
pub_type: 杂志文章
doi:10.1046/j.0141-9838.2001.00438.x
更新日期:2002-02-01 00:00:00
abstract:AIMS:Our aim was to investigate the skin-homing T-cell immune responses triggered in patients with Demodex infestation and/or rosacea. METHODS:Collected whole blood samples were divided into four groups: control subjects; nonrosacea patients with Demodex infestation (Demodex group); papulopustular rosacea (PPR) patien...
journal_title:Parasite immunology
pub_type: 杂志文章
doi:10.1111/pim.12658
更新日期:2019-08-01 00:00:00
abstract::Parasitic nematodes of the small-ruminant gastrointestinal tract pose a problem worldwide. The impact of these pathogens is worsened by the emergence of anthelmintic resistance to all three available classes of drugs. In addition to causing considerable economic loss, these parasites are detrimental to the health and ...
journal_title:Parasite immunology
pub_type: 杂志文章,评审
doi:10.1111/j.1365-3024.2009.01110.x
更新日期:2009-07-01 00:00:00
abstract::The effect of infection and subsequent challenge with Eimeria maxima on the populations of lymphocytes in the small intestine of Light Sussex chickens was assessed by immunohistochemistry. T cells were characterized for CD3, CD4, CD8, TCR1 (gamma delta heterodimer) or TCR2 (alpha beta 1 heterodimer) markers, and B cel...
journal_title:Parasite immunology
pub_type: 杂志文章
doi:10.1111/j.1365-3024.1995.tb00883.x
更新日期:1995-10-01 00:00:00
abstract::Activation of macrophages is a key step in the initiation of immune responses, but the transcriptional mechanisms governing macrophage activation during infection are not fully understood. It was recently shown that the AP-1 family transcription factor JUNB positively regulates macrophage activation in response to Tol...
journal_title:Parasite immunology
pub_type: 杂志文章
doi:10.1111/pim.12215
更新日期:2015-09-01 00:00:00
abstract::Factors governing the sensitization or desensitization of basophils and mast cells are discussed. Mathematical models are proposed which illustrate the effects of rising or falling specific or non-specific IgE titres on the tendency of these cells to degranulate. The models presented are consistent with the hypothesis...
journal_title:Parasite immunology
pub_type: 杂志文章
doi:10.1111/j.1365-3024.1981.tb00394.x
更新日期:1981-07-01 00:00:00
abstract::There is good evidence for costs to both the uses of immune defences and their development and maintenance. The optimal defence will be a balance of these costs with the risk of infection and the virulence of the disease. It is therefore clear that the life-history characteristics of both host and parasite will impact...
journal_title:Parasite immunology
pub_type: 杂志文章,评审
doi:10.1111/pim.12055
更新日期:2013-11-01 00:00:00
abstract::Fulani and Masaleit, sympatric tribes in eastern Sudan, are characterized by marked differences in susceptibility to Plasmodium falciparum malaria. To determine whether the two tribes differ in the frequency of immunoglobulin GM/KM allotypes, which are associated with immunity to several pathogens, serum samples from ...
journal_title:Parasite immunology
pub_type: 杂志文章
doi:10.1111/j.1365-3024.2007.00938.x
更新日期:2007-05-01 00:00:00
abstract::Ascariasis is the most frequent soil transmitted helminthiasis and, as well as other helminth infections, is expected to influence the clinical presentation of allergic diseases such as asthma. Indeed, several clinical and experimental works have shown an important impact either increasing or suppressing symptoms, and...
journal_title:Parasite immunology
pub_type: 杂志文章,评审
doi:10.1111/pim.12595
更新日期:2019-06-01 00:00:00
abstract::Intraperitoneal injection of Trypanosoma brucei AnTat 1.1 into mice of the C3H.He, BALB/c or C57BL/6 strains resulted in impaired immune responses from day 3 onwards, as measured by the reduction in DNA synthesis in spleen cell populations stimulated with concanavalin A (Con-A) in vitro. Adherent cells from the perito...
