Parasite-specific IgM plays a significant role in the protective immune response to asexual erythrocytic stage Plasmodium chabaudi AS infection.

abstract：:The overall performance of quantitative assays in the detection of anti-Toxoplasma IgG is satisfactory, but discrepancies between assays are not uncommon especially when IgG concentrations are close to the limit of detection of the tests. The purpose of our study was to identify soluble and membrane antigens extracted...

journal_title：Parasite immunology

authors： Khammari I,Saghrouni F,Lakhal S,Bougmiza I,Bouratbine A,Ben Said M,Boukadida J

更新日期：2014-12-01 00:00:00

abstract：:During African trypanosomiasis, macrophages play a central role in T cell hyporesponsiveness to parasite-related and unrelated antigens. In this study, the ability of macrophages from Trypanosoma b. brucei-infected mice to present exogenous antigens to a major histocompatibility complex (MHC) class II-restricted CD4+ ...

journal_title：Parasite immunology

authors： Namangala B,Brys L,Magez S,De Baetselier P,Beschin A

更新日期：2000-07-01 00:00:00

abstract：:The impact of intestinal helminth infection, i.e. Ascaris lumbricoides and Trichuris trichiura, on cellular responsiveness and cytokine production was investigated in young adults. Ascaris-specific cellular responsiveness was higher in parasite-free endemic controls than in patients infected with T. trichiura, or A. l...

journal_title：Parasite immunology

authors： Geiger SM,Massara CL,Bethony J,Soboslay PT,Carvalho OS,Corrêa-Oliveira R

更新日期：2002-11-01 00:00:00

abstract：:The humoral responses in mice following vaccination with DNA constructs encoding Fasciola hepatica glutathione S-transferase (GST) have been evaluated. GST47 cDNA was subcloned into two DNA vaccine vectors, VR1012 and VR1020, which direct expression to the cytoplasmic and extracellular compartments, respectively. Expr...

journal_title：Parasite immunology

authors： Smooker PM,Steeper KR,Drew DR,Strugnell RA,Spithill TW

更新日期：1999-07-01 00:00:00

abstract：:We describe an ELISA for trophozoite-specific IgA in the intestinal secretions of mice infected with Giardia muris. Using this method, trophozoite-specific IgA was demonstrated in intestinal secretions of Giardia-infected immunocompetent BALB/c mice. Such antibody was undetectable in the intestinal secretions of Giard...

journal_title：Parasite immunology

authors： Heyworth MF,Kung JE,Caplin AB

更新日期：1988-11-01 00:00:00

abstract：:Sheep were sensitized by weekly infections with Teladorsagia circumcincta over a 9-week period. After a 12-week rest, sheep were divided into four groups and killed without challenge or 3, 5 and 10 days post challenge (DPC) with 50000 L3. Recovery of challenge larvae from abomasal scrapings was highest at 3 DPC while ...

journal_title：Parasite immunology

authors： Balic A,Bowles VM,Liu YS,Meeusen EN

更新日期：2003-07-01 00:00:00

abstract：:Serum from cats (Felis catus) that were repeatedly infected with Brugia pahangi and had become amicrofilaraemic (mf-ve) was injected intravenously into microfilaraemic (mf+ve) cats. If more than 1 microliter of immune serum per 1000 mf was injected, microfilarial counts fell dramatically within minutes and, in some ca...

journal_title：Parasite immunology

authors： Medeiros F,Baldwin CI,Denham DA

更新日期：1996-02-01 00:00:00

abstract：:Leishmania major causes mild-to-severe cutaneous lesions resulting in significant disfigurations, if untreated. The drugs are toxic, and drug-resistance parasites are emerging. Therefore, a prophylactic vaccination is an urgent need. As no vaccine is available, we compared the genes expressed by virulent and avirulent...

journal_title：Parasite immunology

authors： Zutshi S,Kumar S,Sarode A,Roy S,Sarkar A,Saha B

更新日期：2020-02-01 00:00:00

abstract：:The role of CD4+ and CD8+ T cells in protective immunity to Trichuris muris was studied in CD4+ or CD8+ or both CD4+ and CD8+ T cell-depleted BALB/c mice. To assess in vivo depletion of T-cell subsets, CD4+ and CD8+ T cells in the Peyer's patches, the mesenteric lymph nodes (MLN), and the spleens of mice treated with ...

journal_title：Parasite immunology

authors： Koyama K,Tamauchi H,Ito Y

更新日期：1995-03-01 00:00:00

abstract：:Opisthorchis viverrini infection causes opisthorchiasis and is a risk factor for cholangiocarcinoma via chronic inflammation. To investigate the mechanism of O. viverrini -induced liver disease, we applied a proteomic approach to examine alterations in hepatic protein levels in O. viverrini -infected hamsters. Two-dim...

