Abstract：
:The caecal-dwelling nematode Trichuris muris provides a natural model of human whipworm infection. Resistance to T. muris is dependent on a host Th2 response, and CD4+Th2 cells migrate to the gut-associated lymphoid tissue (GALT) to elicit parasite expulsion. Thus, CD4+T cells infiltrate the caecal lamina propria during infection, along with other leucocyte subsets that are not critical for parasite expulsion, such as eosinophils. Trafficking of leucocytes to the GALT has been shown to be dependent on the alpha4beta7/MAdCAM-1 integrin-addressin interaction. However, where inflammation is present, such as during T. muris infection, redundant mechanisms of leucocyte recruitment may also occur in addition to traditional gut-homing interactions. We utilized an anti-integrin/addressin antibody treatment regime to investigate this redundancy in resistant, T. muris-infected C57BL/6 mice. Where only the alpha4beta7/MAdCAM-1 interaction was blocked, mice remained resistant to T. muris infection, making a Th2 response and both CD4+T cells and eosinophils infiltrated the site of infection. However, in the absence of available alpha4beta7 and alpha4beta1, mice became chronically infected with T. muris and mounted a more Th1-biased immune response. Interestingly, CD4+T cells, but not eosinophils, were able to infiltrate the caecum, showing different levels of redundancy between leucocyte subsets during infection.
journal_name
Parasite Immunoljournal_title
Parasite immunologyauthors
Bell LV,Else KJdoi
10.1111/j.1365-3024.2007.01017.xsubject
Has Abstractpub_date
2008-03-01 00:00:00pages
163-70issue
3eissn
0141-9838issn
1365-3024pii
PIM1017journal_volume
30pub_type
杂志文章abstract：:Mice can be immunized to Plasmodium vinckei by repeated infections followed by cure. Such immunity is dependent on CD4 T cells and an architecturally modified spleen, but has little requirement for antibody. Thus, athymic mice can be exposed to P. vinckei and cured, but do not develop immunity. They are resistant to c...
journal_title：Parasite immunology
pub_type： 杂志文章
doi：10.1111/j.1365-3024.1991.tb00548.x
更新日期：1991-09-01 00:00:00
abstract：:The capacity of peritoneal exudate cells (PEC) obtained from mice infected or immunized with Plasmodium berghei to produce reactive oxygen species (ROS) and the biological basis of this response was investigated, using luminol-dependent zymosan-triggered chemiluminescence (CL). CL response of PEC from infected mice in...
journal_title：Parasite immunology
pub_type： 杂志文章
doi：10.1111/j.1365-3024.1987.tb00509.x
更新日期：1987-05-01 00:00:00
abstract：:Leishmania mexicana is the causal agent of cutaneous leishmaniasis in Mexico. Dendritic cells (DC) are one of the host cells of Leishmania parasites. Intracellular microorganisms inhibit host cell apoptosis as a strategy to ensure their survival in infected cells. We have previously shown that Leishmania mexicana prom...
journal_title：Parasite immunology
pub_type： 杂志文章
doi：10.1111/pim.12275
更新日期：2015-11-01 00:00:00
abstract：:The p190 protein (also called MSA1 or MSP1) of the asexual blood stage forms of Plasmodium falciparum, a human malaria vaccine candidate, shows polymorphism between different isolates. Mice were immunized with p190-3, a recombinant protein which contains mostly conserved sequences derived from the p190 protein of the ...
journal_title：Parasite immunology
pub_type： 杂志文章
doi：10.1111/j.1365-3024.1993.tb00592.x
更新日期：1993-03-01 00:00:00
abstract：:Human recombinant tumour necrosis factor (rTNF) enhanced monoclonal IgE-dependent eosinophil-mediated cytotoxicity to schistosomula of Schistosoma japonicum in a dose-dependent manner. The enhancing effect of rTNF was also observed for the antibody-dependent cytotoxicity of a human eosinophilic leukemia cell line, EoL...
