Production of tumour necrosis factor during murine cutaneous leishmaniasis.

abstract：:Inhibitory monoclonal antibody (MoAb) 8E7/55 recognizes a parasitophorous vacuole membrane (PVM) antigen in Plasmodium falciparum. Previous studies have identified the epitope, DNNLVSGP, recognized by the MoAb. A synthetic peptide containing this sequence was synthesized and coupled to diphtheria toxoid (DT) and was f...

journal_title：Parasite immunology

authors： Lord R,Jones GL,Spencer L,Saul A

更新日期：1993-11-01 00:00:00

abstract：:As an orally acquired pathogen, the immune response to Toxoplasma gondii unfolds in the small intestinal mucosa. There, an array of regulatory and effector immune cells are elicited to combat the parasite through secretion of inflammatory mediators, normally resulting in host protection and pathogen control. Recent st...

journal_title：Parasite immunology

authors： Cohen SB,Denkers EY

更新日期：2015-03-01 00:00:00

abstract：:Hyporesponsiveness induced by Heligmosomoides polygyrus was quantified and the relationship between TGF-beta and inflammation was identified in BALB/c mice. The immune response and pathological changes modified by neutralization of TGF-beta were characterized in vivo. Nine and twelve days following infection, BALB/c m...

journal_title：Parasite immunology

authors： Doligalska M,Rzepecka J,Drela N,Donskow K,Gerwel-Wronka M

更新日期：2006-08-01 00:00:00

abstract：:The p190 protein (also called MSA1 or MSP1) of the asexual blood stage forms of Plasmodium falciparum, a human malaria vaccine candidate, shows polymorphism between different isolates. Mice were immunized with p190-3, a recombinant protein which contains mostly conserved sequences derived from the p190 protein of the ...

journal_title：Parasite immunology

authors： Süss G,Matile H,Meloen RH,Takacs B,Pink JR

更新日期：1993-03-01 00:00:00

abstract：:Athymic nude mice of the outbred Zur:ICR-nu and inbred BALB/c strain and scid mice were infected with a cloned human isolate of Giardia lamblia (GS/M-83-H7). Changes in the expression of the major surface epitope of the intestinal trophozoites (characterized by the binding capacity of monoclonal antibody MoAbG10/4) as...

journal_title：Parasite immunology

authors： Gottstein B,Nash TE

更新日期：1991-11-01 00:00:00

abstract：:The zoonotic pathogen Toxoplasma gondii infects over 30% of the human population. The intracellular parasite can persist lifelong in the CNS within neurons modifying their function and structure, thus leading to specific behavioural changes of the host. In recent years, several in vitro studies and murine models have ...

journal_title：Parasite immunology

authors： Parlog A,Schlüter D,Dunay IR

更新日期：2015-03-01 00:00:00

abstract：:A limiting dilution microculture system was optimized to quantify the frequency of Theileria parva-specific cytotoxic T lymphocyte precursors (CTLp) in peripheral blood mononuclear cells (PBMC) from immune cattle. Optimal results were obtained with responder cell input levels ranging from 2 x 10(4)/well to 6.25 x 10(2...

journal_title：Parasite immunology

authors： Taracha EL,Goddeeris BM,Scott JR,Morrison WI

更新日期：1992-03-01 00:00:00

abstract：:UV-irradiated and gamma-irradiated schistosomula of Schistosoma mansoni induce high levels of resistance to challenge infection in experimental hosts. It was observed that both types of irradiation severely inhibited protein synthesis by the parasite larvae. Schistosomula were treated with the metabolic inhibitor acti...

journal_title：Parasite immunology

authors： Wales A,Kusel JR,Jones JT

更新日期：1992-09-01 00:00:00

abstract：:A number of T cell hybridomas were produced to adult worm homogenate (AWH) antigen of the nematode parasite Heligmosomoides polygyrus. All of the hybridomas were of the H-2d haplotype and could potentially accept antigen in the context of either the Ad or Ed, H-2 molecules. Three types of antigen presentation were obs...

journal_title：Parasite immunology

authors： Robinson M,Gustad TR,Garner SD,David CS

更新日期：1995-05-01 00:00:00

abstract：:Cells collected from C57B1/6 mice infected with monomorphic and pleomorphic clones of Trypanosoma brucei parasites (ILTat 1.4 and GUTat 3.1) were analysed for the incorporation of 125I-Iododeoxyuridine into DNA of total splenic lymphocytes and of B and T lymphocytes isolated on a fluorescence activated cell sorter. Th...

