Comparison of antibody and protective immune responses against Trypanosoma cruzi infection elicited by immunization with a parasite antigen delivered as naked DNA or recombinant protein.

abstract：:Activation of macrophages is a key step in the initiation of immune responses, but the transcriptional mechanisms governing macrophage activation during infection are not fully understood. It was recently shown that the AP-1 family transcription factor JUNB positively regulates macrophage activation in response to Tol...

journal_title：Parasite immunology

authors： Fontana MF,Baccarella A,Kellar D,Oniskey TK,Terinate P,Rosenberg SD,Huang EJ,Herbert DR,Kim CC

更新日期：2015-09-01 00:00:00

abstract：:Cysteine proteinase enriched fractions obtained by thiol-sepharose chromatography of Ostertagia ostertagi membrane-bound protein extract (S3-thiol) or total adult excretory-secretory (ES-thiol) products were tested in a vaccination experiment to evaluate their protective efficacy against O. ostertagi in cattle. Calves...

journal_title：Parasite immunology

authors： Geldhof P,Claerebout E,Knox D,Vercauteren I,Looszova A,Vercruysse J

更新日期：2002-05-01 00:00:00

abstract：:The carrier effect, using TNP-labelled schistosomula was used to measure the helper T-cell activity against the schistosomula surface in CBA mice exposed to 30 cercariae of Schistosoma mansoni. After infection the helper T-cell activity reached a peak in 8--10 days, but by 6 weeks it had declined to background levels....

journal_title：Parasite immunology

authors： Ramalho-Pinto FJ,Smithers SR

更新日期：1981-10-01 00:00:00

abstract：:Helminth parasites induce a strong Th2 response, characterized by high levels of IgE and elevated signature cytokines such as IL-5. As many global deworming programmes are underway, there is concern that this might lead to emergence of Th1-mediated pathologies when the counterbalancing helminth-induced Th2 response is...

journal_title：Parasite immunology

authors： de Ruiter K,Tahapary DL,Wammes LJ,Wiria AE,Hamid F,van Lieshout L,Smit JWA,Houwing-Duistermaat JJ,Sartono E,Supali T,Yazdanbakhsh M

更新日期：2017-06-01 00:00:00

abstract：:African trypanosomes cause human and animal African trypanosomiases, which are chronic, debilitating and often fatal diseases of people and livestock in sub-Saharan Africa. The extracellular protozoan parasites are exemplars of antigenic variation. They direct host-protective B-cell and T-cell immune responses towards...

journal_title：Parasite immunology

authors： Black SJ,Mansfield JM

更新日期：2016-12-01 00:00:00

abstract：:In the present study, the cytokines interleukin (IL)-12 and IL-18 were evaluated for their capacity to modulate and to re-direct in vitro parasite antigen-specific cellular responsiveness in patients exposed to Onchocerca volvulus and Entamoeba histolytica infection. We found that IL-18 was highly capable of reducing ...

journal_title：Parasite immunology

authors： Pfaff AW,Kirch AK,Hoffmann WH,Banla M,Schulz-Key H,Geiger SM,Soboslay PT

更新日期：2003-06-01 00:00:00

abstract：:Particular immunopathological features and their effects on the vascular permeability of different ocular structures were analysed in two dogs naturally infected by Leishmania infantum. The existence of specific anti-Leishmania immunoglobulin G (IgG) in the aqueous humour was confirmed by the ELISA technique. There wa...

journal_title：Parasite immunology

authors： García-Alonso M,Blanco A,Reina D,Serrano FJ,Alonso C,Nieto CG

更新日期：1996-12-01 00:00:00

abstract：:In schistosomiasis endemic areas, intensities of reinfection after treatment are greater amongst young children than amongst adults, and high levels of parasite-specific IgE are associated with resistance to reinfection in an age-dependent manner. Previously we have reported that, in Western blots, a 22 kDa band was r...

journal_title：Parasite immunology

authors： Dunne DW,Webster M,Smith P,Langley JG,Richardson BA,Fulford AJ,Butterworth AE,Sturrock RF,Kariuki HC,Ouma JH

更新日期：1997-02-01 00:00:00

abstract：:Peripheral blood eosinophilia, histology of skeletal muscle and brain, and larval recovery were compared between congenitally athymic nude mice (nu/nu) and thymus-bearing heterozygous littermates (nu/+) for 6 weeks following oral infection with Toxocara canis eggs. By comparing patterns of peripheral blood eosinophil ...

journal_title：Parasite immunology

authors： Sugane K,Oshima T

更新日期：1982-09-01 00:00:00

abstract：:The K1 peptide is a CD8(+)T cell HLA-A*0201-restricted epitope derived from the Trypanosoma cruzi KMP-11 protein. We have previously shown that this peptide induces IFN-gamma secretion by CD8(+)T cells. The aim of this study was to characterize the frequency of K1-specific CD8(+)T cells in chagasic patients. Nineteen ...

