Schistosoma haematobium infection modulates Plasmodium falciparum parasite density and antimalarial antibody responses.

abstract：:Opisthorchis viverrini infection causes opisthorchiasis and is a risk factor for cholangiocarcinoma via chronic inflammation. To investigate the mechanism of O. viverrini -induced liver disease, we applied a proteomic approach to examine alterations in hepatic protein levels in O. viverrini -infected hamsters. Two-dim...

journal_title：Parasite immunology

authors： Khoontawad J,Wongkham C,Hiraku Y,Yongvanit P,Prakobwong S,Boonmars T,Pinlaor P,Pinlaor S

更新日期：2010-05-01 00:00:00

abstract：:ES-62 is a glycoprotein secreted by the filarial nematode Acanthocheilonema viteae that protects against ovalbumin (OVA)-induced airway hyper-responsiveness in mice by virtue of covalently attached anti-inflammatory phosphorylcholine (PC) residues. We have recently generated a library of small molecule analogues (SMAs...

journal_title：Parasite immunology

authors： Janicova L,Rzepecka J,Rodgers DT,Doonan J,Bell KS,Lumb FE,Suckling CJ,Harnett MM,Harnett W

更新日期：2016-06-01 00:00:00

abstract：:Chagas' disease or American trypanosomiasis due to Trypanosoma cruzi has existed at least since the time of the Inca empire and contributes significantly to cardiovascular morbidity and mortality in several countries of this continent. Due to the fundamental role of human class II molecules polymorphic residues in the...

journal_title：Parasite immunology

authors： Fernandez-Mestre MT,Layrisse Z,Montagnani S,Acquatella H,Catalioti F,Matos M,Balbas O,Makhatadze N,Dominguez E,Herrera F,Madrigal A

更新日期：1998-04-01 00:00:00

abstract：:Lipopopeptidephosphoglycan (LPPG) is a complex macromolecule from the surface of Entamoeba histolytica trophozoites. We analysed the interaction between LPPG and human macrophages and dendritic cells (DCs) and found that LPPG is internalized by these cells and activates them. The internalization process involves intra...

journal_title：Parasite immunology

authors： Vivanco-Cid H,Alpuche-Aranda C,Wong-Baeza I,Rocha-Ramírez LM,Rios-Sarabia N,Estrada-Garcia I,Villasis-Keever MA,Lopez-Macias C,Isibasi A

更新日期：2007-09-01 00:00:00

abstract：:The protective effect of specific vaccination against Plasmodium berghei (P. berghei) was compared in terms of survival percentage in DBA/2, C3H, outbred albino mice and in two lines of mice produced by selective breeding for either high or low antibody responsiveness to sheep erythrocyte (H and L lines respectively)....

journal_title：Parasite immunology

authors： Heumann AM,Bucci A,Stiffel C,Casaglia O,Zenobi P,Biozzi G

更新日期：1983-03-01 00:00:00

abstract：:Eleven strains of Trypanosoma cruzi, originating from a variety of vertebrate and invertebrate hosts in distinct geographical regions, were examined for the reactivity of metacyclic stages with the monoclonal antibody 1G7. Trypomastigotes of five strains were susceptible to complement-dependent 1G7-mediated lysis. Hig...

journal_title：Parasite immunology

authors： Mortara RA,Araguth MF,Yoshida N

更新日期：1988-07-01 00:00:00

abstract：:Mitogen-activated lymphocytes co-cultured with either purified Trypanosoma cruzi trypomastigotes or the filtrate of trypomastigote suspensions in culture medium manifest a significant decrease in their capacities to express p55 interleukin-2 receptor molecules (p55IL-2R) on their membrane and proliferate. In this stud...

journal_title：Parasite immunology

authors： Kierszenbaum F,Majumder S,Mejia Lopez H,Sztein MB

更新日期：1995-04-01 00:00:00

abstract：:In endemic areas, asymptomatic infection by the malaria parasite Plasmodium falciparum was found associated with elevated percentages of human host's mononuclear cell spontaneous in-vitro apoptosis. In Dielmo, a village where malaria is holoendemic, apoptosis was age-and parasite-dependent. In-vitro exposure of periph...

journal_title：Parasite immunology

authors： Balde AT,Aribot G,Tall A,Spiegel A,Roussilhon C

更新日期：2000-06-01 00:00:00

abstract：:In this study we have investigated the ability of the stage-specific monoclonal antibody (MoAb) 1G7 to neutralize the infectivity of Trypanosoma cruzi metacyclic trypomastigotes (Tulahuen strain). Mice inoculated with metacyclics pre-incubated with 1G7 or the corresponding Fab fragments were found to develop greatly r...

