Differential effects of Trypanosoma cruzi on the transcription of the p55IL-2R, c-fos, c-myc and CD69 genes in activated human lymphocytes.

abstract：:E6020 is a synthetic agonist of Toll-like receptor-4 (TLR4). The purpose of this study was to evaluate the effect of different doses of E6020-SE on Trypanosoma cruzi-specific immune responses and its ability to confer protection against acute lethal infection in mice. Forty female BALB/c were infected with 500 trypoma...

journal_title：Parasite immunology

authors： Villanueva-Lizama LE,Cruz-Chan JV,Versteeg L,Teh-Poot CF,Hoffman K,Kendricks A,Keegan B,Pollet J,Gusovsky F,Hotez PJ,Bottazzi ME,Jones KM

更新日期：2020-10-01 00:00:00

abstract：:In modern societies, diseases that are driven by dysregulated immune responses are increasing at an alarming pace, such as inflammatory bowel diseases and diabetes. There is an urgent need to understand these epidemiological trends, which are likely to be driven by the changing environment of the last few decades. The...

journal_title：Parasite immunology

authors： Loke P,Lim YA

更新日期：2015-06-01 00:00:00

abstract：:Levels of intestinal mast cell protease (IMCP) were quantified in serum, gut tissue and in intestinal fluids taken from mice infected with Trichinella spiralis during primary and secondary infections. The ability to generate a mast cell response was dependent on the response phenotype of the mouse strain used. The mas...

journal_title：Parasite immunology

authors： Tuohy M,Lammas DA,Wakelin D,Huntley JF,Newlands GF,Miller HR

更新日期：1990-11-01 00:00:00

abstract：:The effect of the humoral immune response on the weight and fecundity of the hookworm Necator americanus was examined in an endemically-infected human population. There was a highly significant negative correlation between total IgE levels and parasite weight and fecundity, after controlling for any effects of host ag...

journal_title：Parasite immunology

authors： Pritchard DI,Quinnell RJ,Walsh EA

更新日期：1995-02-01 00:00:00

abstract：:We compared the antigenicity of p126 Plasmodium falciparum peptides with predicted antigenic regions identified using the methods described by Garnier et al. (1978) and Chou & Fasman (1974). For this purpose nine different P. falciparum peptides were synthesized in accordance with the deduced amino acid sequence of th...

journal_title：Parasite immunology

authors： Ferreira-da-Cruz Mde F,Giovanni-de-Simone S,Banic DM,Canto-Cavalheiro M,Camus D,Daniel-Ribeiro CT

更新日期：1996-03-01 00:00:00

abstract：:Fasciola hepatica secretes a cathepsin L proteinase that is suggested to play an in vivo role in immunoprotection since the enzyme can cleave host immunoglobulin. In the present report, rabbit anti-cathepsin L IgG was shown to bind to the cathepsin L enzyme and inhibit its ability to cleave IgG molecules. Cathepsin L ...

journal_title：Parasite immunology

authors： Smith AM,Carmona C,Dowd AJ,McGonigle S,Acosta D,Dalton JP

更新日期：1994-06-01 00:00:00

abstract：:The overall performance of quantitative assays in the detection of anti-Toxoplasma IgG is satisfactory, but discrepancies between assays are not uncommon especially when IgG concentrations are close to the limit of detection of the tests. The purpose of our study was to identify soluble and membrane antigens extracted...

journal_title：Parasite immunology

authors： Khammari I,Saghrouni F,Lakhal S,Bougmiza I,Bouratbine A,Ben Said M,Boukadida J

更新日期：2014-12-01 00:00:00

abstract：:We have tested the hypothesis that activation of T cells by exposure to malaria antigens facilitates both de novo HIV infection and viral reactivation and replication. PBMC from malaria-naive HIV-uninfected European donors could be productively infected with HIV following in vitro stimulation with a lysate of Plasmodi...

journal_title：Parasite immunology

authors： Froebel K,Howard W,Schafer JR,Howie F,Whitworth J,Kaleebu P,Brown AL,Riley E

更新日期：2004-05-01 00:00:00

abstract：:Human immunodeficiency virus (HIV) and Plasmodium parasites are pathogens that induce significant perturbation and activation of the immune system. Due to their geographical overlap, there have been concerns that co-infection with the two pathogens may be a factor in the modification of their development, and in the s...

journal_title：Parasite immunology

authors： Rénia L,Potter SM

更新日期：2006-11-01 00:00:00

abstract：:The natural site of infection for T. gondii is the mucosal surface of the intestine, so the protective immunity obtained after natural infection with T. gondii points to the importance of developing a vaccine that stimulates mucosal defences. In this study, an aroA- and aroD- attenuated strain of Salmonella typhimuriu...

