Testing small molecule analogues of the Acanthocheilonema viteae immunomodulator ES-62 against clinically relevant allergens.

abstract：:Changes in phagocytic and adherent cell numbers were compared during the course of infections of mice with Plasmodium yoelii (Py) and P. berghei (Pb) and in vaccinated mice challenged with homologous parasites. Nucleated cells in the spleen increased in number in Py-infected mice and were maximal at the time of recove...

journal_title：Parasite immunology

authors： Lelchuk R,Taverne J,Agomo PU,Playfair JH

更新日期：1979-04-01 00:00:00

abstract：:The platelets from normal rats interact with microfilariae of Dipetalonema viteae in vitro in the presence of antibodies leading to the killing of the parasite. The antibody involved in this reaction is identified as IgE because the absorption of immune rat serum on anti-rat IgE column or the pretreatment of platelets...

journal_title：Parasite immunology

authors： Haque A,Cuna W,Bonnel B,Capron A,Joseph M

更新日期：1985-09-01 00:00:00

abstract：:Immunization with naked DNA represents an attractive strategy for development of vaccines against a variety of infections including those caused by protozoan parasites. Recently, we have described that immunization with a plasmid containing the trans-sialidase (TS) gene induced protective immunity against Trypanosoma ...

journal_title：Parasite immunology

authors： Pereira-Chioccola VL,Costa F,Ribeirão M,Soares IS,Arena F,Schenkman S,Rodrigues MM

更新日期：1999-02-01 00:00:00

abstract：:Mitogen-activated lymphocytes co-cultured with either purified Trypanosoma cruzi trypomastigotes or the filtrate of trypomastigote suspensions in culture medium manifest a significant decrease in their capacities to express p55 interleukin-2 receptor molecules (p55IL-2R) on their membrane and proliferate. In this stud...

journal_title：Parasite immunology

authors： Kierszenbaum F,Majumder S,Mejia Lopez H,Sztein MB

更新日期：1995-04-01 00:00:00

abstract：:In order to gain insights into the immune response in onchocerciasis during early infection, laboratory-reared calves were infected with 1000 Onchocerca lienalis infective larvae and examined serologically over a period of 508 days. Levels of serum antibodies measured by ELISA against adult worm extract revealed a mul...

journal_title：Parasite immunology

authors： Kuo YM,Bianco AE

更新日期：1995-08-01 00:00:00

abstract：:The ability of Toxoplasma gondii to cause clinical disease in immune-competent and immune-deficient hosts coupled with its ease of use in vitro and availability of murine models has led to its use as a model organism to study how the immune system controls an intracellular infection. This article reviews the studies t...

journal_title：Parasite immunology

authors： Park J,Hunter CA

更新日期：2020-07-01 00:00:00

abstract：:Nitric oxide (NO) plays diverse roles in a variety of pathological processes. We investigated the role of NO in Schistosoma japonicum egg-induced granuloma formation in a mouse hepatic model. Immunohistological analysis revealed that there is the most intense and extensive inducible nitric oxide (iNOS) expression 2 we...

journal_title：Parasite immunology

authors： Hirata M,Hirata K,Kage M,Zhang M,Hara T,Fukuma T

更新日期：2001-06-01 00:00:00

abstract：:The effect of infection and subsequent challenge with Eimeria maxima on the populations of lymphocytes in the small intestine of Light Sussex chickens was assessed by immunohistochemistry. T cells were characterized for CD3, CD4, CD8, TCR1 (gamma delta heterodimer) or TCR2 (alpha beta 1 heterodimer) markers, and B cel...

journal_title：Parasite immunology

authors： Rothwell L,Gramzinski RA,Rose ME,Kaiser P

更新日期：1995-10-01 00:00:00

abstract：:The humoral responses in mice following vaccination with DNA constructs encoding Fasciola hepatica glutathione S-transferase (GST) have been evaluated. GST47 cDNA was subcloned into two DNA vaccine vectors, VR1012 and VR1020, which direct expression to the cytoplasmic and extracellular compartments, respectively. Expr...

journal_title：Parasite immunology

authors： Smooker PM,Steeper KR,Drew DR,Strugnell RA,Spithill TW

更新日期：1999-07-01 00:00:00

abstract：:We have assessed the role of tumour necrosis factor-alpha (TNF) during cutaneous leishmaniasis and demonstrated that significant levels of TNF were released by spleen cells from infected mice after in vitro restimulation with Leishmania major promastigotes. Spleen cells from both genetically resistant and genetically ...

