Abstract：
:The Bacillus thuringiensis Cry1Ac protoxin (pCry1Ac) is a promising mucosal immunogen and adjuvant that induces protective immunity against Naegleria fowleri and malaria infection models. We determined whether pCry1Ac acted as a protective adjuvant against infection with Taenia crassiceps. BALB/C mice were thrice i.p. immunized with (i) pCry1Ac, (ii) metacestode extract, (iii) extract + pCry1Ac or (iv) vehicle, challenged with metacestodes on day 26 and then sacrificed 35 days later. Cysticerci in the peritoneal cavity were counted, while the serum antibody response and cytokines were analysed after immunization and during infection. Only immunization with pCry1Ac plus extract conferred a significant protection (up to 47%). This group presented fluctuating antibody peaks during infection and the highest IgG1 and IgM titres. Immunization with extract alone elicited high IgG1 and the highest IgG2a responses after 25 days of infection, while nonimmunized mice presented a poor, mixed-Th1/Th2 response during infection. Sharp peaks of TNFα and IFN-γ occurred immediately after the first immunization with extract, especially in the presence of pCry1Ac, but not after the challenge, while in the control and pCry1Ac-alone groups, cytokines were only detected after the challenge. The data support the protective-adjuvant effect of co-administration of pCry1Ac in cysticercosis.
journal_name
Parasite Immunoljournal_title
Parasite immunologyauthors
Ibarra-Moreno S,García-Hernández AL,Moreno-Fierros Ldoi
10.1111/pim.12103subject
Has Abstractpub_date
2014-06-01 00:00:00pages
266-70issue
6eissn
0141-9838issn
1365-3024journal_volume
36pub_type
杂志文章abstract：:Immunoprecipitations of in vitro translation products of mRNA from adult Schistosoma mansoni worms with sera from chronically infected mice of 12 inbred strains reveal a strain-dependent heterogeneity in the antibody responses to schistosome antigens. Of the strains tested the response to the 86K antigen was restricte...
journal_title：Parasite immunology
pub_type： 杂志文章
doi：10.1111/j.1365-3024.1986.tb00870.x
更新日期：1986-11-01 00:00:00
abstract：:Net intestinal fluid movement was measured in immunized and non-immunized rats infected with the enteric stages of the nematode, Trichinella spiralis. Animals were studied 30 min, 5 days and 30 days after receiving infective larvae. Net water movement across the mucosal surface of the gut was measured in vivo by perfu...
journal_title：Parasite immunology
pub_type： 杂志文章
doi：10.1111/j.1365-3024.1979.tb00711.x
更新日期：1979-01-01 00:00:00
abstract：:Parasitic nematodes of the small-ruminant gastrointestinal tract pose a problem worldwide. The impact of these pathogens is worsened by the emergence of anthelmintic resistance to all three available classes of drugs. In addition to causing considerable economic loss, these parasites are detrimental to the health and ...
journal_title：Parasite immunology
pub_type： 杂志文章,评审
doi：10.1111/j.1365-3024.2009.01110.x
更新日期：2009-07-01 00:00:00
abstract：:In endemic areas, asymptomatic infection by the malaria parasite Plasmodium falciparum was found associated with elevated percentages of human host's mononuclear cell spontaneous in-vitro apoptosis. In Dielmo, a village where malaria is holoendemic, apoptosis was age-and parasite-dependent. In-vitro exposure of periph...
journal_title：Parasite immunology
pub_type： 杂志文章
doi：10.1046/j.1365-3024.2000.00307.x
更新日期：2000-06-01 00:00:00
abstract：:Previous studies have shown that Leishmania elongation initiation factor (LeIF) antigen causes a partial immunity against leishmaniasis. The antigen develops type I immunity by overexpression of inflammatory cytokines such as interleukin-12 (IL-12), IFN-γ and TNF-α. Therefore, We evaluated immune responses induced by ...
