The immunology of human hookworm infections.

abstract：:Activation of macrophages is a key step in the initiation of immune responses, but the transcriptional mechanisms governing macrophage activation during infection are not fully understood. It was recently shown that the AP-1 family transcription factor JUNB positively regulates macrophage activation in response to Tol...

journal_title：Parasite immunology

authors： Fontana MF,Baccarella A,Kellar D,Oniskey TK,Terinate P,Rosenberg SD,Huang EJ,Herbert DR,Kim CC

更新日期：2015-09-01 00:00:00

abstract：:The chromadorea abundant larval transcript (ALT) family of proteins contains ALT one of the most studied putative vaccine candidate in experimental filariasis. This study reports the characterization of Wuchereria bancrofti 20/22 (Wb20/22) as a member of chromadorea, the ALT family of proteins from the L3 stage of W. ...

journal_title：Parasite immunology

authors： Aparnaa R,Mahalakshmi N,Harini A,Jeyaprita PJ,Anugraha G,Amdare NP,Khatri VK,Reddy MV,Kaliraj P

更新日期：2014-10-01 00:00:00

abstract：:After several in vitro treatments of a virulent population of Leishmania major with the mutagen, N-methyl-N'-nitro-N-nitrosoguanidine (MNNG), five clones (vir-) were obtained that did not produce cutaneous lesions after subcutaneous injection of 10(6) promastigotes. All the control clones (vir+) obtained from the non-...

journal_title：Parasite immunology

authors： Marchand M,Daoud S,Titus RG,Louis J,Boon T

更新日期：1987-01-01 00:00:00

abstract：:Parasitic nematodes of the small-ruminant gastrointestinal tract pose a problem worldwide. The impact of these pathogens is worsened by the emergence of anthelmintic resistance to all three available classes of drugs. In addition to causing considerable economic loss, these parasites are detrimental to the health and ...

journal_title：Parasite immunology

authors： McNeilly TN,Devaney E,Matthews JB

更新日期：2009-07-01 00:00:00

abstract：:Infection with Trypanosoma cruzi was established in the reduviid vector, Dipetalogaster maximus, by repeated feedings on mice with high parasitaemias, and metacyclic trypomastigotes (IMT) were collected in insect urine after blood meals. The infectivity of IMT in mice was assessed by placing varying numbers of organis...

journal_title：Parasite immunology

authors： Kirchhoff LV,Hoft DF

更新日期：1990-01-01 00:00:00

abstract：:In the last years, microRNAs (miRNAs) have been established as important post-transcriptional regulators of critical physiological processes in animals and plants. Here, we summarize what is known about miRNA biosynthesis, expression and function in the malaria vector mosquito Anopheles gambiae with a particular empha...

journal_title：Parasite immunology

authors： Lampe L,Levashina EA

更新日期：2017-02-01 00:00:00

abstract：:Serum from cats (Felis catus) that were repeatedly infected with Brugia pahangi and had become amicrofilaraemic (mf-ve) was injected intravenously into microfilaraemic (mf+ve) cats. If more than 1 microliter of immune serum per 1000 mf was injected, microfilarial counts fell dramatically within minutes and, in some ca...

journal_title：Parasite immunology

authors： Medeiros F,Baldwin CI,Denham DA

更新日期：1996-02-01 00:00:00

abstract：:The role of autoimmunity in the pathogenesis and progression of heart lesions in the chronic phase of Chagas' disease is controversial. In the absence of parasites in situ, the T cell infiltrate seen in heart lesions may be the primary determinant of tissue damage ultimately leading to heart failure and death. We used...

journal_title：Parasite immunology

authors： Cunha-Neto E,Moliterno R,Coelho V,Guilherme L,Bocchi E,Higuchi Mde L,Stolf N,Pileggi F,Steinman L,Kalil J

更新日期：1994-04-01 00:00:00

abstract：:An attenuated line of Leishmania mexicana (the L. mexicana H-line) has been established by culturing in vitro under gentamicin pressure. BALB/c mice infected with the L. mexicana H-line developed a CD4(+)Th1-like response, indicated by the cytokine profile of their splenocytes stimulated by L. mexicana wild-type (WT) ...

journal_title：Parasite immunology

authors： Daneshvar H,Hagan P,Phillips RS

更新日期：2003-11-01 00:00:00

abstract：:The role of the spleen in amoebic infection was examined in mice, using strains selected as being either genetically-susceptible (C57BL/6) or genetically-resistant (A/J) to amoebiasis. Splenectomized and sham-operated animals were inoculated intracaecally with 2.5 X 10(5) polyxenic trophozoites of E. histolytica at 6,...

