Abstract:
:Trichuris muris is an intestinal nematode that invades the colonic epithelium triggering a mucosal inflammation. Vitamin A and its active metabolite retinoic acid are strongly linked with the modulation of gut immune responses. Here, we describe the temporal changes in the expression of aldehyde dehydrogenase (ALDH) enzymes, responsible for converting dietary-absorbed vitamin A into the immuno-modulatory retinoic acid in lamina propria leucocytes post-infection. We show that ALDH enzymes are expressed by both colonic macrophages and dendritic cells. Further, during an on-going T. muris infection, ALDH expression is repressed from uninfected levels and only recovers to normal levels following expulsion of the parasite. These results suggest that local regulation of cellular levels of retinoic acid is an important component of infection-driven inflammation.
journal_name
Parasite Immunoljournal_title
Parasite immunologyauthors
Hurst RJ,Else KJdoi
10.1111/pim.12032subject
Has Abstractpub_date
2013-07-01 00:00:00pages
229-33issue
7-8eissn
0141-9838issn
1365-3024journal_volume
35pub_type
杂志文章abstract::Studies to clarify the mechanisms of apoptosis in host cells, A31 (BALB/3T3 clone A31 fibroblasts), caused by two intracellular protozoan parasites, Toxoplasma gondii and Neospora caninum, were carried out in an in vitro system. The viability of N. caninum-infected cells was significantly reduced following treatment w...
journal_title:Parasite immunology
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journal_title:Parasite immunology
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journal_title:Parasite immunology
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journal_title:Parasite immunology
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journal_title:Parasite immunology
pub_type: 杂志文章
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journal_title:Parasite immunology
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journal_title:Parasite immunology
pub_type: 杂志文章
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journal_title:Parasite immunology
pub_type: 杂志文章
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journal_title:Parasite immunology
pub_type: 杂志文章
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更新日期:1983-09-01 00:00:00
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journal_title:Parasite immunology
pub_type: 杂志文章
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更新日期:1999-02-01 00:00:00
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journal_title:Parasite immunology
pub_type: 杂志文章
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journal_title:Parasite immunology
pub_type: 杂志文章
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journal_title:Parasite immunology
pub_type: 杂志文章
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pub_type: 临床试验,杂志文章,随机对照试验
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journal_title:Parasite immunology
pub_type: 杂志文章
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更新日期:1986-03-01 00:00:00
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pub_type: 杂志文章
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journal_title:Parasite immunology
pub_type: 杂志文章,评审
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更新日期:2009-07-01 00:00:00
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journal_title:Parasite immunology
pub_type: 杂志文章
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更新日期:2011-11-01 00:00:00
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journal_title:Parasite immunology
pub_type: 杂志文章,评审
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更新日期:2013-09-01 00:00:00
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journal_title:Parasite immunology
pub_type: 杂志文章
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更新日期:1997-02-01 00:00:00