journal_title：Parasite immunology
pub_type： 杂志文章
doi：10.1111/pim.12310
更新日期：2016-04-01 00:00:00
abstract：:Modulation of macrophage/dendritic cell (DC) cytokine production by the filarial nematode phosphorylcholine (PC)-containing product, ES-62, is mediated by Toll-like receptor (TLR) 4 and signal transduction depends on the TLR adaptor MyD88. Intriguingly, comparison of TLR4 knock-out (ko) mice with TLR4 mutant C3H/HeJ m...
journal_title：Parasite immunology
pub_type： 杂志文章
doi：10.1111/j.1365-3024.2006.00926.x
更新日期：2007-03-01 00:00:00
abstract：:Immune responses of 97 Gambian women and their neonates were studied. New methods distinguished between active and previous placental malaria, were used to examine relationships between maternal malaria and neonatal immune responses. Many placentas (61%) had active or previous malarial infection. Maternal and cord mal...
journal_title：Parasite immunology
pub_type： 杂志文章
doi：10.1111/j.1365-3024.1995.tb00960.x
更新日期：1995-01-01 00:00:00
abstract：:The serodiagnosis of human toxocariasis is difficult. Specific IgGs detected routinely with ELISA based on Toxocara excretory-secretory (TES) antigens often persist for years at an elevated level, which does not allow either the differentiation between an active and persistent infection or monitoring of the effect of ...
journal_title：Parasite immunology
pub_type： 临床试验,杂志文章
doi：10.1111/pim.12400
更新日期：2017-01-01 00:00:00
abstract：:The capacity of peritoneal exudate cells (PEC) obtained from mice infected or immunized with Plasmodium berghei to produce reactive oxygen species (ROS) and the biological basis of this response was investigated, using luminol-dependent zymosan-triggered chemiluminescence (CL). CL response of PEC from infected mice in...
journal_title：Parasite immunology
pub_type： 杂志文章
doi：10.1111/j.1365-3024.1987.tb00509.x
更新日期：1987-05-01 00:00:00
abstract：:Schistosomiasis japonicum is one of the most serious zoonotic diseases in the world. There is increasing evidence to show that host miRNAs are modulated following Schistosoma japonicum infection, and some of these miRNAs may play important regulatory roles in response to schistosome infection. Several host miRNAs have...
journal_title：Parasite immunology
pub_type： 杂志文章,评审
doi：10.1111/pim.12416
更新日期：2017-02-01 00:00:00
abstract：BACKGROUND:Fasciola hepatica causes economically important disease in livestock worldwide. The relevance of this parasitic infection extends beyond its direct consequences due to its immunoregulatory properties. OBJECTIVES:Given the importance of the T helper 1 (Th1) immune response in controlling infections with Myco...
journal_title：Parasite immunology
pub_type： 杂志文章
doi：10.1111/pim.12779
更新日期：2020-11-01 00:00:00
abstract：:To study the role of autoreactive T cells in the pathogenesis of cardiomyopathy in Chagas' disease, we generated a cell line by repeated in vitro antigenic stimulation of purified splenic CD4+ T lymphocytes from a chronically Trypanosoma cruzi-infected mouse. Cells from this line were confirmed to be CD4+ CD8- and pro...
journal_title：Parasite immunology
pub_type： 杂志文章
doi：10.1046/j.1365-3024.2001.00368.x
更新日期：2001-02-01 00:00:00
abstract：:ES-62 is a glycoprotein secreted by the filarial nematode Acanthocheilonema viteae that protects against ovalbumin (OVA)-induced airway hyper-responsiveness in mice by virtue of covalently attached anti-inflammatory phosphorylcholine (PC) residues. We have recently generated a library of small molecule analogues (SMAs...
