Abstract：
:Human toxocariasis is a helminth zoonosis resulting from accidental infection of humans by the roundworms Toxocara canis (T. canis) and cati (T. cati). The infection occurs in five forms: systemic (VLM), ocular, neurological, covert and asymptomatic. The aim of this study was to characterize the radiological and immunological findings in hepatic inflammation during the course of systemic infection by Toxocara sp. in children. Fifteen children, 2 to 17 years of age, with serological diagnosis of T. canis infection underwent abdominal ultrasonography and computer tomography (CT). Eosinophil counts, immunoglobulin E titres, interleukins IL-1α, IL-4, Il-6, IL-10 and interferon gamma were measured for all patients. Abdominal ultrasound revealed multiple hypoechoic areas in the livers of all patients. On the CT images, the hepatic lesions were seen as multiple, ill-defined, oval low-attenuating nodules that measured 6 to 9 millimetres in diameter. The nodules were usually best seen in the portal venous phase and were not seen on arterial-phase images. Significant intergroup differences were observed in the concentrations of IL-1α, IL-4, IL-6 and IL-10. The level of IFN-γ was not significantly elevated in patient sera relative to controls. The analysis shows that the production of anti-inflammatory cytokines is insufficient for granuloma formation in children presenting liver lesions in the course of VLM.
journal_name
Parasite Immunoljournal_title
Parasite immunologyauthors
Mazur-Melewska K,Jończyk K,Modlińska-Cwalińska A,Figlerowicz M,Służewski Wdoi
10.1111/pim.12143subject
Has Abstractpub_date
2014-12-01 00:00:00pages
668-73issue
12eissn
0141-9838issn
1365-3024journal_volume
36pub_type
杂志文章abstract：:Research undertaken over the past 40 years has established many of the general principals concerning immunity to taeniid cestodes. Although much is well understood about the host-protective mechanisms against taeniids and this knowledge has been exploited in studies on vaccine development, many aspects require further...
journal_title：Parasite immunology
pub_type： 杂志文章,评审
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更新日期：2010-11-01 00:00:00
abstract：:A monoclonal antibody (NIM-M7) has been prepared which reacts with a major surface antigen of adult males and females of Trichinella spiralis. This specificity is only demonstrable when the antigen is liberated by detergent solubilization of surface-labelled worms. When reacted with living adults, on the other hand, N...
journal_title：Parasite immunology
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doi：10.1111/j.1365-3024.1986.tb00874.x
更新日期：1986-11-01 00:00:00
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journal_title：Parasite immunology
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更新日期：2003-07-01 00:00:00
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journal_title：Parasite immunology
pub_type： 杂志文章
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pub_type： 杂志文章,评审
doi：10.1111/pim.12193
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journal_title：Parasite immunology
pub_type： 杂志文章
doi：10.1046/j.1365-3024.2000.00307.x
更新日期：2000-06-01 00:00:00
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journal_title：Parasite immunology
pub_type： 杂志文章
doi：10.1111/j.1365-3024.1994.tb00305.x
更新日期：1994-10-01 00:00:00
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journal_title：Parasite immunology
pub_type： 杂志文章
doi：10.1111/j.1365-3024.1981.tb00405.x
更新日期：1981-10-01 00:00:00
abstract：:Infective larvae of Toxocara canis are well suited for studies of nematode antigen expression in vitro. Larvae were labelled with 3H-glucosamine, an approach permitting dual analysis of antigen quantity and composition. Their excretory/secretory (E/S) glycoproteins were efficiently labelled and antigen identity confir...
journal_title：Parasite immunology
pub_type： 杂志文章
doi：10.1111/j.1365-3024.1990.tb00946.x
更新日期：1990-03-01 00:00:00
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journal_title：Parasite immunology
pub_type： 杂志文章
doi：10.1111/j.1365-3024.1985.tb00067.x
更新日期：1985-03-01 00:00:00
abstract：:We investigated the immune effector mechanisms that underlie protection against F. hepatica in the gut wall of immune rats, using (immuno)histochemistry. In the lamina propria of immune Wistar rats, four weeks after oral infection, frequencies of IgE-positive cells, eosinophils and mucosal mast cells were significantl...
journal_title：Parasite immunology
pub_type： 杂志文章
doi：10.1046/j.1365-3024.1998.00144.x
更新日期：1998-06-01 00:00:00
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journal_title：Parasite immunology
pub_type： 杂志文章,评审
doi：10.1111/pim.12595
更新日期：2019-06-01 00:00:00
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journal_title：Parasite immunology
pub_type： 杂志文章
doi：10.1111/pim.12322
更新日期：2016-06-01 00:00:00
abstract：:Successful endoparasites of mammals must outwit the sophisticated immune systems of their hosts that have evolved to detect and destroy/eradicate them. Many species of helminth parasite can directly or indirectly manipulate host immunity: helminth-derived molecules can suppress or skew activity of many immune cell phe...