journal_title：Parasite immunology
pub_type： 杂志文章
doi：10.1111/j.1365-3024.1992.tb00033.x
更新日期：1992-11-01 00:00:00
abstract：:The kinetics of macrophage activation were compared among inbred strains of mice (C3H, BALB, B6 and B10.A) that are known to differ in their relative resistance to infections with the myotropic strains (Colombian and CL) of Trypanosoma cruzi. The parameters utilized to measure macrophage activation were rapid spreadin...
journal_title：Parasite immunology
pub_type： 杂志文章
doi：10.1111/j.1365-3024.1989.tb00675.x
更新日期：1989-07-01 00:00:00
abstract：:Migration of human peripheral blood granulocytes in response to microfilariae of O. volvulus was demonstrated using modified Boyden chambers. Granulocyte migration was significantly enhanced when microfilariae were preincubated with heat-inactivated immune serum (delta IS), then added to a fresh serum source (P less t...
journal_title：Parasite immunology
pub_type： 杂志文章
doi：10.1111/j.1365-3024.1983.tb00738.x
更新日期：1983-03-01 00:00:00
abstract：:Trichuris muris is an intestinal nematode that invades the colonic epithelium triggering a mucosal inflammation. Vitamin A and its active metabolite retinoic acid are strongly linked with the modulation of gut immune responses. Here, we describe the temporal changes in the expression of aldehyde dehydrogenase (ALDH) e...
journal_title：Parasite immunology
pub_type： 杂志文章
doi：10.1111/pim.12032
更新日期：2013-07-01 00:00:00
abstract：:Antibody isotype and epitope specificities were examined in sheep immunized with EG95, a protective recombinant vaccine against hydatid disease. All sheep immunized with EG95 as a fusion protein with glutathione S-transferase (GST) produced prominent IgG antibodies against the EG95 portion of the protein. Linear, anti...
journal_title：Parasite immunology
pub_type： 杂志文章
doi：10.1046/j.1365-3024.1998.00176.x
更新日期：1998-11-01 00:00:00
abstract：:A number of T cell hybridomas were produced to adult worm homogenate (AWH) antigen of the nematode parasite Heligmosomoides polygyrus. All of the hybridomas were of the H-2d haplotype and could potentially accept antigen in the context of either the Ad or Ed, H-2 molecules. Three types of antigen presentation were obs...
journal_title：Parasite immunology
pub_type： 杂志文章
doi：10.1111/j.1365-3024.1995.tb01021.x
更新日期：1995-05-01 00:00:00
abstract：:SUMMARY Previous experiments have shown that genetic resistance to infection by Teladorsagia circumcincta in sheep can be measured by the level of IgA in gastric mucus, jointly with other parameters. The aim of this study has been to observe the influence of IgA on adult worms. The experiment was carried out with Chur...
journal_title：Parasite immunology
pub_type： 杂志文章
doi：10.1111/j.1365-3024.2005.00769.x
更新日期：2005-06-01 00:00:00
abstract：:The antigenicity of the biosynthetically labelled somatic and excretory/secretory proteins of adult Fasciola hepatica was investigated over 20 weeks of an infection with F. hepatica in sheep. The antibody response was initially detected by ELISA 2 weeks after infection, and was sustained at this level for the remainde...
journal_title：Parasite immunology
pub_type： 杂志文章
doi：10.1111/j.1365-3024.1991.tb00267.x
更新日期：1991-01-01 00:00:00
abstract：:The purpose of this study was to monitor local cytokine responses to Dictyocaulus viviparus in calves during primary infection and re-infection. Bronchoalveolar lavage fluid (BALF) was collected weekly from experimentally infected calves and interleukin-2 (IL-2), IL-4, IL-5, IL-10 and IFN-γ mRNA expression was quantif...
