Phosphorylcholine mimics the effects of ES-62 on macrophages and dendritic cells.

abstract：:Cryptosporidiosis is a zoonotic protozoan disease that affects the gastrointestinal tract of animals and humans. Diarrhoea as the most important indication of the infection leads to high economic losses in livestock industries and is a life threatening infection in immunocompromised individuals. In the absence of the ...

journal_title：Parasite immunology

authors： Askari N,Shayan P,Mokhber-Dezfouli MR,Ebrahimzadeh E,Lotfollahzadeh S,Rostami A,Amininia N,Ragh MJ

更新日期：2016-05-01 00:00:00

abstract：:Cysticercosis is acquired when swine ingest human faeces contaminated with Taenia solium eggs. Humans become tapeworm carriers when they ingest infected pork meat. They can also develop cysticercosis after inadvertently swallowing T. solium eggs. Human neurocysticercosis (NCC) is considered as a public health problem ...

journal_title：Parasite immunology

authors： Flisser A,Gyorkos TW

更新日期：2007-12-01 00:00:00

abstract：:The role of CD4+ and CD8+ T cells in protective immunity to Trichuris muris was studied in CD4+ or CD8+ or both CD4+ and CD8+ T cell-depleted BALB/c mice. To assess in vivo depletion of T-cell subsets, CD4+ and CD8+ T cells in the Peyer's patches, the mesenteric lymph nodes (MLN), and the spleens of mice treated with ...

journal_title：Parasite immunology

authors： Koyama K,Tamauchi H,Ito Y

更新日期：1995-03-01 00:00:00

abstract：:Activation of macrophages is a key step in the initiation of immune responses, but the transcriptional mechanisms governing macrophage activation during infection are not fully understood. It was recently shown that the AP-1 family transcription factor JUNB positively regulates macrophage activation in response to Tol...

journal_title：Parasite immunology

authors： Fontana MF,Baccarella A,Kellar D,Oniskey TK,Terinate P,Rosenberg SD,Huang EJ,Herbert DR,Kim CC

更新日期：2015-09-01 00:00:00

abstract：:Chronic Chagas cardiomyopathy (CCC) is responsible for the disease's greater morbidity and poor prognosis. Although understanding the pathophysiology of CCC and the fundamentals of its clinical management derives from research related to other cardiomyopathies, there are peculiarities that distinguish CCC from the oth...

journal_title：Parasite immunology

authors： Chaves AT,Menezes CAS,Costa HS,Nunes MCP,Rocha MOC

更新日期：2019-10-01 00:00:00

abstract：:Soluble extracts from salivarian trypanosomes (Trypanosoma brucei brucei, T. evansi and T. congolense) were shown to be capable of inducing murine tumour necrosis factor (mTNF) secretion, both in vivo and in vitro, whereas the soluble extract of an intracellular trypanosome (T. cruzi) failed to do so. Furthermore, the...

journal_title：Parasite immunology

authors： Magez S,Lucas R,Darji A,Songa EB,Hamers R,De Baetselier P

更新日期：1993-11-01 00:00:00

abstract：:T-cell-deprived CBA mice were given thymus graft implants during the course of an infection with Trypanosoma musculi and at a time when the parasitaemia was high. As a consequence of the grafts, most of the mice survived the infection whereas control ungrafted mice died. In grafted animals there was generally a period...

journal_title：Parasite immunology

authors： Targett GA,Leuchars E,Davies AJ,Viens P

更新日期：1981-01-01 00:00:00

abstract：:We compared the antigenicity of p126 Plasmodium falciparum peptides with predicted antigenic regions identified using the methods described by Garnier et al. (1978) and Chou & Fasman (1974). For this purpose nine different P. falciparum peptides were synthesized in accordance with the deduced amino acid sequence of th...

journal_title：Parasite immunology

authors： Ferreira-da-Cruz Mde F,Giovanni-de-Simone S,Banic DM,Canto-Cavalheiro M,Camus D,Daniel-Ribeiro CT

更新日期：1996-03-01 00:00:00

abstract：:Urine and stool specimens from 425 school children in Swaziland were examined for evidence of Schistosoma mansoni or Schistosoma haematobium infection. Concurrently, saliva collections were analysed for ABH secretory ability and blood samples were typed for ABO, Rh and Lewis groups. Among individuals infected with S. ...

journal_title：Parasite immunology

authors： Trangle KL,Goluska MJ,O'Leary MJ,Douglas SD

更新日期：1979-07-01 00:00:00

abstract：AIMS:Schistosomiasis and malaria are endemic in sub-Saharan Africa where Schistosoma haematobium (Sh) and Plasmodium falciparum (Pf) coinfections are thus frequent. We explored the effect of Sh infection on antibody responses directed to Pf merozoite antigens and on malaria susceptibility in Beninese children. METHODS...