journal_title：Parasite immunology

authors： Araguth MF,Rodrigues MM,Yoshida N

更新日期：1988-11-01 00:00:00

abstract：:Factors governing the sensitization or desensitization of basophils and mast cells are discussed. Mathematical models are proposed which illustrate the effects of rising or falling specific or non-specific IgE titres on the tendency of these cells to degranulate. The models presented are consistent with the hypothesis...

journal_title：Parasite immunology

authors： Weltman JK,Senft AW

更新日期：1981-07-01 00:00:00

abstract：:Lymphoid cells from genetically-susceptible BALB/c mice immunized against a glycoconjugate of the protozoan parasite, Leishmania major, promote chronic cutaneous disease in BALB/c nude mice. This cell population therefore differs from cells harvested from non-immunized BALB/c mice that are known to be potent mediators...

journal_title：Parasite immunology

authors： Mitchell GF,Handman E

更新日期：1986-05-01 00:00:00

abstract：:Immunization of mammals with irradiated malaria sporozoites protects from a subsequent contact with the parasite. Protective immunity is directed against the pre-erythrocytic stages of the parasite, sporozoites and liver stages. Specific antibodies neutralize part of the infectious sporozoites infected by the mosquito...

journal_title：Parasite immunology

authors： Renggli J,Hahne M,Matile H,Betschart B,Tschopp J,Corradin G

更新日期：1997-03-01 00:00:00

abstract：:Male B10 X 129 (10M) ScSn mice were relatively resistant to cutaneous leishmaniasis, while females frequently developed non-healing expanding ulcers, leading to loss of infected extremities, metastasis to distal skin sites, and in some animals, death. Anti-leishmanial antibody titers were higher, and delayed-type hype...

journal_title：Parasite immunology

authors： Giannini MS

更新日期：1986-01-01 00:00:00

abstract：:In order to characterize immunodominant components of T. spiralis a workshop was organized. In this the reactivity of monoclonal and polyclonal antibodies, provided by different research groups, towards total extracts from adult, new born larvae and muscle larvae as well as to excretory/secretory components of muscle ...

journal_title：Parasite immunology

authors： Ortega-Pierres MG,Yepez-Mulia L,Homan W,Gamble HR,Lim PL,Takahashi Y,Wassom DI,Appleton JA

更新日期：1996-06-01 00:00:00

abstract：:Carboxy-terminus of merozoite surface protein-1 (MSP-1(19) ) is the major protein on the surface of the plasmodial merozoite that acts as one of the most important blood-stage vaccine candidates. The present investigation was designed to evaluate the immune responses when either two recombinant antigens (rPvMSP-1(19) ...

journal_title：Parasite immunology

authors： Mehrizi AA,Zakeri S,Rafati S,Salmanian AH,Djadid ND

更新日期：2011-11-01 00:00:00

abstract：:Leishmania donovani, the causative parasite of Visceral Leishmaniasis (VL), deviously manipulates host monocytes/macrophages to ensure its survival. Although monocytes/macrophages from patients with VL have demonstrated an impaired oxidative burst and antigen presentation, an unanswered yet pertinent question remains ...

journal_title：Parasite immunology

authors： Roy S,Mukhopadhyay D,Mukherjee S,Moulik S,Chatterji S,Brahme N,Pramanik N,Goswami RP,Saha B,Chatterjee M

更新日期：2018-07-01 00:00:00

abstract：:The previously observed MHC-restriction of the antibody response to an 86kDa S. mansoni antigen has been investigated in more detail. The I-A locus of the H-2 complex has been implicated as conferring responder or non-responder status on mice expressing the k and b alleles respectively. Inheritance of responsiveness w...

journal_title：Parasite immunology

authors： Schweitzer AN,Taylor DW

更新日期：1991-05-01 00:00:00

abstract：:Immunity to Schistosoma mansoni in the mouse was induced by vaccination with adult worm surface membrane (mb-S). Of several adjuvants tested, including Freund's, BCG and alum, 50 micrograms of saponin per mouse given subcutaneously with the antigen was the easiest to administer, and gave consistent protection, approac...

journal_title：Parasite immunology

authors： Smithers SR,Hackett F,Ali PO,Simpson AJ

更新日期：1989-07-01 00:00:00

abstract：:Immunoprecipitations of in vitro translation products of mRNA from adult Schistosoma mansoni worms with sera from chronically infected mice of 12 inbred strains reveal a strain-dependent heterogeneity in the antibody responses to schistosome antigens. Of the strains tested the response to the 86K antigen was restricte...

journal_title：Parasite immunology

authors： Kee KC,Taylor DW,Cordingley JS,Butterworth AE,Munro AJ

更新日期：1986-11-01 00:00:00

abstract：:The present study was designed to investigate the role of neutrophils during the development of Schistosoma japonicum egg granulomas, in C57BL/6 and CBA mice. Laid eggs were implanted into the liver and monoclonal antibody, RB6-8C5, was used to eliminate neutrophils. After daily antibody treatment between days 9 and 1...

