Active suppression of interleukin 2 secretion in mice infected with Trypanosoma brucei AnTat 1.1.E.

abstract：:Modulation of macrophage/dendritic cell (DC) cytokine production by the filarial nematode phosphorylcholine (PC)-containing product, ES-62, is mediated by Toll-like receptor (TLR) 4 and signal transduction depends on the TLR adaptor MyD88. Intriguingly, comparison of TLR4 knock-out (ko) mice with TLR4 mutant C3H/HeJ m...

journal_title：Parasite immunology

authors： Goodridge HS,McGuiness S,Houston KM,Egan CA,Al-Riyami L,Alcocer MJ,Harnett MM,Harnett W

更新日期：2007-03-01 00:00:00

abstract：AIMS:Industrial growth has increased the exposure to endocrine disruptor compounds (EDCs) in all organisms. Bisphenol A (BPA), an EDC, has been demonstrated to be involved in the susceptibility to parasite infections. However, few studies have analysed this connection in more depth. The aim of this study was to determi...

journal_title：Parasite immunology

authors： Nava-Castro KE,Togno-Peirce C,Palacios-Arreola MI,Del Rio-Araiza VH,Hernandez-Bello R,Morales Montor J

更新日期：2020-09-01 00:00:00

abstract：:Leishmania enter macrophages through receptor-mediated phagocytosis and survive the harsh environment of a phagolysosome. Here, we investigated the interaction between mannose receptor (MR), Toll-like receptor 2 (TLR2), and Leishmania, and the subsequent impact on phagosome maturation. Leishmania parasites are able to...

journal_title：Parasite immunology

authors： Polando RE,Jones BC,Ricardo C,Whitcomb J,Ballhorn W,McDowell MA

更新日期：2018-04-01 00:00:00

abstract：:In the present study we have investigated and compared in vitro the specific complement (C) activating activity of three metacestode preparations of Echinococcus granulosus. Extracts from hydatid cyst fluid (HCF-ext), protoscoleces (PSC-ext) and hydatid cyst membrane (HCM-ext) activated human C producing C3 conversion...

journal_title：Parasite immunology

authors： Irigoín F,Würzner R,Sim RB,Ferreira AM

更新日期：1996-07-01 00:00:00

abstract：:Infection with Trypanosoma cruzi was established in the reduviid vector, Dipetalogaster maximus, by repeated feedings on mice with high parasitaemias, and metacyclic trypomastigotes (IMT) were collected in insect urine after blood meals. The infectivity of IMT in mice was assessed by placing varying numbers of organis...

journal_title：Parasite immunology

authors： Kirchhoff LV,Hoft DF

更新日期：1990-01-01 00:00:00

abstract：:The previously observed MHC-restriction of the antibody response to an 86kDa S. mansoni antigen has been investigated in more detail. The I-A locus of the H-2 complex has been implicated as conferring responder or non-responder status on mice expressing the k and b alleles respectively. Inheritance of responsiveness w...

journal_title：Parasite immunology

authors： Schweitzer AN,Taylor DW

更新日期：1991-05-01 00:00:00

abstract：:Sheep scab is caused by the noninvasive mite, Psoroptes ovis, which initiates a profound pro-inflammatory skin response leading to lesion development. To investigate these early events between the skin and the parasite, primary ovine epidermal keratinocyte cultures were generated and challenged with mite derived antig...

journal_title：Parasite immunology

authors： Watkins CA,Mackellar A,Frew D,Mackie C,George A,Hopkins J,Burgess ST,McNeilly TN,Huntley JF

更新日期：2009-06-01 00:00:00

abstract：:A surface enriched fraction was prepared from adults of Onchocerca volvulus by brief extraction of entire worms with detergent. This was then gel filtered to yield a low molecular weight fraction which functioned specifically in ELISA analysis. An identical result was also obtained when the related cattle parasite, O....

journal_title：Parasite immunology

authors： Cabrera Z,Parkhouse RM

更新日期：1987-01-01 00:00:00

abstract：:UV-irradiated and gamma-irradiated schistosomula of Schistosoma mansoni induce high levels of resistance to challenge infection in experimental hosts. It was observed that both types of irradiation severely inhibited protein synthesis by the parasite larvae. Schistosomula were treated with the metabolic inhibitor acti...

journal_title：Parasite immunology

authors： Wales A,Kusel JR,Jones JT

更新日期：1992-09-01 00:00:00

abstract：:We have investigated whether a protective immune response occurred in mice infected with a virulent cloned strain of Plasmodium chabaudi. Animals inoculated intravenously with 10(7) parasitized erythrocytes (PE) showed an exponentially increasing parasitaemia and died by day 6 of the infection, presenting a pronounced...

