Abstract:
:Visceral leishmaniasis (VL) or Kala azar (KA) is a systemic disease caused by the parasites of the Leishmania donovani complex. Control measures rely on treatment with antileishmanial agents, however, fraught with problems such as toxicity or drug resistance. The incidence rate is on the rise for children, for reasons yet undefined. Previously we have shown significantly elevated level of IL-10 in children compared to adult KA cases. Here, antileishmanial antibody and C-reactive protein (CRP) levels were investigated in paediatrics and adult patients of KA and post-KA dermal leishmaniasis (PKDL). Level of IgG4 was significantly elevated in PKDL compared to KA, although total IgG and IgG1 were significantly lower. The antileishmania antibody levels of subclass IgG3 and IgG4 were found significantly elevated in paediatrics, however, levels of IgG, IgG1, IgG2 and CRP were comparable in paediatric and adult KA cases. In case of PKDL, levels of IgG and it subclass were similar in the two groups. No significant difference in antileishmanial antibody level was noticed between macular or polymorphic cases of PKDL. The differential antibody intensity in paediatric cases, together with significant level of circulating IL-10, could be considered as a marker of differential disease susceptibility.
journal_name
Parasite Immunoljournal_title
Parasite immunologyauthors
Ansari NA,Kumar R,Raj A,Salotra Pdoi
10.1111/j.1365-3024.2008.01036.xsubject
Has Abstractpub_date
2008-08-01 00:00:00pages
403-9issue
8eissn
0141-9838issn
1365-3024pii
PIM1036journal_volume
30pub_type
杂志文章abstract::Polyclonal human anti-hydatid antibodies were affinity purified from a hydatid patient serum and used to produce a rabbit anti-idiotypic serum. These anti-Id antibodies cross-reacted in ELISA with sera from 11 of 12 hydatid patients studied and with 13 infected or immunized mice sera. All mice primed and boosted with ...
journal_title:Parasite immunology
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journal_title:Parasite immunology
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journal_title:Parasite immunology
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journal_title:Parasite immunology
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journal_title:Parasite immunology
pub_type: 杂志文章
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journal_title:Parasite immunology
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pub_type: 杂志文章,评审
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更新日期:2006-07-01 00:00:00
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journal_title:Parasite immunology
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更新日期:2004-11-01 00:00:00
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journal_title:Parasite immunology
pub_type: 杂志文章
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journal_title:Parasite immunology
pub_type: 杂志文章,评审
doi:10.1111/j.1365-3024.2009.01110.x
更新日期:2009-07-01 00:00:00
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更新日期:2012-08-01 00:00:00
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journal_title:Parasite immunology
pub_type: 杂志文章
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更新日期:2007-09-01 00:00:00
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journal_title:Parasite immunology
pub_type: 杂志文章
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更新日期:2014-05-01 00:00:00
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journal_title:Parasite immunology
pub_type: 杂志文章
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更新日期:1997-02-01 00:00:00
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pub_type: 杂志文章
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journal_title:Parasite immunology
pub_type: 杂志文章
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更新日期:1984-05-01 00:00:00
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journal_title:Parasite immunology
pub_type: 杂志文章,评审
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更新日期:2005-10-01 00:00:00
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journal_title:Parasite immunology
pub_type: 杂志文章
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更新日期:2000-07-01 00:00:00
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journal_title:Parasite immunology
pub_type: 杂志文章
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journal_title:Parasite immunology
pub_type: 杂志文章
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更新日期:1990-03-01 00:00:00
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journal_title:Parasite immunology
pub_type: 杂志文章
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更新日期:2008-11-01 00:00:00
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journal_title:Parasite immunology
pub_type: 杂志文章
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更新日期:2015-12-01 00:00:00
abstract::The present paper reviews the available literature on the development of immunity to animal Schistosoma infections. The majority of the studies on animal schistosomiasis were performed in cattle and pigs and only Schistosoma mattheei, S. bovis and S. japonicum received particular attention, mainly because of their rec...
journal_title:Parasite immunology
pub_type: 杂志文章,评审
doi:10.1111/j.1365-3024.2005.00766.x
更新日期:2005-07-01 00:00:00
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journal_title:Parasite immunology
pub_type: 杂志文章,评审
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更新日期:2015-06-01 00:00:00
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journal_title:Parasite immunology
pub_type: 杂志文章
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更新日期:2002-03-01 00:00:00