journal_title：Parasite immunology

authors： Khoontawad J,Wongkham C,Hiraku Y,Yongvanit P,Prakobwong S,Boonmars T,Pinlaor P,Pinlaor S

更新日期：2010-05-01 00:00:00

abstract：:The anti-leishmanial effect of the 'carbohydrate-fraction', isolated from an edible mushroom Astraeus hygrometricus, was evaluated against Leishmania donovani infection both in vitro and in vivo. Ahf-Car induced the expression of inducible nitric oxide synthase 2 (iNOS2) and pro-inflammatory cytokines like TNF-α and I...

journal_title：Parasite immunology

authors： Hussain A,Ghosh S,Roy K,Nath S,Sarkar B,Dutta A,Maji P,Basu S,Paul S,Dey S,Chakraborty K,Raychaudhury B,Acharya K,Ganguly J,Pal C

更新日期：2020-10-31 00:00:00

abstract：:Polyclonal human anti-hydatid antibodies were affinity purified from a hydatid patient serum and used to produce a rabbit anti-idiotypic serum. These anti-Id antibodies cross-reacted in ELISA with sera from 11 of 12 hydatid patients studied and with 13 infected or immunized mice sera. All mice primed and boosted with ...

journal_title：Parasite immunology

authors： Carol H,Hernandez A,Baz A,Nieto A

更新日期：1989-03-01 00:00:00

abstract：:Hyporesponsiveness induced by Heligmosomoides polygyrus was quantified and the relationship between TGF-beta and inflammation was identified in BALB/c mice. The immune response and pathological changes modified by neutralization of TGF-beta were characterized in vivo. Nine and twelve days following infection, BALB/c m...

journal_title：Parasite immunology

authors： Doligalska M,Rzepecka J,Drela N,Donskow K,Gerwel-Wronka M

更新日期：2006-08-01 00:00:00

abstract：:Infective larvae of Toxocara canis are well suited for studies of nematode antigen expression in vitro. Larvae were labelled with 3H-glucosamine, an approach permitting dual analysis of antigen quantity and composition. Their excretory/secretory (E/S) glycoproteins were efficiently labelled and antigen identity confir...

journal_title：Parasite immunology

authors： Williamson HJ,Allardyce RA,Clemett RS,Hidajat RR

更新日期：1990-03-01 00:00:00

abstract：:Parasitic nematodes of the small-ruminant gastrointestinal tract pose a problem worldwide. The impact of these pathogens is worsened by the emergence of anthelmintic resistance to all three available classes of drugs. In addition to causing considerable economic loss, these parasites are detrimental to the health and ...

journal_title：Parasite immunology

authors： McNeilly TN,Devaney E,Matthews JB

更新日期：2009-07-01 00:00:00

abstract：:Male B10 X 129 (10M) ScSn mice were relatively resistant to cutaneous leishmaniasis, while females frequently developed non-healing expanding ulcers, leading to loss of infected extremities, metastasis to distal skin sites, and in some animals, death. Anti-leishmanial antibody titers were higher, and delayed-type hype...

journal_title：Parasite immunology

authors： Giannini MS

更新日期：1986-01-01 00:00:00

abstract：:Chronic Chagas cardiomyopathy (CCC) is responsible for the disease's greater morbidity and poor prognosis. Although understanding the pathophysiology of CCC and the fundamentals of its clinical management derives from research related to other cardiomyopathies, there are peculiarities that distinguish CCC from the oth...

journal_title：Parasite immunology

authors： Chaves AT,Menezes CAS,Costa HS,Nunes MCP,Rocha MOC

更新日期：2019-10-01 00:00:00

abstract：:Leishmania donovani, the causative parasite of Visceral Leishmaniasis (VL), deviously manipulates host monocytes/macrophages to ensure its survival. Although monocytes/macrophages from patients with VL have demonstrated an impaired oxidative burst and antigen presentation, an unanswered yet pertinent question remains ...

journal_title：Parasite immunology

authors： Roy S,Mukhopadhyay D,Mukherjee S,Moulik S,Chatterji S,Brahme N,Pramanik N,Goswami RP,Saha B,Chatterjee M

更新日期：2018-07-01 00:00:00

abstract：:Human toxocariasis is a helminth zoonosis resulting from accidental infection of humans by the roundworms Toxocara canis (T. canis) and cati (T. cati). The infection occurs in five forms: systemic (VLM), ocular, neurological, covert and asymptomatic. The aim of this study was to characterize the radiological and immun...

journal_title：Parasite immunology

authors： Mazur-Melewska K,Jończyk K,Modlińska-Cwalińska A,Figlerowicz M,Służewski W

更新日期：2014-12-01 00:00:00

abstract：:The effect of the humoral immune response on the weight and fecundity of the hookworm Necator americanus was examined in an endemically-infected human population. There was a highly significant negative correlation between total IgE levels and parasite weight and fecundity, after controlling for any effects of host ag...