journal_title：Parasite immunology

authors： Tokplonou L,Nouatin O,Sonon P,M'po G,Glitho S,Agniwo P,Gonzalez-Ortiz D,Tchégninougbo T,Ayitchédji A,Favier B,Donadi EA,Milet J,Luty AJF,Massougbodji A,Garcia A,Ibikounlé M,Courtin D

更新日期：2020-04-01 00:00:00

abstract：:Studies in animal models suggest that protection against malaria induced by intradermal (ID) administration of sporozoites is less effective compared to intravenous injection (IV). We investigated in a murine model the protective efficacy and immune responses after ID or IV immunization of sporozoites. Mice were immun...

journal_title：Parasite immunology

authors： Nganou-Makamdop K,Ploemen I,Behet M,Van Gemert GJ,Hermsen C,Roestenberg M,Sauerwein RW

更新日期：2012-12-01 00:00:00

abstract：:Infective larvae of Toxocara canis are well suited for studies of nematode antigen expression in vitro. Larvae were labelled with 3H-glucosamine, an approach permitting dual analysis of antigen quantity and composition. Their excretory/secretory (E/S) glycoproteins were efficiently labelled and antigen identity confir...

journal_title：Parasite immunology

authors： Williamson HJ,Allardyce RA,Clemett RS,Hidajat RR

更新日期：1990-03-01 00:00:00

abstract：:Fasciola hepatica secretes a cathepsin L proteinase that is suggested to play an in vivo role in immunoprotection since the enzyme can cleave host immunoglobulin. In the present report, rabbit anti-cathepsin L IgG was shown to bind to the cathepsin L enzyme and inhibit its ability to cleave IgG molecules. Cathepsin L ...

journal_title：Parasite immunology

authors： Smith AM,Carmona C,Dowd AJ,McGonigle S,Acosta D,Dalton JP

更新日期：1994-06-01 00:00:00

abstract：:We demonstrated recently that immunization with recombinant Neospora caninum profilin (rNcPRO) induces limited protection and a regulatory T-cell response in mice. The aim of this study was to evaluate the immune response elicited by rNcPRO in cattle and assess a strategy to enhance its immunogenicity, combining the a...

journal_title：Parasite immunology

authors： Mansilla FC,Quintana ME,Cardoso NP,Capozzo AV

更新日期：2016-11-01 00:00:00

abstract：:African trypanosomes are well known for their ability to avoid immune elimination by switching the immunodominant variant surface glycoprotein (VSG) coat during infection. However, antigenic variation is only one of several means by which trypanosomes manipulate the immune system of their hosts. In this article, the r...

journal_title：Parasite immunology

authors： Mansfield JM,Paulnock DM

更新日期：2005-10-01 00:00:00

abstract：:Specific CD8(-) T-lymphocyte (CTL) activity against Plasmodium pre-erythrocytic stages (P-ES) derived antigens is considered one of the most important mechanisms for malaria protection. Plasmodium vivax is the second most prevalent human malaria parasite species distributed worldwide. Although several CTL epitopes hav...

journal_title：Parasite immunology

authors： Arévalo-Herrera M,Valencia AZ,Vergara J,Bonelo A,Fleischhauer K,González JM,Restrepo JC,López JA,Valmori D,Corradin G,Herrera S

更新日期：2002-03-01 00:00:00

abstract：:A number of T cell hybridomas were produced to adult worm homogenate (AWH) antigen of the nematode parasite Heligmosomoides polygyrus. All of the hybridomas were of the H-2d haplotype and could potentially accept antigen in the context of either the Ad or Ed, H-2 molecules. Three types of antigen presentation were obs...

journal_title：Parasite immunology

authors： Robinson M,Gustad TR,Garner SD,David CS

更新日期：1995-05-01 00:00:00

abstract：:Plasmodium falciparum-specific antibodies tend to be short-lived, but their cognate memory B cells (MBCs) circulate in the peripheral blood of exposed subjects for several months or years after the last infection. However, the time course of antigen-specific antibodies and B-cell responses to the relatively neglected ...

journal_title：Parasite immunology

authors： Soares RR,Cunha CF,Ferraz-Nogueira R,Marins-Dos-Santos A,Rodrigues-da-Silva RN,da Silva Soares I,da Costa Lima-Junior J,Bertho AL,Ferreira MU,Scopel KKG

更新日期：2019-09-01 00:00:00

abstract：:To investigate whether soluble Plasmodium falciparum antigens possess endotoxin-like properties, the interaction of Limulus amoebocyte lysate (LAL) with defined soluble antigens from Plasmodium falciparum was studied by various crossed immunoelectrophoretic methods and immunoblotting. The soluble P. falciparum antigen...

journal_title：Parasite immunology

authors： Jakobsen PH,Baek L,Jepsen S

更新日期：1988-11-01 00:00:00

abstract：:Toxoplasma gondii is a highly successful parasite that can manipulate host immune responses to optimize its persistence and spread. As a result, a highly complex relationship exists between T. gondii and the immune system of the host. Advances in imaging techniques, and in particular, the application of two-photon mic...