journal_title：Parasite immunology

authors： Cong H,Gu QM,Jiang Y,He SY,Zhou HY,Yang TT,Li Y,Zhao QL

更新日期：2005-01-01 00:00:00

abstract：:The ability of Toxoplasma gondii to cause clinical disease in immune-competent and immune-deficient hosts coupled with its ease of use in vitro and availability of murine models has led to its use as a model organism to study how the immune system controls an intracellular infection. This article reviews the studies t...

journal_title：Parasite immunology

authors： Park J,Hunter CA

更新日期：2020-07-01 00:00:00

abstract：:Opisthorchis viverrini infection causes opisthorchiasis and is a risk factor for cholangiocarcinoma via chronic inflammation. To investigate the mechanism of O. viverrini -induced liver disease, we applied a proteomic approach to examine alterations in hepatic protein levels in O. viverrini -infected hamsters. Two-dim...

journal_title：Parasite immunology

authors： Khoontawad J,Wongkham C,Hiraku Y,Yongvanit P,Prakobwong S,Boonmars T,Pinlaor P,Pinlaor S

更新日期：2010-05-01 00:00:00

abstract：:Analysis by one-dimensional (1-D) SDS-PAGE/Western blotting of whole mite extract (larval and adult stages) with sheep sera taken 0-84 days after infection with the sheep scab mite, Psoroptes ovis revealed a progressive IgE antibody response, with a dominant high molecular weight allergen (MW 180 kDa) detected early d...

journal_title：Parasite immunology

authors： Huntley JF,Machell J,Nisbet AJ,Van den Broek A,Chua KY,Cheong N,Hales BJ,Thomas WR

更新日期：2004-08-01 00:00:00

abstract：:The pathogenesis of Acanthamoeba keratitis (AK) is complicated. In our previous studies, TLR4 was found involved in the process of infection by Acanthamoeba in human corneal cells. The purpose of this study was to investigate the role of Toll-like receptor 4 (TLR4) signalling pathway in Wistar rats challenged with Aca...

journal_title：Parasite immunology

authors： Ren MY,Wu XY

更新日期：2011-01-01 00:00:00

abstract：:During African trypanosomiasis, macrophages play a central role in T cell hyporesponsiveness to parasite-related and unrelated antigens. In this study, the ability of macrophages from Trypanosoma b. brucei-infected mice to present exogenous antigens to a major histocompatibility complex (MHC) class II-restricted CD4+ ...

journal_title：Parasite immunology

authors： Namangala B,Brys L,Magez S,De Baetselier P,Beschin A

更新日期：2000-07-01 00:00:00

abstract：:Infections with the nematode Nematospiroides dubius fail to elicit mucosal mast cell (MMC) responses in the intestines of host mice, and suppress MMC responses generated by heterologous infection. Larval N. dubius have the capacity to prime for mastocytosis, and to elicit this response in primed mice during a challeng...

journal_title：Parasite immunology

authors： Dehlawi MS,Wakelin D

更新日期：1988-01-01 00:00:00

abstract：:A protein-lipopolysaccharide complex has previously been postulated as necessary to protect susceptible mice against Salmonella typhimurium infection. Lipopolysaccharide attached to non-specific proteins, bovine serum albumin or methylated BSA, gave a specific delayed-type hypersensitivity (DTH) reaction when injected...

journal_title：Parasite immunology

authors： Plant JE,Wilson BM,Glynn AA

更新日期：1982-07-01 00:00:00

abstract：:Toxoplasma gondii is a worldwide protozoan parasite which causes severe disease in congenitally infected children and in immunocompromised patients. Besides the well-defined cytoplasmic and membrane antigens of tachyzoites, we felt that excreted/secreted antigens could play a major role in the immune response. We firs...

journal_title：Parasite immunology

authors： Darcy F,Deslee D,Santoro F,Charif H,Auriault C,Decoster A,Duquesne V,Capron A

更新日期：1988-09-01 00:00:00

abstract：:The chromadorea abundant larval transcript (ALT) family of proteins contains ALT one of the most studied putative vaccine candidate in experimental filariasis. This study reports the characterization of Wuchereria bancrofti 20/22 (Wb20/22) as a member of chromadorea, the ALT family of proteins from the L3 stage of W. ...

journal_title：Parasite immunology

authors： Aparnaa R,Mahalakshmi N,Harini A,Jeyaprita PJ,Anugraha G,Amdare NP,Khatri VK,Reddy MV,Kaliraj P

更新日期：2014-10-01 00:00:00

abstract：:The platelets from normal rats interact with microfilariae of Dipetalonema viteae in vitro in the presence of antibodies leading to the killing of the parasite. The antibody involved in this reaction is identified as IgE because the absorption of immune rat serum on anti-rat IgE column or the pretreatment of platelets...

