Restricted heterogeneity of T cell receptor variable alpha chain transcripts in hearts of Chagas' disease cardiomyopathy patients.

abstract：:Cells collected from C57B1/6 mice infected with monomorphic and pleomorphic clones of Trypanosoma brucei parasites (ILTat 1.4 and GUTat 3.1) were analysed for the incorporation of 125I-Iododeoxyuridine into DNA of total splenic lymphocytes and of B and T lymphocytes isolated on a fluorescence activated cell sorter. Th...

journal_title：Parasite immunology

authors： Sendashonga CN,Black SJ

更新日期：1986-09-01 00:00:00

abstract：:Infections with the nematode Nematospiroides dubius fail to elicit mucosal mast cell (MMC) responses in the intestines of host mice, and suppress MMC responses generated by heterologous infection. Larval N. dubius have the capacity to prime for mastocytosis, and to elicit this response in primed mice during a challeng...

journal_title：Parasite immunology

authors： Dehlawi MS,Wakelin D

更新日期：1988-01-01 00:00:00

abstract：:The humoral responses of eight cats infected with Brugia pahangi to somatic antigens from all life-cycle stages were examined quantitatively by ELISA and qualitatively by immunoblotting for almost a year post infection. Six cats spontaneously became amicrofilaraemic: their production of IgG antibodies against somatic ...

journal_title：Parasite immunology

authors： Fletcher C,Birch DW,Samad R,Denham DA

更新日期：1986-07-01 00:00:00

abstract：:Naturally acquired humoral immune responses to Pfs16, an integral membrane protein expressed in Plasmodium falciparum gametocytes and sporozoites, were investigated in The Gambia. A high prevalence of antibodies to this molecule was detected by peptide ELISA. Ninety-three per cent of the people taking part in a survey...

journal_title：Parasite immunology

authors： Baker DA,Drakeley CJ,Ong CS,Lulat AG,Greenwood BM,Targett GA

更新日期：1996-10-01 00:00:00

abstract：:A monoclonal antibody (NIM-M7) has been prepared which reacts with a major surface antigen of adult males and females of Trichinella spiralis. This specificity is only demonstrable when the antigen is liberated by detergent solubilization of surface-labelled worms. When reacted with living adults, on the other hand, N...

journal_title：Parasite immunology

authors： Ortega-Pierres G,Clark NW,Parkhouse RM

更新日期：1986-11-01 00:00:00

abstract：:Isotype/subclass-specific antibody responses to adult Onchocerca volvulus extract (OvAg) were assessed by both ELISA and immunoblotting for a group of putatively immune individuals (PIs, n = 29) from a hyperendemic area in Ecuador and for a group of infected individuals (INFs, n = 470) from the same regions. As a grou...

journal_title：Parasite immunology

authors： Stewart GR,Elson L,Araujo E,Guderian R,Nutman TB,Bradley JE

更新日期：1995-07-01 00:00:00

abstract：:The zoonotic pathogen Toxoplasma gondii infects over 30% of the human population. The intracellular parasite can persist lifelong in the CNS within neurons modifying their function and structure, thus leading to specific behavioural changes of the host. In recent years, several in vitro studies and murine models have ...

journal_title：Parasite immunology

authors： Parlog A,Schlüter D,Dunay IR

更新日期：2015-03-01 00:00:00

abstract：:Carboxy-terminus of merozoite surface protein-1 (MSP-1(19) ) is the major protein on the surface of the plasmodial merozoite that acts as one of the most important blood-stage vaccine candidates. The present investigation was designed to evaluate the immune responses when either two recombinant antigens (rPvMSP-1(19) ...

journal_title：Parasite immunology

authors： Mehrizi AA,Zakeri S,Rafati S,Salmanian AH,Djadid ND

更新日期：2011-11-01 00:00:00

abstract：:The efficacy of vaccination against Haemonchus contortus infection with two recombinant proteins, rHco-gal-m and rHco-gal-f, was studied in 9-10-month-old goats. Vaccination with 100 microg protein reduced faecal egg output and worm burdens by 37.25% and 41.1%, respectively. Corresponding reductions with 200 microg pr...

journal_title：Parasite immunology

authors： Yanming S,Ruofeng Y,Muleke CI,Guangwei Z,Lixin X,Xiangrui L

更新日期：2007-06-01 00:00:00

abstract：:The effect of Toxocara (T.) canis antigen (TcAg) on lymphocytes was studied in vitro using normal murine spleen cells and human peripheral blood lymphocytes. TcAg prepared from adult worms stimulated murine spleen cells to proliferate at concentrations of 1-125 micrograms/ml. The responder cells TcAg are B cells, beca...

