Lack of interspecies barriers in anti-Id stimulated antibody production against Echinococcus granulosus antigens.

abstract：:Fasciola hepatica infection has been shown to suppress sheep lymphocyte proliferation in vitro and this is at least partially attributable to excretory/secretory products (ES) released by F. hepatica parasites. We identified a suppressive component in ES by analysing the effect of ES fractions, separated by gel filtra...

journal_title：Parasite immunology

authors： Prowse RK,Chaplin P,Robinson HC,Spithill TW

更新日期：2002-02-01 00:00:00

abstract：:Fulani and Masaleit, sympatric tribes in eastern Sudan, are characterized by marked differences in susceptibility to Plasmodium falciparum malaria. To determine whether the two tribes differ in the frequency of immunoglobulin GM/KM allotypes, which are associated with immunity to several pathogens, serum samples from ...

journal_title：Parasite immunology

authors： Pandey JP,Nasr A,Rocca KM,Troy-Blomberg M,Elghazali G

更新日期：2007-05-01 00:00:00

abstract：:To study the role of autoreactive T cells in the pathogenesis of cardiomyopathy in Chagas' disease, we generated a cell line by repeated in vitro antigenic stimulation of purified splenic CD4+ T lymphocytes from a chronically Trypanosoma cruzi-infected mouse. Cells from this line were confirmed to be CD4+ CD8- and pro...

journal_title：Parasite immunology

authors： Ribeiro-Dos-Santos R,Mengel JO,Postol E,Soares RA,Ferreira-Fernandez E,Soares MB,Pontes-De-Carvalho LC

更新日期：2001-02-01 00:00:00

abstract：:A comparison of Plasmodium chabaudi AS infection in BALB/c and BALB/c IgM-deficient mice demonstrated a protective role for IgM during infection. IgM-/- mice, unlike microMT mice, display competent B cell humoral immune responses. Increased susceptibility of IgM-/- mice was demonstrated by increased mortality, an adva...

journal_title：Parasite immunology

authors： Couper KN,Phillips RS,Brombacher F,Alexander J

更新日期：2005-05-01 00:00:00

abstract：:Lymphoid cells from genetically-susceptible BALB/c mice immunized against a glycoconjugate of the protozoan parasite, Leishmania major, promote chronic cutaneous disease in BALB/c nude mice. This cell population therefore differs from cells harvested from non-immunized BALB/c mice that are known to be potent mediators...

journal_title：Parasite immunology

authors： Mitchell GF,Handman E

更新日期：1986-05-01 00:00:00

abstract：:Entamoeba histolytica is known to induce host cell death via activation of calpain and caspases. In this study, we investigated the specific proteases involved in the degradation of cytoskeletal proteins during Jurkat T-cell death induced by E. histolytica. Amoebic trophozoites induced marked degradation of paxillin, ...

journal_title：Parasite immunology

authors： Lee YA,Kim KA,Shin MH

更新日期：2011-06-01 00:00:00

abstract：:In schistosomiasis endemic areas, intensities of reinfection after treatment are greater amongst young children than amongst adults, and high levels of parasite-specific IgE are associated with resistance to reinfection in an age-dependent manner. Previously we have reported that, in Western blots, a 22 kDa band was r...

journal_title：Parasite immunology

authors： Dunne DW,Webster M,Smith P,Langley JG,Richardson BA,Fulford AJ,Butterworth AE,Sturrock RF,Kariuki HC,Ouma JH

更新日期：1997-02-01 00:00:00

abstract：:Intestinal helminth infections are highly prevalent in the developing world, often resulting in chronic infection and inflicting high host morbidity. With the emergence of drug-resistant parasites, a limited number of chemotherapeutic drugs available and stalling vaccine efforts, an increased understanding of antihelm...

journal_title：Parasite immunology

authors： Entwistle LJ,Wilson MS

更新日期：2017-02-01 00:00:00

abstract：:The immunological basis of resistance to Brugia pahangi infection in rats was studied. Infections were investigated in athymic rnu/rnu rats and in rats treated with the immuno-suppressive agents cyclosporin A (CsA) or cyclophosphamide (Cy). The recovery of adult worms in normal rats was 1-2% in comparison to 12.2% rec...

journal_title：Parasite immunology

authors： Lawrence R,Denham DA

更新日期：1992-07-01 00:00:00

abstract：:E6020 is a synthetic agonist of Toll-like receptor-4 (TLR4). The purpose of this study was to evaluate the effect of different doses of E6020-SE on Trypanosoma cruzi-specific immune responses and its ability to confer protection against acute lethal infection in mice. Forty female BALB/c were infected with 500 trypoma...

