Abstract：
:Data from experimental and human cryptosporidiosis have established a major role of specific immunity in the control of Cryptosporidium parvum infection. In this work, alterations in spleen and Peyer's patch (Pp) lymphocytes were investigated in the course of a spontaneously resolutive gut cryptosporidiosis in four-day-old suckling NMRI mice infected with either 4 x 10(5) or 30 viable oocysts. Oocysts from entire small intestines, and spleen and Pp lymphocytes were examined using flow cytometry from day 7 to day 27 post-infection. Compared to uninfected animals, a 3-5 fold increase in the numbers of spleen TCR alphabeta+, CD4+, CD8+, TCR gammadelta+ and CD45R/B220+ lymphocytes was observed on day 17 post-infection in heavily infected animals. In Pp, more than ten-fold increases were observed, except for TCR gammadelta+ lymphocytes. At termination of infection, i.e. on days 21-23 after ingestion of 4 x 105 oocysts, T and B lymphocytes decreased rapidly in both organs, and remained lower than in uninfected animals on days 19-23 post-infection. In mice infected with 30 oocysts, similar alterations were observed in Pp, but not in spleen. Data suggest that in normally developing mice, clearance of gut C. parvum infection is associated with an initial increase in systemic and local lymphocyte numbers, followed by their decrease to below control levels during the recovery phase.
journal_name
Parasite Immunoljournal_title
Parasite immunologyauthors
Mariotte D,Comby E,Brasseur P,Ballet JJdoi
10.1111/j.0141-9838.2004.00676.xkeywords:
subject
Has Abstractpub_date
2004-01-01 00:00:00pages
1-6issue
1eissn
0141-9838issn
1365-3024pii
PIM676journal_volume
26pub_type
杂志文章abstract：:Cells collected from C57B1/6 mice infected with monomorphic and pleomorphic clones of Trypanosoma brucei parasites (ILTat 1.4 and GUTat 3.1) were analysed for the incorporation of 125I-Iododeoxyuridine into DNA of total splenic lymphocytes and of B and T lymphocytes isolated on a fluorescence activated cell sorter. Th...
journal_title：Parasite immunology
pub_type： 杂志文章
doi：10.1111/j.1365-3024.1986.tb00860.x
更新日期：1986-09-01 00:00:00
abstract：:The incidence of both type 1 (T1D) and type 2 diabetes (T2D) is drastically increasing, and it is predicted that the global prevalence of diabetes will reach almost 600 million cases by 2035. Even though the pathogenesis of both types of diabetes is distinct, the immune system is actively involved in both forms of the...
journal_title：Parasite immunology
pub_type： 杂志文章,评审
doi：10.1111/pim.12401
更新日期：2017-05-01 00:00:00
abstract：:In the present study we have investigated and compared in vitro the specific complement (C) activating activity of three metacestode preparations of Echinococcus granulosus. Extracts from hydatid cyst fluid (HCF-ext), protoscoleces (PSC-ext) and hydatid cyst membrane (HCM-ext) activated human C producing C3 conversion...
journal_title：Parasite immunology
pub_type： 杂志文章
doi：10.1046/j.1365-3024.1996.d01-112.x
更新日期：1996-07-01 00:00:00
abstract：:We investigated the immune effector mechanisms that underlie protection against F. hepatica in the gut wall of immune rats, using (immuno)histochemistry. In the lamina propria of immune Wistar rats, four weeks after oral infection, frequencies of IgE-positive cells, eosinophils and mucosal mast cells were significantl...
journal_title：Parasite immunology
pub_type： 杂志文章
doi：10.1046/j.1365-3024.1998.00144.x
更新日期：1998-06-01 00:00:00
abstract：:We have tested the hypothesis that activation of T cells by exposure to malaria antigens facilitates both de novo HIV infection and viral reactivation and replication. PBMC from malaria-naive HIV-uninfected European donors could be productively infected with HIV following in vitro stimulation with a lysate of Plasmodi...