journal_title：Parasite immunology
pub_type： 杂志文章
doi：10.1111/pim.12083
更新日期：2014-02-01 00:00:00
abstract：:Isotype/subclass-specific antibody responses to adult Onchocerca volvulus extract (OvAg) were assessed by both ELISA and immunoblotting for a group of putatively immune individuals (PIs, n = 29) from a hyperendemic area in Ecuador and for a group of infected individuals (INFs, n = 470) from the same regions. As a grou...
journal_title：Parasite immunology
pub_type： 杂志文章
doi：10.1111/j.1365-3024.1995.tb00904.x
更新日期：1995-07-01 00:00:00
abstract：:After several in vitro treatments of a virulent population of Leishmania major with the mutagen, N-methyl-N'-nitro-N-nitrosoguanidine (MNNG), five clones (vir-) were obtained that did not produce cutaneous lesions after subcutaneous injection of 10(6) promastigotes. All the control clones (vir+) obtained from the non-...
journal_title：Parasite immunology
pub_type： 杂志文章
doi：10.1111/j.1365-3024.1987.tb00490.x
更新日期：1987-01-01 00:00:00
abstract：:Trypanosoma congolense is one of the main species responsible for Animal African Trypanosomosis (AAT). As preventive vaccination strategies for AAT have been unsuccessful so far, investigating the mechanisms underlying vaccine failure has to be prioritized. In T. brucei and T. vivax infections, recent studies revealed...
journal_title：Parasite immunology
pub_type： 杂志文章
doi：10.1111/pim.12099
更新日期：2014-05-01 00:00:00
abstract：:Longitudinal cohort studies are important to describe the dynamics of naturally acquired antibody response profiles to defined Plasmodium falciparum malaria antigens relative to clinical malaria episodes. In children under 7 years of age in The Gambia, serum IgG responses were measured to P. falciparum merozoite antig...
journal_title：Parasite immunology
pub_type： 杂志文章
doi：10.1111/j.1365-3024.2009.01193.x
更新日期：2010-04-01 00:00:00
abstract：:Eleven strains of Trypanosoma cruzi, originating from a variety of vertebrate and invertebrate hosts in distinct geographical regions, were examined for the reactivity of metacyclic stages with the monoclonal antibody 1G7. Trypomastigotes of five strains were susceptible to complement-dependent 1G7-mediated lysis. Hig...
journal_title：Parasite immunology
pub_type： 杂志文章
doi：10.1111/j.1365-3024.1988.tb00227.x
更新日期：1988-07-01 00:00:00
abstract：:Intestinal helminth infections are highly prevalent in the developing world, often resulting in chronic infection and inflicting high host morbidity. With the emergence of drug-resistant parasites, a limited number of chemotherapeutic drugs available and stalling vaccine efforts, an increased understanding of antihelm...
journal_title：Parasite immunology
pub_type： 杂志文章,评审
doi：10.1111/pim.12406
更新日期：2017-02-01 00:00:00
abstract：:A 17 kD protein of Necator americanus was isolated by SDS-PAGE and used to raise monospecific antisera in rabbits. ELISA and Western blotting against a range of parasite extracts demonstrated the species specificity of this protein. It is expressed at all stages of the life-cycle, appears to be accumulated through the...
journal_title：Parasite immunology
pub_type： 杂志文章
doi：10.1111/j.1365-3024.1990.tb00953.x
更新日期：1990-05-01 00:00:00
abstract：:To determine the role of T cells and mast cells in intestinal pathology and immune expulsion of intestinal nematodes, worm burdens, goblet cell responses and villus structures were analysed in T- and B-cell-deficient severe combined immunodeficiency (SCID) mice, athymic nu/nu mice and mast cell deficient W/W(v) mice a...
journal_title：Parasite immunology
pub_type： 杂志文章
doi：10.1111/j.1365-3024.2009.01123.x
更新日期：2009-08-01 00:00:00
abstract：:Crude total antigen (CTA) from Leishmania infantum and recombinant antigen K39 (rK39) and recombinant antigen K28 (rK28) were compared using an ELISA for the diagnosis of canine visceral leishmaniosis (CVL). Forty-two blood samples from healthy dogs from a nonendemic area and 80 blood samples from an endemic area for ...