journal_title：Parasite immunology

authors： Luu L,Coombes JL

更新日期：2015-03-01 00:00:00

abstract：:Many studies on the role of merozoite surface protein 3 (MSP3) in immunity against malaria have focused on a conserved section of MSP3. New evidence suggests that polymorphic sequences within MSP3 are under immune selection. We report a detailed analysis of naturally-acquired antibodies to allele-specific and conserve...

journal_title：Parasite immunology

authors： Osier FH,Polley SD,Mwangi T,Lowe B,Conway DJ,Marsh K

更新日期：2007-08-01 00:00:00

abstract：:African trypanosomes cause human and animal African trypanosomiases, which are chronic, debilitating and often fatal diseases of people and livestock in sub-Saharan Africa. The extracellular protozoan parasites are exemplars of antigenic variation. They direct host-protective B-cell and T-cell immune responses towards...

journal_title：Parasite immunology

authors： Black SJ,Mansfield JM

更新日期：2016-12-01 00:00:00

abstract：:We have characterized various anti-schistosomular surface MoAbs previously shown to partially block in-vitro killing of schistosomula by human sera and eosinophils (Dunne et al. 1987). Immunodiffusion analysis showed that four IgM and one IgG3 MoAbs recognized periodate sensitive epitopes on the same molecular species...

journal_title：Parasite immunology

authors： Bickle QD,Andrews BJ

更新日期：1988-03-01 00:00:00

abstract：:The knowledge on immune mechanisms of chronic urticaria (CU) at the cytokine level is widely scarce. We compared pro- and anti-inflammatory as well as Th1- and Th2-associated serum cytokine levels in two phenotypes of CU: associated with (CU+) and without (CU⁻) sensitization against Anisakis simplex, a ubiquitous fish...

journal_title：Parasite immunology

authors： Daschner A,Rodero M,DE Frutos C,Valls A,Vega F,Blanco C,Cuéllar C

更新日期：2011-06-01 00:00:00

abstract：:Malaria parasites have a complex, multistage life cycle and there is a widely held view that each stage displays a distinct set of antigens presented to the immune system. Yet, molecular analysis of malaria parasites suggests that many putative antigenic targets are shared amongst the different stages. The specificiti...

journal_title：Parasite immunology

authors： Müller K,Gibbins MP,Matuschewski K,Hafalla JCR

更新日期：2017-07-01 00:00:00

abstract：:The impact of intestinal helminth infection, i.e. Ascaris lumbricoides and Trichuris trichiura, on cellular responsiveness and cytokine production was investigated in young adults. Ascaris-specific cellular responsiveness was higher in parasite-free endemic controls than in patients infected with T. trichiura, or A. l...

journal_title：Parasite immunology

authors： Geiger SM,Massara CL,Bethony J,Soboslay PT,Carvalho OS,Corrêa-Oliveira R

更新日期：2002-11-01 00:00:00

abstract：:The anti-leishmanial effect of the 'carbohydrate-fraction', isolated from an edible mushroom Astraeus hygrometricus, was evaluated against Leishmania donovani infection both in vitro and in vivo. Ahf-Car induced the expression of inducible nitric oxide synthase 2 (iNOS2) and pro-inflammatory cytokines like TNF-α and I...

journal_title：Parasite immunology

authors： Hussain A,Ghosh S,Roy K,Nath S,Sarkar B,Dutta A,Maji P,Basu S,Paul S,Dey S,Chakraborty K,Raychaudhury B,Acharya K,Ganguly J,Pal C

更新日期：2020-10-31 00:00:00

abstract：:Sheep scab is caused by the noninvasive mite, Psoroptes ovis, which initiates a profound pro-inflammatory skin response leading to lesion development. To investigate these early events between the skin and the parasite, primary ovine epidermal keratinocyte cultures were generated and challenged with mite derived antig...

journal_title：Parasite immunology

authors： Watkins CA,Mackellar A,Frew D,Mackie C,George A,Hopkins J,Burgess ST,McNeilly TN,Huntley JF

更新日期：2009-06-01 00:00:00

abstract：:A surface enriched fraction was prepared from adults of Onchocerca volvulus by brief extraction of entire worms with detergent. This was then gel filtered to yield a low molecular weight fraction which functioned specifically in ELISA analysis. An identical result was also obtained when the related cattle parasite, O....

journal_title：Parasite immunology

authors： Cabrera Z,Parkhouse RM

更新日期：1987-01-01 00:00:00

abstract：:The serodiagnosis of human toxocariasis is difficult. Specific IgGs detected routinely with ELISA based on Toxocara excretory-secretory (TES) antigens often persist for years at an elevated level, which does not allow either the differentiation between an active and persistent infection or monitoring of the effect of ...

journal_title：Parasite immunology

authors： Rudzińska M,Kowalewska B,Sikorska K

更新日期：2017-01-01 00:00:00