journal_title：Parasite immunology

authors： Villanueva-Lizama LE,Cruz-Chan JV,Versteeg L,Teh-Poot CF,Hoffman K,Kendricks A,Keegan B,Pollet J,Gusovsky F,Hotez PJ,Bottazzi ME,Jones KM

更新日期：2020-10-01 00:00:00

abstract：:Factors governing the sensitization or desensitization of basophils and mast cells are discussed. Mathematical models are proposed which illustrate the effects of rising or falling specific or non-specific IgE titres on the tendency of these cells to degranulate. The models presented are consistent with the hypothesis...

journal_title：Parasite immunology

authors： Weltman JK,Senft AW

更新日期：1981-07-01 00:00:00

abstract：:An indirect enzyme linked immunsorbent assay (ELISA) for detection of antibodies to Neospora caninum in serum from dogs is described. Extracted tachyzoite proteins incorporated into immunostimulating complexes (iscoms) were used as coating antigen. A mixture of a monoclonal antibody to dog immunoglobulin G and a horse...

journal_title：Parasite immunology

authors： Björkman C,Lundén A,Holmdahl J,Barber J,Trees AJ,Uggla A

更新日期：1994-12-01 00:00:00

abstract：:Sheep were sensitized by weekly infections with Teladorsagia circumcincta over a 9-week period. After a 12-week rest, sheep were divided into four groups and killed without challenge or 3, 5 and 10 days post challenge (DPC) with 50000 L3. Recovery of challenge larvae from abomasal scrapings was highest at 3 DPC while ...

journal_title：Parasite immunology

authors： Balic A,Bowles VM,Liu YS,Meeusen EN

更新日期：2003-07-01 00:00:00

abstract：:Dipetalonema viteae (Filarioidea) infections were established in inbred strains of mice by the s.c. implantation of adult female worms and the resulting microfilaraemia and adult worm survival monitored. BALB/c mice were the most susceptible strain examined, showing a high level microfilaraemia of approximately 6 mont...

journal_title：Parasite immunology

authors： Storey N,Wakelin D,Behnke JM

更新日期：1985-07-01 00:00:00

abstract：:The number of individuals catching schistosomiasis has increased with the popularity of 'primitive tourism' in Africa. Highly immunogenic material originating from the intestine of intravascular adult schistosomes gives rise to an antibody response making possible early identification of infected individuals using ser...

journal_title：Parasite immunology

authors： Thors C,Linder E

更新日期：1998-10-01 00:00:00

abstract：:We have assessed the role of tumour necrosis factor-alpha (TNF) during cutaneous leishmaniasis and demonstrated that significant levels of TNF were released by spleen cells from infected mice after in vitro restimulation with Leishmania major promastigotes. Spleen cells from both genetically resistant and genetically ...

journal_title：Parasite immunology

authors： Moll H,Binöder K,Bogdan C,Solbach W,Röllinghoff M

更新日期：1990-09-01 00:00:00

abstract：:A recent working group convened by the World Health Organization recommended that time to first or only episode of clinical malaria should be used to evaluate vaccine efficacy in phase III trials. However, calculating vaccine efficacy based on this endpoint misses important aspects of malaria disease and transmission....

journal_title：Parasite immunology

authors： O'Meara WP,Lang T

更新日期：2009-09-01 00:00:00

abstract：:Infection with Trypanosoma cruzi was established in the reduviid vector, Dipetalogaster maximus, by repeated feedings on mice with high parasitaemias, and metacyclic trypomastigotes (IMT) were collected in insect urine after blood meals. The infectivity of IMT in mice was assessed by placing varying numbers of organis...

journal_title：Parasite immunology

authors： Kirchhoff LV,Hoft DF

更新日期：1990-01-01 00:00:00

abstract：:Net intestinal fluid movement was measured in immunized and non-immunized rats infected with the enteric stages of the nematode, Trichinella spiralis. Animals were studied 30 min, 5 days and 30 days after receiving infective larvae. Net water movement across the mucosal surface of the gut was measured in vivo by perfu...

journal_title：Parasite immunology

authors： Castro GA,Hessel JJ,Whalen G

更新日期：1979-01-01 00:00:00

abstract：:Infections with the nematode Nematospiroides dubius fail to elicit mucosal mast cell (MMC) responses in the intestines of host mice, and suppress MMC responses generated by heterologous infection. Larval N. dubius have the capacity to prime for mastocytosis, and to elicit this response in primed mice during a challeng...

