Functional correlations between mucosal mast cell activity and immunity to Trichinella spiralis in high and low responder mice.

Abstract:

:Levels of intestinal mast cell protease (IMCP) were quantified in serum, gut tissue and in intestinal fluids taken from mice infected with Trichinella spiralis during primary and secondary infections. The ability to generate a mast cell response was dependent on the response phenotype of the mouse strain used. The mast cell response in rapid responder mice (NIH) occurred sooner and was more pronounced than in either intermediate (SWR) and low responder (B1O) mice. This pattern was also reflected in the concentration of IMCP found in various tissues examined. The correlations between IMCP concentrations in blood, and worm expulsion, are discussed.

journal_name

Parasite Immunol

journal_title

Parasite immunology

authors

Tuohy M,Lammas DA,Wakelin D,Huntley JF,Newlands GF,Miller HR

doi

10.1111/j.1365-3024.1990.tb00996.x

subject

Has Abstract

pub_date

1990-11-01 00:00:00

pages

675-85

issue

6

eissn

0141-9838

issn

1365-3024

journal_volume

12

pub_type

杂志文章
  • Effect of nitric oxide synthase inhibition on Schistosoma japonicum egg-induced granuloma formation in the mouse liver.

    abstract::Nitric oxide (NO) plays diverse roles in a variety of pathological processes. We investigated the role of NO in Schistosoma japonicum egg-induced granuloma formation in a mouse hepatic model. Immunohistological analysis revealed that there is the most intense and extensive inducible nitric oxide (iNOS) expression 2 we...

    journal_title:Parasite immunology

    pub_type: 杂志文章

    doi:10.1046/j.1365-3024.2001.00384.x

    authors: Hirata M,Hirata K,Kage M,Zhang M,Hara T,Fukuma T

    更新日期:2001-06-01 00:00:00

  • Genetic control of immunity to Heligmosomoides polygyrus: presentation of promiscuous antigens to parasite-specific T cell hybridomas.

    abstract::The role of MHC class II in the presentation of Heligmosomoides polygyrus antigens has been investigated, using a number of T cell hybridomas produced in A and E positive and negative mice. By using fixed and irradiated antigen presenting cells (APC), further evidence has emerged, to support earlier data, that there c...

    journal_title:Parasite immunology

    pub_type: 杂志文章

    doi:10.1111/j.1365-3024.1996.tb01028.x

    authors: Mason SD,Gustad TR,David CS,Robinson M

    更新日期:1996-09-01 00:00:00

  • Murine Th1 clone defines a 60 kD tachyzoite antigen of Toxoplasma gondii.

    abstract::Toxoplasma gondii-specific murine CD4+ T cell clone 3Tx9 belongs to the Th1 subtype by virtue of secreting high levels of interleukin(IL)-2, interferon-gamma and tumor necrosis factor without producing IL4 and IL10. To characterize the clonal antigen, Toxoplasma lysate-was separated by SDS-PAGE and probed in T cell bl...

    journal_title:Parasite immunology

    pub_type: 杂志文章

    doi:10.1046/j.1365-3024.1997.d01-201.x

    authors: Reichmann G,Dlugonska H,Fischer HG

    更新日期:1997-05-01 00:00:00

  • Regional specialization of the surface of a parasitic nematode.

    abstract::A monoclonal antibody (NIM-M7) has been prepared which reacts with a major surface antigen of adult males and females of Trichinella spiralis. This specificity is only demonstrable when the antigen is liberated by detergent solubilization of surface-labelled worms. When reacted with living adults, on the other hand, N...

    journal_title:Parasite immunology

    pub_type: 杂志文章

    doi:10.1111/j.1365-3024.1986.tb00874.x

    authors: Ortega-Pierres G,Clark NW,Parkhouse RM

    更新日期:1986-11-01 00:00:00

  • Reactivity of stage-specific monoclonal antibody 1G7 with metacyclic trypomastigotes of Trypanosoma cruzi strains: lytic property and 90,000 mol. wt surface antigen polymorphism.

    abstract::Eleven strains of Trypanosoma cruzi, originating from a variety of vertebrate and invertebrate hosts in distinct geographical regions, were examined for the reactivity of metacyclic stages with the monoclonal antibody 1G7. Trypomastigotes of five strains were susceptible to complement-dependent 1G7-mediated lysis. Hig...