journal_title：Parasite immunology

authors： Ghadirian E,Kongshavn PA

更新日期：1985-09-01 00:00:00

abstract：:Studies to clarify the mechanisms of apoptosis in host cells, A31 (BALB/3T3 clone A31 fibroblasts), caused by two intracellular protozoan parasites, Toxoplasma gondii and Neospora caninum, were carried out in an in vitro system. The viability of N. caninum-infected cells was significantly reduced following treatment w...

journal_title：Parasite immunology

authors： Nishikawa Y,Makala L,Otsuka H,Mikami T,Nagasawa H

更新日期：2002-07-01 00:00:00

abstract：:Human immunodeficiency virus (HIV) and Plasmodium parasites are pathogens that induce significant perturbation and activation of the immune system. Due to their geographical overlap, there have been concerns that co-infection with the two pathogens may be a factor in the modification of their development, and in the s...

journal_title：Parasite immunology

authors： Rénia L,Potter SM

更新日期：2006-11-01 00:00:00

abstract：:Crude total antigen (CTA) from Leishmania infantum and recombinant antigen K39 (rK39) and recombinant antigen K28 (rK28) were compared using an ELISA for the diagnosis of canine visceral leishmaniosis (CVL). Forty-two blood samples from healthy dogs from a nonendemic area and 80 blood samples from an endemic area for ...

journal_title：Parasite immunology

authors： Venturin GL,Bragato JP,Silva KL,de Lima VM

更新日期：2015-12-01 00:00:00

abstract：:SUMMARY Previous experiments have shown that genetic resistance to infection by Teladorsagia circumcincta in sheep can be measured by the level of IgA in gastric mucus, jointly with other parameters. The aim of this study has been to observe the influence of IgA on adult worms. The experiment was carried out with Chur...

journal_title：Parasite immunology

authors： Martínez-Valladares M,Vara-Del Río MP,Cruz-Rojo MA,Rojo-Vázquez FA

更新日期：2005-06-01 00:00:00

abstract：:On a B10 (Lshs) genetic background, the development of acquired T cell mediated immunity to Leishmania donovani infection in mice is under H-2 linked genetic control. Following intravenous inoculation of 10(7) amastigotes three phenotypic patterns of recovery have been described: 'early cure' (H-2r,s), 'cure' (H-2b) a...

journal_title：Parasite immunology

authors： Ulczak OM,Blackwell JM

更新日期：1983-09-01 00:00:00

abstract：:Two monoclonal antibodies against the surface of S. mansoni schistosomula were found to confer significant passive protection to mice (M7B3A, range 28-70%; M22H12C, range 14-58%). No additive effect was observed when both were transferred together. Neither McAb bound to the cercarial surface but both bound to the surf...

journal_title：Parasite immunology

authors： Bickle QD,Andrews BJ,Taylor MG

更新日期：1986-01-01 00:00:00

abstract：:In the present study we have investigated and compared in vitro the specific complement (C) activating activity of three metacestode preparations of Echinococcus granulosus. Extracts from hydatid cyst fluid (HCF-ext), protoscoleces (PSC-ext) and hydatid cyst membrane (HCM-ext) activated human C producing C3 conversion...

journal_title：Parasite immunology

authors： Irigoín F,Würzner R,Sim RB,Ferreira AM

更新日期：1996-07-01 00:00:00

abstract：:The number of individuals catching schistosomiasis has increased with the popularity of 'primitive tourism' in Africa. Highly immunogenic material originating from the intestine of intravascular adult schistosomes gives rise to an antibody response making possible early identification of infected individuals using ser...

journal_title：Parasite immunology

authors： Thors C,Linder E

更新日期：1998-10-01 00:00:00

abstract：:Mitogen-activated lymphocytes co-cultured with either purified Trypanosoma cruzi trypomastigotes or the filtrate of trypomastigote suspensions in culture medium manifest a significant decrease in their capacities to express p55 interleukin-2 receptor molecules (p55IL-2R) on their membrane and proliferate. In this stud...

journal_title：Parasite immunology

authors： Kierszenbaum F,Majumder S,Mejia Lopez H,Sztein MB

更新日期：1995-04-01 00:00:00

abstract：:We investigated the immune effector mechanisms that underlie protection against F. hepatica in the gut wall of immune rats, using (immuno)histochemistry. In the lamina propria of immune Wistar rats, four weeks after oral infection, frequencies of IgE-positive cells, eosinophils and mucosal mast cells were significantl...

