Abstract:
:In order to characterize immunodominant components of T. spiralis a workshop was organized. In this the reactivity of monoclonal and polyclonal antibodies, provided by different research groups, towards total extracts from adult, new born larvae and muscle larvae as well as to excretory/secretory components of muscle larvae were tested by ELISA, Western blot and immunoprecipitation assays. As a result of this workshop T. spiralis ML antigens have been classified into eight groups (TSL-1-TSL-8) according to their recognition by monoclonal and polyclonal antibodies. Among them, TSL-1 antigens have been the most extensively characterized both biochemically and immunologically. These antigens are stage specific, originate in the muscle stichosome and are abundant in both E/S and on the larval cuticular surface. The TSL-1 antigens share an immunodominant carbohydrate epitope (tyvelose), which is unique for Trichinella and is not associated with phosphorylcholine. The data collected in this workshop has allowed both the unification of the nomenclature for T. spiralis antigens and their biochemical characterization. It also has provided a platform for further studies on the characterization of other T. spiralis antigens and indeed for other Trichinella species.
journal_name
Parasite Immunoljournal_title
Parasite immunologyauthors
Ortega-Pierres MG,Yepez-Mulia L,Homan W,Gamble HR,Lim PL,Takahashi Y,Wassom DI,Appleton JAdoi
10.1046/j.1365-3024.1996.d01-103.xsubject
Has Abstractpub_date
1996-06-01 00:00:00pages
273-84issue
6eissn
0141-9838issn
1365-3024journal_volume
18pub_type
杂志文章,评审abstract::Factors governing the sensitization or desensitization of basophils and mast cells are discussed. Mathematical models are proposed which illustrate the effects of rising or falling specific or non-specific IgE titres on the tendency of these cells to degranulate. The models presented are consistent with the hypothesis...
journal_title:Parasite immunology
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doi:10.1111/j.1365-3024.1981.tb00394.x
更新日期:1981-07-01 00:00:00
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journal_title:Parasite immunology
pub_type: 杂志文章,随机对照试验
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pub_type: 杂志文章
doi:10.1111/j.1365-3024.1984.tb00796.x
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journal_title:Parasite immunology
pub_type: 杂志文章
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journal_title:Parasite immunology
pub_type: 杂志文章
doi:10.1111/j.1365-3024.1979.tb00696.x
更新日期:1979-04-01 00:00:00
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journal_title:Parasite immunology
pub_type: 杂志文章
doi:10.1046/j.1365-3024.1998.00185.x
更新日期:1998-10-01 00:00:00
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journal_title:Parasite immunology
pub_type: 杂志文章
doi:10.1111/j.1365-3024.1984.tb00790.x
更新日期:1984-03-01 00:00:00
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journal_title:Parasite immunology
pub_type: 杂志文章
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更新日期:2014-10-01 00:00:00
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更新日期:2014-08-01 00:00:00
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journal_title:Parasite immunology
pub_type: 杂志文章
doi:10.1111/j.1365-3024.1986.tb00860.x
更新日期:1986-09-01 00:00:00
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journal_title:Parasite immunology
pub_type: 杂志文章
doi:10.1111/j.1365-3024.2008.01066.x
更新日期:2009-01-01 00:00:00
abstract::Phosphorylcholine-bearing component levels in extracts of various parasites were determined by a capillary precipitin test using anti-phosphorylcholine Ig A myeloma protein. TEPC-15. Phosphorylcholine was demonstrated as a structural component not only in nematodes but also in trematodes and cestodes. The phosphorylch...
journal_title:Parasite immunology
pub_type: 杂志文章
doi:10.1111/j.1365-3024.1983.tb00754.x
更新日期:1983-07-01 00:00:00
abstract::We describe an ELISA for trophozoite-specific IgA in the intestinal secretions of mice infected with Giardia muris. Using this method, trophozoite-specific IgA was demonstrated in intestinal secretions of Giardia-infected immunocompetent BALB/c mice. Such antibody was undetectable in the intestinal secretions of Giard...
journal_title:Parasite immunology
pub_type: 杂志文章
doi:10.1111/j.1365-3024.1988.tb00257.x
更新日期:1988-11-01 00:00:00
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journal_title:Parasite immunology
pub_type: 杂志文章
doi:10.1111/j.1365-3024.1991.tb00281.x
更新日期:1991-05-01 00:00:00
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journal_title:Parasite immunology
pub_type: 杂志文章
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更新日期:1983-05-01 00:00:00
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journal_title:Parasite immunology
pub_type: 临床试验,杂志文章,随机对照试验
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更新日期:2000-09-01 00:00:00
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journal_title:Parasite immunology
pub_type: 杂志文章
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更新日期:1986-03-01 00:00:00
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journal_title:Parasite immunology
pub_type: 杂志文章
doi:10.1111/j.1365-3024.1995.tb01018.x
更新日期:1995-03-01 00:00:00
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pub_type: 杂志文章
doi:10.1111/j.1365-3024.1995.tb00893.x
更新日期:1995-06-01 00:00:00
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pub_type: 杂志文章
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更新日期:2005-01-01 00:00:00
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pub_type: 杂志文章
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更新日期:2014-12-01 00:00:00
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pub_type: 杂志文章
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更新日期:2010-09-01 00:00:00
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pub_type: 杂志文章,评审
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更新日期:2015-05-01 00:00:00
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journal_title:Parasite immunology
pub_type: 杂志文章,评审
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更新日期:2018-04-01 00:00:00
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更新日期:2010-05-01 00:00:00
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更新日期:2019-08-01 00:00:00
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journal_title:Parasite immunology
pub_type: 杂志文章
doi:10.1111/j.1365-3024.2008.01060.x
更新日期:2008-11-01 00:00:00
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journal_title:Parasite immunology
pub_type: 杂志文章
doi:10.1111/j.1365-3024.1985.tb00091.x
更新日期:1985-09-01 00:00:00
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journal_title:Parasite immunology
pub_type: 杂志文章
doi:10.1111/j.1365-3024.1994.tb00356.x
更新日期:1994-06-01 00:00:00
abstract::The overall performance of quantitative assays in the detection of anti-Toxoplasma IgG is satisfactory, but discrepancies between assays are not uncommon especially when IgG concentrations are close to the limit of detection of the tests. The purpose of our study was to identify soluble and membrane antigens extracted...
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pub_type: 杂志文章
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更新日期:2014-12-01 00:00:00