journal_title：Parasite immunology

authors： Moll H,Binöder K,Bogdan C,Solbach W,Röllinghoff M

更新日期：1990-09-01 00:00:00

abstract：:Net intestinal fluid movement was measured in immunized and non-immunized rats infected with the enteric stages of the nematode, Trichinella spiralis. Animals were studied 30 min, 5 days and 30 days after receiving infective larvae. Net water movement across the mucosal surface of the gut was measured in vivo by perfu...

journal_title：Parasite immunology

authors： Castro GA,Hessel JJ,Whalen G

更新日期：1979-01-01 00:00:00

abstract：:Cryptosporidiosis is a zoonotic protozoan disease that affects the gastrointestinal tract of animals and humans. Diarrhoea as the most important indication of the infection leads to high economic losses in livestock industries and is a life threatening infection in immunocompromised individuals. In the absence of the ...

journal_title：Parasite immunology

authors： Askari N,Shayan P,Mokhber-Dezfouli MR,Ebrahimzadeh E,Lotfollahzadeh S,Rostami A,Amininia N,Ragh MJ

更新日期：2016-05-01 00:00:00

abstract：:Nematode parasites cause significant infections in both humans and animals. They are complex, multicellular organisms that present unique challenges for the host, in particular with respect to the recognition of their unusual surface structures by the innate defence system. The innate immune system is now recognized t...

journal_title：Parasite immunology

authors： de Veer MJ,Kemp JM,Meeusen EN

更新日期：2007-01-01 00:00:00

abstract：:An attenuated line of Leishmania mexicana (the L. mexicana H-line) has been established by culturing in vitro under gentamicin pressure. BALB/c mice infected with the L. mexicana H-line developed a CD4(+)Th1-like response, indicated by the cytokine profile of their splenocytes stimulated by L. mexicana wild-type (WT) ...

journal_title：Parasite immunology

authors： Daneshvar H,Hagan P,Phillips RS

更新日期：2003-11-01 00:00:00

abstract：:Specific CD8(-) T-lymphocyte (CTL) activity against Plasmodium pre-erythrocytic stages (P-ES) derived antigens is considered one of the most important mechanisms for malaria protection. Plasmodium vivax is the second most prevalent human malaria parasite species distributed worldwide. Although several CTL epitopes hav...

journal_title：Parasite immunology

authors： Arévalo-Herrera M,Valencia AZ,Vergara J,Bonelo A,Fleischhauer K,González JM,Restrepo JC,López JA,Valmori D,Corradin G,Herrera S

更新日期：2002-03-01 00:00:00

abstract：:The role of MHC class II in the presentation of Heligmosomoides polygyrus antigens has been investigated, using a number of T cell hybridomas produced in A and E positive and negative mice. By using fixed and irradiated antigen presenting cells (APC), further evidence has emerged, to support earlier data, that there c...

journal_title：Parasite immunology

authors： Mason SD,Gustad TR,David CS,Robinson M

更新日期：1996-09-01 00:00:00

abstract：:Lysates of the haematoprotozoa Trypanosoma brucei or Plasmodium berghei stimulated murine peritoneal exudate cells to release a mediator, which suppressed lipoprotein lipase activity in differentiating 3T3-L1 preadipocytes. The parasite-induced mediator suppressed the activity of cell surface lipoprotein lipase up to ...

journal_title：Parasite immunology

authors： Hotez PJ,Le Trang N,Fairlamb AH,Cerami A

更新日期：1984-05-01 00:00:00

abstract：:Peripheral blood eosinophilia, histology of skeletal muscle and brain, and larval recovery were compared between congenitally athymic nude mice (nu/nu) and thymus-bearing heterozygous littermates (nu/+) for 6 weeks following oral infection with Toxocara canis eggs. By comparing patterns of peripheral blood eosinophil ...

journal_title：Parasite immunology

authors： Sugane K,Oshima T

更新日期：1982-09-01 00:00:00

abstract：:In the present study we have investigated and compared in vitro the specific complement (C) activating activity of three metacestode preparations of Echinococcus granulosus. Extracts from hydatid cyst fluid (HCF-ext), protoscoleces (PSC-ext) and hydatid cyst membrane (HCM-ext) activated human C producing C3 conversion...

journal_title：Parasite immunology

authors： Irigoín F,Würzner R,Sim RB,Ferreira AM

更新日期：1996-07-01 00:00:00

abstract：:Golden hamsters (Mesocricetus auratus) infected with Leishmania donovani develop a disease similar to human kala-azar. There is conspicuous hypergammaglobulinaemia and their T cells do not respond to stimulation by parasite antigens. The impairment of the cellular immune response seems to be restricted to parasite ant...

