Comparison of complement activation in vitro by different Echinococcus granulosus extracts.

abstract：:Infections with the nematode Nematospiroides dubius fail to elicit mucosal mast cell (MMC) responses in the intestines of host mice, and suppress MMC responses generated by heterologous infection. Larval N. dubius have the capacity to prime for mastocytosis, and to elicit this response in primed mice during a challeng...

journal_title：Parasite immunology

authors： Dehlawi MS,Wakelin D

更新日期：1988-01-01 00:00:00

abstract：:Sheep scab is caused by the noninvasive mite, Psoroptes ovis, which initiates a profound pro-inflammatory skin response leading to lesion development. To investigate these early events between the skin and the parasite, primary ovine epidermal keratinocyte cultures were generated and challenged with mite derived antig...

journal_title：Parasite immunology

authors： Watkins CA,Mackellar A,Frew D,Mackie C,George A,Hopkins J,Burgess ST,McNeilly TN,Huntley JF

更新日期：2009-06-01 00:00:00

abstract：:Phosphorylcholine-bearing component levels in extracts of various parasites were determined by a capillary precipitin test using anti-phosphorylcholine Ig A myeloma protein. TEPC-15. Phosphorylcholine was demonstrated as a structural component not only in nematodes but also in trematodes and cestodes. The phosphorylch...

journal_title：Parasite immunology

authors： Sugane K,Oshima T

更新日期：1983-07-01 00:00:00

abstract：:Na-ASP-2 is a major protein secreted by infective third-stage larvae (L3) of the human hookworm Necator americanus upon host entry. It was chosen as a lead vaccine candidate for its ability to elicit protective immune responses. However, clinical development of this antigen as a recombinant vaccine was halted because ...

journal_title：Parasite immunology

authors： Zhan B,Santiago H,Keegan B,Gillespie P,Xue J,Bethony J,de Oliveira LM,Jiang D,Diemert D,Xiao SH,Jones K,Feng X,Hotez PJ,Bottazzi ME

更新日期：2012-08-01 00:00:00

abstract：:The in vitro binding serum complement (C) components to Schistosoma mansoni worms was studied. By exposing frozen sections of adult male and female parasites to normal human serum, binding of both classical and alternative pathway C components was observed. By immunofluorescence (IFL) microscopy selective binding of C...

journal_title：Parasite immunology

authors： Linder E,Huldt G

更新日期：1983-03-01 00:00:00

abstract：:The variant surface glycoprotein (VSG) coat of African trypanosomes exhibits immunobiological functions distinct from its prominent role as a variant surface antigen. In order to address questions regarding immune stealth effects of VSG switch-variant coats, and the innate immune system activating effects of shed VSG ...

journal_title：Parasite immunology

authors： Mansfield JM,Paulnock DM

更新日期：2008-04-01 00:00:00

abstract：:An essential element for continuing transmission of Plasmodium falciparum is the availability of mature gametocytes in human peripheral circulation for uptake by mosquitoes. Natural immune responses to circulating gametocytes may play a role in reducing transmission from humans to mosquitoes. Here, antibody recognitio...

journal_title：Parasite immunology

authors： Dinko B,King E,Targett GA,Sutherland CJ

更新日期：2016-06-01 00:00:00

abstract：:The efficacy of vaccination against Haemonchus contortus infection with two recombinant proteins, rHco-gal-m and rHco-gal-f, was studied in 9-10-month-old goats. Vaccination with 100 microg protein reduced faecal egg output and worm burdens by 37.25% and 41.1%, respectively. Corresponding reductions with 200 microg pr...

journal_title：Parasite immunology

authors： Yanming S,Ruofeng Y,Muleke CI,Guangwei Z,Lixin X,Xiangrui L

更新日期：2007-06-01 00:00:00

abstract：:The knowledge on immune mechanisms of chronic urticaria (CU) at the cytokine level is widely scarce. We compared pro- and anti-inflammatory as well as Th1- and Th2-associated serum cytokine levels in two phenotypes of CU: associated with (CU+) and without (CU⁻) sensitization against Anisakis simplex, a ubiquitous fish...

journal_title：Parasite immunology

authors： Daschner A,Rodero M,DE Frutos C,Valls A,Vega F,Blanco C,Cuéllar C

更新日期：2011-06-01 00:00:00

abstract：:Chagas' disease or American trypanosomiasis due to Trypanosoma cruzi has existed at least since the time of the Inca empire and contributes significantly to cardiovascular morbidity and mortality in several countries of this continent. Due to the fundamental role of human class II molecules polymorphic residues in the...

journal_title：Parasite immunology

authors： Fernandez-Mestre MT,Layrisse Z,Montagnani S,Acquatella H,Catalioti F,Matos M,Balbas O,Makhatadze N,Dominguez E,Herrera F,Madrigal A