journal_title：Parasite immunology

authors： Pritchard DI,Quinnell RJ,Walsh EA

更新日期：1995-02-01 00:00:00

abstract：:The zymosan-triggered chemiluminescence response of peritoneal exudate cells from mice infected with relatively virulent or avirulent Toxoplasma gondii strains was examined at various intervals after infection. Toxoplasma infections increased the background chemiluminescence compared with controls, but higher values w...

journal_title：Parasite immunology

authors： Masihi KN,Werner H,Gillert KE,Lange W

更新日期：1984-05-01 00:00:00

abstract：:Hookworms are one of the most prevalent parasites of humans in developing countries, but we know relatively little about the immune response generated to hookworm infection. This can be attributed to a lack of permissive animal models and a relatively small research community compared with those of the more high-profi...

journal_title：Parasite immunology

authors： McSorley HJ,Loukas A

更新日期：2010-08-01 00:00:00

abstract：:An essential element for continuing transmission of Plasmodium falciparum is the availability of mature gametocytes in human peripheral circulation for uptake by mosquitoes. Natural immune responses to circulating gametocytes may play a role in reducing transmission from humans to mosquitoes. Here, antibody recognitio...

journal_title：Parasite immunology

authors： Dinko B,King E,Targett GA,Sutherland CJ

更新日期：2016-06-01 00:00:00

abstract：:We have previously reported the usefulness of a 26-28 kDa coproantigen of Fasciola hepatica for diagnosis of infection. In this study, the 26-28 kDa coproantigen was biochemically characterized with the aid of monoclonal antibodies (MoAb) in an effort to better understand the biology of the antigen. Differential stain...

journal_title：Parasite immunology

authors： Abdel-Rahman S,O'Reilly KL,Malone JB

更新日期：1999-06-01 00:00:00

abstract：:A pilot safety and immunogenicity trial of the malaria vaccine SPf66 was undertaken in The Gambia in 1993. One hundred and fifty infants aged 6-11 months were immunized with either 0.5 mg or 1.0 mg of SPf66 produced either in Colombia or in the USA or with a control vaccine. Children who received SPf66 experienced mor...

journal_title：Parasite immunology

authors： Bojang KA,Obaro SK,Leach A,D'Alessandro U,Bennett S,Metzger W,Ballou WR,Targett GA,Greenwood BM

更新日期：1997-12-01 00:00:00

abstract：:A limiting dilution microculture system was optimized to quantify the frequency of Theileria parva-specific cytotoxic T lymphocyte precursors (CTLp) in peripheral blood mononuclear cells (PBMC) from immune cattle. Optimal results were obtained with responder cell input levels ranging from 2 x 10(4)/well to 6.25 x 10(2...

journal_title：Parasite immunology

authors： Taracha EL,Goddeeris BM,Scott JR,Morrison WI

更新日期：1992-03-01 00:00:00

abstract：:Leishmaniasis has recently garnered attention as one of the diseases 'most neglected' by drug research and development, as the current therapeutic modalities available for the patients are ridden with unacceptable toxicity due to high dosage of the drug, prolonged treatment schedules, resistance and prohibitive costs....

journal_title：Parasite immunology

authors： Joshi J,Kaur S

更新日期：2014-01-01 00:00:00

abstract：:In the present study, the cytokines interleukin (IL)-12 and IL-18 were evaluated for their capacity to modulate and to re-direct in vitro parasite antigen-specific cellular responsiveness in patients exposed to Onchocerca volvulus and Entamoeba histolytica infection. We found that IL-18 was highly capable of reducing ...

journal_title：Parasite immunology

authors： Pfaff AW,Kirch AK,Hoffmann WH,Banla M,Schulz-Key H,Geiger SM,Soboslay PT

更新日期：2003-06-01 00:00:00

abstract：:Schistosomiasis poses a serious threat to public health, and the infection will develop into chronic and advanced late-stage disease if not treated. Apart from the clinical signs due to immune reactions to schistosome eggs trapped in host tissues, it also increases the risk for the development of autoimmunity reflecte...

journal_title：Parasite immunology

authors： Wang X,Fu Q,Song R,Duan B,Bergquist R,Xu J,Li S,Zhou D,Qin Z

更新日期：2018-10-01 00:00:00

abstract：:Neospora caninum is a coccidian parasite of veterinary importance by causing abortion or stillbirth in cattle among other problems in diverse animal species. We assessed an experimental murine model for its suitability to study the immune response to N. caninum infection. Thus, wild-type (wt) C57BL/6 mice and B-cell (...

journal_title：Parasite immunology

authors： Eperon S,Brönnimann K,Hemphill A,Gottstein B

更新日期：1999-05-01 00:00:00