Activated CD8+ T cells contribute to clearance of gastric Cryptosporidium muris infections.

abstract：:Successful endoparasites of mammals must outwit the sophisticated immune systems of their hosts that have evolved to detect and destroy/eradicate them. Many species of helminth parasite can directly or indirectly manipulate host immunity: helminth-derived molecules can suppress or skew activity of many immune cell phe...

journal_title：Parasite immunology

authors： McKay DM

更新日期：2015-06-01 00:00:00

abstract：:Intraperitoneal injection of Trypanosoma brucei AnTat 1.1 into mice of the C3H.He, BALB/c or C57BL/6 strains resulted in impaired immune responses from day 3 onwards, as measured by the reduction in DNA synthesis in spleen cell populations stimulated with concanavalin A (Con-A) in vitro. Adherent cells from the perito...

journal_title：Parasite immunology

authors： Borowy NK,Sternberg JM,Schreiber D,Nonnengasser C,Overath P

更新日期：1990-05-01 00:00:00

abstract：:The impact of intestinal helminth infection, i.e. Ascaris lumbricoides and Trichuris trichiura, on cellular responsiveness and cytokine production was investigated in young adults. Ascaris-specific cellular responsiveness was higher in parasite-free endemic controls than in patients infected with T. trichiura, or A. l...

journal_title：Parasite immunology

authors： Geiger SM,Massara CL,Bethony J,Soboslay PT,Carvalho OS,Corrêa-Oliveira R

更新日期：2002-11-01 00:00:00

abstract：:Dirofilaria immitis is the agent of the heartworm disease in canids and felids, and of pulmonary dirofilariosis in man. Like other filariae, D. immitis harbours endosymbion Wolbachia bacteriae. In this work we analyse the response of specific IgE antibodies against both D. immitis antigens and the Wolbachia surface pr...

journal_title：Parasite immunology

authors： Pou-Barreto C,Quispe-Ricalde MA,Morchón R,Vázquez C,Genchi M,Postigo I,Valladares B,Simón F

更新日期：2008-11-01 00:00:00

abstract：:Fulani and Masaleit, sympatric tribes in eastern Sudan, are characterized by marked differences in susceptibility to Plasmodium falciparum malaria. To determine whether the two tribes differ in the frequency of immunoglobulin GM/KM allotypes, which are associated with immunity to several pathogens, serum samples from ...

journal_title：Parasite immunology

authors： Pandey JP,Nasr A,Rocca KM,Troy-Blomberg M,Elghazali G

更新日期：2007-05-01 00:00:00

abstract：:Previous work has shown that a protein extract enriched for cysteine protease activity (TSBP) prepared from adult Haemonchus contortus using thiol sepharose affinity chromatography confers substantial protection against a single challenge infection. TSBP comprised proteases and other proteins. Here, TSBP were further ...

journal_title：Parasite immunology

authors： Knox DP,Smith SK,Redmond DL,Smith WD

更新日期：2005-04-01 00:00:00

abstract：:Antibody isotype and epitope specificities were examined in sheep immunized with EG95, a protective recombinant vaccine against hydatid disease. All sheep immunized with EG95 as a fusion protein with glutathione S-transferase (GST) produced prominent IgG antibodies against the EG95 portion of the protein. Linear, anti...

journal_title：Parasite immunology

authors： Woollard DJ,Gauci CG,Heath DD,Lightowlers MW

更新日期：1998-11-01 00:00:00

abstract：:Theileria parva is a tick-borne intracellular protozoan of cattle, with obligate sequential differentiation stages in lymphocytes and erythrocytes. Immunity is mediated by cytotoxic T lymphocytes (CTL) that target and clear parasitized lymphocytes but allow persistence of infected erythrocytes, which are required for ...

journal_title：Parasite immunology

authors： McKeever DJ

更新日期：2006-07-01 00:00:00

abstract：:Athymic nude mice of the outbred Zur:ICR-nu and inbred BALB/c strain and scid mice were infected with a cloned human isolate of Giardia lamblia (GS/M-83-H7). Changes in the expression of the major surface epitope of the intestinal trophozoites (characterized by the binding capacity of monoclonal antibody MoAbG10/4) as...

journal_title：Parasite immunology

authors： Gottstein B,Nash TE

更新日期：1991-11-01 00:00:00

abstract：:Very little has been reported comparing resistance to coccidiosis in fast or slow growing broilers, the latter of which are becoming more prevalent in the broiler industry. We examined mRNA expression in the intestines of fast and slow growing broilers following Eimeria infection. We show that by day 13 post-infection...