更新日期：1998-04-01 00:00:00

abstract：:Opisthorchis viverrini infection causes opisthorchiasis and is a risk factor for cholangiocarcinoma via chronic inflammation. To investigate the mechanism of O. viverrini -induced liver disease, we applied a proteomic approach to examine alterations in hepatic protein levels in O. viverrini -infected hamsters. Two-dim...

journal_title：Parasite immunology

authors： Khoontawad J,Wongkham C,Hiraku Y,Yongvanit P,Prakobwong S,Boonmars T,Pinlaor P,Pinlaor S

更新日期：2010-05-01 00:00:00

abstract：:The immunological basis of resistance to Brugia pahangi infection in rats was studied. Infections were investigated in athymic rnu/rnu rats and in rats treated with the immuno-suppressive agents cyclosporin A (CsA) or cyclophosphamide (Cy). The recovery of adult worms in normal rats was 1-2% in comparison to 12.2% rec...

journal_title：Parasite immunology

authors： Lawrence R,Denham DA

更新日期：1992-07-01 00:00:00

abstract：:In vitro released products of the adult stage of the bovine lungworm. Dictyocaulus viviparus, were characterized according to their SDS-PAGE profile, glycosylation pattern, in vitro synthesis and antigenicity in the context of infection and vaccination with irradiated larvae. Biosynthetic labelling experiments with 35...

journal_title：Parasite immunology

authors： Britton C,Canto GJ,Urquhart GM,Kennedy MW

更新日期：1993-03-01 00:00:00

abstract：:The incidence of both type 1 (T1D) and type 2 diabetes (T2D) is drastically increasing, and it is predicted that the global prevalence of diabetes will reach almost 600 million cases by 2035. Even though the pathogenesis of both types of diabetes is distinct, the immune system is actively involved in both forms of the...

journal_title：Parasite immunology

authors： Surendar J,Indulekha K,Hoerauf A,Hübner MP

更新日期：2017-05-01 00:00:00

abstract：:Schistosomiasis poses a serious threat to public health, and the infection will develop into chronic and advanced late-stage disease if not treated. Apart from the clinical signs due to immune reactions to schistosome eggs trapped in host tissues, it also increases the risk for the development of autoimmunity reflecte...

journal_title：Parasite immunology

authors： Wang X,Fu Q,Song R,Duan B,Bergquist R,Xu J,Li S,Zhou D,Qin Z

更新日期：2018-10-01 00:00:00

abstract：:A comparison of Plasmodium chabaudi AS infection in BALB/c and BALB/c IgM-deficient mice demonstrated a protective role for IgM during infection. IgM-/- mice, unlike microMT mice, display competent B cell humoral immune responses. Increased susceptibility of IgM-/- mice was demonstrated by increased mortality, an adva...

journal_title：Parasite immunology

authors： Couper KN,Phillips RS,Brombacher F,Alexander J

更新日期：2005-05-01 00:00:00

abstract：:In the present study, the cytokines interleukin (IL)-12 and IL-18 were evaluated for their capacity to modulate and to re-direct in vitro parasite antigen-specific cellular responsiveness in patients exposed to Onchocerca volvulus and Entamoeba histolytica infection. We found that IL-18 was highly capable of reducing ...

journal_title：Parasite immunology

authors： Pfaff AW,Kirch AK,Hoffmann WH,Banla M,Schulz-Key H,Geiger SM,Soboslay PT

更新日期：2003-06-01 00:00:00

abstract：:Entamoeba histolytica is the aetiological agent of invasive amoebiasis, the third leading parasitic cause of mortality in the world. The disease can be easily cured by chemotherapy; however, prevention, mainly in the form of vaccination, could greatly decrease the incidence of the disease, and possibly help in its era...

journal_title：Parasite immunology

authors： Gaucher D,Chadee K

更新日期：2003-02-01 00:00:00

abstract：:Isotype/subclass-specific antibody responses to adult Onchocerca volvulus extract (OvAg) were assessed by both ELISA and immunoblotting for a group of putatively immune individuals (PIs, n = 29) from a hyperendemic area in Ecuador and for a group of infected individuals (INFs, n = 470) from the same regions. As a grou...

journal_title：Parasite immunology

authors： Stewart GR,Elson L,Araujo E,Guderian R,Nutman TB,Bradley JE

更新日期：1995-07-01 00:00:00

abstract：:During African trypanosomiasis, macrophages play a central role in T cell hyporesponsiveness to parasite-related and unrelated antigens. In this study, the ability of macrophages from Trypanosoma b. brucei-infected mice to present exogenous antigens to a major histocompatibility complex (MHC) class II-restricted CD4+ ...

journal_title：Parasite immunology

authors： Namangala B,Brys L,Magez S,De Baetselier P,Beschin A

更新日期：2000-07-01 00:00:00

abstract：:Immune responses of 97 Gambian women and their neonates were studied. New methods distinguished between active and previous placental malaria, were used to examine relationships between maternal malaria and neonatal immune responses. Many placentas (61%) had active or previous malarial infection. Maternal and cord mal...