journal_title：Parasite immunology
pub_type： 杂志文章
doi：10.1111/pim.12322
更新日期：2016-06-01 00:00:00
abstract：:A pilot safety and immunogenicity trial of the malaria vaccine SPf66 was undertaken in The Gambia in 1993. One hundred and fifty infants aged 6-11 months were immunized with either 0.5 mg or 1.0 mg of SPf66 produced either in Colombia or in the USA or with a control vaccine. Children who received SPf66 experienced mor...
journal_title：Parasite immunology
pub_type： 临床试验,杂志文章
doi：10.1046/j.1365-3024.1997.d01-171.x
更新日期：1997-12-01 00:00:00
abstract：:Translationally controlled tumour protein (TCTP) may play an important role in the establishment or maintenance of parasitemia in a malarial infection. In this study, the potential of TCTP as a malaria vaccine was investigated in two trials. In the initial vaccine trial, Plasmodium falciparum TCTP (PfTCTP) was express...
journal_title：Parasite immunology
pub_type： 杂志文章
doi：10.1111/pim.12158
更新日期：2015-01-01 00:00:00
abstract：:A recent working group convened by the World Health Organization recommended that time to first or only episode of clinical malaria should be used to evaluate vaccine efficacy in phase III trials. However, calculating vaccine efficacy based on this endpoint misses important aspects of malaria disease and transmission....
journal_title：Parasite immunology
pub_type： 杂志文章,评审
doi：10.1111/j.1365-3024.2009.01144.x
更新日期：2009-09-01 00:00:00
abstract：:The kinetics of macrophage activation were compared among inbred strains of mice (C3H, BALB, B6 and B10.A) that are known to differ in their relative resistance to infections with the myotropic strains (Colombian and CL) of Trypanosoma cruzi. The parameters utilized to measure macrophage activation were rapid spreadin...
journal_title：Parasite immunology
pub_type： 杂志文章
doi：10.1111/j.1365-3024.1989.tb00675.x
更新日期：1989-07-01 00:00:00
abstract：:The present paper reviews the available literature on the development of immunity to animal Schistosoma infections. The majority of the studies on animal schistosomiasis were performed in cattle and pigs and only Schistosoma mattheei, S. bovis and S. japonicum received particular attention, mainly because of their rec...
journal_title：Parasite immunology
pub_type： 杂志文章,评审
doi：10.1111/j.1365-3024.2005.00766.x
更新日期：2005-07-01 00:00:00
abstract：:Mitogen-activated lymphocytes co-cultured with either purified Trypanosoma cruzi trypomastigotes or the filtrate of trypomastigote suspensions in culture medium manifest a significant decrease in their capacities to express p55 interleukin-2 receptor molecules (p55IL-2R) on their membrane and proliferate. In this stud...
journal_title：Parasite immunology
pub_type： 杂志文章
doi：10.1111/j.1365-3024.1995.tb00889.x
更新日期：1995-04-01 00:00:00
abstract：:Onchocerca volvulus and the human immunodeficiency virus (HIV) are two immunocompromising infectious agents of major public health concern in Uganda. To examine the effect of coinfection with O. volvulus and HIV on cellular immune responses, lymphocyte proliferative responses and cytokine production of peripheral bloo...
journal_title：Parasite immunology
pub_type： 杂志文章
doi：10.1046/j.1365-3024.1998.00170.x
更新日期：1998-09-01 00:00:00
abstract：:The in vitro binding serum complement (C) components to Schistosoma mansoni worms was studied. By exposing frozen sections of adult male and female parasites to normal human serum, binding of both classical and alternative pathway C components was observed. By immunofluorescence (IFL) microscopy selective binding of C...
journal_title：Parasite immunology
pub_type： 杂志文章
doi：10.1111/j.1365-3024.1983.tb00736.x
更新日期：1983-03-01 00:00:00
abstract：:Factors governing the sensitization or desensitization of basophils and mast cells are discussed. Mathematical models are proposed which illustrate the effects of rising or falling specific or non-specific IgE titres on the tendency of these cells to degranulate. The models presented are consistent with the hypothesis...