journal_title:Parasite immunology
pub_type: 杂志文章
doi:10.1111/j.1365-3024.1990.tb00951.x
更新日期:1990-05-01 00:00:00
abstract::Onchocerca volvulus and the human immunodeficiency virus (HIV) are two immunocompromising infectious agents of major public health concern in Uganda. To examine the effect of coinfection with O. volvulus and HIV on cellular immune responses, lymphocyte proliferative responses and cytokine production of peripheral bloo...
journal_title:Parasite immunology
pub_type: 杂志文章
doi:10.1046/j.1365-3024.1998.00170.x
更新日期:1998-09-01 00:00:00
abstract::The zymosan-triggered chemiluminescence response of peritoneal exudate cells from mice infected with relatively virulent or avirulent Toxoplasma gondii strains was examined at various intervals after infection. Toxoplasma infections increased the background chemiluminescence compared with controls, but higher values w...
journal_title:Parasite immunology
pub_type: 杂志文章
doi:10.1111/j.1365-3024.1984.tb00796.x
更新日期:1984-05-01 00:00:00
abstract::Golden hamsters (Mesocricetus auratus) infected with Leishmania donovani develop a disease similar to human kala-azar. There is conspicuous hypergammaglobulinaemia and their T cells do not respond to stimulation by parasite antigens. The impairment of the cellular immune response seems to be restricted to parasite ant...
journal_title:Parasite immunology
pub_type: 杂志文章
doi:10.1111/j.1365-3024.1992.tb00005.x
更新日期:1992-01-01 00:00:00
abstract::The protein-energy malnutrition (PEM) and visceral leishmaniasis (VL) are important problems of public health, which affect millions of people worldwide. Currently, it has been accepted that the immunity or susceptibility to infect-parasitic diseases are directly related to the nutritional status of the host. However,...
journal_title:Parasite immunology
pub_type: 杂志文章,评审
doi:10.1111/j.1365-3024.2009.01117.x
更新日期:2009-10-01 00:00:00
abstract::Impairment of T cell proliferation in mice infected with the pleomorphic Trypanosoma brucei AnTat 1.1 E clone was found not to be related to a depletion of T cells or to an absence of functional accessory cells, but rather to an active suppression of interleukin 2 (IL-2) production. Lymph node cells derived from infec...
journal_title:Parasite immunology
pub_type: 杂志文章
doi:10.1111/j.1365-3024.1986.tb00877.x
更新日期:1986-11-01 00:00:00
abstract::The pathogenesis of the tissue lesions observed in American trypanosomiasis (Chagas' disease) seems to depend on a variety of mechanisms. The present study was dedicated to the investigation of the evolution of muscle lesions and its relationship with immunological and parasitological parameters. Mice were infected i....
journal_title:Parasite immunology
pub_type: 杂志文章
doi:10.1111/j.1365-3024.1985.tb00091.x
更新日期:1985-09-01 00:00:00
abstract::The Bacillus thuringiensis Cry1Ac protoxin (pCry1Ac) is a promising mucosal immunogen and adjuvant that induces protective immunity against Naegleria fowleri and malaria infection models. We determined whether pCry1Ac acted as a protective adjuvant against infection with Taenia crassiceps. BALB/C mice were thrice i.p....
journal_title:Parasite immunology
pub_type: 杂志文章
doi:10.1111/pim.12103
更新日期:2014-06-01 00:00:00
abstract::Nematode parasites cause significant infections in both humans and animals. They are complex, multicellular organisms that present unique challenges for the host, in particular with respect to the recognition of their unusual surface structures by the innate defence system. The innate immune system is now recognized t...
journal_title:Parasite immunology
pub_type: 杂志文章,评审
doi:10.1111/j.1365-3024.2006.00910.x
更新日期:2007-01-01 00:00:00
abstract::Previous work has shown that a protein extract enriched for cysteine protease activity (TSBP) prepared from adult Haemonchus contortus using thiol sepharose affinity chromatography confers substantial protection against a single challenge infection. TSBP comprised proteases and other proteins. Here, TSBP were further ...