    journal_title:Parasite immunology

    pub_type: 杂志文章

    doi:10.1111/j.1365-3024.1988.tb00227.x

    authors: Mortara RA,Araguth MF,Yoshida N

    更新日期:1988-07-01 00:00:00

  • The magnitude of CD4(+) T-cell activation rather than TCR diversity determines the outcome of Leishmania infection in mice.

    abstract::CD4(+) T cells play a critical role in determining the disease outcome in murine cutaneous leishmaniasis, and selective usage of T-cell receptor (TCR) is implied in promoting Leishmania major infection. However, little information is available on TCR usage in Leishmania-specific, IFN-γ-producing CD4(+) T cells. In thi...

    journal_title:Parasite immunology

    pub_type: 杂志文章

    doi:10.1111/j.1365-3024.2010.01268.x

    authors: Xin L,Wanderley JL,Wang Y,Vargas-Inchaustegui DA,Soong L

    更新日期:2011-03-01 00:00:00

  • Development and suppression of a population of late-adhering macrophages in mouse malaria.

    abstract::Changes in phagocytic and adherent cell numbers were compared during the course of infections of mice with Plasmodium yoelii (Py) and P. berghei (Pb) and in vaccinated mice challenged with homologous parasites. Nucleated cells in the spleen increased in number in Py-infected mice and were maximal at the time of recove...

    journal_title:Parasite immunology

    pub_type: 杂志文章

    doi:10.1111/j.1365-3024.1979.tb00696.x

    authors: Lelchuk R,Taverne J,Agomo PU,Playfair JH

    更新日期:1979-04-01 00:00:00

  • Susceptibility of B-cell deficient C57BL/6 (microMT) mice to Neospora caninum infection.

    abstract::Neospora caninum is a coccidian parasite of veterinary importance by causing abortion or stillbirth in cattle among other problems in diverse animal species. We assessed an experimental murine model for its suitability to study the immune response to N. caninum infection. Thus, wild-type (wt) C57BL/6 mice and B-cell (...

    journal_title:Parasite immunology

    pub_type: 杂志文章

    doi:10.1046/j.1365-3024.1999.00223.x

    authors: Eperon S,Brönnimann K,Hemphill A,Gottstein B

    更新日期:1999-05-01 00:00:00

  • Trypanosoma cruzi metacyclic trypomastigotes: neutralization by the stage-specific monoclonal antibody 1G7 and immunogenicity of 90 kD surface antigen.

    abstract::In this study we have investigated the ability of the stage-specific monoclonal antibody (MoAb) 1G7 to neutralize the infectivity of Trypanosoma cruzi metacyclic trypomastigotes (Tulahuen strain). Mice inoculated with metacyclics pre-incubated with 1G7 or the corresponding Fab fragments were found to develop greatly r...

    journal_title:Parasite immunology

    pub_type: 杂志文章

    doi:10.1111/j.1365-3024.1988.tb00256.x

    authors: Araguth MF,Rodrigues MM,Yoshida N

    更新日期:1988-11-01 00:00:00

  • Influence of the HLA class II polymorphism in chronic Chagas' disease.

    abstract::Chagas' disease or American trypanosomiasis due to Trypanosoma cruzi has existed at least since the time of the Inca empire and contributes significantly to cardiovascular morbidity and mortality in several countries of this continent. Due to the fundamental role of human class II molecules polymorphic residues in the...

    journal_title:Parasite immunology

    pub_type: 杂志文章

    doi:

    authors: Fernandez-Mestre MT,Layrisse Z,Montagnani S,Acquatella H,Catalioti F,Matos M,Balbas O,Makhatadze N,Dominguez E,Herrera F,Madrigal A

    更新日期:1998-04-01 00:00:00

  • Antilymphocyte autoantibody in lethal mouse malaria and its suppression by non-lethal malaria.

    abstract::Mice infected with lethal P. berghei or P. yoelii malaria develop anti-lymphocyte autoantibodies less than a week after infection. The autoantibodies are IgM, T-dependent and cytotoxic to a subpopulation of non-T lymphocytes at 37 degrees C in the presence of mouse or guinea-pig complement. Non-lethal P. yoelii and P....