journal_title：Parasite immunology

authors： Wang MQ,Jiang HJ,Inoue H,Myozaki M,Yamashita U

更新日期：1995-12-01 00:00:00

abstract：:Cysticercosis is acquired when swine ingest human faeces contaminated with Taenia solium eggs. Humans become tapeworm carriers when they ingest infected pork meat. They can also develop cysticercosis after inadvertently swallowing T. solium eggs. Human neurocysticercosis (NCC) is considered as a public health problem ...

journal_title：Parasite immunology

authors： Flisser A,Gyorkos TW

更新日期：2007-12-01 00:00:00

abstract：BACKGROUND:Fasciola hepatica causes economically important disease in livestock worldwide. The relevance of this parasitic infection extends beyond its direct consequences due to its immunoregulatory properties. OBJECTIVES:Given the importance of the T helper 1 (Th1) immune response in controlling infections with Myco...

journal_title：Parasite immunology

authors： Naranjo-Lucena A,García-Campos A,Garza-Cuartero L,Britton L,Blanco A,Zintl A,Mulcahy G

更新日期：2020-11-01 00:00:00

abstract：:Cryptosporidiosis is a zoonotic protozoan disease that affects the gastrointestinal tract of animals and humans. Diarrhoea as the most important indication of the infection leads to high economic losses in livestock industries and is a life threatening infection in immunocompromised individuals. In the absence of the ...

journal_title：Parasite immunology

authors： Askari N,Shayan P,Mokhber-Dezfouli MR,Ebrahimzadeh E,Lotfollahzadeh S,Rostami A,Amininia N,Ragh MJ

更新日期：2016-05-01 00:00:00

abstract：:Host cell death induced by Entamoeba histolytica is an important mechanism for both host defence and microbial immune evasion during human amoebiasis. However, the signalling pathways underlying cell death induced by E. histolytica are not fully understood. This study investigated the involvement of the protein tyrosi...

journal_title：Parasite immunology

authors： Kim KA,Lee YA,Shin MH

更新日期：2010-03-01 00:00:00

abstract：:The humoral responses in mice following vaccination with DNA constructs encoding Fasciola hepatica glutathione S-transferase (GST) have been evaluated. GST47 cDNA was subcloned into two DNA vaccine vectors, VR1012 and VR1020, which direct expression to the cytoplasmic and extracellular compartments, respectively. Expr...

journal_title：Parasite immunology

authors： Smooker PM,Steeper KR,Drew DR,Strugnell RA,Spithill TW

更新日期：1999-07-01 00:00:00

abstract：:We assayed the vaccine potentialities of a recombinant S. bovis-derived glutathione S-transferase (rSb28GST), member of a molecular family already shown to have protective capacities in the S. mansoni and S. japonicum models. Injection of the rSb28GST in Freund's Complete Adjuvant resulted in good specific IgG respons...

journal_title：Parasite immunology

authors： Boulanger D,Trottein F,Mauny F,Bremond P,Couret D,Pierce RJ,Kadri S,Godin C,Sellin E,Lecocq JP

更新日期：1994-08-01 00:00:00

abstract：:After several in vitro treatments of a virulent population of Leishmania major with the mutagen, N-methyl-N'-nitro-N-nitrosoguanidine (MNNG), five clones (vir-) were obtained that did not produce cutaneous lesions after subcutaneous injection of 10(6) promastigotes. All the control clones (vir+) obtained from the non-...

journal_title：Parasite immunology

authors： Marchand M,Daoud S,Titus RG,Louis J,Boon T

更新日期：1987-01-01 00:00:00

abstract：:Lymphoid cells from genetically-susceptible BALB/c mice immunized against a glycoconjugate of the protozoan parasite, Leishmania major, promote chronic cutaneous disease in BALB/c nude mice. This cell population therefore differs from cells harvested from non-immunized BALB/c mice that are known to be potent mediators...

journal_title：Parasite immunology

authors： Mitchell GF,Handman E

更新日期：1986-05-01 00:00:00

abstract：:The effect of the humoral immune response on the weight and fecundity of the hookworm Necator americanus was examined in an endemically-infected human population. There was a highly significant negative correlation between total IgE levels and parasite weight and fecundity, after controlling for any effects of host ag...

journal_title：Parasite immunology

authors： Pritchard DI,Quinnell RJ,Walsh EA

更新日期：1995-02-01 00:00:00

abstract：:Na-ASP-2 is a major protein secreted by infective third-stage larvae (L3) of the human hookworm Necator americanus upon host entry. It was chosen as a lead vaccine candidate for its ability to elicit protective immune responses. However, clinical development of this antigen as a recombinant vaccine was halted because ...

journal_title：Parasite immunology

authors： Zhan B,Santiago H,Keegan B,Gillespie P,Xue J,Bethony J,de Oliveira LM,Jiang D,Diemert D,Xiao SH,Jones K,Feng X,Hotez PJ,Bottazzi ME