journal_title：Parasite immunology

authors： Hirata M,Hara T,Kage M,Fukuma T,Sendo F

更新日期：2002-09-01 00:00:00

abstract：:Antigenic proteins of Echinostoma caproni (Trematoda) against mouse IgM, IgA, IgG, IgG1 and IgG2a were investigated by immunoproteomics. Excretory/secretory products (ESP) of E. caproni separated by two-dimensional (2D) gel electrophoresis were transferred to nitrocellulose membranes and probed with the different mous...

journal_title：Parasite immunology

authors： Sotillo J,Valero L,Sánchez Del Pino MM,Fried B,Esteban JG,Marcilla A,Toledo R

更新日期：2008-05-01 00:00:00

abstract：:In order to gain insights into the immune response in onchocerciasis during early infection, laboratory-reared calves were infected with 1000 Onchocerca lienalis infective larvae and examined serologically over a period of 508 days. Levels of serum antibodies measured by ELISA against adult worm extract revealed a mul...

journal_title：Parasite immunology

authors： Kuo YM,Bianco AE

更新日期：1995-08-01 00:00:00

abstract：:Antigen specific and concanavalin A (Con A)-induced lymphocyte blastogenesis responses were monitored in the spleens of rats infected with Plasmodium berghei. Con A responses were depressed only at the time of peak parasitaemia. The antigen specific blastogenesis response was either not in evidence, or at a low level ...

journal_title：Parasite immunology

authors： Raybourne R,Desowitz RS,Sanghirun C

更新日期：1984-09-01 00:00:00

abstract：:A model for the in vitro infection of ovine cells with Toxoplasma gondii tachyzoites has been developed and used to investigate the effect of treatment with ovine recombinant interferon-gamma (ov.rIFN gamma) on parasite replication. Treatment of both alveolar macrophages and fibroblast cells either 24 h pre-infection ...

journal_title：Parasite immunology

authors： Oura CA,Innes EA,Wastling JM,Entrican G,Panton WR

更新日期：1993-09-01 00:00:00

abstract：:We assayed the vaccine potentialities of a recombinant S. bovis-derived glutathione S-transferase (rSb28GST), member of a molecular family already shown to have protective capacities in the S. mansoni and S. japonicum models. Injection of the rSb28GST in Freund's Complete Adjuvant resulted in good specific IgG respons...

journal_title：Parasite immunology

authors： Boulanger D,Trottein F,Mauny F,Bremond P,Couret D,Pierce RJ,Kadri S,Godin C,Sellin E,Lecocq JP

更新日期：1994-08-01 00:00:00

abstract：:The role of the spleen in amoebic infection was examined in mice, using strains selected as being either genetically-susceptible (C57BL/6) or genetically-resistant (A/J) to amoebiasis. Splenectomized and sham-operated animals were inoculated intracaecally with 2.5 X 10(5) polyxenic trophozoites of E. histolytica at 6,...

journal_title：Parasite immunology

authors： Ghadirian E,Kongshavn PA

更新日期：1985-09-01 00:00:00

abstract：:Schistosomiasis japonicum is one of the most serious zoonotic diseases in the world. There is increasing evidence to show that host miRNAs are modulated following Schistosoma japonicum infection, and some of these miRNAs may play important regulatory roles in response to schistosome infection. Several host miRNAs have...

journal_title：Parasite immunology

authors： Hong Y,Fu Z,Cao X,Lin J

更新日期：2017-02-01 00:00:00

abstract：:Helminth parasites induce a strong Th2 response, characterized by high levels of IgE and elevated signature cytokines such as IL-5. As many global deworming programmes are underway, there is concern that this might lead to emergence of Th1-mediated pathologies when the counterbalancing helminth-induced Th2 response is...

journal_title：Parasite immunology

authors： de Ruiter K,Tahapary DL,Wammes LJ,Wiria AE,Hamid F,van Lieshout L,Smit JWA,Houwing-Duistermaat JJ,Sartono E,Supali T,Yazdanbakhsh M

更新日期：2017-06-01 00:00:00

abstract：:The merozoite surface protein 2 of P. falciparum is highly polymorphic in nature, but has regions of almost complete conservation at its N- and C-termini. We produced a chimeric recombinant protein comprising these regions only (hereafter termed NC). Mice immunized with the NC antigen produce antibodies at levels comp...

journal_title：Parasite immunology

authors： Lawrence N,Stowers A,Mann V,Taylor D,Saul A

更新日期：2000-05-01 00:00:00

abstract：:Parasitic nematodes of the small-ruminant gastrointestinal tract pose a problem worldwide. The impact of these pathogens is worsened by the emergence of anthelmintic resistance to all three available classes of drugs. In addition to causing considerable economic loss, these parasites are detrimental to the health and ...

journal_title：Parasite immunology

authors： McNeilly TN,Devaney E,Matthews JB

更新日期：2009-07-01 00:00:00