journal_title：Parasite immunology
pub_type： 杂志文章
doi：10.1111/j.0141-9838.2004.00701.x
更新日期：2004-05-01 00:00:00
abstract：:Inhibitory monoclonal antibody (MoAb) 8E7/55 recognizes a parasitophorous vacuole membrane (PVM) antigen in Plasmodium falciparum. Previous studies have identified the epitope, DNNLVSGP, recognized by the MoAb. A synthetic peptide containing this sequence was synthesized and coupled to diphtheria toxoid (DT) and was f...
journal_title：Parasite immunology
pub_type： 杂志文章
doi：10.1111/j.1365-3024.1993.tb00574.x
更新日期：1993-11-01 00:00:00
abstract：:Crude total antigen (CTA) from Leishmania infantum and recombinant antigen K39 (rK39) and recombinant antigen K28 (rK28) were compared using an ELISA for the diagnosis of canine visceral leishmaniosis (CVL). Forty-two blood samples from healthy dogs from a nonendemic area and 80 blood samples from an endemic area for ...
journal_title：Parasite immunology
pub_type： 杂志文章
doi：10.1111/pim.12281
更新日期：2015-12-01 00:00:00
abstract：:The previously observed MHC-restriction of the antibody response to an 86kDa S. mansoni antigen has been investigated in more detail. The I-A locus of the H-2 complex has been implicated as conferring responder or non-responder status on mice expressing the k and b alleles respectively. Inheritance of responsiveness w...
journal_title：Parasite immunology
pub_type： 杂志文章
doi：10.1111/j.1365-3024.1991.tb00281.x
更新日期：1991-05-01 00:00:00
abstract：:The role of CD4+ and CD8+ T cells in protective immunity to Trichuris muris was studied in CD4+ or CD8+ or both CD4+ and CD8+ T cell-depleted BALB/c mice. To assess in vivo depletion of T-cell subsets, CD4+ and CD8+ T cells in the Peyer's patches, the mesenteric lymph nodes (MLN), and the spleens of mice treated with ...
journal_title：Parasite immunology
pub_type： 杂志文章
doi：10.1111/j.1365-3024.1995.tb01018.x
更新日期：1995-03-01 00:00:00
abstract：:In this study we have investigated the ability of the stage-specific monoclonal antibody (MoAb) 1G7 to neutralize the infectivity of Trypanosoma cruzi metacyclic trypomastigotes (Tulahuen strain). Mice inoculated with metacyclics pre-incubated with 1G7 or the corresponding Fab fragments were found to develop greatly r...
journal_title：Parasite immunology
pub_type： 杂志文章
doi：10.1111/j.1365-3024.1988.tb00256.x
更新日期：1988-11-01 00:00:00
abstract：:Factors governing the sensitization or desensitization of basophils and mast cells are discussed. Mathematical models are proposed which illustrate the effects of rising or falling specific or non-specific IgE titres on the tendency of these cells to degranulate. The models presented are consistent with the hypothesis...
journal_title：Parasite immunology
pub_type： 杂志文章
doi：10.1111/j.1365-3024.1981.tb00394.x
更新日期：1981-07-01 00:00:00
abstract：:TSOL18 is a recombinant protein that has been shown in repeated experimental trials to be capable of protecting pigs against challenge infection with the cestode parasite Taenia solium. Antibodies raised by the vaccine are capable of killing the parasite in an in vitro culture and it is believed that antibody and comp...
journal_title：Parasite immunology
pub_type： 杂志文章
doi：10.1111/j.1365-3024.2009.01197.x
更新日期：2010-06-01 00:00:00
abstract：:A protein-lipopolysaccharide complex has previously been postulated as necessary to protect susceptible mice against Salmonella typhimurium infection. Lipopolysaccharide attached to non-specific proteins, bovine serum albumin or methylated BSA, gave a specific delayed-type hypersensitivity (DTH) reaction when injected...
