Abstract:
BACKGROUND:Fasciola hepatica causes economically important disease in livestock worldwide. The relevance of this parasitic infection extends beyond its direct consequences due to its immunoregulatory properties. OBJECTIVES:Given the importance of the T helper 1 (Th1) immune response in controlling infections with Mycobacterium avium subspecies paratuberculosis (MAP) in cattle, we aimed to establish the immunological consequences that co-infection with F. hepatica might have on the course of Johne's disease (JD). METHODS:This study compared the in vitro response of bovine immune cells to infection with MAP or exposure to MAP antigens following F. hepatica infection or stimulation with F. hepatica products. RESULTS:We found a decreased proliferation of peripheral blood mononuclear cells (PBMCs) after infection with F. hepatica. This reduction was inversely correlated with fluke burden. Pre-stimulation with F. hepatica molecules produced a significant reduction of ileocaecal lymph node leucocyte proliferation in response to MAP antigens. Additionally,F. hepatica products reduced expression of the CD14 receptor by macrophages and increased levels of apoptosis and bacterial (MAP) uptake. CONCLUSIONS:Overall, F. hepatica infection had little impact on the in vitro response of immune cells to MAP, whereas in vitro co-stimulation with F. hepatica molecules had a measurable effect. Whether this is likely to affect JD progression during in vivo chronic conditions remains unclear.
journal_name
Parasite Immunoljournal_title
Parasite immunologyauthors
Naranjo-Lucena A,García-Campos A,Garza-Cuartero L,Britton L,Blanco A,Zintl A,Mulcahy Gdoi
10.1111/pim.12779subject
Has Abstractpub_date
2020-11-01 00:00:00pages
e12779issue
11eissn
0141-9838issn
1365-3024journal_volume
42pub_type
杂志文章abstract::Malaria, particularly Plasmodium falciparum, continues to disproportionately affect pregnant women. In addition to the profoundly deleterious impact of maternal malaria on the health of the mother and foetus, malaria infection in pregnancy has been shown to affect the development of the foetal and infant immune system...
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journal_title:Parasite immunology
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journal_title:Parasite immunology
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journal_title:Parasite immunology
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journal_title:Parasite immunology
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journal_title:Parasite immunology
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journal_title:Parasite immunology
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journal_title:Parasite immunology
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journal_title:Parasite immunology
pub_type: 杂志文章
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journal_title:Parasite immunology
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journal_title:Parasite immunology
pub_type: 杂志文章
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pub_type: 杂志文章
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journal_title:Parasite immunology
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更新日期:2012-08-01 00:00:00
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journal_title:Parasite immunology
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pub_type: 杂志文章
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更新日期:1995-12-01 00:00:00
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journal_title:Parasite immunology
pub_type: 杂志文章
doi:10.1111/j.1365-3024.1982.tb00442.x
更新日期:1982-09-01 00:00:00
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journal_title:Parasite immunology
pub_type: 杂志文章
doi:10.1111/j.1365-3024.1995.tb00968.x
更新日期:1995-02-01 00:00:00
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更新日期:2019-02-01 00:00:00