journal_title：Parasite immunology

authors： Giles T,Sakkas P,Belkhiri A,Barrow P,Kyriazakis I,Foster N

更新日期：2019-09-01 00:00:00

abstract：:Gastrointestinal (GI) nematodes are a group of successful multicellular parasites that have evolved to coexist within the intestinal niche of multiple species. It is estimated that over 10% of the world's population are chronically infected by GI nematodes, making this group of parasitic nematodes a major burden to gl...

journal_title：Parasite immunology

authors： Sharpe C,Thornton DJ,Grencis RK

更新日期：2018-04-01 00:00:00

abstract：:In vitro released products of the adult stage of the bovine lungworm. Dictyocaulus viviparus, were characterized according to their SDS-PAGE profile, glycosylation pattern, in vitro synthesis and antigenicity in the context of infection and vaccination with irradiated larvae. Biosynthetic labelling experiments with 35...

journal_title：Parasite immunology

authors： Britton C,Canto GJ,Urquhart GM,Kennedy MW

更新日期：1993-03-01 00:00:00

abstract：:An attenuated line of Leishmania mexicana (the L. mexicana H-line) has been established by culturing in vitro under gentamicin pressure. BALB/c mice infected with the L. mexicana H-line developed a CD4(+)Th1-like response, indicated by the cytokine profile of their splenocytes stimulated by L. mexicana wild-type (WT) ...

journal_title：Parasite immunology

authors： Daneshvar H,Hagan P,Phillips RS

更新日期：2003-11-01 00:00:00

abstract：:The soluble portion of a large particle fraction which was derived from the muscle larva of T. spiralis was subjected to molecular sizing column chromatography using Sephacryl S-200. Five major peaks of 280 nm absorbing material were obtained. Analysis by immunoelectrophoresis revealed that each peak contained antigen...

journal_title：Parasite immunology

authors： Despommier DD

更新日期：1981-10-01 00:00:00

abstract：:Schistosomiasis poses a serious threat to public health, and the infection will develop into chronic and advanced late-stage disease if not treated. Apart from the clinical signs due to immune reactions to schistosome eggs trapped in host tissues, it also increases the risk for the development of autoimmunity reflecte...

journal_title：Parasite immunology

authors： Wang X,Fu Q,Song R,Duan B,Bergquist R,Xu J,Li S,Zhou D,Qin Z

更新日期：2018-10-01 00:00:00

abstract：:During African trypanosomiasis, macrophages play a central role in T cell hyporesponsiveness to parasite-related and unrelated antigens. In this study, the ability of macrophages from Trypanosoma b. brucei-infected mice to present exogenous antigens to a major histocompatibility complex (MHC) class II-restricted CD4+ ...

journal_title：Parasite immunology

authors： Namangala B,Brys L,Magez S,De Baetselier P,Beschin A

更新日期：2000-07-01 00:00:00

abstract：:Culex pipiens and Aedes aegypti mosquitoes were fed on C3H/HeJ mice and systemic cytokine production was quantified from stimulated lymphocytes harvested four to ten days after feeding. Mosquito feeding on C3H/HeJ mice significantly down regulated IFN gamma production seven to ten days post feeding by Cx. pipiens and ...

journal_title：Parasite immunology

authors： Zeidner NS,Higgs S,Happ CM,Beaty BJ,Miller BR

更新日期：1999-01-01 00:00:00

abstract：:The serodiagnosis of human toxocariasis is difficult. Specific IgGs detected routinely with ELISA based on Toxocara excretory-secretory (TES) antigens often persist for years at an elevated level, which does not allow either the differentiation between an active and persistent infection or monitoring of the effect of ...

journal_title：Parasite immunology

authors： Rudzińska M,Kowalewska B,Sikorska K

更新日期：2017-01-01 00:00:00

abstract：:Activation of macrophages is a key step in the initiation of immune responses, but the transcriptional mechanisms governing macrophage activation during infection are not fully understood. It was recently shown that the AP-1 family transcription factor JUNB positively regulates macrophage activation in response to Tol...

journal_title：Parasite immunology

authors： Fontana MF,Baccarella A,Kellar D,Oniskey TK,Terinate P,Rosenberg SD,Huang EJ,Herbert DR,Kim CC

更新日期：2015-09-01 00:00:00

abstract：:The zoonotic pathogen Toxoplasma gondii infects over 30% of the human population. The intracellular parasite can persist lifelong in the CNS within neurons modifying their function and structure, thus leading to specific behavioural changes of the host. In recent years, several in vitro studies and murine models have ...