journal_title：Parasite immunology

authors： Rodrigues Júnior V,Da Silva JS,Campos-Neto A

更新日期：1992-01-01 00:00:00

abstract：:Previous work has shown that a protein extract enriched for cysteine protease activity (TSBP) prepared from adult Haemonchus contortus using thiol sepharose affinity chromatography confers substantial protection against a single challenge infection. TSBP comprised proteases and other proteins. Here, TSBP were further ...

journal_title：Parasite immunology

authors： Knox DP,Smith SK,Redmond DL,Smith WD

更新日期：2005-04-01 00:00:00

abstract：:On a B10 (Lshs) genetic background, the development of acquired T cell mediated immunity to Leishmania donovani infection in mice is under H-2 linked genetic control. Following intravenous inoculation of 10(7) amastigotes three phenotypic patterns of recovery have been described: 'early cure' (H-2r,s), 'cure' (H-2b) a...

journal_title：Parasite immunology

authors： Ulczak OM,Blackwell JM

更新日期：1983-09-01 00:00:00

abstract：:The caecal-dwelling nematode Trichuris muris provides a natural model of human whipworm infection. Resistance to T. muris is dependent on a host Th2 response, and CD4+Th2 cells migrate to the gut-associated lymphoid tissue (GALT) to elicit parasite expulsion. Thus, CD4+T cells infiltrate the caecal lamina propria duri...

journal_title：Parasite immunology

authors： Bell LV,Else KJ

更新日期：2008-03-01 00:00:00

abstract：:Immunoprecipitations of in vitro translation products of mRNA from adult Schistosoma mansoni worms with sera from chronically infected mice of 12 inbred strains reveal a strain-dependent heterogeneity in the antibody responses to schistosome antigens. Of the strains tested the response to the 86K antigen was restricte...

journal_title：Parasite immunology

authors： Kee KC,Taylor DW,Cordingley JS,Butterworth AE,Munro AJ

更新日期：1986-11-01 00:00:00

abstract：:Despite the plethora of evidence on the consequences of host nutrition on their immune responses to gastrointestinal parasites, the identity of molecules and mechanisms that drive the manifestations of immunity under nutrient abundance are not yet known. This is partly due to limitations of the methodologies employed ...

journal_title：Parasite immunology

authors： Athanasiadou S,Huntley JF

更新日期：2008-02-01 00:00:00

abstract：:The soluble portion of a large particle fraction which was derived from the muscle larva of T. spiralis was subjected to molecular sizing column chromatography using Sephacryl S-200. Five major peaks of 280 nm absorbing material were obtained. Analysis by immunoelectrophoresis revealed that each peak contained antigen...

journal_title：Parasite immunology

authors： Despommier DD

更新日期：1981-10-01 00:00:00

abstract：:The mechanisms by which antibodies interfere with Plasmodium growth are still under debate. Characterizing the asexual erythrocyte stages susceptible to antibodies from hyperimmune individuals is therefore a relevant contribution to vaccine research. In this study, using a virulent and synchronous murine malaria paras...

journal_title：Parasite immunology

authors： Cavinato RA,Bastos KR,Sardinha LR,Elias RM,Alvarez JM,d'Império Lima MR

更新日期：2001-11-01 00:00:00

abstract：:A comparison of Plasmodium chabaudi AS infection in BALB/c and BALB/c IgM-deficient mice demonstrated a protective role for IgM during infection. IgM-/- mice, unlike microMT mice, display competent B cell humoral immune responses. Increased susceptibility of IgM-/- mice was demonstrated by increased mortality, an adva...

journal_title：Parasite immunology

authors： Couper KN,Phillips RS,Brombacher F,Alexander J

更新日期：2005-05-01 00:00:00

abstract：:The previously observed MHC-restriction of the antibody response to an 86kDa S. mansoni antigen has been investigated in more detail. The I-A locus of the H-2 complex has been implicated as conferring responder or non-responder status on mice expressing the k and b alleles respectively. Inheritance of responsiveness w...

journal_title：Parasite immunology

authors： Schweitzer AN,Taylor DW

更新日期：1991-05-01 00:00:00

abstract：:The natural site of infection for T. gondii is the mucosal surface of the intestine, so the protective immunity obtained after natural infection with T. gondii points to the importance of developing a vaccine that stimulates mucosal defences. In this study, an aroA- and aroD- attenuated strain of Salmonella typhimuriu...

journal_title：Parasite immunology

authors： Cong H,Gu QM,Jiang Y,He SY,Zhou HY,Yang TT,Li Y,Zhao QL

更新日期：2005-01-01 00:00:00