journal_title：Parasite immunology

authors： Lasso P,Mesa D,Cuéllar A,Guzmán F,Bolaños N,Rosas F,Velasco V,Thomas Mdel C,Lopez MC,Gonzalez JM,Puerta CJ

更新日期：2010-07-01 00:00:00

abstract：:We describe an ELISA for trophozoite-specific IgA in the intestinal secretions of mice infected with Giardia muris. Using this method, trophozoite-specific IgA was demonstrated in intestinal secretions of Giardia-infected immunocompetent BALB/c mice. Such antibody was undetectable in the intestinal secretions of Giard...

journal_title：Parasite immunology

authors： Heyworth MF,Kung JE,Caplin AB

更新日期：1988-11-01 00:00:00

abstract：:Ascariasis is the most frequent soil transmitted helminthiasis and, as well as other helminth infections, is expected to influence the clinical presentation of allergic diseases such as asthma. Indeed, several clinical and experimental works have shown an important impact either increasing or suppressing symptoms, and...

journal_title：Parasite immunology

authors： Caraballo L,Acevedo N,Zakzuk J

更新日期：2019-06-01 00:00:00

abstract：:Despite the plethora of evidence on the consequences of host nutrition on their immune responses to gastrointestinal parasites, the identity of molecules and mechanisms that drive the manifestations of immunity under nutrient abundance are not yet known. This is partly due to limitations of the methodologies employed ...

journal_title：Parasite immunology

authors： Athanasiadou S,Huntley JF

更新日期：2008-02-01 00:00:00

abstract：:We investigated the immune effector mechanisms that underlie protection against F. hepatica in the gut wall of immune rats, using (immuno)histochemistry. In the lamina propria of immune Wistar rats, four weeks after oral infection, frequencies of IgE-positive cells, eosinophils and mucosal mast cells were significantl...

journal_title：Parasite immunology

authors： Van Milligen FJ,Cornelissen JB,Hendriks IM,Gaasenbeek CP,Bokhout BA

更新日期：1998-06-01 00:00:00

abstract：:Na-ASP-2 is a major protein secreted by infective third-stage larvae (L3) of the human hookworm Necator americanus upon host entry. It was chosen as a lead vaccine candidate for its ability to elicit protective immune responses. However, clinical development of this antigen as a recombinant vaccine was halted because ...

journal_title：Parasite immunology

authors： Zhan B,Santiago H,Keegan B,Gillespie P,Xue J,Bethony J,de Oliveira LM,Jiang D,Diemert D,Xiao SH,Jones K,Feng X,Hotez PJ,Bottazzi ME

更新日期：2012-08-01 00:00:00

abstract：AIMS:Merozoite surface protein 8 (MSP-8) of Plasmodium parasites plays an important role in erythrocyte invasion and is a potential malaria vaccine candidate. METHODS AND RESULTS:In this study, virus-like particles (VLPs) expressing MSP-8 of Plasmodium berghei on the surface of influenza virus matrix protein 1 (M1) co...

journal_title：Parasite immunology

authors： Lee SH,Chu KB,Kang HJ,Basak S,Kim MJ,Park H,Jin H,Moon EK,Quan FS

更新日期：2020-11-01 00:00:00

abstract：:In a double-blind study 393 seronegative dogs, residing in a holoendemic area for Leishmania donovani infantum infection, were randomly assigned to an immunization with a partly purified L.d. infantum-derived preparation, or received adjuvant only. During the first year of the study period the rate of infection was si...

journal_title：Parasite immunology

authors： Dunan S,Frommel D,Monjour L,Ogunkolade BW,Cruz A,Quilici M

更新日期：1989-07-01 00:00:00

abstract：:Over the past several decades, outbreaks of emerging infectious diseases (EIDs) in wild birds have attracted worldwide media attention, either because of their extreme virulence or because of alarming spillovers into agricultural animals or humans. The pathogens involved have been found to infect a variety of bird hos...

journal_title：Parasite immunology

authors： Staley M,Bonneaud C

更新日期：2015-05-01 00:00:00

abstract：:Factors governing the sensitization or desensitization of basophils and mast cells are discussed. Mathematical models are proposed which illustrate the effects of rising or falling specific or non-specific IgE titres on the tendency of these cells to degranulate. The models presented are consistent with the hypothesis...

journal_title：Parasite immunology

authors： Weltman JK,Senft AW

更新日期：1981-07-01 00:00:00

abstract：:The objective of this study was to evaluate abomasal cytokine responses in helminth-naive calves and calves vaccinated with protective antigen fractions from Ostertagia ostertagi after an experimental challenge infection with infective third stage (L3) larvae. Abomasal lymph nodes and/or abomasal mucosa were collected...