journal_title：Parasite immunology

authors： Van Milligen FJ,Cornelissen JB,Hendriks IM,Gaasenbeek CP,Bokhout BA

更新日期：1998-06-01 00:00:00

abstract：:Nematode parasites cause significant infections in both humans and animals. They are complex, multicellular organisms that present unique challenges for the host, in particular with respect to the recognition of their unusual surface structures by the innate defence system. The innate immune system is now recognized t...

journal_title：Parasite immunology

authors： de Veer MJ,Kemp JM,Meeusen EN

更新日期：2007-01-01 00:00:00

abstract：:Host cell death induced by Entamoeba histolytica is an important mechanism for both host defence and microbial immune evasion during human amoebiasis. However, the signalling pathways underlying cell death induced by E. histolytica are not fully understood. This study investigated the involvement of the protein tyrosi...

journal_title：Parasite immunology

authors： Kim KA,Lee YA,Shin MH

更新日期：2010-03-01 00:00:00

abstract：:Male B10 X 129 (10M) ScSn mice were relatively resistant to cutaneous leishmaniasis, while females frequently developed non-healing expanding ulcers, leading to loss of infected extremities, metastasis to distal skin sites, and in some animals, death. Anti-leishmanial antibody titers were higher, and delayed-type hype...

journal_title：Parasite immunology

authors： Giannini MS

更新日期：1986-01-01 00:00:00

abstract：:Over the past several decades, outbreaks of emerging infectious diseases (EIDs) in wild birds have attracted worldwide media attention, either because of their extreme virulence or because of alarming spillovers into agricultural animals or humans. The pathogens involved have been found to infect a variety of bird hos...

journal_title：Parasite immunology

authors： Staley M,Bonneaud C

更新日期：2015-05-01 00:00:00

abstract：:The protein-energy malnutrition (PEM) and visceral leishmaniasis (VL) are important problems of public health, which affect millions of people worldwide. Currently, it has been accepted that the immunity or susceptibility to infect-parasitic diseases are directly related to the nutritional status of the host. However,...

journal_title：Parasite immunology

authors： Malafaia G

更新日期：2009-10-01 00:00:00

abstract：:Use of the pig as an animal model in schistosomiasis research is increasing, but knowledge of the porcine immune response to schistosome infection is still very limited. We investigated the immunohistology of different maturation stages of the Schistosoma japonicum egg granuloma in pigs. Liver sections from pigs exper...

journal_title：Parasite immunology

authors： Hurst MH,Willingham AL,Lindberg R

更新日期：2002-03-01 00:00:00

abstract：:Fasciola hepatica infection has been shown to suppress sheep lymphocyte proliferation in vitro and this is at least partially attributable to excretory/secretory products (ES) released by F. hepatica parasites. We identified a suppressive component in ES by analysing the effect of ES fractions, separated by gel filtra...

journal_title：Parasite immunology

authors： Prowse RK,Chaplin P,Robinson HC,Spithill TW

更新日期：2002-02-01 00:00:00

abstract：:Infective forms of Trypanosoma cruzi, the parasite that causes Chagas' disease, express on their surface an enzyme denominated trans-sialidase (TS). The present study was designed to evaluate the naturally acquired immune responses to a bacterial recombinant protein representing the catalytic domain of TS in chronical...

journal_title：Parasite immunology

authors： Ribeirão M,Pereira-Chioccola VL,Rénia L,Augusto Fragata Filho A,Schenkman S,Rodrigues MM

更新日期：2000-01-01 00:00:00

abstract：:A whole-killed malaria blood-stage vaccine (WKV) is promising in reducing the morbidity and mortality of malaria patients, but its efficacy needs to be improved. We found that the antimalarial drug chloroquine could augment the protective efficacy of the WKV of Plasmodium yoelii. The direct antimalarial effect of chlo...

journal_title：Parasite immunology

authors： Fu Y,Lu X,Zhu F,Zhao Y,Ding Y,Ye L,Guo B,Liu T,Xu W

更新日期：2020-01-01 00:00:00

abstract：:Cutaneous leishmaniasis, caused by the parasite Leishmania major, results in lesions at the site of infection, which are self-healing in resistant hosts. However, in the absence of the chemokine receptor CCR7, mice are unable to heal the lesion and develop chronic disease. These B6.CCR7(-/-) mice display an increased ...

journal_title：Parasite immunology

authors： Kling JC,Darby J,Körner H

更新日期：2014-04-01 00:00:00