journal_title：Parasite immunology

authors： Sendashonga CN,Black SJ

更新日期：1986-09-01 00:00:00

abstract：:Human immunodeficiency virus (HIV) and Plasmodium parasites are pathogens that induce significant perturbation and activation of the immune system. Due to their geographical overlap, there have been concerns that co-infection with the two pathogens may be a factor in the modification of their development, and in the s...

journal_title：Parasite immunology

authors： Rénia L,Potter SM

更新日期：2006-11-01 00:00:00

abstract：:Antibody isotype and epitope specificities were examined in sheep immunized with EG95, a protective recombinant vaccine against hydatid disease. All sheep immunized with EG95 as a fusion protein with glutathione S-transferase (GST) produced prominent IgG antibodies against the EG95 portion of the protein. Linear, anti...

journal_title：Parasite immunology

authors： Woollard DJ,Gauci CG,Heath DD,Lightowlers MW

更新日期：1998-11-01 00:00:00

abstract：:Fasciola hepatica secretes a cathepsin L proteinase that is suggested to play an in vivo role in immunoprotection since the enzyme can cleave host immunoglobulin. In the present report, rabbit anti-cathepsin L IgG was shown to bind to the cathepsin L enzyme and inhibit its ability to cleave IgG molecules. Cathepsin L ...

journal_title：Parasite immunology

authors： Smith AM,Carmona C,Dowd AJ,McGonigle S,Acosta D,Dalton JP

更新日期：1994-06-01 00:00:00

abstract：:The impact of intestinal helminth infection, i.e. Ascaris lumbricoides and Trichuris trichiura, on cellular responsiveness and cytokine production was investigated in young adults. Ascaris-specific cellular responsiveness was higher in parasite-free endemic controls than in patients infected with T. trichiura, or A. l...

journal_title：Parasite immunology

authors： Geiger SM,Massara CL,Bethony J,Soboslay PT,Carvalho OS,Corrêa-Oliveira R

更新日期：2002-11-01 00:00:00

abstract：:Malaria parasites have a complex, multistage life cycle and there is a widely held view that each stage displays a distinct set of antigens presented to the immune system. Yet, molecular analysis of malaria parasites suggests that many putative antigenic targets are shared amongst the different stages. The specificiti...

journal_title：Parasite immunology

authors： Müller K,Gibbins MP,Matuschewski K,Hafalla JCR

更新日期：2017-07-01 00:00:00

abstract：:Antibodies and B cells are critical in the protective immune response to the blood stage of the malaria parasite, Plasmodium chabaudi. However, little is known about the development of memory B cells and their differentiation into plasma cells during infection or after re-infection. Here we have shown that B cells wit...

journal_title：Parasite immunology

authors： Stephens R,Ndungu FM,Langhorne J

更新日期：2009-01-01 00:00:00

abstract：:The prostaglandins (PG) are known to regulate immune cell function(s) and participate in the progression of both acute and chronic inflammatory reactions. Using an in vitro model of Schistosoma mansoni egg-induced hypersensitivity granulomas, we have delineated the role of immune complexes (IC) in the induction and re...

journal_title：Parasite immunology

authors： Goes AM,Rezende SA,Gazzinelli G,Doughty BL

更新日期：1994-01-01 00:00:00

abstract：:Neospora caninum is a coccidian parasite of veterinary importance by causing abortion or stillbirth in cattle among other problems in diverse animal species. We assessed an experimental murine model for its suitability to study the immune response to N. caninum infection. Thus, wild-type (wt) C57BL/6 mice and B-cell (...

journal_title：Parasite immunology

authors： Eperon S,Brönnimann K,Hemphill A,Gottstein B

更新日期：1999-05-01 00:00:00

abstract：:Carboxy-terminus of merozoite surface protein-1 (MSP-1(19) ) is the major protein on the surface of the plasmodial merozoite that acts as one of the most important blood-stage vaccine candidates. The present investigation was designed to evaluate the immune responses when either two recombinant antigens (rPvMSP-1(19) ...

journal_title：Parasite immunology

authors： Mehrizi AA,Zakeri S,Rafati S,Salmanian AH,Djadid ND

更新日期：2011-11-01 00:00:00

abstract：AIMS:Schistosomiasis and malaria are endemic in sub-Saharan Africa where Schistosoma haematobium (Sh) and Plasmodium falciparum (Pf) coinfections are thus frequent. We explored the effect of Sh infection on antibody responses directed to Pf merozoite antigens and on malaria susceptibility in Beninese children. METHODS...

journal_title：Parasite immunology

authors： Tokplonou L,Nouatin O,Sonon P,M'po G,Glitho S,Agniwo P,Gonzalez-Ortiz D,Tchégninougbo T,Ayitchédji A,Favier B,Donadi EA,Milet J,Luty AJF,Massougbodji A,Garcia A,Ibikounlé M,Courtin D