journal_title：Parasite immunology

authors： Falanga PB,Pereira da Silva L

更新日期：1989-11-01 00:00:00

abstract：:DNA immunization represents a promising vaccine strategy that has been reasonably successful, and will likely play an even greater role in vaccine development as these vaccines continue to be improved. We have developed a partially protective DNA vaccine against schistosome infection based on a 23-kDa integral membran...

journal_title：Parasite immunology

authors： Da'Dara AA,Skelly PJ,Walker CM,Harn DA

更新日期：2003-08-01 00:00:00

abstract：:The chromadorea abundant larval transcript (ALT) family of proteins contains ALT one of the most studied putative vaccine candidate in experimental filariasis. This study reports the characterization of Wuchereria bancrofti 20/22 (Wb20/22) as a member of chromadorea, the ALT family of proteins from the L3 stage of W. ...

journal_title：Parasite immunology

authors： Aparnaa R,Mahalakshmi N,Harini A,Jeyaprita PJ,Anugraha G,Amdare NP,Khatri VK,Reddy MV,Kaliraj P

更新日期：2014-10-01 00:00:00

abstract：:Factors governing the sensitization or desensitization of basophils and mast cells are discussed. Mathematical models are proposed which illustrate the effects of rising or falling specific or non-specific IgE titres on the tendency of these cells to degranulate. The models presented are consistent with the hypothesis...

journal_title：Parasite immunology

authors： Weltman JK,Senft AW

更新日期：1981-07-01 00:00:00

abstract：:Fasciola hepatica infection has been shown to suppress sheep lymphocyte proliferation in vitro and this is at least partially attributable to excretory/secretory products (ES) released by F. hepatica parasites. We identified a suppressive component in ES by analysing the effect of ES fractions, separated by gel filtra...

journal_title：Parasite immunology

authors： Prowse RK,Chaplin P,Robinson HC,Spithill TW

更新日期：2002-02-01 00:00:00

abstract：:Cryptocaryon irritans is one of the most important ectoparasites of marine fish. To identify the potential role of immune-related genes in antiparasitic immune responses in fish, we monitored the expression change of IL-8, COX-2, C-type lectin and transferrin in local and systemic immune organs of orange-spotted group...

journal_title：Parasite immunology

authors： Li YW,Dan XM,Zhang TW,Luo XC,Li AX

更新日期：2011-12-01 00:00:00

abstract：:Helminth parasites induce a strong Th2 response, characterized by high levels of IgE and elevated signature cytokines such as IL-5. As many global deworming programmes are underway, there is concern that this might lead to emergence of Th1-mediated pathologies when the counterbalancing helminth-induced Th2 response is...

journal_title：Parasite immunology

authors： de Ruiter K,Tahapary DL,Wammes LJ,Wiria AE,Hamid F,van Lieshout L,Smit JWA,Houwing-Duistermaat JJ,Sartono E,Supali T,Yazdanbakhsh M

更新日期：2017-06-01 00:00:00

abstract：:The protective effect of specific vaccination against Plasmodium berghei (P. berghei) was compared in terms of survival percentage in DBA/2, C3H, outbred albino mice and in two lines of mice produced by selective breeding for either high or low antibody responsiveness to sheep erythrocyte (H and L lines respectively)....

journal_title：Parasite immunology

authors： Heumann AM,Bucci A,Stiffel C,Casaglia O,Zenobi P,Biozzi G

更新日期：1983-03-01 00:00:00

abstract：:Leishmania donovani, the causative parasite of Visceral Leishmaniasis (VL), deviously manipulates host monocytes/macrophages to ensure its survival. Although monocytes/macrophages from patients with VL have demonstrated an impaired oxidative burst and antigen presentation, an unanswered yet pertinent question remains ...

journal_title：Parasite immunology

authors： Roy S,Mukhopadhyay D,Mukherjee S,Moulik S,Chatterji S,Brahme N,Pramanik N,Goswami RP,Saha B,Chatterjee M

更新日期：2018-07-01 00:00:00

abstract：:Male B10 X 129 (10M) ScSn mice were relatively resistant to cutaneous leishmaniasis, while females frequently developed non-healing expanding ulcers, leading to loss of infected extremities, metastasis to distal skin sites, and in some animals, death. Anti-leishmanial antibody titers were higher, and delayed-type hype...

journal_title：Parasite immunology

authors： Giannini MS

更新日期：1986-01-01 00:00:00

abstract：:In the present study, the cytokines interleukin (IL)-12 and IL-18 were evaluated for their capacity to modulate and to re-direct in vitro parasite antigen-specific cellular responsiveness in patients exposed to Onchocerca volvulus and Entamoeba histolytica infection. We found that IL-18 was highly capable of reducing ...

journal_title：Parasite immunology

authors： Pfaff AW,Kirch AK,Hoffmann WH,Banla M,Schulz-Key H,Geiger SM,Soboslay PT