journal_title：Parasite immunology

authors： Dehlawi MS,Wakelin D

更新日期：1988-01-01 00:00:00

abstract：:Cryptosporidiosis is a zoonotic protozoan disease that affects the gastrointestinal tract of animals and humans. Diarrhoea as the most important indication of the infection leads to high economic losses in livestock industries and is a life threatening infection in immunocompromised individuals. In the absence of the ...

journal_title：Parasite immunology

authors： Askari N,Shayan P,Mokhber-Dezfouli MR,Ebrahimzadeh E,Lotfollahzadeh S,Rostami A,Amininia N,Ragh MJ

更新日期：2016-05-01 00:00:00

abstract：:Naturally acquired humoral immune responses to Pfs16, an integral membrane protein expressed in Plasmodium falciparum gametocytes and sporozoites, were investigated in The Gambia. A high prevalence of antibodies to this molecule was detected by peptide ELISA. Ninety-three per cent of the people taking part in a survey...

journal_title：Parasite immunology

authors： Baker DA,Drakeley CJ,Ong CS,Lulat AG,Greenwood BM,Targett GA

更新日期：1996-10-01 00:00:00

abstract：:In this study, supplementation with the probiotic Saccharomyces boulardii promoted a reduction in intensity of infection by Toxocara canis and modulates cytokines mRNA expression in experimentally infected mice. IL-12 gene transcription had 40-fold increase in S. boulardii supplemented uninfected mice and sevenfold in...

journal_title：Parasite immunology

authors： de Avila LF,de Leon PM,de Moura MQ,Berne ME,Scaini CJ,Leivas Leite FP

更新日期：2016-05-01 00:00:00

abstract：:Malaria remains one of the most serious health problems globally, but our understanding of the biology of the parasite and the pathogenesis of severe disease is still limited. Multiple cellular effector mechanisms that mediate parasite elimination from the liver have been described, but how effector cells use classica...

journal_title：Parasite immunology

authors： Frevert U,Nacer A

更新日期：2013-09-01 00:00:00

abstract：:Indonesian thin-tail (ITT) sheep can resist infection with Fasciola gigantica but not F. hepatica and presents an ideal model to investigate the mechanisms of liver fluke resistance in a natural host. This study examines the local and systemic immune responses of sheep during Fasciola infection and demonstrates that d...

journal_title：Parasite immunology

authors： Pleasance J,Wiedosari E,Raadsma HW,Meeusen E,Piedrafita D

更新日期：2011-09-01 00:00:00

abstract：:Advances in hookworm immunoepidemiology are reviewed. Recent studies demonstrate a mixed Th1/Th2 response in human hookworm infection, with immunosuppression of specific and nonspecific IFN-gamma responses. There is increasing evidence for protective immunity in human hookworm infection, including anti-larval IL-5- an...

journal_title：Parasite immunology

authors： Quinnell RJ,Bethony J,Pritchard DI

更新日期：2004-11-01 00:00:00

abstract：:There is good evidence for costs to both the uses of immune defences and their development and maintenance. The optimal defence will be a balance of these costs with the risk of infection and the virulence of the disease. It is therefore clear that the life-history characteristics of both host and parasite will impact...

journal_title：Parasite immunology

authors： Boots M,Donnelly R,White A

更新日期：2013-11-01 00:00:00

abstract：:Use of the pig as an animal model in schistosomiasis research is increasing, but knowledge of the porcine immune response to schistosome infection is still very limited. We investigated the immunohistology of different maturation stages of the Schistosoma japonicum egg granuloma in pigs. Liver sections from pigs exper...

journal_title：Parasite immunology

authors： Hurst MH,Willingham AL,Lindberg R

更新日期：2002-03-01 00:00:00

abstract：:As an orally acquired pathogen, the immune response to Toxoplasma gondii unfolds in the small intestinal mucosa. There, an array of regulatory and effector immune cells are elicited to combat the parasite through secretion of inflammatory mediators, normally resulting in host protection and pathogen control. Recent st...

journal_title：Parasite immunology

authors： Cohen SB,Denkers EY

更新日期：2015-03-01 00:00:00

abstract：:Toxoplasma gondii is a highly successful parasite that can manipulate host immune responses to optimize its persistence and spread. As a result, a highly complex relationship exists between T. gondii and the immune system of the host. Advances in imaging techniques, and in particular, the application of two-photon mic...

journal_title：Parasite immunology

authors： Luu L,Coombes JL

更新日期：2015-03-01 00:00:00