journal_title：Parasite immunology
pub_type： 杂志文章
doi：10.1111/pim.12281
更新日期：2015-12-01 00:00:00
abstract：:Net intestinal fluid movement was measured in immunized and non-immunized rats infected with the enteric stages of the nematode, Trichinella spiralis. Animals were studied 30 min, 5 days and 30 days after receiving infective larvae. Net water movement across the mucosal surface of the gut was measured in vivo by perfu...
journal_title：Parasite immunology
pub_type： 杂志文章
doi：10.1111/j.1365-3024.1979.tb00711.x
更新日期：1979-01-01 00:00:00
abstract：:Successful endoparasites of mammals must outwit the sophisticated immune systems of their hosts that have evolved to detect and destroy/eradicate them. Many species of helminth parasite can directly or indirectly manipulate host immunity: helminth-derived molecules can suppress or skew activity of many immune cell phe...
journal_title：Parasite immunology
pub_type： 杂志文章
doi：10.1111/pim.12160
更新日期：2015-06-01 00:00:00
abstract：:Serum from cats (Felis catus) that were repeatedly infected with Brugia pahangi and had become amicrofilaraemic (mf-ve) was injected intravenously into microfilaraemic (mf+ve) cats. If more than 1 microliter of immune serum per 1000 mf was injected, microfilarial counts fell dramatically within minutes and, in some ca...
journal_title：Parasite immunology
pub_type： 杂志文章
doi：10.1046/j.1365-3024.1996.d01-50.x
更新日期：1996-02-01 00:00:00
abstract：:Changes in phagocytic and adherent cell numbers were compared during the course of infections of mice with Plasmodium yoelii (Py) and P. berghei (Pb) and in vaccinated mice challenged with homologous parasites. Nucleated cells in the spleen increased in number in Py-infected mice and were maximal at the time of recove...
journal_title：Parasite immunology
pub_type： 杂志文章
doi：10.1111/j.1365-3024.1979.tb00696.x
更新日期：1979-04-01 00:00:00
abstract：:We assayed the vaccine potentialities of a recombinant S. bovis-derived glutathione S-transferase (rSb28GST), member of a molecular family already shown to have protective capacities in the S. mansoni and S. japonicum models. Injection of the rSb28GST in Freund's Complete Adjuvant resulted in good specific IgG respons...
journal_title：Parasite immunology
pub_type： 杂志文章
doi：10.1111/j.1365-3024.1994.tb00367.x
更新日期：1994-08-01 00:00:00
abstract：:Particular immunopathological features and their effects on the vascular permeability of different ocular structures were analysed in two dogs naturally infected by Leishmania infantum. The existence of specific anti-Leishmania immunoglobulin G (IgG) in the aqueous humour was confirmed by the ELISA technique. There wa...
journal_title：Parasite immunology
pub_type： 杂志文章
doi：10.1046/j.1365-3024.1996.d01-39.x
更新日期：1996-12-01 00:00:00
abstract：:Infection with Trypanosoma cruzi was established in the reduviid vector, Dipetalogaster maximus, by repeated feedings on mice with high parasitaemias, and metacyclic trypomastigotes (IMT) were collected in insect urine after blood meals. The infectivity of IMT in mice was assessed by placing varying numbers of organis...
journal_title：Parasite immunology
pub_type： 杂志文章
doi：10.1111/j.1365-3024.1990.tb00936.x
更新日期：1990-01-01 00:00:00
abstract：:The soluble portion of a large particle fraction which was derived from the muscle larva of T. spiralis was subjected to molecular sizing column chromatography using Sephacryl S-200. Five major peaks of 280 nm absorbing material were obtained. Analysis by immunoelectrophoresis revealed that each peak contained antigen...
journal_title：Parasite immunology
pub_type： 杂志文章
doi：10.1111/j.1365-3024.1981.tb00405.x
更新日期：1981-10-01 00:00:00