更新日期：2003-06-01 00:00:00

abstract：:Infective larvae of Toxocara canis are well suited for studies of nematode antigen expression in vitro. Larvae were labelled with 3H-glucosamine, an approach permitting dual analysis of antigen quantity and composition. Their excretory/secretory (E/S) glycoproteins were efficiently labelled and antigen identity confir...

journal_title：Parasite immunology

authors： Williamson HJ,Allardyce RA,Clemett RS,Hidajat RR

更新日期：1990-03-01 00:00:00

abstract：:The role of CD4+ and CD8+ T lymphocytes in the development of a protective immune response against Cryptosporidium muris infection was studied by the reconstitution of severe combined immunodeficient (SCID) mice with well-defined populations of either naive or immune CD8+ or CD4+ T lymphocytes. Adoptive transfer of bo...

journal_title：Parasite immunology

authors： Kváč M,Kodádková A,Sak B,Květoňová D,Jalovecká M,Rost M,Salát J

更新日期：2011-04-01 00:00:00

abstract：:Helper T cell cytokine and antibody responses were investigated in mice after infection with Babesia microti (King strain). Infection of CBA mice with 106 parasitized erythrocytes resulted in the development of a transitory high parasitaemia which peaked 14 days post infection (DPI), and was resolved at 24 DPI. Th1 re...

journal_title：Parasite immunology

authors： Chen D,Copeman DB,Burnell J,Hutchinson GW

更新日期：2000-02-01 00:00:00

abstract：:The protein-energy malnutrition (PEM) and visceral leishmaniasis (VL) are important problems of public health, which affect millions of people worldwide. Currently, it has been accepted that the immunity or susceptibility to infect-parasitic diseases are directly related to the nutritional status of the host. However,...

journal_title：Parasite immunology

authors： Malafaia G

更新日期：2009-10-01 00:00:00

abstract：:Activation of macrophages is a key step in the initiation of immune responses, but the transcriptional mechanisms governing macrophage activation during infection are not fully understood. It was recently shown that the AP-1 family transcription factor JUNB positively regulates macrophage activation in response to Tol...

journal_title：Parasite immunology

authors： Fontana MF,Baccarella A,Kellar D,Oniskey TK,Terinate P,Rosenberg SD,Huang EJ,Herbert DR,Kim CC

更新日期：2015-09-01 00:00:00

abstract：:CBA/J mice are resistant to Leishmania major infection but are permissive to L. amazonensis infection. In addition, CBA/J macrophages control L. major but not L. amazonensis infection in vitro. Phagocytosis by macrophages is known to determine the outcome of Leishmania infection. Pattern recognition receptors (PRR) ad...

journal_title：Parasite immunology

authors： Gomes IN,Palma LC,Campos GO,Lima JG,DE Almeida TF,DE Menezes JP,Ferreira CA,Santos RR,Buck GA,Manque PA,Ozaki LS,Probst CM,DE Freitas LA,Krieger MA,Veras PS

更新日期：2009-04-01 00:00:00

abstract：:An indirect enzyme linked immunsorbent assay (ELISA) for detection of antibodies to Neospora caninum in serum from dogs is described. Extracted tachyzoite proteins incorporated into immunostimulating complexes (iscoms) were used as coating antigen. A mixture of a monoclonal antibody to dog immunoglobulin G and a horse...

journal_title：Parasite immunology

authors： Björkman C,Lundén A,Holmdahl J,Barber J,Trees AJ,Uggla A

更新日期：1994-12-01 00:00:00

abstract：:SUMMARY Previous experiments have shown that genetic resistance to infection by Teladorsagia circumcincta in sheep can be measured by the level of IgA in gastric mucus, jointly with other parameters. The aim of this study has been to observe the influence of IgA on adult worms. The experiment was carried out with Chur...

journal_title：Parasite immunology

authors： Martínez-Valladares M,Vara-Del Río MP,Cruz-Rojo MA,Rojo-Vázquez FA

更新日期：2005-06-01 00:00:00

abstract：:The caecal-dwelling nematode Trichuris muris provides a natural model of human whipworm infection. Resistance to T. muris is dependent on a host Th2 response, and CD4+Th2 cells migrate to the gut-associated lymphoid tissue (GALT) to elicit parasite expulsion. Thus, CD4+T cells infiltrate the caecal lamina propria duri...

journal_title：Parasite immunology

authors： Bell LV,Else KJ

更新日期：2008-03-01 00:00:00

abstract：:Neospora caninum is a cyst-forming coccidian parasite which in cattle can cause abortion and birth of feeble calves. For the serological diagnosis of neosporosis, antibodies directed to the parasite can be demonstrated by ELISA, utilizing N. caninum proteins incorporated into iscoms (immunostimulating complexes) as an...

journal_title：Parasite immunology

authors： Björkman C,Hemphill A

更新日期：1998-02-01 00:00:00