更新日期：2020-04-01 00:00:00

abstract：:Toxoplasma gondii-specific murine CD4+ T cell clone 3Tx9 belongs to the Th1 subtype by virtue of secreting high levels of interleukin(IL)-2, interferon-gamma and tumor necrosis factor without producing IL4 and IL10. To characterize the clonal antigen, Toxoplasma lysate-was separated by SDS-PAGE and probed in T cell bl...

journal_title：Parasite immunology

authors： Reichmann G,Dlugonska H,Fischer HG

更新日期：1997-05-01 00:00:00

abstract：:Modulation of macrophage/dendritic cell (DC) cytokine production by the filarial nematode phosphorylcholine (PC)-containing product, ES-62, is mediated by Toll-like receptor (TLR) 4 and signal transduction depends on the TLR adaptor MyD88. Intriguingly, comparison of TLR4 knock-out (ko) mice with TLR4 mutant C3H/HeJ m...

journal_title：Parasite immunology

authors： Goodridge HS,McGuiness S,Houston KM,Egan CA,Al-Riyami L,Alcocer MJ,Harnett MM,Harnett W

更新日期：2007-03-01 00:00:00

abstract：:Factors governing the sensitization or desensitization of basophils and mast cells are discussed. Mathematical models are proposed which illustrate the effects of rising or falling specific or non-specific IgE titres on the tendency of these cells to degranulate. The models presented are consistent with the hypothesis...

journal_title：Parasite immunology

authors： Weltman JK,Senft AW

更新日期：1981-07-01 00:00:00

abstract：:Hookworms are one of the most prevalent parasites of humans in developing countries, but we know relatively little about the immune response generated to hookworm infection. This can be attributed to a lack of permissive animal models and a relatively small research community compared with those of the more high-profi...

journal_title：Parasite immunology

authors： McSorley HJ,Loukas A

更新日期：2010-08-01 00:00:00

abstract：:The capacity of peritoneal exudate cells (PEC) obtained from mice infected or immunized with Plasmodium berghei to produce reactive oxygen species (ROS) and the biological basis of this response was investigated, using luminol-dependent zymosan-triggered chemiluminescence (CL). CL response of PEC from infected mice in...

journal_title：Parasite immunology

authors： Li M,Li YJ

更新日期：1987-05-01 00:00:00

abstract：:Cutaneous leishmaniasis, caused by the parasite Leishmania major, results in lesions at the site of infection, which are self-healing in resistant hosts. However, in the absence of the chemokine receptor CCR7, mice are unable to heal the lesion and develop chronic disease. These B6.CCR7(-/-) mice display an increased ...

journal_title：Parasite immunology

authors： Kling JC,Darby J,Körner H

更新日期：2014-04-01 00:00:00

abstract：:Crude total antigen (CTA) from Leishmania infantum and recombinant antigen K39 (rK39) and recombinant antigen K28 (rK28) were compared using an ELISA for the diagnosis of canine visceral leishmaniosis (CVL). Forty-two blood samples from healthy dogs from a nonendemic area and 80 blood samples from an endemic area for ...

journal_title：Parasite immunology

authors： Venturin GL,Bragato JP,Silva KL,de Lima VM

更新日期：2015-12-01 00:00:00

abstract：:Schistosomiasis japonicum is one of the most serious zoonotic diseases in the world. There is increasing evidence to show that host miRNAs are modulated following Schistosoma japonicum infection, and some of these miRNAs may play important regulatory roles in response to schistosome infection. Several host miRNAs have...

journal_title：Parasite immunology

authors： Hong Y,Fu Z,Cao X,Lin J

更新日期：2017-02-01 00:00:00

abstract：:To determine the role of T cells and mast cells in intestinal pathology and immune expulsion of intestinal nematodes, worm burdens, goblet cell responses and villus structures were analysed in T- and B-cell-deficient severe combined immunodeficiency (SCID) mice, athymic nu/nu mice and mast cell deficient W/W(v) mice a...

journal_title：Parasite immunology

authors： Hashimoto K,Uchikawa R,Tegoshi T,Takeda K,Yamada M,Arizono N

更新日期：2009-08-01 00:00:00

abstract：:The merozoite surface protein 2 of P. falciparum is highly polymorphic in nature, but has regions of almost complete conservation at its N- and C-termini. We produced a chimeric recombinant protein comprising these regions only (hereafter termed NC). Mice immunized with the NC antigen produce antibodies at levels comp...

journal_title：Parasite immunology

authors： Lawrence N,Stowers A,Mann V,Taylor D,Saul A

更新日期：2000-05-01 00:00:00