journal_title：Parasite immunology
pub_type： 杂志文章
doi：10.1111/j.1365-3024.1982.tb00437.x
更新日期：1982-07-01 00:00:00
abstract：:A monoclonal antibody (NIM-M7) has been prepared which reacts with a major surface antigen of adult males and females of Trichinella spiralis. This specificity is only demonstrable when the antigen is liberated by detergent solubilization of surface-labelled worms. When reacted with living adults, on the other hand, N...
journal_title：Parasite immunology
pub_type： 杂志文章
doi：10.1111/j.1365-3024.1986.tb00874.x
更新日期：1986-11-01 00:00:00
abstract：:The effect of the humoral immune response on the weight and fecundity of the hookworm Necator americanus was examined in an endemically-infected human population. There was a highly significant negative correlation between total IgE levels and parasite weight and fecundity, after controlling for any effects of host ag...
journal_title：Parasite immunology
pub_type： 杂志文章
doi：10.1111/j.1365-3024.1995.tb00968.x
更新日期：1995-02-01 00:00:00
abstract：:The development of a malaria vaccine is a priority for improved and sustained malaria control. Optimal use of a vaccine in Africa will only be achieved if it can be delivered through the Expanded Programme of Immunization (EPI). We have completed a trial of the peptide vaccine SPf66 in Tanzanian infants, given alongsi...
journal_title：Parasite immunology
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1046/j.1365-3024.2000.00322.x
更新日期：2000-09-01 00:00:00
abstract：:To determine the role of T cells and mast cells in intestinal pathology and immune expulsion of intestinal nematodes, worm burdens, goblet cell responses and villus structures were analysed in T- and B-cell-deficient severe combined immunodeficiency (SCID) mice, athymic nu/nu mice and mast cell deficient W/W(v) mice a...
journal_title：Parasite immunology
pub_type： 杂志文章
doi：10.1111/j.1365-3024.2009.01123.x
更新日期：2009-08-01 00:00:00
abstract：:Malaria remains one of the most serious health problems globally, but our understanding of the biology of the parasite and the pathogenesis of severe disease is still limited. Multiple cellular effector mechanisms that mediate parasite elimination from the liver have been described, but how effector cells use classica...
journal_title：Parasite immunology
pub_type： 杂志文章,评审
doi：10.1111/pim.12039
更新日期：2013-09-01 00:00:00
abstract：:Use of the pig as an animal model in schistosomiasis research is increasing, but knowledge of the porcine immune response to schistosome infection is still very limited. We investigated the immunohistology of different maturation stages of the Schistosoma japonicum egg granuloma in pigs. Liver sections from pigs exper...
journal_title：Parasite immunology
pub_type： 杂志文章
doi：10.1046/j.1365-3024.2002.00448.x
更新日期：2002-03-01 00:00:00
abstract：:The role of CD4+ and CD8+ T lymphocytes in the development of a protective immune response against Cryptosporidium muris infection was studied by the reconstitution of severe combined immunodeficient (SCID) mice with well-defined populations of either naive or immune CD8+ or CD4+ T lymphocytes. Adoptive transfer of bo...
journal_title：Parasite immunology
pub_type： 杂志文章
doi：10.1111/j.1365-3024.2010.01271.x
更新日期：2011-04-01 00:00:00
abstract：:Neospora caninum is a coccidian parasite of veterinary importance by causing abortion or stillbirth in cattle among other problems in diverse animal species. We assessed an experimental murine model for its suitability to study the immune response to N. caninum infection. Thus, wild-type (wt) C57BL/6 mice and B-cell (...
journal_title：Parasite immunology
pub_type： 杂志文章
doi：10.1046/j.1365-3024.1999.00223.x
更新日期：1999-05-01 00:00:00
abstract：:Very little has been reported comparing resistance to coccidiosis in fast or slow growing broilers, the latter of which are becoming more prevalent in the broiler industry. We examined mRNA expression in the intestines of fast and slow growing broilers following Eimeria infection. We show that by day 13 post-infection...
