Prospect for an Entamoeba histolytica Gal-lectin-based vaccine.

Abstract:

:Entamoeba histolytica is the aetiological agent of invasive amoebiasis, the third leading parasitic cause of mortality in the world. The disease can be easily cured by chemotherapy; however, prevention, mainly in the form of vaccination, could greatly decrease the incidence of the disease, and possibly help in its eradication. The parasite's surface galactose and N-acetyl-d-galactosamine-inhibitable adherence lectin (Gal-lectin) is highly antigenic and is the most promising subunit vaccine candidate. We have generated a Gal-lectin-based DNA vaccine and tested its immunogenicity in mice. Although further optimization will probably be required, this vaccine could help in the generation of an amoebiasis DNA vaccine for use in humans.

journal_name

Parasite Immunol

journal_title

Parasite immunology

authors

Gaucher D,Chadee K

doi

10.1046/j.1365-3024.2003.00607.x

keywords:

subject

Has Abstract

pub_date

2003-02-01 00:00:00

pages

55-8

issue

2

eissn

0141-9838

issn

1365-3024

pii

607

journal_volume

25

pub_type

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