    journal_title:Parasite immunology

    pub_type: 杂志文章

    doi:10.1111/j.1365-3024.1983.tb00742.x

    authors: de Souza JB,Playfair JH

    更新日期:1983-05-01 00:00:00

  • Identification of the complement 9-binding protein in Setaria equina excretory-secretory products.

    abstract::The current study aimed to detect the complement-binding proteins in the excretory-secretory (ES) products of adult filarial parasite Setaria equina (SeqES). Tests for complement activation pathways (CH50 and APH50 ) in normal human serum (NHS) after incubation with SeqES were performed. Quantitative detection of comp...

    journal_title:Parasite immunology

    pub_type: 杂志文章

    doi:10.1111/pim.12686

    authors: Abdel-Latif M

    更新日期:2020-02-01 00:00:00

  • Prospect for an Entamoeba histolytica Gal-lectin-based vaccine.

    abstract::Entamoeba histolytica is the aetiological agent of invasive amoebiasis, the third leading parasitic cause of mortality in the world. The disease can be easily cured by chemotherapy; however, prevention, mainly in the form of vaccination, could greatly decrease the incidence of the disease, and possibly help in its era...

    journal_title:Parasite immunology

    pub_type: 杂志文章,评审

    doi:10.1046/j.1365-3024.2003.00607.x

    authors: Gaucher D,Chadee K

    更新日期:2003-02-01 00:00:00

  • Toxoplasma and schizophrenia.

    abstract::Research on infectious agents as a possible cause of schizophrenia has become prominent in the past decade. Toxoplasma gondii has emerged as a prime candidate for a variety of reasons; (i) many studies have reported that individuals with schizophrenia, compared to controls, have a higher prevalence of antibodies to T....

    journal_title:Parasite immunology

    pub_type: 杂志文章,评审

    doi:10.1111/j.1365-3024.2009.01131.x

    authors: Yolken RH,Dickerson FB,Fuller Torrey E

    更新日期:2009-11-01 00:00:00

  • Naturally acquired antibodies to polymorphic and conserved epitopes of Plasmodium falciparum merozoite surface protein 3.

    abstract::Many studies on the role of merozoite surface protein 3 (MSP3) in immunity against malaria have focused on a conserved section of MSP3. New evidence suggests that polymorphic sequences within MSP3 are under immune selection. We report a detailed analysis of naturally-acquired antibodies to allele-specific and conserve...

    journal_title:Parasite immunology

    pub_type: 杂志文章

    doi:10.1111/j.1365-3024.2007.00951.x

    authors: Osier FH,Polley SD,Mwangi T,Lowe B,Conway DJ,Marsh K

    更新日期:2007-08-01 00:00:00

  • Germinal centre and marginal zone B cells expand quickly in a second Plasmodium chabaudi malaria infection producing mature plasma cells.

    abstract::Antibodies and B cells are critical in the protective immune response to the blood stage of the malaria parasite, Plasmodium chabaudi. However, little is known about the development of memory B cells and their differentiation into plasma cells during infection or after re-infection. Here we have shown that B cells wit...

    journal_title:Parasite immunology

    pub_type: 杂志文章

    doi:10.1111/j.1365-3024.2008.01066.x

    authors: Stephens R,Ndungu FM,Langhorne J

    更新日期:2009-01-01 00:00:00

  • The production of reactive oxygen species in mice infected or immunized with Plasmodium berghei.

    abstract::The capacity of peritoneal exudate cells (PEC) obtained from mice infected or immunized with Plasmodium berghei to produce reactive oxygen species (ROS) and the biological basis of this response was investigated, using luminol-dependent zymosan-triggered chemiluminescence (CL). CL response of PEC from infected mice in...

    journal_title:Parasite immunology

    pub_type: 杂志文章

    doi:10.1111/j.1365-3024.1987.tb00509.x

    authors: Li M,Li YJ

    更新日期:1987-05-01 00:00:00

  • Humoral immune responses in Gambians to Pfs16, an immunodominant, Plasmodium falciparum integral membrane protein.

    abstract::Naturally acquired humoral immune responses to Pfs16, an integral membrane protein expressed in Plasmodium falciparum gametocytes and sporozoites, were investigated in The Gambia. A high prevalence of antibodies to this molecule was detected by peptide ELISA. Ninety-three per cent of the people taking part in a survey...