更新日期：2012-08-01 00:00:00

abstract：:Phosphorylcholine-bearing component levels in extracts of various parasites were determined by a capillary precipitin test using anti-phosphorylcholine Ig A myeloma protein. TEPC-15. Phosphorylcholine was demonstrated as a structural component not only in nematodes but also in trematodes and cestodes. The phosphorylch...

journal_title：Parasite immunology

authors： Sugane K,Oshima T

更新日期：1983-07-01 00:00:00

abstract：:In this study, supplementation with the probiotic Saccharomyces boulardii promoted a reduction in intensity of infection by Toxocara canis and modulates cytokines mRNA expression in experimentally infected mice. IL-12 gene transcription had 40-fold increase in S. boulardii supplemented uninfected mice and sevenfold in...

journal_title：Parasite immunology

authors： de Avila LF,de Leon PM,de Moura MQ,Berne ME,Scaini CJ,Leivas Leite FP

更新日期：2016-05-01 00:00:00

abstract：:The variant surface glycoprotein (VSG) coat of African trypanosomes exhibits immunobiological functions distinct from its prominent role as a variant surface antigen. In order to address questions regarding immune stealth effects of VSG switch-variant coats, and the innate immune system activating effects of shed VSG ...

journal_title：Parasite immunology

authors： Mansfield JM,Paulnock DM

更新日期：2008-04-01 00:00:00

abstract：:Very little has been reported comparing resistance to coccidiosis in fast or slow growing broilers, the latter of which are becoming more prevalent in the broiler industry. We examined mRNA expression in the intestines of fast and slow growing broilers following Eimeria infection. We show that by day 13 post-infection...

journal_title：Parasite immunology

authors： Giles T,Sakkas P,Belkhiri A,Barrow P,Kyriazakis I,Foster N

更新日期：2019-09-01 00:00:00

abstract：:Factors governing the sensitization or desensitization of basophils and mast cells are discussed. Mathematical models are proposed which illustrate the effects of rising or falling specific or non-specific IgE titres on the tendency of these cells to degranulate. The models presented are consistent with the hypothesis...

journal_title：Parasite immunology

authors： Weltman JK,Senft AW

更新日期：1981-07-01 00:00:00

abstract：:Neospora caninum is a cyst-forming coccidian parasite which in cattle can cause abortion and birth of feeble calves. For the serological diagnosis of neosporosis, antibodies directed to the parasite can be demonstrated by ELISA, utilizing N. caninum proteins incorporated into iscoms (immunostimulating complexes) as an...

journal_title：Parasite immunology

authors： Björkman C,Hemphill A

更新日期：1998-02-01 00:00:00

abstract：:Urine and stool specimens from 425 school children in Swaziland were examined for evidence of Schistosoma mansoni or Schistosoma haematobium infection. Concurrently, saliva collections were analysed for ABH secretory ability and blood samples were typed for ABO, Rh and Lewis groups. Among individuals infected with S. ...

journal_title：Parasite immunology

authors： Trangle KL,Goluska MJ,O'Leary MJ,Douglas SD

更新日期：1979-07-01 00:00:00

abstract：:Mitogen-activated lymphocytes co-cultured with either purified Trypanosoma cruzi trypomastigotes or the filtrate of trypomastigote suspensions in culture medium manifest a significant decrease in their capacities to express p55 interleukin-2 receptor molecules (p55IL-2R) on their membrane and proliferate. In this stud...

journal_title：Parasite immunology

authors： Kierszenbaum F,Majumder S,Mejia Lopez H,Sztein MB

更新日期：1995-04-01 00:00:00

abstract：:A whole-killed malaria blood-stage vaccine (WKV) is promising in reducing the morbidity and mortality of malaria patients, but its efficacy needs to be improved. We found that the antimalarial drug chloroquine could augment the protective efficacy of the WKV of Plasmodium yoelii. The direct antimalarial effect of chlo...

journal_title：Parasite immunology

authors： Fu Y,Lu X,Zhu F,Zhao Y,Ding Y,Ye L,Guo B,Liu T,Xu W

更新日期：2020-01-01 00:00:00

abstract：:Studies to clarify the mechanisms of apoptosis in host cells, A31 (BALB/3T3 clone A31 fibroblasts), caused by two intracellular protozoan parasites, Toxoplasma gondii and Neospora caninum, were carried out in an in vitro system. The viability of N. caninum-infected cells was significantly reduced following treatment w...

journal_title：Parasite immunology

authors： Nishikawa Y,Makala L,Otsuka H,Mikami T,Nagasawa H

更新日期：2002-07-01 00:00:00