journal_title：Parasite immunology
pub_type： 杂志文章
doi：10.1111/pim.12160
更新日期：2015-06-01 00:00:00
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journal_title：Parasite immunology
pub_type： 杂志文章
doi：10.1111/j.1365-3024.1984.tb00793.x
更新日期：1984-05-01 00:00:00
abstract：:Onchocerciasis is caused by the filarial nematode Onchocerca volvulus and is a major public health problem in West and Central Africa. With only partial and long-term treatment currently available, there is a need to develop a suitable vaccine. We analysed the antibody response to infective L3 larvae because this stag...
journal_title：Parasite immunology
pub_type： 杂志文章
doi：10.1046/j.1365-3024.2001.00408.x
更新日期：2001-09-01 00:00:00
abstract：:The antigenicity of the biosynthetically labelled somatic and excretory/secretory proteins of adult Fasciola hepatica was investigated over 20 weeks of an infection with F. hepatica in sheep. The antibody response was initially detected by ELISA 2 weeks after infection, and was sustained at this level for the remainde...
journal_title：Parasite immunology
pub_type： 杂志文章
doi：10.1111/j.1365-3024.1991.tb00267.x
更新日期：1991-01-01 00:00:00
abstract：:Culex pipiens and Aedes aegypti mosquitoes were fed on C3H/HeJ mice and systemic cytokine production was quantified from stimulated lymphocytes harvested four to ten days after feeding. Mosquito feeding on C3H/HeJ mice significantly down regulated IFN gamma production seven to ten days post feeding by Cx. pipiens and ...
journal_title：Parasite immunology
pub_type： 杂志文章
doi：10.1046/j.1365-3024.1999.00199.x
更新日期：1999-01-01 00:00:00
abstract：:Chronic Chagas cardiomyopathy (CCC) is responsible for the disease's greater morbidity and poor prognosis. Although understanding the pathophysiology of CCC and the fundamentals of its clinical management derives from research related to other cardiomyopathies, there are peculiarities that distinguish CCC from the oth...
journal_title：Parasite immunology
pub_type： 杂志文章,评审
doi：10.1111/pim.12663
更新日期：2019-10-01 00:00:00
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journal_title：Parasite immunology
pub_type： 杂志文章
doi：10.1111/j.1365-3024.1979.tb00701.x
更新日期：1979-07-01 00:00:00
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pub_type： 杂志文章
doi：10.1111/j.1365-3024.2009.01193.x
更新日期：2010-04-01 00:00:00
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journal_title：Parasite immunology
pub_type： 杂志文章
doi：10.1111/j.1365-3024.1989.tb00658.x
更新日期：1989-03-01 00:00:00
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journal_title：Parasite immunology
pub_type： 杂志文章
doi：10.1111/j.1365-3024.1991.tb00553.x
更新日期：1991-11-01 00:00:00
abstract：:Na-ASP-2 is a major protein secreted by infective third-stage larvae (L3) of the human hookworm Necator americanus upon host entry. It was chosen as a lead vaccine candidate for its ability to elicit protective immune responses. However, clinical development of this antigen as a recombinant vaccine was halted because ...
journal_title：Parasite immunology
pub_type： 杂志文章
doi：10.1111/j.1365-3024.2012.01371.x
更新日期：2012-08-01 00:00:00
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journal_title：Parasite immunology
pub_type： 杂志文章
doi：10.1111/j.1365-3024.1981.tb00401.x
更新日期：1981-10-01 00:00:00
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journal_title：Parasite immunology
pub_type： 杂志文章
doi：10.1111/j.1365-3024.1988.tb00256.x
更新日期：1988-11-01 00:00:00
abstract：:Leishmania donovani, the causative parasite of Visceral Leishmaniasis (VL), deviously manipulates host monocytes/macrophages to ensure its survival. Although monocytes/macrophages from patients with VL have demonstrated an impaired oxidative burst and antigen presentation, an unanswered yet pertinent question remains ...
journal_title：Parasite immunology
pub_type： 杂志文章
doi：10.1111/pim.12535
更新日期：2018-07-01 00:00:00
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journal_title：Parasite immunology
pub_type： 杂志文章
doi：10.1111/j.1365-3024.2006.00845.x
更新日期：2006-08-01 00:00:00
abstract：:The platelets from normal rats interact with microfilariae of Dipetalonema viteae in vitro in the presence of antibodies leading to the killing of the parasite. The antibody involved in this reaction is identified as IgE because the absorption of immune rat serum on anti-rat IgE column or the pretreatment of platelets...
journal_title：Parasite immunology
pub_type： 杂志文章
doi：10.1111/j.1365-3024.1985.tb00096.x
更新日期：1985-09-01 00:00:00
abstract：:Naturally acquired humoral immune responses to Pfs16, an integral membrane protein expressed in Plasmodium falciparum gametocytes and sporozoites, were investigated in The Gambia. A high prevalence of antibodies to this molecule was detected by peptide ELISA. Ninety-three per cent of the people taking part in a survey...
journal_title：Parasite immunology
pub_type： 杂志文章
doi：10.1046/j.1365-3024.1996.d01-17.x
更新日期：1996-10-01 00:00:00
