Proteomic identification of peroxiredoxin 6 for host defence against Opisthorchis viverrini infection.

abstract：:The effect of Toxocara (T.) canis antigen (TcAg) on lymphocytes was studied in vitro using normal murine spleen cells and human peripheral blood lymphocytes. TcAg prepared from adult worms stimulated murine spleen cells to proliferate at concentrations of 1-125 micrograms/ml. The responder cells TcAg are B cells, beca...

journal_title：Parasite immunology

authors： Wang MQ,Jiang HJ,Inoue H,Myozaki M,Yamashita U

更新日期：1995-12-01 00:00:00

abstract：:Visceral leishmaniasis (VL) or Kala azar (KA) is a systemic disease caused by the parasites of the Leishmania donovani complex. Control measures rely on treatment with antileishmanial agents, however, fraught with problems such as toxicity or drug resistance. The incidence rate is on the rise for children, for reasons...

journal_title：Parasite immunology

authors： Ansari NA,Kumar R,Raj A,Salotra P

更新日期：2008-08-01 00:00:00

abstract：:Entamoeba histolytica is known to induce host cell death via activation of calpain and caspases. In this study, we investigated the specific proteases involved in the degradation of cytoskeletal proteins during Jurkat T-cell death induced by E. histolytica. Amoebic trophozoites induced marked degradation of paxillin, ...

journal_title：Parasite immunology

authors： Lee YA,Kim KA,Shin MH

更新日期：2011-06-01 00:00:00

abstract：:Neospora caninum is a coccidian parasite of veterinary importance by causing abortion or stillbirth in cattle among other problems in diverse animal species. We assessed an experimental murine model for its suitability to study the immune response to N. caninum infection. Thus, wild-type (wt) C57BL/6 mice and B-cell (...

journal_title：Parasite immunology

authors： Eperon S,Brönnimann K,Hemphill A,Gottstein B

更新日期：1999-05-01 00:00:00

abstract：:We have investigated whether a protective immune response occurred in mice infected with a virulent cloned strain of Plasmodium chabaudi. Animals inoculated intravenously with 10(7) parasitized erythrocytes (PE) showed an exponentially increasing parasitaemia and died by day 6 of the infection, presenting a pronounced...

journal_title：Parasite immunology

authors： Falanga PB,Pereira da Silva L

更新日期：1989-11-01 00:00:00

abstract：:A recent working group convened by the World Health Organization recommended that time to first or only episode of clinical malaria should be used to evaluate vaccine efficacy in phase III trials. However, calculating vaccine efficacy based on this endpoint misses important aspects of malaria disease and transmission....

journal_title：Parasite immunology

authors： O'Meara WP,Lang T

更新日期：2009-09-01 00:00:00

abstract：:SUMMARY Previous experiments have shown that genetic resistance to infection by Teladorsagia circumcincta in sheep can be measured by the level of IgA in gastric mucus, jointly with other parameters. The aim of this study has been to observe the influence of IgA on adult worms. The experiment was carried out with Chur...

journal_title：Parasite immunology

authors： Martínez-Valladares M,Vara-Del Río MP,Cruz-Rojo MA,Rojo-Vázquez FA

更新日期：2005-06-01 00:00:00

abstract：:The role of MHC class II in the presentation of Heligmosomoides polygyrus antigens has been investigated, using a number of T cell hybridomas produced in A and E positive and negative mice. By using fixed and irradiated antigen presenting cells (APC), further evidence has emerged, to support earlier data, that there c...

journal_title：Parasite immunology

authors： Mason SD,Gustad TR,David CS,Robinson M

更新日期：1996-09-01 00:00:00

abstract：:Malaria parasites have a complex, multistage life cycle and there is a widely held view that each stage displays a distinct set of antigens presented to the immune system. Yet, molecular analysis of malaria parasites suggests that many putative antigenic targets are shared amongst the different stages. The specificiti...

journal_title：Parasite immunology

authors： Müller K,Gibbins MP,Matuschewski K,Hafalla JCR

更新日期：2017-07-01 00:00:00

abstract：:Immunohistochemistry and immunofluorescence with confocal microscopy were used to localize the host-protective antigens of Taenia saginata (TSA9 and TSA18) and Taenia solium (TSOL16, TSOL18 and TSOL45). In nonactivated oncospheres, TSA9 and TSOL45 antigens were found primarily in the cytoplasm of the penetration gland...

journal_title：Parasite immunology

authors： Jabbar A,Verástegui M,Lackenby JA,Walduck AK,Gauci CG,Gilman RH,Lightowlers MW

更新日期：2010-09-01 00:00:00

abstract：:Immunization with naked DNA represents an attractive strategy for development of vaccines against a variety of infections including those caused by protozoan parasites. Recently, we have described that immunization with a plasmid containing the trans-sialidase (TS) gene induced protective immunity against Trypanosoma ...

