Abstract:
:We have cloned the cDNA of TBA-1, the Nematode polyprotein allergen (NPA) of Toxocara canis and found it to be most similar to ABA-1, the Ascaris NPA, on the basis of amino acid sequence. We could study the antigenic properties of an E-coli synthesized fusion protein prepared with the cloned gene since no glycosylation site was expected from the deduced amino acid sequence. Although no IgE responses to TBA-1 were detected, recombinant TBA-1 was differently recognized by serum IgG antibodies when the recombinant TBA-1 was directly adsorbed vs when immobilized via a streptavidin linkage on polystyrene microtitre wells. One group of sera recognized TBA-1 directly immobilized while the second only recognized TBA-1 immobilized via streptavidin linkage. The former were from rodents immunized with a Toxocara sp. adult worm extract while the latter were obtained from rodents infected with T. canis larva or immunized with a Anisakis simplex L3 larval extract. These observations suggest that the two in vivo forms of TBA-1 are expressed, but during different stages of the parasite's life cycle.
journal_name
Parasite Immunoljournal_title
Parasite immunologyauthors
Yahiro S,Cain G,Butler JEdoi
10.1046/j.1365-3024.1998.00160.xsubject
Has Abstractpub_date
1998-08-01 00:00:00pages
351-7issue
8eissn
0141-9838issn
1365-3024journal_volume
20pub_type
杂志文章abstract::Attempts to produce monoclonal antibodies specific for a parasite-encoded or induced antigen on the surface of Theileria parva lawrencei-transformed bovine lymphocytes resulted in the identification of the monoclonal antibody J7. This antibody recognizes a membrane glycoprotein on some T.p. lawrencei-infected bovine l...
journal_title:Parasite immunology
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journal_title:Parasite immunology
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journal_title:Parasite immunology
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journal_title:Parasite immunology
pub_type: 杂志文章
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更新日期:1990-01-01 00:00:00
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journal_title:Parasite immunology
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更新日期:1979-01-01 00:00:00
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journal_title:Parasite immunology
pub_type: 杂志文章
doi:10.1111/pim.12310
更新日期:2016-04-01 00:00:00
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journal_title:Parasite immunology
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更新日期:2020-02-01 00:00:00
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journal_title:Parasite immunology
pub_type: 杂志文章,评审
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更新日期:2007-12-01 00:00:00
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更新日期:2020-02-01 00:00:00
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pub_type: 杂志文章,随机对照试验
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更新日期:2017-06-01 00:00:00
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journal_title:Parasite immunology
pub_type: 杂志文章
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更新日期:2009-04-01 00:00:00
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journal_title:Parasite immunology
pub_type: 杂志文章,评审
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更新日期:2009-07-01 00:00:00
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journal_title:Parasite immunology
pub_type: 杂志文章
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更新日期:1996-01-01 00:00:00