journal_title：Parasite immunology

authors： Parlog A,Schlüter D,Dunay IR

更新日期：2015-03-01 00:00:00

abstract：BACKGROUND:Fasciola hepatica causes economically important disease in livestock worldwide. The relevance of this parasitic infection extends beyond its direct consequences due to its immunoregulatory properties. OBJECTIVES:Given the importance of the T helper 1 (Th1) immune response in controlling infections with Myco...

journal_title：Parasite immunology

authors： Naranjo-Lucena A,García-Campos A,Garza-Cuartero L,Britton L,Blanco A,Zintl A,Mulcahy G

更新日期：2020-11-01 00:00:00

abstract：:Hyporesponsiveness induced by Heligmosomoides polygyrus was quantified and the relationship between TGF-beta and inflammation was identified in BALB/c mice. The immune response and pathological changes modified by neutralization of TGF-beta were characterized in vivo. Nine and twelve days following infection, BALB/c m...

journal_title：Parasite immunology

authors： Doligalska M,Rzepecka J,Drela N,Donskow K,Gerwel-Wronka M

更新日期：2006-08-01 00:00:00

abstract：:The present study was designed to investigate the role of neutrophils during the development of Schistosoma japonicum egg granulomas, in C57BL/6 and CBA mice. Laid eggs were implanted into the liver and monoclonal antibody, RB6-8C5, was used to eliminate neutrophils. After daily antibody treatment between days 9 and 1...

journal_title：Parasite immunology

authors： Hirata M,Hara T,Kage M,Fukuma T,Sendo F

更新日期：2002-09-01 00:00:00

abstract：:The kinetics of macrophage activation were compared among inbred strains of mice (C3H, BALB, B6 and B10.A) that are known to differ in their relative resistance to infections with the myotropic strains (Colombian and CL) of Trypanosoma cruzi. The parameters utilized to measure macrophage activation were rapid spreadin...

journal_title：Parasite immunology

authors： Russo M,Starobinas N,Ribeiro-Dos-Santos R,Minoprio P,Eisen H,Hontebeyrie-Joskowicz M

更新日期：1989-07-01 00:00:00

abstract：BACKGROUND:More than 11 million people were estimated to have been infected by Schistosoma japonicum in China before the 1950s. However, few studies have been conducted to evaluate the longitudinal effects of previous schistosome infection (PSI). OBJECTIVE:We aimed to evaluate the association of PSI with fatty liver a...

journal_title：Parasite immunology

authors： Zou ZQ,Liu M,Zhong HQ,Guan GY

更新日期：2021-01-17 00:00:00

abstract：:Naegleria fowleri, a free-living amoeba, is the causative pathogen of primary amoebic meningoencephalitis in humans and experimental mice. N. fowleri is capable of destroying tissues and host cells through lytic necrosis. However, the mechanism by which N. fowleri induces host cell death is unknown. Electron microscop...

journal_title：Parasite immunology

authors： Song KJ,Jang YS,Lee YA,Kim KA,Lee SK,Shin MH

更新日期：2011-07-01 00:00:00

abstract：:Trypanosoma congolense is one of the main species responsible for Animal African Trypanosomosis (AAT). As preventive vaccination strategies for AAT have been unsuccessful so far, investigating the mechanisms underlying vaccine failure has to be prioritized. In T. brucei and T. vivax infections, recent studies revealed...

journal_title：Parasite immunology

authors： Obishakin E,de Trez C,Magez S

更新日期：2014-05-01 00:00:00

abstract：:We demonstrated recently that immunization with recombinant Neospora caninum profilin (rNcPRO) induces limited protection and a regulatory T-cell response in mice. The aim of this study was to evaluate the immune response elicited by rNcPRO in cattle and assess a strategy to enhance its immunogenicity, combining the a...

journal_title：Parasite immunology

authors： Mansilla FC,Quintana ME,Cardoso NP,Capozzo AV

更新日期：2016-11-01 00:00:00

abstract：:Humoral immunity develops in the spleen during blood-stage Plasmodium infection. This elicits parasite-specific IgM and IgG, which control parasites and protect against malaria. Studies in mice have elucidated cells and molecules driving humoral immunity to Plasmodium, including CD4+ T cells, B cells, interleukin (IL)...

journal_title：Parasite immunology

authors： Sebina I,Fogg LG,James KR,Soon MSF,Akter J,Thomas BS,Hill GR,Engwerda CR,Haque A

更新日期：2017-10-01 00:00:00

abstract：:Haemonchus contortus is an economically important parasite that survives the host defense system by modulating the immune response. Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) is secreted by the parasite and the host responds by producing anti-enzyme antibodies. The enzyme inhibits complement cascade, an arm of t...

journal_title：Parasite immunology

authors： Rajan P,Mishra PKK,Joshi P

更新日期：2019-02-01 00:00:00