journal_title：Parasite immunology

authors： Pereira-Chioccola VL,Costa F,Ribeirão M,Soares IS,Arena F,Schenkman S,Rodrigues MM

更新日期：1999-02-01 00:00:00

abstract：AIMS:Industrial growth has increased the exposure to endocrine disruptor compounds (EDCs) in all organisms. Bisphenol A (BPA), an EDC, has been demonstrated to be involved in the susceptibility to parasite infections. However, few studies have analysed this connection in more depth. The aim of this study was to determi...

journal_title：Parasite immunology

authors： Nava-Castro KE,Togno-Peirce C,Palacios-Arreola MI,Del Rio-Araiza VH,Hernandez-Bello R,Morales Montor J

更新日期：2020-09-01 00:00:00

abstract：:TSOL18 is a recombinant protein that has been shown in repeated experimental trials to be capable of protecting pigs against challenge infection with the cestode parasite Taenia solium. Antibodies raised by the vaccine are capable of killing the parasite in an in vitro culture and it is believed that antibody and comp...

journal_title：Parasite immunology

authors： Assana E,Gauci CG,Kyngdon CT,Zoli AP,Dorny P,Geerts S,Lightowlers MW

更新日期：2010-06-01 00:00:00

abstract：:Male B10 X 129 (10M) ScSn mice were relatively resistant to cutaneous leishmaniasis, while females frequently developed non-healing expanding ulcers, leading to loss of infected extremities, metastasis to distal skin sites, and in some animals, death. Anti-leishmanial antibody titers were higher, and delayed-type hype...

journal_title：Parasite immunology

authors： Giannini MS

更新日期：1986-01-01 00:00:00

abstract：:Resistance to S. mansoni cercarial challenge, induced by prior infection of rats with cercariae, is analysed by substitution of alternatives to the primary cercarial exposure. Intravenous injections of either live or killed 4-week stage worms have been examined, utilizing two different routes of injection, one or two ...

journal_title：Parasite immunology

authors： Knopf PM,Spitalny KC,Dang A

更新日期：1984-03-01 00:00:00

abstract：:A longitudinal study was undertaken in Burkina Faso among 293 children aged 6 months to 9 years in order to determine the correlation between an antibody response to several individual malarial antigens and malarial infection. It was found that the presence of a positive antibody response at the beginning of the rainy...

journal_title：Parasite immunology

authors： Meraldi V,Nebié I,Tiono AB,Diallo D,Sanogo E,Theisen M,Druilhe P,Corradin G,Moret R,Sirima BS

更新日期：2004-06-01 00:00:00

abstract：:We have studied the properties of 16 newly derived monoclonal antibodies (MoAbs) against Pfs230, a gamete surface protein of Plasmodium falciparum and a target of transmission-blocking antibodies. All 16 MoAbs recognized Pfs230 by immunoprecipitation from non-ionic detergent extracts of the protein radio-labelled with...

journal_title：Parasite immunology

authors： Read D,Lensen AH,Begarnie S,Haley S,Raza A,Carter R

更新日期：1994-10-01 00:00:00

abstract：:The current study aimed to detect the complement-binding proteins in the excretory-secretory (ES) products of adult filarial parasite Setaria equina (SeqES). Tests for complement activation pathways (CH50 and APH50 ) in normal human serum (NHS) after incubation with SeqES were performed. Quantitative detection of comp...

journal_title：Parasite immunology

authors： Abdel-Latif M

更新日期：2020-02-01 00:00:00

abstract：:ES-62 is a glycoprotein secreted by the filarial nematode Acanthocheilonema viteae that protects against ovalbumin (OVA)-induced airway hyper-responsiveness in mice by virtue of covalently attached anti-inflammatory phosphorylcholine (PC) residues. We have recently generated a library of small molecule analogues (SMAs...

journal_title：Parasite immunology

authors： Janicova L,Rzepecka J,Rodgers DT,Doonan J,Bell KS,Lumb FE,Suckling CJ,Harnett MM,Harnett W

更新日期：2016-06-01 00:00:00

abstract：:The caecal-dwelling nematode Trichuris muris provides a natural model of human whipworm infection. Resistance to T. muris is dependent on a host Th2 response, and CD4+Th2 cells migrate to the gut-associated lymphoid tissue (GALT) to elicit parasite expulsion. Thus, CD4+T cells infiltrate the caecal lamina propria duri...

journal_title：Parasite immunology

authors： Bell LV,Else KJ

更新日期：2008-03-01 00:00:00

abstract：:Isotype/subclass-specific antibody responses to adult Onchocerca volvulus extract (OvAg) were assessed by both ELISA and immunoblotting for a group of putatively immune individuals (PIs, n = 29) from a hyperendemic area in Ecuador and for a group of infected individuals (INFs, n = 470) from the same regions. As a grou...