journal_title:Parasite immunology
pub_type: 临床试验,杂志文章
doi:10.1111/j.1365-3024.2005.00750.x
更新日期:2005-04-01 00:00:00
abstract::The development of a malaria vaccine is a priority for improved and sustained malaria control. Optimal use of a vaccine in Africa will only be achieved if it can be delivered through the Expanded Programme of Immunization (EPI). We have completed a trial of the peptide vaccine SPf66 in Tanzanian infants, given alongsi...
journal_title:Parasite immunology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1046/j.1365-3024.2000.00322.x
更新日期:2000-09-01 00:00:00
abstract::In order to characterize immunodominant components of T. spiralis a workshop was organized. In this the reactivity of monoclonal and polyclonal antibodies, provided by different research groups, towards total extracts from adult, new born larvae and muscle larvae as well as to excretory/secretory components of muscle ...
journal_title:Parasite immunology
pub_type: 杂志文章,评审
doi:10.1046/j.1365-3024.1996.d01-103.x
更新日期:1996-06-01 00:00:00
abstract::The role of autoimmunity in the pathogenesis and progression of heart lesions in the chronic phase of Chagas' disease is controversial. In the absence of parasites in situ, the T cell infiltrate seen in heart lesions may be the primary determinant of tissue damage ultimately leading to heart failure and death. We used...
journal_title:Parasite immunology
pub_type: 杂志文章
doi:10.1111/j.1365-3024.1994.tb00337.x
更新日期:1994-04-01 00:00:00
abstract::Resistance to S. mansoni cercarial challenge, induced by prior infection of rats with cercariae, is analysed by substitution of alternatives to the primary cercarial exposure. Intravenous injections of either live or killed 4-week stage worms have been examined, utilizing two different routes of injection, one or two ...
journal_title:Parasite immunology
pub_type: 杂志文章
doi:10.1111/j.1365-3024.1984.tb00790.x
更新日期:1984-03-01 00:00:00
abstract::Recent advances in molecular genetics and in imaging mean that it is now increasingly feasible to image biological processes within helminth parasites and to visualize interactions between worms and their hosts. Moreover, other innovative imaging approaches that are not dependent on transgenic parasites have been appl...
journal_title:Parasite immunology
pub_type: 杂志文章,评审
doi:10.1111/pim.12051
更新日期:2013-09-01 00:00:00
abstract::As an orally acquired pathogen, the immune response to Toxoplasma gondii unfolds in the small intestinal mucosa. There, an array of regulatory and effector immune cells are elicited to combat the parasite through secretion of inflammatory mediators, normally resulting in host protection and pathogen control. Recent st...
journal_title:Parasite immunology
pub_type: 杂志文章,评审
doi:10.1111/pim.12164
更新日期:2015-03-01 00:00:00
abstract::Athymic nude mice of the outbred Zur:ICR-nu and inbred BALB/c strain and scid mice were infected with a cloned human isolate of Giardia lamblia (GS/M-83-H7). Changes in the expression of the major surface epitope of the intestinal trophozoites (characterized by the binding capacity of monoclonal antibody MoAbG10/4) as...
journal_title:Parasite immunology
pub_type: 杂志文章
doi:10.1111/j.1365-3024.1991.tb00560.x
更新日期:1991-11-01 00:00:00
abstract::African trypanosomes are well known for their ability to avoid immune elimination by switching the immunodominant variant surface glycoprotein (VSG) coat during infection. However, antigenic variation is only one of several means by which trypanosomes manipulate the immune system of their hosts. In this article, the r...
journal_title:Parasite immunology
pub_type: 杂志文章,评审
doi:10.1111/j.1365-3024.2005.00791.x
更新日期:2005-10-01 00:00:00