journal_title：Parasite immunology
pub_type： 杂志文章
doi：10.1111/j.1365-3024.1981.tb00394.x
更新日期：1981-07-01 00:00:00
abstract：:In order to characterize immunodominant components of T. spiralis a workshop was organized. In this the reactivity of monoclonal and polyclonal antibodies, provided by different research groups, towards total extracts from adult, new born larvae and muscle larvae as well as to excretory/secretory components of muscle ...
journal_title：Parasite immunology
pub_type： 杂志文章,评审
doi：10.1046/j.1365-3024.1996.d01-103.x
更新日期：1996-06-01 00:00:00
abstract：:CD4(+) T cells respond to antigen immunization through a process of activation, clonal expansion to generate activated effector T cells followed by activation-induced clonal deletion of the responding T cells. While loss of responding T cells in post-activation death by apoptosis is a major factor regulating immune ho...
journal_title：Parasite immunology
pub_type： 杂志文章
doi：10.1111/j.1365-3024.2008.01050.x
更新日期：2008-10-01 00:00:00
abstract：:Athymic nude mice of the outbred Zur:ICR-nu and inbred BALB/c strain and scid mice were infected with a cloned human isolate of Giardia lamblia (GS/M-83-H7). Changes in the expression of the major surface epitope of the intestinal trophozoites (characterized by the binding capacity of monoclonal antibody MoAbG10/4) as...
journal_title：Parasite immunology
pub_type： 杂志文章
doi：10.1111/j.1365-3024.1991.tb00560.x
更新日期：1991-11-01 00:00:00
abstract：:The humoral responses in mice following vaccination with DNA constructs encoding Fasciola hepatica glutathione S-transferase (GST) have been evaluated. GST47 cDNA was subcloned into two DNA vaccine vectors, VR1012 and VR1020, which direct expression to the cytoplasmic and extracellular compartments, respectively. Expr...
journal_title：Parasite immunology
pub_type： 杂志文章
doi：10.1046/j.1365-3024.1999.00235.x
更新日期：1999-07-01 00:00:00
abstract：:The immunological basis of resistance to Brugia pahangi infection in rats was studied. Infections were investigated in athymic rnu/rnu rats and in rats treated with the immuno-suppressive agents cyclosporin A (CsA) or cyclophosphamide (Cy). The recovery of adult worms in normal rats was 1-2% in comparison to 12.2% rec...
journal_title：Parasite immunology
pub_type： 杂志文章
doi：10.1111/j.1365-3024.1992.tb00012.x
更新日期：1992-07-01 00:00:00
abstract：:Lymphoid cells from genetically-susceptible BALB/c mice immunized against a glycoconjugate of the protozoan parasite, Leishmania major, promote chronic cutaneous disease in BALB/c nude mice. This cell population therefore differs from cells harvested from non-immunized BALB/c mice that are known to be potent mediators...
journal_title：Parasite immunology
pub_type： 杂志文章
doi：10.1111/j.1365-3024.1986.tb01037.x
更新日期：1986-05-01 00:00:00
abstract：:Changes in phagocytic and adherent cell numbers were compared during the course of infections of mice with Plasmodium yoelii (Py) and P. berghei (Pb) and in vaccinated mice challenged with homologous parasites. Nucleated cells in the spleen increased in number in Py-infected mice and were maximal at the time of recove...
journal_title：Parasite immunology
pub_type： 杂志文章
doi：10.1111/j.1365-3024.1979.tb00696.x
更新日期：1979-04-01 00:00:00
abstract：:Cryptocaryon irritans is one of the most important ectoparasites of marine fish. To identify the potential role of immune-related genes in antiparasitic immune responses in fish, we monitored the expression change of IL-8, COX-2, C-type lectin and transferrin in local and systemic immune organs of orange-spotted group...
journal_title：Parasite immunology
pub_type： 杂志文章
doi：10.1111/j.1365-3024.2011.01337.x
更新日期：2011-12-01 00:00:00