journal_title：Parasite immunology

authors： Claerebout E,Vercauteren I,Geldhof P,Olbrechts A,Zarlenga DS,Goddeeris BM,Vercruysse J

更新日期：2005-09-01 00:00:00

abstract：:During African trypanosomiasis, macrophages play a central role in T cell hyporesponsiveness to parasite-related and unrelated antigens. In this study, the ability of macrophages from Trypanosoma b. brucei-infected mice to present exogenous antigens to a major histocompatibility complex (MHC) class II-restricted CD4+ ...

journal_title：Parasite immunology

authors： Namangala B,Brys L,Magez S,De Baetselier P,Beschin A

更新日期：2000-07-01 00:00:00

abstract：:In modern societies, diseases that are driven by dysregulated immune responses are increasing at an alarming pace, such as inflammatory bowel diseases and diabetes. There is an urgent need to understand these epidemiological trends, which are likely to be driven by the changing environment of the last few decades. The...

journal_title：Parasite immunology

authors： Loke P,Lim YA

更新日期：2015-06-01 00:00:00

abstract：:Cryptosporidiosis is a zoonotic protozoan disease that affects the gastrointestinal tract of animals and humans. Diarrhoea as the most important indication of the infection leads to high economic losses in livestock industries and is a life threatening infection in immunocompromised individuals. In the absence of the ...

journal_title：Parasite immunology

authors： Askari N,Shayan P,Mokhber-Dezfouli MR,Ebrahimzadeh E,Lotfollahzadeh S,Rostami A,Amininia N,Ragh MJ

更新日期：2016-05-01 00:00:00

abstract：:Trichuris muris is an intestinal nematode that invades the colonic epithelium triggering a mucosal inflammation. Vitamin A and its active metabolite retinoic acid are strongly linked with the modulation of gut immune responses. Here, we describe the temporal changes in the expression of aldehyde dehydrogenase (ALDH) e...

journal_title：Parasite immunology

authors： Hurst RJ,Else KJ

更新日期：2013-07-01 00:00:00

abstract：:We have characterized various anti-schistosomular surface MoAbs previously shown to partially block in-vitro killing of schistosomula by human sera and eosinophils (Dunne et al. 1987). Immunodiffusion analysis showed that four IgM and one IgG3 MoAbs recognized periodate sensitive epitopes on the same molecular species...

journal_title：Parasite immunology

authors： Bickle QD,Andrews BJ

更新日期：1988-03-01 00:00:00

abstract：:Helper T cell cytokine and antibody responses were investigated in mice after infection with Babesia microti (King strain). Infection of CBA mice with 106 parasitized erythrocytes resulted in the development of a transitory high parasitaemia which peaked 14 days post infection (DPI), and was resolved at 24 DPI. Th1 re...

journal_title：Parasite immunology

authors： Chen D,Copeman DB,Burnell J,Hutchinson GW

更新日期：2000-02-01 00:00:00

abstract：:Parasitic nematodes are constantly exposed to the immune effector mechanisms of their hosts. One strategy of the worms to cope with these defence reactions is the secretion of modulatory proteins that down-regulate cell-mediated immune responses. We analysed the proliferation of mesenteric lymph node cells of mice inf...

journal_title：Parasite immunology

authors： Rzepecka J,Lucius R,Doligalska M,Beck S,Rausch S,Hartmann S

更新日期：2006-09-01 00:00:00

abstract：:Serum antibody responses of mice exposed to Philippine isolates of Schistosoma japonicum have been analysed by immunoprecipitation of exogenously radiolabelled antigens extracted from adult worms. Attention was focused on labelled protein antigens differentially recognized by sera of mice that differ genetically in th...

journal_title：Parasite immunology

authors： Mitchell GF,Beall JA,Cruise KM,Tiu WU,Garcia EG

更新日期：1985-03-01 00:00:00

abstract：:Type I hypersensitivity reactions in the intestinal tract of sensitized animals may contribute to resistance to reinfection with Fasciola hepatica. Colonic mucosae isolated from previously infected rats were voltage clamped in Ussing chambers. Antigen was prepared as a crude homogenate from adult liver fluke. Assay of...

journal_title：Parasite immunology

authors： O'Malley KE,Sloan T,Joyce P,Baird AW

更新日期：1993-08-01 00:00:00

abstract：:Leishmania major causes mild-to-severe cutaneous lesions resulting in significant disfigurations, if untreated. The drugs are toxic, and drug-resistance parasites are emerging. Therefore, a prophylactic vaccination is an urgent need. As no vaccine is available, we compared the genes expressed by virulent and avirulent...

journal_title：Parasite immunology

authors： Zutshi S,Kumar S,Sarode A,Roy S,Sarkar A,Saha B

更新日期：2020-02-01 00:00:00