    journal_title:Parasite immunology

    pub_type: 杂志文章

    doi:10.1046/j.1365-3024.1996.d01-17.x

    authors: Baker DA,Drakeley CJ,Ong CS,Lulat AG,Greenwood BM,Targett GA

    更新日期:1996-10-01 00:00:00

  • Visceral larva migrans syndrome: analysis of serum cytokine levels in children with hepatic lesions confirmed in radiological findings.

    abstract::Human toxocariasis is a helminth zoonosis resulting from accidental infection of humans by the roundworms Toxocara canis (T. canis) and cati (T. cati). The infection occurs in five forms: systemic (VLM), ocular, neurological, covert and asymptomatic. The aim of this study was to characterize the radiological and immun...

    journal_title:Parasite immunology

    pub_type: 杂志文章

    doi:10.1111/pim.12143

    authors: Mazur-Melewska K,Jończyk K,Modlińska-Cwalińska A,Figlerowicz M,Służewski W

    更新日期:2014-12-01 00:00:00

  • Identification of antigenic proteins from Echinostoma caproni (Trematoda) recognized by mouse immunoglobulins M, A and G using an immunoproteomic approach.

    abstract::Antigenic proteins of Echinostoma caproni (Trematoda) against mouse IgM, IgA, IgG, IgG1 and IgG2a were investigated by immunoproteomics. Excretory/secretory products (ESP) of E. caproni separated by two-dimensional (2D) gel electrophoresis were transferred to nitrocellulose membranes and probed with the different mous...

    journal_title:Parasite immunology

    pub_type: 杂志文章

    doi:10.1111/j.1365-3024.2007.01019.x

    authors: Sotillo J,Valero L,Sánchez Del Pino MM,Fried B,Esteban JG,Marcilla A,Toledo R

    更新日期:2008-05-01 00:00:00

  • Suppressive macrophages occurring in murine Trypanosoma brucei infection inhibit T-cell responses in vivo and in vitro.

    abstract::Intraperitoneal injection of Trypanosoma brucei AnTat 1.1 into mice of the C3H.He, BALB/c or C57BL/6 strains resulted in impaired immune responses from day 3 onwards, as measured by the reduction in DNA synthesis in spleen cell populations stimulated with concanavalin A (Con-A) in vitro. Adherent cells from the perito...

    journal_title:Parasite immunology

    pub_type: 杂志文章

    doi:10.1111/j.1365-3024.1990.tb00951.x

    authors: Borowy NK,Sternberg JM,Schreiber D,Nonnengasser C,Overath P

    更新日期:1990-05-01 00:00:00

  • Immune responses of wild birds to emerging infectious diseases.

    abstract::Over the past several decades, outbreaks of emerging infectious diseases (EIDs) in wild birds have attracted worldwide media attention, either because of their extreme virulence or because of alarming spillovers into agricultural animals or humans. The pathogens involved have been found to infect a variety of bird hos...

    journal_title:Parasite immunology

    pub_type: 杂志文章,评审

    doi:10.1111/pim.12191

    authors: Staley M,Bonneaud C

    更新日期:2015-05-01 00:00:00

  • Granulomatous hypersensitivity to Schistosoma mansoni EGG antigens in human schistosomiasis. IV. A role for prostaglandin-induced inhibition of in vitro granuloma formation.

    abstract::The prostaglandins (PG) are known to regulate immune cell function(s) and participate in the progression of both acute and chronic inflammatory reactions. Using an in vitro model of Schistosoma mansoni egg-induced hypersensitivity granulomas, we have delineated the role of immune complexes (IC) in the induction and re...

    journal_title:Parasite immunology

    pub_type: 杂志文章

    doi:10.1111/j.1365-3024.1994.tb00299.x

    authors: Goes AM,Rezende SA,Gazzinelli G,Doughty BL

    更新日期:1994-01-01 00:00:00

  • Dynamic two-photon imaging of the immune response to Toxoplasma gondii infection.

    abstract::Toxoplasma gondii is a highly successful parasite that can manipulate host immune responses to optimize its persistence and spread. As a result, a highly complex relationship exists between T. gondii and the immune system of the host. Advances in imaging techniques, and in particular, the application of two-photon mic...