journal_title：Parasite immunology

authors： Stewart GR,Elson L,Araujo E,Guderian R,Nutman TB,Bradley JE

更新日期：1995-07-01 00:00:00

abstract：BACKGROUND:Fasciola hepatica causes economically important disease in livestock worldwide. The relevance of this parasitic infection extends beyond its direct consequences due to its immunoregulatory properties. OBJECTIVES:Given the importance of the T helper 1 (Th1) immune response in controlling infections with Myco...

journal_title：Parasite immunology

authors： Naranjo-Lucena A,García-Campos A,Garza-Cuartero L,Britton L,Blanco A,Zintl A,Mulcahy G

更新日期：2020-11-01 00:00:00

abstract：:A surface enriched fraction was prepared from adults of Onchocerca volvulus by brief extraction of entire worms with detergent. This was then gel filtered to yield a low molecular weight fraction which functioned specifically in ELISA analysis. An identical result was also obtained when the related cattle parasite, O....

journal_title：Parasite immunology

authors： Cabrera Z,Parkhouse RM

更新日期：1987-01-01 00:00:00

abstract：:Although the precise host-defence mechanisms are not completely understood, T-cell-mediated immune responses are believed to play a pivotal role in controlling parasite infection. In this study, the potential HLA*A2 restricted peptides were predicted and the ability of peptides to bind HLA-A*02 was confirmed by a MHC ...

journal_title：Parasite immunology

authors： Dikhit MR,Amit A,Singh AK,Kumar A,Mansuri R,Sinha S,Topno RK,Mishra R,Das VNR,Pandey K,Sahoo GC,Ali V,Bimal S,Das P

更新日期：2017-09-01 00:00:00

abstract：:CD4(+) T cells play a critical role in determining the disease outcome in murine cutaneous leishmaniasis, and selective usage of T-cell receptor (TCR) is implied in promoting Leishmania major infection. However, little information is available on TCR usage in Leishmania-specific, IFN-γ-producing CD4(+) T cells. In thi...

journal_title：Parasite immunology

authors： Xin L,Wanderley JL,Wang Y,Vargas-Inchaustegui DA,Soong L

更新日期：2011-03-01 00:00:00

abstract：:Antigen specific and concanavalin A (Con A)-induced lymphocyte blastogenesis responses were monitored in the spleens of rats infected with Plasmodium berghei. Con A responses were depressed only at the time of peak parasitaemia. The antigen specific blastogenesis response was either not in evidence, or at a low level ...

journal_title：Parasite immunology

authors： Raybourne R,Desowitz RS,Sanghirun C

更新日期：1984-09-01 00:00:00

abstract：:Lysates of the haematoprotozoa Trypanosoma brucei or Plasmodium berghei stimulated murine peritoneal exudate cells to release a mediator, which suppressed lipoprotein lipase activity in differentiating 3T3-L1 preadipocytes. The parasite-induced mediator suppressed the activity of cell surface lipoprotein lipase up to ...

journal_title：Parasite immunology

authors： Hotez PJ,Le Trang N,Fairlamb AH,Cerami A

更新日期：1984-05-01 00:00:00

abstract：:Antigenic proteins of Echinostoma caproni (Trematoda) against mouse IgM, IgA, IgG, IgG1 and IgG2a were investigated by immunoproteomics. Excretory/secretory products (ESP) of E. caproni separated by two-dimensional (2D) gel electrophoresis were transferred to nitrocellulose membranes and probed with the different mous...

journal_title：Parasite immunology

authors： Sotillo J,Valero L,Sánchez Del Pino MM,Fried B,Esteban JG,Marcilla A,Toledo R

更新日期：2008-05-01 00:00:00

abstract：:We demonstrated recently that immunization with recombinant Neospora caninum profilin (rNcPRO) induces limited protection and a regulatory T-cell response in mice. The aim of this study was to evaluate the immune response elicited by rNcPRO in cattle and assess a strategy to enhance its immunogenicity, combining the a...

journal_title：Parasite immunology

authors： Mansilla FC,Quintana ME,Cardoso NP,Capozzo AV

更新日期：2016-11-01 00:00:00

abstract：:CBA/J mice are resistant to Leishmania major infection but are permissive to L. amazonensis infection. In addition, CBA/J macrophages control L. major but not L. amazonensis infection in vitro. Phagocytosis by macrophages is known to determine the outcome of Leishmania infection. Pattern recognition receptors (PRR) ad...

journal_title：Parasite immunology

authors： Gomes IN,Palma LC,Campos GO,Lima JG,DE Almeida TF,DE Menezes JP,Ferreira CA,Santos RR,Buck GA,Manque PA,Ozaki LS,Probst CM,DE Freitas LA,Krieger MA,Veras PS

更新日期：2009-04-01 00:00:00