journal_title：Parasite immunology

authors： Haque A,Cuna W,Bonnel B,Capron A,Joseph M

更新日期：1985-09-01 00:00:00

abstract：:Serum from cats (Felis catus) that were repeatedly infected with Brugia pahangi and had become amicrofilaraemic (mf-ve) was injected intravenously into microfilaraemic (mf+ve) cats. If more than 1 microliter of immune serum per 1000 mf was injected, microfilarial counts fell dramatically within minutes and, in some ca...

journal_title：Parasite immunology

authors： Medeiros F,Baldwin CI,Denham DA

更新日期：1996-02-01 00:00:00

abstract：:Hyporesponsiveness induced by Heligmosomoides polygyrus was quantified and the relationship between TGF-beta and inflammation was identified in BALB/c mice. The immune response and pathological changes modified by neutralization of TGF-beta were characterized in vivo. Nine and twelve days following infection, BALB/c m...

journal_title：Parasite immunology

authors： Doligalska M,Rzepecka J,Drela N,Donskow K,Gerwel-Wronka M

更新日期：2006-08-01 00:00:00

abstract：:Two monoclonal antibodies against the surface of S. mansoni schistosomula were found to confer significant passive protection to mice (M7B3A, range 28-70%; M22H12C, range 14-58%). No additive effect was observed when both were transferred together. Neither McAb bound to the cercarial surface but both bound to the surf...

journal_title：Parasite immunology

authors： Bickle QD,Andrews BJ,Taylor MG

更新日期：1986-01-01 00:00:00

abstract：:The current study aimed to detect the complement-binding proteins in the excretory-secretory (ES) products of adult filarial parasite Setaria equina (SeqES). Tests for complement activation pathways (CH50 and APH50 ) in normal human serum (NHS) after incubation with SeqES were performed. Quantitative detection of comp...

journal_title：Parasite immunology

authors： Abdel-Latif M

更新日期：2020-02-01 00:00:00

abstract：:In endemic areas, asymptomatic infection by the malaria parasite Plasmodium falciparum was found associated with elevated percentages of human host's mononuclear cell spontaneous in-vitro apoptosis. In Dielmo, a village where malaria is holoendemic, apoptosis was age-and parasite-dependent. In-vitro exposure of periph...

journal_title：Parasite immunology

authors： Balde AT,Aribot G,Tall A,Spiegel A,Roussilhon C

更新日期：2000-06-01 00:00:00

abstract：:The role of CD4+ and CD8+ T lymphocytes in the development of a protective immune response against Cryptosporidium muris infection was studied by the reconstitution of severe combined immunodeficient (SCID) mice with well-defined populations of either naive or immune CD8+ or CD4+ T lymphocytes. Adoptive transfer of bo...

journal_title：Parasite immunology

authors： Kváč M,Kodádková A,Sak B,Květoňová D,Jalovecká M,Rost M,Salát J

更新日期：2011-04-01 00:00:00

abstract：:Factors governing the sensitization or desensitization of basophils and mast cells are discussed. Mathematical models are proposed which illustrate the effects of rising or falling specific or non-specific IgE titres on the tendency of these cells to degranulate. The models presented are consistent with the hypothesis...

journal_title：Parasite immunology

authors： Weltman JK,Senft AW

更新日期：1981-07-01 00:00:00

abstract：:Cyclophosphamide (Cy) is known to produce a marked eosinophilia in mice after antigen challenge. In this study, we studied the effect of Cy on eosinophilia in helminthic infection. Peripheral blood eosinophils were counted in SJL mice following a large dose of Cy injection, infection with Toxocara canis, and both Cy i...

journal_title：Parasite immunology

authors： Sugane K,Oshima T

更新日期：1985-05-01 00:00:00

abstract：:Data from experimental and human cryptosporidiosis have established a major role of specific immunity in the control of Cryptosporidium parvum infection. In this work, alterations in spleen and Peyer's patch (Pp) lymphocytes were investigated in the course of a spontaneously resolutive gut cryptosporidiosis in four-da...

journal_title：Parasite immunology

authors： Mariotte D,Comby E,Brasseur P,Ballet JJ

更新日期：2004-01-01 00:00:00

abstract：:Immunization with naked DNA represents an attractive strategy for development of vaccines against a variety of infections including those caused by protozoan parasites. Recently, we have described that immunization with a plasmid containing the trans-sialidase (TS) gene induced protective immunity against Trypanosoma ...

journal_title：Parasite immunology

authors： Pereira-Chioccola VL,Costa F,Ribeirão M,Soares IS,Arena F,Schenkman S,Rodrigues MM

更新日期：1999-02-01 00:00:00