journal_title：Parasite immunology
pub_type： 杂志文章
doi：10.1111/pim.12660
更新日期：2019-09-01 00:00:00
abstract：:A recent working group convened by the World Health Organization recommended that time to first or only episode of clinical malaria should be used to evaluate vaccine efficacy in phase III trials. However, calculating vaccine efficacy based on this endpoint misses important aspects of malaria disease and transmission....
journal_title：Parasite immunology
pub_type： 杂志文章,评审
doi：10.1111/j.1365-3024.2009.01144.x
更新日期：2009-09-01 00:00:00
abstract：:Immunization of mammals with irradiated malaria sporozoites protects from a subsequent contact with the parasite. Protective immunity is directed against the pre-erythrocytic stages of the parasite, sporozoites and liver stages. Specific antibodies neutralize part of the infectious sporozoites infected by the mosquito...
journal_title：Parasite immunology
pub_type： 杂志文章
doi：10.1046/j.1365-3024.1997.d01-190.x
更新日期：1997-03-01 00:00:00
abstract：:Previous studies have shown that Leishmania elongation initiation factor (LeIF) antigen causes a partial immunity against leishmaniasis. The antigen develops type I immunity by overexpression of inflammatory cytokines such as interleukin-12 (IL-12), IFN-γ and TNF-α. Therefore, We evaluated immune responses induced by ...
journal_title：Parasite immunology
pub_type： 杂志文章
doi：10.1111/pim.12310
更新日期：2016-04-01 00:00:00
abstract：:In a double-blind study 393 seronegative dogs, residing in a holoendemic area for Leishmania donovani infantum infection, were randomly assigned to an immunization with a partly purified L.d. infantum-derived preparation, or received adjuvant only. During the first year of the study period the rate of infection was si...
journal_title：Parasite immunology
pub_type： 杂志文章
doi：10.1111/j.1365-3024.1989.tb00676.x
更新日期：1989-07-01 00:00:00
abstract：:Dipetalonema viteae (Filarioidea) infections were established in inbred strains of mice by the s.c. implantation of adult female worms and the resulting microfilaraemia and adult worm survival monitored. BALB/c mice were the most susceptible strain examined, showing a high level microfilaraemia of approximately 6 mont...
journal_title：Parasite immunology
pub_type： 杂志文章
doi：10.1111/j.1365-3024.1985.tb00081.x
更新日期：1985-07-01 00:00:00
abstract：:The impact of intestinal helminth infection, i.e. Ascaris lumbricoides and Trichuris trichiura, on cellular responsiveness and cytokine production was investigated in young adults. Ascaris-specific cellular responsiveness was higher in parasite-free endemic controls than in patients infected with T. trichiura, or A. l...
journal_title：Parasite immunology
pub_type： 杂志文章
doi：10.1046/j.1365-3024.2002.00600.x
更新日期：2002-11-01 00:00:00
abstract：:Malaria parasites have a complex, multistage life cycle and there is a widely held view that each stage displays a distinct set of antigens presented to the immune system. Yet, molecular analysis of malaria parasites suggests that many putative antigenic targets are shared amongst the different stages. The specificiti...
journal_title：Parasite immunology
pub_type： 杂志文章
doi：10.1111/pim.12434
更新日期：2017-07-01 00:00:00
abstract：:Cyclophosphamide (Cy) is known to produce a marked eosinophilia in mice after antigen challenge. In this study, we studied the effect of Cy on eosinophilia in helminthic infection. Peripheral blood eosinophils were counted in SJL mice following a large dose of Cy injection, infection with Toxocara canis, and both Cy i...
journal_title：Parasite immunology
pub_type： 杂志文章
doi：10.1111/j.1365-3024.1985.tb00074.x
更新日期：1985-05-01 00:00:00
