Abstract:
:During African trypanosomiasis, macrophages play a central role in T cell hyporesponsiveness to parasite-related and unrelated antigens. In this study, the ability of macrophages from Trypanosoma b. brucei-infected mice to present exogenous antigens to a major histocompatibility complex (MHC) class II-restricted CD4+ T cell hybridoma was analysed. We demonstrate that the antigen presentation capacity of macrophages from infected mice is markedly reduced as a result of a lower expression of [MHC class II-peptide] complexes on their plasma membrane. This defect did not result from a decreased antigen uptake/catabolism, a reduced MHC class II and intercellular adhesion molecule 1 expression on the surface of macrophages, a decreased affinity of MHC class II molecules for antigenic peptides, a competition between exogenous and parasite antigens, or the generation of inhibitory peptides. Our data indicate that the step resulting in coexpression of processed antigens and MHC class II molecules is affected in T. b. brucei-infected mice. Additionally, macrophages from infected mice secreted IL-10 that in turn contributes to the impairment of T cell activation.
journal_name
Parasite Immunoljournal_title
Parasite immunologyauthors
Namangala B,Brys L,Magez S,De Baetselier P,Beschin Adoi
10.1046/j.1365-3024.2000.00314.xkeywords:
subject
Has Abstractpub_date
2000-07-01 00:00:00pages
361-70issue
7eissn
0141-9838issn
1365-3024pii
pim314journal_volume
22pub_type
杂志文章abstract::Specific CD8(-) T-lymphocyte (CTL) activity against Plasmodium pre-erythrocytic stages (P-ES) derived antigens is considered one of the most important mechanisms for malaria protection. Plasmodium vivax is the second most prevalent human malaria parasite species distributed worldwide. Although several CTL epitopes hav...
journal_title:Parasite immunology
pub_type: 杂志文章
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journal_title:Parasite immunology
pub_type: 杂志文章,评审
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abstract::A limiting dilution microculture system was optimized to quantify the frequency of Theileria parva-specific cytotoxic T lymphocyte precursors (CTLp) in peripheral blood mononuclear cells (PBMC) from immune cattle. Optimal results were obtained with responder cell input levels ranging from 2 x 10(4)/well to 6.25 x 10(2...
journal_title:Parasite immunology
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更新日期:1992-03-01 00:00:00
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journal_title:Parasite immunology
pub_type: 杂志文章
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abstract::The current study aimed to detect the complement-binding proteins in the excretory-secretory (ES) products of adult filarial parasite Setaria equina (SeqES). Tests for complement activation pathways (CH50 and APH50 ) in normal human serum (NHS) after incubation with SeqES were performed. Quantitative detection of comp...
journal_title:Parasite immunology
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journal_title:Parasite immunology
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journal_title:Parasite immunology
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journal_title:Parasite immunology
pub_type: 杂志文章
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更新日期:1996-10-01 00:00:00
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journal_title:Parasite immunology
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doi:10.1111/pim.12779
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journal_title:Parasite immunology
pub_type: 杂志文章,评审
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更新日期:2019-03-01 00:00:00
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journal_title:Parasite immunology
pub_type: 杂志文章
doi:10.1111/j.1365-3024.1993.tb00592.x
更新日期:1993-03-01 00:00:00
abstract::The experimental protocol of immunization tested here confirms its protective effect against Haemonchus contortus in goats. This protection translated into a 65.5% mean reduction in adult worm burden after a homologous challenge, and a significant decrease (73.2%) in cumulative faecal egg counts (FECs). These parasito...
journal_title:Parasite immunology
pub_type: 杂志文章
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更新日期:2018-09-01 00:00:00
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journal_title:Parasite immunology
pub_type: 杂志文章
doi:10.1111/j.1365-3024.2008.01050.x
更新日期:2008-10-01 00:00:00
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journal_title:Parasite immunology
pub_type: 杂志文章
doi:10.1046/j.1365-3024.1998.00185.x
更新日期:1998-10-01 00:00:00
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journal_title:Parasite immunology
pub_type: 杂志文章
doi:10.1046/j.1365-3024.1998.00127.x
更新日期:1998-02-01 00:00:00
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pub_type: 杂志文章,随机对照试验
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更新日期:2017-06-01 00:00:00
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journal_title:Parasite immunology
pub_type: 杂志文章
doi:10.1046/j.1365-3024.1999.00199.x
更新日期:1999-01-01 00:00:00
abstract::The carrier effect, using TNP-labelled schistosomula was used to measure the helper T-cell activity against the schistosomula surface in CBA mice exposed to 30 cercariae of Schistosoma mansoni. After infection the helper T-cell activity reached a peak in 8--10 days, but by 6 weeks it had declined to background levels....
journal_title:Parasite immunology
pub_type: 杂志文章
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更新日期:1981-10-01 00:00:00
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journal_title:Parasite immunology
pub_type: 杂志文章
doi:10.1111/pim.12455
更新日期:2017-10-01 00:00:00
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journal_title:Parasite immunology
pub_type: 杂志文章
doi:
更新日期:1998-04-01 00:00:00
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journal_title:Parasite immunology
pub_type: 杂志文章
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更新日期:1988-01-01 00:00:00
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journal_title:Parasite immunology
pub_type: 杂志文章
doi:10.1111/j.1365-3024.2005.00760.x
更新日期:2005-05-01 00:00:00
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journal_title:Parasite immunology
pub_type: 杂志文章
doi:10.1046/j.1365-3024.1998.00160.x
更新日期:1998-08-01 00:00:00
abstract::The immunological basis of resistance to Brugia pahangi infection in rats was studied. Infections were investigated in athymic rnu/rnu rats and in rats treated with the immuno-suppressive agents cyclosporin A (CsA) or cyclophosphamide (Cy). The recovery of adult worms in normal rats was 1-2% in comparison to 12.2% rec...
journal_title:Parasite immunology
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更新日期:1992-07-01 00:00:00
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journal_title:Parasite immunology
pub_type: 杂志文章,评审
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更新日期:2017-02-01 00:00:00
abstract::Research on infectious agents as a possible cause of schizophrenia has become prominent in the past decade. Toxoplasma gondii has emerged as a prime candidate for a variety of reasons; (i) many studies have reported that individuals with schizophrenia, compared to controls, have a higher prevalence of antibodies to T....
journal_title:Parasite immunology
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更新日期:2009-11-01 00:00:00
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journal_title:Parasite immunology
pub_type: 杂志文章
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更新日期:1989-07-01 00:00:00
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journal_title:Parasite immunology
pub_type: 杂志文章
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更新日期:1999-02-01 00:00:00
abstract::Type I hypersensitivity reactions in the intestinal tract of sensitized animals may contribute to resistance to reinfection with Fasciola hepatica. Colonic mucosae isolated from previously infected rats were voltage clamped in Ussing chambers. Antigen was prepared as a crude homogenate from adult liver fluke. Assay of...
journal_title:Parasite immunology
pub_type: 杂志文章
doi:10.1111/j.1365-3024.1993.tb00630.x
更新日期:1993-08-01 00:00:00
abstract::In this study, supplementation with the probiotic Saccharomyces boulardii promoted a reduction in intensity of infection by Toxocara canis and modulates cytokines mRNA expression in experimentally infected mice. IL-12 gene transcription had 40-fold increase in S. boulardii supplemented uninfected mice and sevenfold in...
journal_title:Parasite immunology
pub_type: 杂志文章
doi:10.1111/pim.12314
更新日期:2016-05-01 00:00:00