    journal_title:Parasite immunology

    pub_type: 杂志文章,评审

    doi:10.1111/pim.12161

    authors: Luu L,Coombes JL

    更新日期:2015-03-01 00:00:00

  • Elimination of P. berghei liver stages is independent of Fas (CD95/Apo-I) or perforin-mediated cytotoxicity.

    abstract::Immunization of mammals with irradiated malaria sporozoites protects from a subsequent contact with the parasite. Protective immunity is directed against the pre-erythrocytic stages of the parasite, sporozoites and liver stages. Specific antibodies neutralize part of the infectious sporozoites infected by the mosquito...

    journal_title:Parasite immunology

    pub_type: 杂志文章

    doi:10.1046/j.1365-3024.1997.d01-190.x

    authors: Renggli J,Hahne M,Matile H,Betschart B,Tschopp J,Corradin G

    更新日期:1997-03-01 00:00:00

  • Chemotaxis of human granulocytes toward microfilariae of Onchocerca volvulus.

    abstract::Migration of human peripheral blood granulocytes in response to microfilariae of O. volvulus was demonstrated using modified Boyden chambers. Granulocyte migration was significantly enhanced when microfilariae were preincubated with heat-inactivated immune serum (delta IS), then added to a fresh serum source (P less t...

    journal_title:Parasite immunology

    pub_type: 杂志文章

    doi:10.1111/j.1365-3024.1983.tb00738.x

    authors: King CH,Spagnuolo PJ,Greene BM

    更新日期:1983-03-01 00:00:00

  • Protection induced by vaccinating sheep with a thiol-binding extract of Haemonchus contortus membranes is associated with its protease components.

    abstract::Previous work has shown that a protein extract enriched for cysteine protease activity (TSBP) prepared from adult Haemonchus contortus using thiol sepharose affinity chromatography confers substantial protection against a single challenge infection. TSBP comprised proteases and other proteins. Here, TSBP were further ...

    journal_title:Parasite immunology

    pub_type: 临床试验,杂志文章

    doi:10.1111/j.1365-3024.2005.00750.x

    authors: Knox DP,Smith SK,Redmond DL,Smith WD

    更新日期:2005-04-01 00:00:00

  • Mechanisms of leucocyte recruitment to the inflamed large intestine: redundancy in integrin and addressin usage.

    abstract::The caecal-dwelling nematode Trichuris muris provides a natural model of human whipworm infection. Resistance to T. muris is dependent on a host Th2 response, and CD4+Th2 cells migrate to the gut-associated lymphoid tissue (GALT) to elicit parasite expulsion. Thus, CD4+T cells infiltrate the caecal lamina propria duri...

    journal_title:Parasite immunology

    pub_type: 杂志文章

    doi:10.1111/j.1365-3024.2007.01017.x

    authors: Bell LV,Else KJ

    更新日期:2008-03-01 00:00:00

  • Variation in the cellular localization of host-protective oncospheral antigens in Taenia saginata and Taenia solium.

    abstract::Immunohistochemistry and immunofluorescence with confocal microscopy were used to localize the host-protective antigens of Taenia saginata (TSA9 and TSA18) and Taenia solium (TSOL16, TSOL18 and TSOL45). In nonactivated oncospheres, TSA9 and TSOL45 antigens were found primarily in the cytoplasm of the penetration gland...

    journal_title:Parasite immunology

    pub_type: 杂志文章

    doi:10.1111/j.1365-3024.2010.01230.x

    authors: Jabbar A,Verástegui M,Lackenby JA,Walduck AK,Gauci CG,Gilman RH,Lightowlers MW

    更新日期:2010-09-01 00:00:00

  • Boosting antibody responses to Plasmodium falciparum merozoite antigens in children with highly seasonal exposure to infection.

    abstract::Longitudinal cohort studies are important to describe the dynamics of naturally acquired antibody response profiles to defined Plasmodium falciparum malaria antigens relative to clinical malaria episodes. In children under 7 years of age in The Gambia, serum IgG responses were measured to P. falciparum merozoite antig...

    journal_title:Parasite immunology

    pub_type: 杂志文章

    doi:10.1111/j.1365-3024.2009.01193.x

    authors: Akpogheneta OJ,Dunyo S,Pinder M,Conway DJ

    更新日期:2010-04-01 00:00:00