journal_title：Parasite immunology

authors： Rasheed FN,Bulmer JN,De Francisco A,Jawla MF,Jakobsen PH,Jepson A,Greenwood BM

更新日期：1995-01-01 00:00:00

abstract：:Cysticercosis is acquired when swine ingest human faeces contaminated with Taenia solium eggs. Humans become tapeworm carriers when they ingest infected pork meat. They can also develop cysticercosis after inadvertently swallowing T. solium eggs. Human neurocysticercosis (NCC) is considered as a public health problem ...

journal_title：Parasite immunology

authors： Flisser A,Gyorkos TW

更新日期：2007-12-01 00:00:00

abstract：:Lymphoid cells from genetically-susceptible BALB/c mice immunized against a glycoconjugate of the protozoan parasite, Leishmania major, promote chronic cutaneous disease in BALB/c nude mice. This cell population therefore differs from cells harvested from non-immunized BALB/c mice that are known to be potent mediators...

journal_title：Parasite immunology

authors： Mitchell GF,Handman E

更新日期：1986-05-01 00:00:00

abstract：:Mice infected with lethal P. berghei or P. yoelii malaria develop anti-lymphocyte autoantibodies less than a week after infection. The autoantibodies are IgM, T-dependent and cytotoxic to a subpopulation of non-T lymphocytes at 37 degrees C in the presence of mouse or guinea-pig complement. Non-lethal P. yoelii and P....

journal_title：Parasite immunology

authors： de Souza JB,Playfair JH

更新日期：1983-05-01 00:00:00

abstract：:The natural site of infection for T. gondii is the mucosal surface of the intestine, so the protective immunity obtained after natural infection with T. gondii points to the importance of developing a vaccine that stimulates mucosal defences. In this study, an aroA- and aroD- attenuated strain of Salmonella typhimuriu...

journal_title：Parasite immunology

authors： Cong H,Gu QM,Jiang Y,He SY,Zhou HY,Yang TT,Li Y,Zhao QL

更新日期：2005-01-01 00:00:00

abstract：:Inhibitory monoclonal antibody (MoAb) 8E7/55 recognizes a parasitophorous vacuole membrane (PVM) antigen in Plasmodium falciparum. Previous studies have identified the epitope, DNNLVSGP, recognized by the MoAb. A synthetic peptide containing this sequence was synthesized and coupled to diphtheria toxoid (DT) and was f...

journal_title：Parasite immunology

authors： Lord R,Jones GL,Spencer L,Saul A

更新日期：1993-11-01 00:00:00

abstract：:Although the precise host-defence mechanisms are not completely understood, T-cell-mediated immune responses are believed to play a pivotal role in controlling parasite infection. In this study, the potential HLA*A2 restricted peptides were predicted and the ability of peptides to bind HLA-A*02 was confirmed by a MHC ...

journal_title：Parasite immunology

authors： Dikhit MR,Amit A,Singh AK,Kumar A,Mansuri R,Sinha S,Topno RK,Mishra R,Das VNR,Pandey K,Sahoo GC,Ali V,Bimal S,Das P

更新日期：2017-09-01 00:00:00

abstract：:CBA/J mice are resistant to Leishmania major infection but are permissive to L. amazonensis infection. In addition, CBA/J macrophages control L. major but not L. amazonensis infection in vitro. Phagocytosis by macrophages is known to determine the outcome of Leishmania infection. Pattern recognition receptors (PRR) ad...

journal_title：Parasite immunology

authors： Gomes IN,Palma LC,Campos GO,Lima JG,DE Almeida TF,DE Menezes JP,Ferreira CA,Santos RR,Buck GA,Manque PA,Ozaki LS,Probst CM,DE Freitas LA,Krieger MA,Veras PS

更新日期：2009-04-01 00:00:00

abstract：:Net intestinal fluid movement was measured in immunized and non-immunized rats infected with the enteric stages of the nematode, Trichinella spiralis. Animals were studied 30 min, 5 days and 30 days after receiving infective larvae. Net water movement across the mucosal surface of the gut was measured in vivo by perfu...

journal_title：Parasite immunology

authors： Castro GA,Hessel JJ,Whalen G

更新日期：1979-01-01 00:00:00

abstract：:The protective effect of specific vaccination against Plasmodium berghei (P. berghei) was compared in terms of survival percentage in DBA/2, C3H, outbred albino mice and in two lines of mice produced by selective breeding for either high or low antibody responsiveness to sheep erythrocyte (H and L lines respectively)....

journal_title：Parasite immunology

authors： Heumann AM,Bucci A,Stiffel C,Casaglia O,Zenobi P,Biozzi G

更新日期：1983-03-01 00:00:00